Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers

Seminars in Radiation Oncology

Volumn 6, Issue 1, 1996, Pages 10-21

  Overgaard, J ^a   Horsman, M R ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RADIOTHERAPY; HUMAN; HYPOXIA; PRIORITY JOURNAL; RADIOSENSITIVITY; REVIEW; SOLID TUMOR; TREATMENT OUTCOME; TUMOR BLOOD FLOW;

EID: 0030069889     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-4296(96)80032-4     Document Type: Article

References (59)

1. Schwarz G über Desensibiliserung gegen Röntgen- und Radiumstrahlen Munchener Medizinische Wochenschrift 24 1909 1 2
2. Schwarz G Merkwürdige Schwankungen der Röntgenempfindlichkeit bein einem und demselben Patienten Wiener Medizinische Wochenschrift 64 1914 2597 2598
3. Müller C Eine neue Behandlungsmethode bösartiger Geschwülste Munchener Medizinische Wochenschrift 28 1910 1490 1493
4. Gray LH Conger AD Ebert M The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy Br J Radiol 26 1953 638 648
5. Thomlinson RH Gray LH The histological structure of some human lung cancers and the possible implications for radiotherapy Br J Cancer 9 1955 539 549
6. Tannock IF The relationship between cell proliferation and the vascular system in a transplanted mouse mammary tumour Br J Cancer 22 1968 258 273
7. Horsman MR Overgaard J Overcoming tumour radiation resistance resulting from acute hypoxia Eur J Cancer 28A 1992 717 718
8. Brown JM Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation Br J Radiol 52 1979 650 656
9. Chaplin DJ Olive PL Durand RE Intermittent blood flow in a murine tumor: radiobiological effects Cancer Res 47 1987 597 601
10. Horsman MR Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours Acta Oncologica 34 1995 571 587
11. Moulder JE Rockwell S Hypoxic fractions of solid tumour Int J Radiat Oncol Biol Phys 10 1984 695 712
12. Horsman MR Khalil AA Nordsmark M Relationship between radiobiological hypoxia in clonogenic tumour cells and direct estimates of tumour oxygenation in a mouse tumour model Radiother Oncol 28 1993 69 71
13. Overgaard J Sensitization of hypoxic tumour cells-clinical experience Int J Radiat Biol 56 1989 801 811
14. Kolstad P Vascularization, oxygen tension, and radiocurability in cancer of the cervix 1963 Scandinavian University Books Oslo
15. Gatenby RA Kessler HB Rosenblum JS Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy Int J Radiat Oncol Biol Phys 14 1988 831 838
16. Höckel M Knoop C Schlenger K Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix Radiother Oncol 26 1993 45 50
17. Nordsmark M Bentzen SM Overgaard J Measurement of human tumour oxygenation status by a polarographic needle electrode Acta Oncologica 33 1994 383 389
18. Du Sault LA The effect of oxygen on the response of spontaneous tumours in mice to radiotherapy Br J Radiol 36 1963 749 754
19. Suit HD Marshall N Woerner D Oxygen, oxygen plus carbon dioxide, and radiation therapy of a mouse mammary carcinoma Cancer 30 1972 1154 1158
20. Siemann DW Hill RP Bush RA The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2; 95% O2) on the in vivo radiation response of a murine sarcoma Int J Radiat Oncol Biol Phys 2 1977 903 911
21. Rojas A Radiosensitization with normobaric oxygen and carbogen Radiother Oncol 20 suppl 1 1991 65 70
22. Grau C Horsman WR Overgaard J Improving the radiation response in a C3H mouse mammary carcinoma by normobaric oxygen and carbogen breathing Int J Radiat Oncol Biol Phys 22 1992 415 419
23. Churchill-Davidson I The oxygen effect in radiotherapy-historical review Frontiers of Radiation Therapeutic Oncology 1 1968 1 15
24. Dische S Anderson PJ Sealy R Carcinoma of the cervix-anaemia, radiotherapy and hyperbaric oxygen Br J Radiol 56 1983 251 255
25. Dische S Hyperbaric oxygen: the Medical Research Council trials and their clinical significance Br J Radiol 51 1979 888 894
26. Henk JM Does hyperbaric oxygen have a future in radiation therapy? Int J Radiat Oncol Biol Phys 7 1981 1125 1128
27. Henk JM Kunkler PB Smith CW Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial Lancet 313 1977 101 103
28. Henk JM Smith CW Radiotherapy and hyperbaric oxygen in head and neck cancer. Interim report of second clinical trial Lancet 313 1977 104 105
29. Watson ER Halnan KE Dische S Hyperbaric oxygen and radiotherapy: A medical research council trial in carcinoma of the cervix Br J Radiol 51 1978 879 887
30. Bergsjø P Kolstad P Clinical trial with atmospheric oxygen breathing during radiotherapy of cancer of the cervix Scand J Clin Lab Invest 106 1968 167 171
31. Rubin P Hanley J Keys HM Carbogen breathing during radiation therapy. The RTOG study Int J Radiat Oncol Biol Phys 5 1979 1963 1970
32. Horsman MR Siemann DW Nordsmark M The combination of nicotinamide and carbogen breathing to improve tumour oxygenation prior to radiation treatment Hogan MC Mathiev-Costello O Poole DC Oxygen Transport to Tissue XVI 1994 Plenum Press New York, NY 635 642
33. Adams GE Cooke MS Electron-affinic sensitization. I. A structural basis for chemical radiosensitizers in bacteria Int J Radiat Biol 15 1969 457 471
34. Adams GE Flockhart IR Smithen CE Electron-affinic sensitization VII: A correlation between structures, oneelectron reduction potentials and efficiencies of some nitroimidazoles as hypoxic cell radiosensitizers Radiat Res 67 1976 9 20
35. Asquith JC Watts ME Patel K Electron-affinic sensitization V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles Radiat Res 60 1974 108 118
36. Overgaard J Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors Oncology Research 6 1994 509 518
37. Dische S Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy Radiother Oncol 3 1985 97 115
38. Congress Proceedings Overgaard J Sand Hansen H Overgaard M The Danish Head and Neck Cancer study group (DAHANCA) randomized trials with hypoxic radiosensitizers in carcinoma of the larynx and pharynx Dewey WC Edington M Fry RJM Radiation Research. A Twentieth-Century Perspective Volume II 1991 ICRR Toronto 573 577
39. Dische S Machin D Chassagne D A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix Radiother Oncol 26 1993 93 103
40. Lee D-J Cosmatos D Marcial VA Results of RTORTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole (SR-2508) with radiotherapy alone for locally advanced head and neck carcinomas Int J Radiat Oncol Biol Phys 32 1995 567 576
41. Overgaard J Overgaard M Nielsen OS A comparative investigation of nimorazole and misonidazole as a hypoxic radiosensitizer in a C3H mammary carcinoma in vivo Br J Cancer 46 1982 904 911
42. Overgaard J Advances in clinical applications of radiobiology: phase III studies of radiosensitizers and novel fractionation schedules Johnson JT Didolkar MS Head and Neck Cancer Volume III 1993 Elsevier Science Publishers Amsterdam 863 869
43. Hirst DG Anemia: A problem or an opportunity in radiotherapy? Int J Radiat Oncol Biol Phys 12 1986 2009 2017
44. suppl 189 Overgaard J The influence of hemoglobin concentration on the response to radiotherapy Scand J Clin Lab Invest 48 1988 49 53
45. Dische S Radiotherapy and anaemia—the clinical experience Radiother Oncol 20 1991 35 40
46. Overgaard J Hansen HS Andersen AP Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the Dahanca 2 study Int J Radiat Oncol Biol Phys 16 1989 1065 1068
47. Dische S Saunders MI Warburton MF Hemoglobin, radiation, morbidity and survival Int J Radiat Oncol Biol Phys 12 1986 1335 1337
48. Bush BS The significance of anemia in clinical radiation therapy Int J Radiat Oncol Biol Phys 12 1986 2047 2050
49. Sealy R Jacobs P Wood L The treatment of tumours by the induction of anemia and irradiation in hyperbaric oxygen Cancer 64 1989 646 652
50. Coleman NC Hypoxia in tumors: A paradigm for the approach to biochemical and physiologic heterogeneity J Nat Cancer Inst 80 1988 310 317
51. Lavey RS Dempsey WH Erythropoietin increased hemoglobin in cancer patients during radiation therapy Int J Radiat Oncol Biol Phys 27 1993 1147 1152
52. Overgaard J Nielsen JE Grau C Tumour oxygen unloading capacity in patients with squamous cell carcinoma in head and neck Int J Radiat Oncol Biol Phys 22 1992 407 410
53. Browman GP Wong G Hodson I Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer New Engl J Med 328 1993 159 163
54. Horsman MR Hypoxia in tumours: Its relevance, identification and modification Beck-Bornholdt HP Current topics in clinical radiobiology of tumours 1993 Springer Verlag Berlin 99 112
55. Horsman MR Chaplin DJ Overgaard J Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells Cancer Res 50 1990 7430 7436
56. Horsman MR Høyer M Honess DJ Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy Radiother Oncol 27 1993 131 139
57. Overgaard J Modification of hypoxia-from Gottwald Schwarz to nicotinamide. Have we learned the lesson? Kogelnik HD Progress in Radio-Oncology V 1995 Monduzzi Editore Bologna 469 475
58. Bentzen SM Radiobiological considerations in the design of clinical trials Radiother Oncol 32 1994 1 11
59. (abstr) Nordsmark M Overgaard M Overgaard J Oxygenation status predicts radiation response in advanced squamous cell carcinoma of head and neck Eur J Cancer 1995