메뉴 건너뛰기




Volumn 17, Issue 2, 1998, Pages 187-194

The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target

Author keywords

Angiogenesis; bHLH PAS proteins; EPAS 1; Glycolysis; HIF 1; Hypoxia

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOTOXIC AGENT; DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN EPAS 1; TIRAPAZAMINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 0031823016     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006002419244     Document Type: Review
Times cited : (131)

References (30)
  • 1
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor-I
    • Wenger RH, Gassman M: Oxygen(es) and the hypoxia-inducible factor-I. Biol Chem 378: 609-616, 1997
    • (1997) Biol Chem , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassman, M.2
  • 2
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor-1 is a basic-helix-loop-helix-pas heterodimer regulated by cellular O-2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL: Hypoxia-inducible factor-1 is a basic-helix-loop-helix-pas heterodimer regulated by cellular O-2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 3
    • 0026625037 scopus 로고
    • Ah receptor nuclear translocator protein (ARNT) as a component of the DNA binding form of the Ah receptor
    • Reyes H. S. R-P. Hankinson O: Ah receptor nuclear translocator protein (ARNT) as a component of the DNA binding form of the Ah receptor. Science 256: 1193-1195, 1992
    • (1992) Science , vol.256 , pp. 1193-1195
    • Reyes, H.S.R.-P.1    Hankinson, O.2
  • 4
    • 0031459411 scopus 로고    scopus 로고
    • Molecular evolution of 2 vertebrate aryl-hydrocarbon (dioxin) receptors (ahr1 and ahr2) and the pas family
    • Hahn ME, Karchner SI, Shapiro MA, Perera SA: Molecular evolution of 2 vertebrate aryl-hydrocarbon (dioxin) receptors (ahr1 and ahr2) and the pas family. Proc Natl Acad Sci USA 94: 13743-13748, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13743-13748
    • Hahn, M.E.1    Karchner, S.I.2    Shapiro, M.A.3    Perera, S.A.4
  • 6
    • 0030851024 scopus 로고    scopus 로고
    • The pas domain confers target gene specificity of drosophila bhlh/pas proteins
    • Zelzer E, Wappner P, Shilo BZ: The pas domain confers target gene specificity of drosophila bhlh/pas proteins. Genes Dev 11: 2079-2089, 1997
    • (1997) Genes Dev , vol.11 , pp. 2079-2089
    • Zelzer, E.1    Wappner, P.2    Shilo, B.Z.3
  • 7
    • 0029859510 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
    • Jiang BJ, Semenza GL, Bauer C, Marti HH: Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 271: C1172-C1180, 1996
    • (1996) Am J Physiol , vol.271
    • Jiang, B.J.1    Semenza, G.L.2    Bauer, C.3    Marti, H.H.4
  • 8
    • 0030200804 scopus 로고    scopus 로고
    • Transcriptional regulation by hypoxia-inducible factor 1. Molecular mechanisms of oxygen homeostasis
    • Semenza GL: Transcriptional regulation by hypoxia-inducible factor 1. Molecular mechanisms of oxygen homeostasis. Trends Cardiovasc Med 6: 151-157, 1996
    • (1996) Trends Cardiovasc Med , vol.6 , pp. 151-157
    • Semenza, G.L.1
  • 9
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn HF, Poyton RO: Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76: 839-885, 1996
    • (1996) Physiol Rev , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 10
    • 0028844810 scopus 로고
    • Deiphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: Implications for the mechanism of oxygen sensing
    • Gleadle JM, Ebert BL, Ratcliffe PJ: Deiphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: Implications for the mechanism of oxygen sensing. Eur J Biochem 234: 92-99, 1995
    • (1995) Eur J Biochem , vol.234 , pp. 92-99
    • Gleadle, J.M.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 11
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha (hif-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J: Hypoxia-inducible factor 1 alpha (hif-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 12
    • 0030914648 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1-alpha-posttranscriptional regulation and conformational change by recruitment of the arnt transcription factor
    • Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L: Activation of hypoxia-inducible factor 1-alpha-posttranscriptional regulation and conformational change by recruitment of the arnt transcription factor. Proc Natl Acad Sci USA 94: 5667-5672, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5667-5672
    • Kallio, P.J.1    Pongratz, I.2    Gradin, K.3    McGuire, J.4    Poellinger, L.5
  • 13
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russel DW: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-82, 1997
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russel, D.W.3
  • 14
    • 0343417089 scopus 로고    scopus 로고
    • The p300/CBP family: Integrating signals with transcription factors and chromatin
    • Shikama N, Lyon J, La Thangue NB: The p300/CBP family: Integrating signals with transcription factors and chromatin. Trends in Cell Biology 7: 230-236, 1997
    • (1997) Trends in Cell Biology , vol.7 , pp. 230-236
    • Shikama, N.1    Lyon, J.2    La Thangue, N.B.3
  • 16
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
    • Firth JD, Ebert BL, Ratcliffe PJ: Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem 270: 21021-21027, 1995
    • (1995) J Biol Chem , vol.270 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 17
    • 0031027287 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene
    • Levy AP, Levy NS, Iliopoulos O, Jiang C, Kaelin WG, Goldberg MA: Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene. Kidney International 51: 575-578, 1997
    • (1997) Kidney International , vol.51 , pp. 575-578
    • Levy, A.P.1    Levy, N.S.2    Iliopoulos, O.3    Jiang, C.4    Kaelin, W.G.5    Goldberg, M.A.6
  • 18
    • 0029795584 scopus 로고    scopus 로고
    • Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein
    • Levy AP, Levy NS, Goldberg MA: Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J Biol Chem 271: 25492-25497, 1996
    • (1996) J Biol Chem , vol.271 , pp. 25492-25497
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 19
    • 0030713446 scopus 로고    scopus 로고
    • Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia- Induced transcriptional activation of vascular-endothelial growth-factor expression in c6 glioma-cells
    • Damert A, Ikeda E, Risau W: Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia- induced transcriptional activation of vascular-endothelial growth-factor expression in c6 glioma-cells. Biochem J 327: 419-423, 1997
    • (1997) Biochem J , vol.327 , pp. 419-423
    • Damert, A.1    Ikeda, E.2    Risau, W.3
  • 20
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth-factor expression
    • Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ: Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth-factor expression. Cancer Res 56: 3436-3440, 1996
    • (1996) Cancer Res , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Laderoute, K.R.4    Giaccia, A.J.5
  • 21
    • 0028822834 scopus 로고
    • Mutant ras oncogenes up-regulate vegf/ vpf expression - Implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel RS: Mutant ras oncogenes up-regulate vegf/ vpf expression - implications for induction and inhibition of tumor angiogenesis. Cancer Res 55: 4575-4580, 1995
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 22
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth-factor and erbb-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth-factor production by tumor-cells in-vitro and in-vivo-angiogenic implications for signal-transduction therapy of solid tumours
    • Petit AMV, Rak J, Hung MC, Rockwell P, Goldstein N, Fendly B, Kerbel RS: Neutralizing antibodies against epidermal growth-factor and erbb-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth-factor production by tumor-cells in-vitro and in-vivo-angiogenic implications for signal-transduction therapy of solid tumours. Am J Pathol 151: 1523-1530, 1997
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.V.1    Rak, J.2    Hung, M.C.3    Rockwell, P.4    Goldstein, N.5    Fendly, B.6    Kerbel, R.S.7
  • 23
    • 0031058350 scopus 로고    scopus 로고
    • The influence of oxygen-tension and pH on the expression of platelet-derived endothelial-cell growth-factor thymidine phosphorylase in human breast-tumor cells grown in-vitro and in-vivo
    • Griffiths L, Dachs GU, Bicknell R, Harris AL, Stratford IJ: The influence of oxygen-tension and pH on the expression of platelet-derived endothelial-cell growth-factor thymidine phosphorylase in human breast-tumor cells grown in-vitro and in-vivo. Cancer Res 57: 570-572, 1997
    • (1997) Cancer Res , vol.57 , pp. 570-572
    • Griffiths, L.1    Dachs, G.U.2    Bicknell, R.3    Harris, A.L.4    Stratford, I.J.5
  • 25
    • 0030744115 scopus 로고    scopus 로고
    • Radiation, hypoxia and genetic stimulation-implications for future therapies
    • Adams GE, Hasan NM, Joiner MC: Radiation, hypoxia and genetic stimulation-implications for future therapies. Radiother Oncol 44: 101-109, 1997
    • (1997) Radiother Oncol , vol.44 , pp. 101-109
    • Adams, G.E.1    Hasan, N.M.2    Joiner, M.C.3
  • 26
    • 0030926491 scopus 로고    scopus 로고
    • Cells at intermediate oxygen levels can be more important than the hypoxic fraction in determining tumor response to fractionated radiotherapy
    • Wouters BG, Brown JM: Cells at intermediate oxygen levels can be more important than the hypoxic fraction in determining tumor response to fractionated radiotherapy. Radiat Res 147: 541-550, 1997
    • (1997) Radiat Res , vol.147 , pp. 541-550
    • Wouters, B.G.1    Brown, J.M.2
  • 28
    • 0030692717 scopus 로고    scopus 로고
    • Overexpression of human NADPH: Cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069
    • Patterson AV, Saunders MP, Chinje EC, Talbot DC, Harris AL, Stratford IJ: Overexpression of human NADPH: cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069. Br J Cancer 76: 1338-1347, 1997
    • (1997) Br J Cancer , vol.76 , pp. 1338-1347
    • Patterson, A.V.1    Saunders, M.P.2    Chinje, E.C.3    Talbot, D.C.4    Harris, A.L.5    Stratford, I.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.