메뉴 건너뛰기




Volumn 75, Issue 4, 1999, Pages 395-405

DNA damage and repair in individual cells: Applications of the comet assay in radiobiology

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

EID: 0032959983     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099140311     Document Type: Review
Times cited : (288)

References (85)
  • 1
    • 0031021024 scopus 로고    scopus 로고
    • The comet assay as a repair test for prenatal diagnosis of Xeroderma pigmentosum and trichothiodystrophy
    • Alapetite, C., Benoit, A., Moustacchi, E. and Sarasin, A., 1997, The comet assay as a repair test for prenatal diagnosis of Xeroderma pigmentosum and trichothiodystrophy. Journal of Investigative Dermatology, 108, 154-159.
    • (1997) Journal of Investigative Dermatology , vol.108 , pp. 154-159
    • Alapetite, C.1    Benoit, A.2    Moustacchi, E.3    Sarasin, A.4
  • 3
    • 0031851548 scopus 로고    scopus 로고
    • Rejoining of DNA single-and double-strand breaks in human white blood cells exposed to ionizing radiation
    • Banáth, J. P., Fushiki, M. and Olive, P. L., 1998, Rejoining of DNA single-and double-strand breaks in human white blood cells exposed to ionizing radiation. International Journal of Radiation Biology, 73, 649-660.
    • (1998) International Journal of Radiation Biology , vol.73 , pp. 649-660
    • Banáth, J.P.1    Fushiki, M.2    Olive, P.L.3
  • 5
    • 0032499298 scopus 로고    scopus 로고
    • Radioresistant MTp53-expressing rat embryo cell transformants exhibit increase DNA-dsb rejoining during exposure to ionising radiation
    • Bristow, R. G., Hu, Q., Jang, A., Chung, S., Peacock, J., Benghimol, S. and Hill, R., 1998, Radioresistant MTp53-expressing rat embryo cell transformants exhibit increase DNA-dsb rejoining during exposure to ionising radiation. Oncogene, 16, 1789-1002.
    • (1998) Oncogene , vol.16 , pp. 1789-11002
    • Bristow, R.G.1    Hu, Q.2    Jang, A.3    Chung, S.4    Peacock, J.5    Benghimol, S.6    Hill, R.7
  • 6
    • 0030961394 scopus 로고    scopus 로고
    • The DNA 'comet assay' as a rapid screening technique to control irradiated food
    • Cerda, H., Delincee, H., Haine, H. and Rupp, H., 1997, The DNA 'comet assay' as a rapid screening technique to control irradiated food. Mutation Research, 375, 167-181.
    • (1997) Mutation Research , vol.375 , pp. 167-181
    • Cerda, H.1    Delincee, H.2    Haine, H.3    Rupp, H.4
  • 8
    • 0027375157 scopus 로고
    • Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
    • Collins, A. R., Duthie, S. J. and Dobson, V. L., 1993, Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis, 14, 1733-1735.
    • (1993) Carcinogenesis , vol.14 , pp. 1733-1735
    • Collins, A.R.1    Duthie, S.J.2    Dobson, V.L.3
  • 10
    • 0017883642 scopus 로고
    • Spectrofluorometric measurement of the binding of ethidium to superhelical DNA from cell nuclei
    • Cook, P. R. and Brazell, I. A., 1978, Spectrofluorometric measurement of the binding of ethidium to superhelical DNA from cell nuclei. European Journal of Biochemistry, 84, 465-477.
    • (1978) European Journal of Biochemistry , vol.84 , pp. 465-477
    • Cook, P.R.1    Brazell, I.A.2
  • 12
    • 0027012915 scopus 로고
    • Single-cell microgel electrophoresis: An in vitro assay of radiosensitivity
    • Deeley, J. O. T. and Moore, J. L., 1992, Single-cell microgel electrophoresis: an in vitro assay of radiosensitivity. British Journal of Radiology, 24S, 65-69.
    • (1992) British Journal of Radiology , vol.24 S , pp. 65-69
    • Deeley, J.O.T.1    Moore, J.L.2
  • 13
    • 0027170754 scopus 로고
    • DNA double-strand break repair deficiency in TK6 and other human B lymphoblast cell lines
    • Evans, H. H., Ricanati, M., Horng, M., Jiang, Q., Mencl, J. and Olive, P. L., 1993, DNA double-strand break repair deficiency in TK6 and other human B lymphoblast cell lines. Radiation Research, 134, 307-315.
    • (1993) Radiation Research , vol.134 , pp. 307-315
    • Evans, H.H.1    Ricanati, M.2    Horng, M.3    Jiang, Q.4    Mencl, J.5    Olive, P.L.6
  • 16
    • 0030317595 scopus 로고    scopus 로고
    • Key morphologic changes and DNA strand breaks in human lymphoid cells: Discriminating apoptosis from necrosis
    • Fairbairn, D. W., Walburger, D. K., Fairbairn, J. J. and O'Neill, K. L., 1996, Key morphologic changes and DNA strand breaks in human lymphoid cells: discriminating apoptosis from necrosis. Scanning, 18, 407-416.
    • (1996) Scanning , vol.18 , pp. 407-416
    • Fairbairn, D.W.1    Walburger, D.K.2    Fairbairn, J.J.3    O'Neill, K.L.4
  • 17
    • 0026738581 scopus 로고
    • Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells
    • Gedik, C. M., Ewen, S. W. and Collins, A. R., 1992, Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells. International Journal of Radiation Biology, 62, 313-320.
    • (1992) International Journal of Radiation Biology , vol.62 , pp. 313-320
    • Gedik, C.M.1    Ewen, S.W.2    Collins, A.R.3
  • 19
    • 0026501421 scopus 로고
    • UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and Xeroderma pigmentosum donors in the comet assay: A potential diagnostic technique
    • Green, M. H., Lowe, J. E. Harcourt, S. A. Akinluvi, P., Rowe, T., Cole, J., Anstey, A. V. and Arlett, C. F., 1992, UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and Xeroderma pigmentosum donors in the comet assay: a potential diagnostic technique. Mutation Research, 273, 137-144.
    • (1992) Mutation Research , vol.273 , pp. 137-144
    • Green, M.H.1    Lowe, J.E.2    Harcourt, S.A.3    Akinluvi, P.4    Rowe, T.5    Cole, J.6    Anstey, A.V.7    Arlett, C.F.8
  • 20
    • 0029819981 scopus 로고    scopus 로고
    • Radiosensitivity, apoptosis and repair of DNA double-strand breaks in radiation-sensitive Chinese hamster ovary cell mutants treated at different dose rates
    • Hu, Q. and Hill, R. P., 1996, Radiosensitivity, apoptosis and repair of DNA double-strand breaks in radiation-sensitive Chinese hamster ovary cell mutants treated at different dose rates. Radiation Research, 146, 636-645.
    • (1996) Radiation Research , vol.146 , pp. 636-645
    • Hu, Q.1    Hill, R.P.2
  • 21
    • 0028821921 scopus 로고
    • Detection of hypoxic fractions in murine tumours by comet assay: Comparison with other techniques
    • Hu, Q., Kavanagh, M., Newcombe, D. and Hill, R. P., 1995, Detection of hypoxic fractions in murine tumours by comet assay: comparison with other techniques. Radiation Research, 144, 266-275.
    • (1995) Radiation Research , vol.144 , pp. 266-275
    • Hu, Q.1    Kavanagh, M.2    Newcombe, D.3    Hill, R.P.4
  • 22
    • 0030758934 scopus 로고    scopus 로고
    • Elevated frequency of p53-independent apoptosis after irradiation increases levels of DNA breaks in ataxia telangiectasia lymphoblasts
    • Humar, B., Muller, H. and Scott, R. J., 1997, Elevated frequency of p53-independent apoptosis after irradiation increases levels of DNA breaks in ataxia telangiectasia lymphoblasts. International Journal of Radiation Biology, 72, 257-269.
    • (1997) International Journal of Radiation Biology , vol.72 , pp. 257-269
    • Humar, B.1    Muller, H.2    Scott, R.J.3
  • 23
    • 0026087508 scopus 로고
    • Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: Calibration by means of 1251 decay
    • Iliakis, G. E., Ciciloni, O. and Metzger, L., 1991, Measurement of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibration by means of 1251 decay. International Journal of Radiation Biology, 59, 343-357.
    • (1991) International Journal of Radiation Biology , vol.59 , pp. 343-357
    • Iliakis, G.E.1    Ciciloni, O.2    Metzger, L.3
  • 24
    • 0027243442 scopus 로고
    • Single-cell gel technique supports hit probability calculations
    • Jostes, R. F., Hui, T. E. and Cross, F. T., 1993, Single-cell gel technique supports hit probability calculations. Health Physics, 64, 675-679.
    • (1993) Health Physics , vol.64 , pp. 675-679
    • Jostes, R.F.1    Hui, T.E.2    Cross, F.T.3
  • 25
    • 0030575556 scopus 로고    scopus 로고
    • The alkaline comet test on plant cells: A new genotoxicity test for DNA strand breaks in Vicia faba root cells
    • Koppen, G. and Verschaeve, L., 1996, The alkaline comet test on plant cells: a new genotoxicity test for DNA strand breaks in Vicia faba root cells. Mutation Research, 360, 193-200.
    • (1996) Mutation Research , vol.360 , pp. 193-200
    • Koppen, G.1    Verschaeve, L.2
  • 26
    • 0029187206 scopus 로고
    • Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells
    • Lai, H. and Singh, N. P., 1995, Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics, 16, 207-210.
    • (1995) Bioelectromagnetics , vol.16 , pp. 207-210
    • Lai, H.1    Singh, N.P.2
  • 27
    • 0031776788 scopus 로고    scopus 로고
    • Kinetics of DNA strand breaks and protection by antioxidants in UVA-or UVB-irradiated HaCaT keratinocytes using the single cell gel electrophoresis assay
    • Lehmann, J., Pollet, D., Peker, S., Steinkraus, V. and Hoppe, U., 1998, Kinetics of DNA strand breaks and protection by antioxidants in UVA-or UVB-irradiated HaCaT keratinocytes using the single cell gel electrophoresis assay. Mutation Research, 407, 97-108.
    • (1998) Mutation Research , vol.407 , pp. 97-108
    • Lehmann, J.1    Pollet, D.2    Peker, S.3    Steinkraus, V.4    Hoppe, U.5
  • 28
    • 0031833665 scopus 로고    scopus 로고
    • DNA damage in rat brain cells after in vivo exposure to 2450 MHz electromagnetic radiation and various methods of euthanasia
    • Malyapa, R. S., Ahern, E. W., Bi, C., Straube, W. L., Laregina, M., Pickard, W. F. and Roti Roti, J. L., 1998b, DNA damage in rat brain cells after in vivo exposure to 2450 MHz electromagnetic radiation and various methods of euthanasia. Radiation Research, 149, 637-645.
    • (1998) Radiation Research , vol.149 , pp. 637-645
    • Malyapa, R.S.1    Ahern, E.W.2    Bi, C.3    Straube, W.L.4    Laregina, M.5    Pickard, W.F.6    Roti Roti, J.L.7
  • 29
    • 0031922151 scopus 로고    scopus 로고
    • Detection of DNA damage by the alkaline comet assay after exposure to low-dose gamma radiation
    • Malyapa, R. S., Bi, C., Ahern, E. W. and Roti Roti, J. L., 1998a, Detection of DNA damage by the alkaline comet assay after exposure to low-dose gamma radiation. Radiation Research, 149, 396-400.
    • (1998) Radiation Research , vol.149 , pp. 396-400
    • Malyapa, R.S.1    Bi, C.2    Ahern, E.W.3    Roti Roti, J.L.4
  • 30
    • 0031929914 scopus 로고    scopus 로고
    • The ratio of initial/residual DNA damage predicts intrinsic radiosensitivity in seven cervix carcinoma cell lines
    • Marples, B., Longhurst, D., Eastham, A. M. and West, C. M., 1998, The ratio of initial/residual DNA damage predicts intrinsic radiosensitivity in seven cervix carcinoma cell lines. British Journal of Cancer, 77, 1108-1114.
    • (1998) British Journal of Cancer , vol.77 , pp. 1108-1114
    • Marples, B.1    Longhurst, D.2    Eastham, A.M.3    West, C.M.4
  • 31
    • 0031021258 scopus 로고    scopus 로고
    • Delayed repair of DNA damage by ionising radiation in cells from patients with juvenile systemic lupus erythematosus and rheumatoid arthritis
    • McCurdy, D., Tail, L. Q., Frias, S. and Wang, Z., 1997, Delayed repair of DNA damage by ionising radiation in cells from patients with juvenile systemic lupus erythematosus and rheumatoid arthritis. Radiation Research, 147, 48-51.
    • (1997) Radiation Research , vol.147 , pp. 48-51
    • McCurdy, D.1    Tail, L.Q.2    Frias, S.3    Wang, Z.4
  • 33
    • 0031962281 scopus 로고    scopus 로고
    • Emerging applications of the single cell gel electrophoresis (comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individuals
    • McKelvey-Martin, V. J., Ho, E. T., McKeown, S. R., Johnston, S. R., McCarthy, P. J., Rajab, N. F. and Downes, C. S., 1998, Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization Comets for the identification of damaged and repaired DNA sequences in individuals. Mutagenesis, 13, 1-8.
    • (1998) Mutagenesis , vol.13 , pp. 1-8
    • McKelvey-Martin, V.J.1    Ho, E.T.2    McKeown, S.R.3    Johnston, S.R.4    McCarthy, P.J.5    Rajab, N.F.6    Downes, C.S.7
  • 34
    • 0031282214 scopus 로고    scopus 로고
    • Impact of nicotinamide on human tumour hypoxic fraction measured using the comet assay
    • McLaren, D. B., Pickles, T., Thomson, T. and Olive, P. L., 1997, Impact of nicotinamide on human tumour hypoxic fraction measured using the comet assay. Radiotherapy and Oncology, 45, 175-182.
    • (1997) Radiotherapy and Oncology , vol.45 , pp. 175-182
    • McLaren, D.B.1    Pickles, T.2    Thomson, T.3    Olive, P.L.4
  • 35
    • 0029101757 scopus 로고
    • Comet assay reveals DNA strand breaks induced by ultrasonic cavitation in vivo
    • Miller, D. L., Thomas, R. M. and Buschbom, R. L., 1995, Comet assay reveals DNA strand breaks induced by ultrasonic cavitation in vivo. Ultrasound in Medicine and Biology, 21, 841-848.
    • (1995) Ultrasound in Medicine and Biology , vol.21 , pp. 841-848
    • Miller, D.L.1    Thomas, R.M.2    Buschbom, R.L.3
  • 36
    • 0031011238 scopus 로고    scopus 로고
    • Radiation-induced DNA damage in tumours and normal tissues. IV. Influence of proliferation status and cell type on the formation of oxygen-dependent DNA damage in cultured cells
    • Miyaga, Y., Zhang, H. and Wheeler, K. T., 1997, Radiation-induced DNA damage in tumours and normal tissues. IV. Influence of proliferation status and cell type on the formation of oxygen-dependent DNA damage in cultured cells. Radiation Research, 148, 29-34.
    • (1997) Radiation Research , vol.148 , pp. 29-34
    • Miyaga, Y.1    Zhang, H.2    Wheeler, K.T.3
  • 38
    • 0030935764 scopus 로고    scopus 로고
    • DNA double-strand break distributions in x-ray and alpha-particle irradiated V79 cells: Evidence for non-random breakage
    • Newman, H. C., Prise, K. M., Folkard, M. and Michael, B. D., 1997, DNA double-strand break distributions in x-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage. International Journal of Radiation Biology, 71, 347-363.
    • (1997) International Journal of Radiation Biology , vol.71 , pp. 347-363
    • Newman, H.C.1    Prise, K.M.2    Folkard, M.3    Michael, B.D.4
  • 39
    • 0029991677 scopus 로고    scopus 로고
    • Comet assay demonstrates a higher ultraviolet B sensitivity to DNA damage in dysplastic nevus cells than in common melanocytic nevus cells and foreskin melanocytes
    • Noz, K. C., Bauwens, M., van Buul, P. P., Vrolijk, H., Schothorst, A. A., Pavel, S., Tanke, H. J. and Vermeer, B. J., 1996, Comet assay demonstrates a higher ultraviolet B sensitivity to DNA damage in dysplastic nevus cells than in common melanocytic nevus cells and foreskin melanocytes. Journal of Investigative Dermatology, 196, 1198-1202.
    • (1996) Journal of Investigative Dermatology , vol.196 , pp. 1198-1202
    • Noz, K.C.1    Bauwens, M.2    Van Buul, P.P.3    Vrolijk, H.4    Schothorst, A.A.5    Pavel, S.6    Tanke, H.J.7    Vermeer, B.J.8
  • 40
    • 0024544297 scopus 로고
    • Cell proliferation as a requirement for development of the contact effect in Chinese hamster V79 spheroids
    • Olive, P. L., 1989, Cell proliferation as a requirement for development of the contact effect in Chinese hamster V79 spheroids. Radiation Research, 117, 79-92.
    • (1989) Radiation Research , vol.117 , pp. 79-92
    • Olive, P.L.1
  • 41
    • 0028986423 scopus 로고
    • Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine
    • Olive, P. L., 1995a, Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine. British Journal of Cancer, 71, 529-536.
    • (1995) British Journal of Cancer , vol.71 , pp. 529-536
    • Olive, P.L.1
  • 42
    • 0028923172 scopus 로고
    • Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to the bioreductive drugs. II. RSU-1069
    • Olive, P. L., 1995b, Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to the bioreductive drugs. II. RSU-1069. British Journal of Cancer, 71, 537-542.
    • (1995) British Journal of Cancer , vol.71 , pp. 537-542
    • Olive, P.L.1
  • 43
    • 0031742958 scopus 로고    scopus 로고
    • The role of DNA single-and double-strand breaks in cell killing by ionising radiation
    • Olive, P. L., 1998, The role of DNA single-and double-strand breaks in cell killing by ionising radiation. Radiation Research, 150, S42-S51.
    • (1998) Radiation Research , vol.150
    • Olive, P.L.1
  • 45
    • 0027358748 scopus 로고
    • Induction and rejoining of radiation induced DNA single-strand breaks: 'Tail moment' as a function of position in the cell cycle
    • Olive, P. L. and Banáth, J. P., 1993b, Induction and rejoining of radiation induced DNA single-strand breaks: 'tail moment' as a function of position in the cell cycle. Mutation Research (DNA Repair), 294, 275-283.
    • (1993) Mutation Research (DNA Repair) , vol.294 , pp. 275-283
    • Olive, P.L.1    Banáth, J.P.2
  • 46
    • 0028884765 scopus 로고
    • Sizing highly fragmented DNA in individual apoptotic cells using the comet assay and a DNA crosslinking agent
    • Olive, P. L. and Banáth, J. P., 1995a, Sizing highly fragmented DNA in individual apoptotic cells using the comet assay and a DNA crosslinking agent. Experimental Cell Research, 221, 19-26.
    • (1995) Experimental Cell Research , vol.221 , pp. 19-26
    • Olive, P.L.1    Banáth, J.P.2
  • 47
    • 0028968957 scopus 로고
    • Radiation-induced DNA double-strand breaks produced in histone-depleted nuclei measured using the neutral comet assay
    • Olive, P. L. and Banáth, J. P., 1995b, Radiation-induced DNA double-strand breaks produced in histone-depleted nuclei measured using the neutral comet assay. Radiation Research, 142, 144-152.
    • (1995) Radiation Research , vol.142 , pp. 144-152
    • Olive, P.L.1    Banáth, J.P.2
  • 48
    • 0031454075 scopus 로고    scopus 로고
    • Multicell spheroid response to drugs predicted with the comet assay
    • Olive, P. L. and Banáth, J. P., 1997, Multicell spheroid response to drugs predicted with the comet assay. Cancer Research, 57, 5528-5533.
    • (1997) Cancer Research , vol.57 , pp. 5528-5533
    • Olive, P.L.1    Banáth, J.P.2
  • 49
    • 0025270234 scopus 로고
    • Heterogeneity in radiation-induced DNA damage and repair in tumour and normal cells measured using the 'comet' assay
    • Olive, P. L., Banáth, J. P. and Durand, R. E., 1990, Heterogeneity in radiation-induced DNA damage and repair in tumour and normal cells measured using the 'comet' assay. Radiation Research, 122, 69-72.
    • (1990) Radiation Research , vol.122 , pp. 69-72
    • Olive, P.L.1    Banáth, J.P.2    Durand, R.E.3
  • 50
    • 0026659839 scopus 로고
    • Detection of hypoxic cells in a murine tumour with the use of the comet assay
    • Olive, P. L. and Durand, R. E., 1992, Detection of hypoxic cells in a murine tumour with the use of the comet assay. Journal of the National Cancer Institute, 85, 707-711.
    • (1992) Journal of the National Cancer Institute , vol.85 , pp. 707-711
    • Olive, P.L.1    Durand, R.E.2
  • 52
    • 0027534567 scopus 로고
    • Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers
    • Olive, P. L., Durand, R. E., Le Riche, J., Olivotto, I. and Jackson, S. M., 1993b, Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Research, 53, 733-736.
    • (1993) Cancer Research , vol.53 , pp. 733-736
    • Olive, P.L.1    Durand, R.E.2    Le Riche, J.3    Olivotto, I.4    Jackson, S.M.5
  • 53
    • 0026592534 scopus 로고
    • Factors influencing DNA migration from individual cells subjected to gel electrophoresis
    • Olive, P. L., Durand, R. E., Wlodek, D. and Banath, J. P., 1992, Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Experimental Cell Research, 198, 259-267.
    • (1992) Experimental Cell Research , vol.198 , pp. 259-267
    • Olive, P.L.1    Durand, R.E.2    Wlodek, D.3    Banath, J.P.4
  • 54
    • 0027423615 scopus 로고
    • Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay
    • Olive, P. L., Frazer, G. and Banáth, J. P., 1993a, Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay. Radiation Research, 136, 130-136.
    • (1993) Radiation Research , vol.136 , pp. 130-136
    • Olive, P.L.1    Frazer, G.2    Banáth, J.P.3
  • 55
    • 0030818472 scopus 로고    scopus 로고
    • Detection of hypoxic cells in a C3H mouse mammary carcinoma using the comet assay
    • Olive, P. L., Horsman, M., Grau, C. and Overgaard, J., 1997. Detection of hypoxic cells in a C3H mouse mammary carcinoma using the comet assay. British Journal of Cancer, 76, 694-699.
    • (1997) British Journal of Cancer , vol.76 , pp. 694-699
    • Olive, P.L.1    Horsman, M.2    Grau, C.3    Overgaard, J.4
  • 56
    • 0031306970 scopus 로고    scopus 로고
    • DNA damage from oxidants: Lesion complexity and chromatin organization
    • Olive, P. L. and Johnston, P. J., 1997, DNA damage from oxidants: lesion complexity and chromatin organization. Oncology Research, 9, 287-294.
    • (1997) Oncology Research , vol.9 , pp. 287-294
    • Olive, P.L.1    Johnston, P.J.2
  • 57
    • 0031939561 scopus 로고    scopus 로고
    • The comet assay: A new method to examine heterogencity associated with solid tumours
    • Olive, P. L., Johnston, P. J., Banáth, J. P. and Durand, R. E., 1998. The comet assay: a new method to examine heterogencity associated with solid tumours. Nature Medicine., 4, 103-105.
    • (1998) Nature Medicine , vol.4 , pp. 103-105
    • Olive, P.L.1    Johnston, P.J.2    Banáth, J.P.3    Durand, R.E.4
  • 58
    • 0028048029 scopus 로고
    • Lack of correlation between DNA double-strand break induction/rejoining and radiosensitivity in six human tumour cell lines
    • Olive, P. L, MacPhail, S. H. and Banáth, J. P., 1994a, Lack of correlation between DNA double-strand break induction/rejoining and radiosensitivity in six human tumour cell lines. Cancer Research, 54, 3939-3946.
    • (1994) Cancer Research , vol.54 , pp. 3939-3946
    • Olive, P.L.1    MacPhail, S.H.2    Banáth, J.P.3
  • 59
    • 0029740039 scopus 로고    scopus 로고
    • Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumours in mice
    • Olive, P. L., Vikse, C. M. and Banáth, J. P., 1996, Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumours in mice. Cancer Research, 56, 4460-4463.
    • (1996) Cancer Research , vol.56 , pp. 4460-4463
    • Olive, P.L.1    Vikse, C.M.2    Banáth, J.P.3
  • 61
    • 0025988295 scopus 로고
    • DNA double-strand breaks measured in individual cells subjected to gel electrophoresis
    • Olive, P. L., Wlodek, D. and Banáth, J. P, 1991, DNA double-strand breaks measured in individual cells subjected to gel electrophoresis. Cancer Research, 51, 1071-4676.
    • (1991) Cancer Research , vol.51 , pp. 1071-4676
    • Olive, P.L.1    Wlodek, D.2    Banáth, J.P.3
  • 62
    • 0021193203 scopus 로고
    • Microelectrophoretic study of radiation-induced DNA damage in individual mammalian cells
    • Ostling, O. and Johanson, K. J., 1984, Microelectrophoretic study of radiation-induced DNA damage in individual mammalian cells. Biochemical and Biophysical Research Communications, 123, 291-298.
    • (1984) Biochemical and Biophysical Research Communications , vol.123 , pp. 291-298
    • Ostling, O.1    Johanson, K.J.2
  • 63
    • 0023640885 scopus 로고
    • Bleomycin, in contrast to gamma irradiation, induces extreme variation of DNA strand breakage from cell to cell
    • Ostling, O. and Johanson, K. J., 1987, Bleomycin, in contrast to gamma irradiation, induces extreme variation of DNA strand breakage from cell to cell. International Journal of Radiation Biology, 52, 683-691.
    • (1987) International Journal of Radiation Biology , vol.52 , pp. 683-691
    • Ostling, O.1    Johanson, K.J.2
  • 64
    • 0030012151 scopus 로고    scopus 로고
    • Detection of DNA-crosslinking agents with the alkaline comet assay
    • Pfuhler, S. and Wolf, H. U., 1996, Detection of DNA-crosslinking agents with the alkaline comet assay. Environmental and Molecular Mutagenesis, 27, 196-201.
    • (1996) Environmental and Molecular Mutagenesis , vol.27 , pp. 196-201
    • Pfuhler, S.1    Wolf, H.U.2
  • 65
    • 0028957970 scopus 로고
    • DNA strand break rejoining defect in xrs-6 is complemented by transfection with the human Ku80 gene
    • Ross, G. M., Eady, J. J., Mithal, N. P., Bush, C., Steel, G. G., Jeggo, P. A. and McMillan, T. J., 1995, DNA strand break rejoining defect in xrs-6 is complemented by transfection with the human Ku80 gene. Cancer Research, 55, 1235-1238.
    • (1995) Cancer Research , vol.55 , pp. 1235-1238
    • Ross, G.M.1    Eady, J.J.2    Mithal, N.P.3    Bush, C.4    Steel, G.G.5    Jeggo, P.A.6    McMillan, T.J.7
  • 66
    • 0023228268 scopus 로고
    • Visualization of DNA loops in nucleoids from HeLa cells: Assays for DNA damage and repair
    • Roti Roti, J. L. and Wright, W. D., 1987, Visualization of DNA loops in nucleoids from HeLa cells: assays for DNA damage and repair. Cytometry, 8, 461-467.
    • (1987) Cytometry , vol.8 , pp. 461-467
    • Roti Roti, J.L.1    Wright, W.D.2
  • 67
    • 0021711867 scopus 로고
    • Detection of DNA strand breaks in single cells using flow cytometry
    • Rydberg, B., 1984, Detection of DNA strand breaks in single cells using flow cytometry. International Journal of Radiation Biology, 46, 521-527.
    • (1984) International Journal of Radiation Biology , vol.46 , pp. 521-527
    • Rydberg, B.1
  • 68
    • 0030023098 scopus 로고    scopus 로고
    • Clusters of DNA damage induced by ionising radiation: Formation of short DNA fragments. II. Experimental detection
    • Rydberg, B., 1996, Clusters of DNA damage induced by ionising radiation: formation of short DNA fragments. II. Experimental detection. Radiation Research, 145, 200-209.
    • (1996) Radiation Research , vol.145 , pp. 200-209
    • Rydberg, B.1
  • 69
    • 0001410557 scopus 로고
    • Estimation of DNA strand breaks in single mammalian cells
    • edited by P. C. Hanawalt, E. C. Friedberg and C. F. Fox (New York: Academic Press)
    • Rydberg, B. and Johanson, K. J., 1978, Estimation of DNA strand breaks in single mammalian cells. In DNA Repair Mechanisms, edited by P. C. Hanawalt, E. C. Friedberg and C. F. Fox (New York: Academic Press), pp. 465-468.
    • (1978) DNA Repair Mechanisms , pp. 465-468
    • Rydberg, B.1    Johanson, K.J.2
  • 70
    • 0029921918 scopus 로고    scopus 로고
    • The comet assay for the detection of genotoxic damage in the earthworm: A promising tool for assessing the biological hazards of pollution siles
    • Salagovic, J., Gilles, J., Verschaeve, L. and Kalini, I., 1996, The comet assay for the detection of genotoxic damage in the earthworm: a promising tool for assessing the biological hazards of pollution siles. Folia Biologica (Praha), 42, 17-21.
    • (1996) Folia Biologica (Praha) , vol.42 , pp. 17-21
    • Salagovic, J.1    Gilles, J.2    Verschaeve, L.3    Kalini, I.4
  • 72
    • 0031802892 scopus 로고    scopus 로고
    • Comparison between pulsed-field gel electrophoresis and the comet assay as predictive assays for radiosensitivity in fibroblasts
    • Sarkaria, J. N., Bush, C., Eady, J. J., Peacock, J. H., Steel, G. G. and Arnold, J. R., 1998, Comparison between pulsed-field gel electrophoresis and the comet assay as predictive assays for radiosensitivity in fibroblasts. Radiation Research, 150, 17-22.
    • (1998) Radiation Research , vol.150 , pp. 17-22
    • Sarkaria, J.N.1    Bush, C.2    Eady, J.J.3    Peacock, J.H.4    Steel, G.G.5    Arnold, J.R.6
  • 73
    • 0028980555 scopus 로고
    • Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: Possible role of apoptosis
    • Schwartz, J. L., Jordan, R., Sedita, B. A., Swenningson, M. J., Banath, J. P. and Olive, P. L., 1995, Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis. Mutagenesis, 10, 227-233.
    • (1995) Mutagenesis , vol.10 , pp. 227-233
    • Schwartz, J.L.1    Jordan, R.2    Sedita, B.A.3    Swenningson, M.J.4    Banath, J.P.5    Olive, P.L.6
  • 74
    • 0030009223 scopus 로고    scopus 로고
    • Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro
    • Simm, B. G., van Zijl, P. L. and Brown, J. M., 1996, Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. British Journal of Cancer, 73, 952-960.
    • (1996) British Journal of Cancer , vol.73 , pp. 952-960
    • Simm, B.G.1    Van Zijl, P.L.2    Brown, J.M.3
  • 75
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh, N. P., McCoy, M. T., Tice, R. R. and Schneider, E. L., 1988, A simple technique for quantitation of low levels of DNA damage in individual cells. Experimental Call Research, 175, 184-191.
    • (1988) Experimental Call Research , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 76
    • 0030968310 scopus 로고    scopus 로고
    • Microgel electrophoresis: Sensitivity, mechanisms and DNA electrostretching
    • Singh, N. P. and Stephens, R. E., 1997, Microgel electrophoresis: sensitivity, mechanisms and DNA electrostretching. Mutation Research, 383, 167-175.
    • (1997) Mutation Research , vol.383 , pp. 167-175
    • Singh, N.P.1    Stephens, R.E.2
  • 77
    • 0028092855 scopus 로고
    • Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage
    • Singh, N. P., Stephens, R. E. and Schneider, E. L., 1994, Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. International Journal of Radiation Biology, 66, 23-28.
    • (1994) International Journal of Radiation Biology , vol.66 , pp. 23-28
    • Singh, N.P.1    Stephens, R.E.2    Schneider, E.L.3
  • 78
    • 0029102911 scopus 로고
    • The single cell gel electrophoresis/comet assay: A potential tool for detecting radiation-induced DNA damage in humans
    • Tice, R. R. and Strauss, G. H., 1995, The single cell gel electrophoresis/comet assay: a potential tool for detecting radiation-induced DNA damage in humans. Stem Cells, 13, 207-214.
    • (1995) Stem Cells , vol.13 , pp. 207-214
    • Tice, R.R.1    Strauss, G.H.2
  • 79
    • 0024161399 scopus 로고
    • AP endonucleases and DNA glycosylases that recognize oxidative DNA damage
    • Wallace, S. S., 1988, AP endonucleases and DNA glycosylases that recognize oxidative DNA damage. Environmental and Molecular Mutagenesis, 12, 431-477.
    • (1988) Environmental and Molecular Mutagenesis , vol.12 , pp. 431-477
    • Wallace, S.S.1
  • 80
    • 0030920810 scopus 로고    scopus 로고
    • Comet assay studies on the activation of two diaziridinylbenoquinones in K562 cells
    • Ward, T. H., Butler, J., Shabakhti, H. and Richards, J. T., 1997, Comet assay studies on the activation of two diaziridinylbenoquinones in K562 cells. Biochemical Pharmacology, 53, 1115-1121.
    • (1997) Biochemical Pharmacology , vol.53 , pp. 1115-1121
    • Ward, T.H.1    Butler, J.2    Shabakhti, H.3    Richards, J.T.4
  • 81
    • 0029940104 scopus 로고    scopus 로고
    • Analysis of DNA damage recovery processes in the adaptive response to ionising radiation in human lymphocytes
    • Wojcik, A., Sauer, C., Zolzer, F., Bauch, T. and Muller, W. U., 1996, Analysis of DNA damage recovery processes in the adaptive response to ionising radiation in human lymphocytes. Mutagenesis, 11, 291-297.
    • (1996) Mutagenesis , vol.11 , pp. 291-297
    • Wojcik, A.1    Sauer, C.2    Zolzer, F.3    Bauch, T.4    Muller, W.U.5
  • 82
    • 0028903297 scopus 로고
    • Radiation-induced DNA damage in tumours and normal tissues. III. Oxygen dependence of the formation of strand breaks and dna-protein crosslinks
    • Zhang, H., Koch, C. J., Wallen, C. A. and Wheeler, K. T., 1995, Radiation-induced DNA damage in tumours and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA-protein crosslinks. Radiation Research, 142, 163-168.
    • (1995) Radiation Research , vol.142 , pp. 163-168
    • Zhang, H.1    Koch, C.J.2    Wallen, C.A.3    Wheeler, K.T.4
  • 83
    • 0030004193 scopus 로고    scopus 로고
    • Reduction of tumour hypoxia and inhibition of DNA repair by nicotinamide after irradiation of SCCVH murine tumours and normal tissues
    • Zheng, H. and Olive, P. L., 1996, Reduction of tumour hypoxia and inhibition of DNA repair by nicotinamide after irradiation of SCCVH murine tumours and normal tissues. Cancer Research, 56, 2801-2808.
    • (1996) Cancer Research , vol.56 , pp. 2801-2808
    • Zheng, H.1    Olive, P.L.2
  • 84
    • 0030941613 scopus 로고    scopus 로고
    • Influence of oxygen on radiation-induced DNA damage and repair in testicular cells of C3H mice
    • Zheng, H. and Olive, P. L., 1997, Influence of oxygen on radiation-induced DNA damage and repair in testicular cells of C3H mice. International Journal of Radiation Biology, 71, 275-282.
    • (1997) International Journal of Radiation Biology , vol.71 , pp. 275-282
    • Zheng, H.1    Olive, P.L.2
  • 85
    • 0031777393 scopus 로고    scopus 로고
    • The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks
    • Zhou, P.-K., Sproston, A. R., Marples, B., West, C. M., Margison, G. P. and Hendry, J. H., 1998, The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks. Radiotherapy and Oncology, 47, 271-276.
    • (1998) Radiotherapy and Oncology , vol.47 , pp. 271-276
    • Zhou, P.-K.1    Sproston, A.R.2    Marples, B.3    West, C.M.4    Margison, G.P.5    Hendry, J.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.