Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging

International Journal of Radiation Oncology Biology Physics

Volumn 53, Issue 5, 2002, Pages 1185-1191

  Rijpkema, Mark ^a   Kaanders, Johannes H A M ^a   Joosten, Frank B M ^a   Van der Kogel, Albert J ^a   Heerschap, Arend ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Head neck tumors; Hypercapnia; Hyperoxygenation; Magnetic resonance imaging; Vascularity

Indexed keywords

BLOOD; MAGNETIC RESONANCE IMAGING; OXYGEN; PATIENT MONITORING; TUMORS;

GAS MIXTURE;

RADIOTHERAPY;

DEOXYHEMOGLOBIN; GADOLINIUM;

ADULT; AGED; ARTICLE; BLOOD OXYGENATION; BREATHING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAS; HEAD AND NECK TUMOR; HEMOGLOBIN DETERMINATION; HUMAN; HYPERCAPNIA; HYPEROXIA; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN BLOOD LEVEL; PRIORITY JOURNAL; VASCULAR TUMOR; VASCULARIZATION;

AGED; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; HYPERCAPNIA; HYPEROXIA; LARYNGEAL NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; OXYGEN;

EID: 0036680134     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)02825-0     Document Type: Article

References (59)

1. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
2. The histological structure of some human lung cancers and the possible implications for radiotherapy
3. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
4. Intermittent blood flow in a murine tumour: Radiobiological effects
5. Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer
6. ARCON: Experience in 215 patients with advanced head-and-neck cancer
7. Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: Hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide
8. Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing
9. Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: Effects of carbogen and nicotinamide
10. Enhancement of tumour perfusion and oxygenation by carbogen and nicotinamide during single and multi-fraction irradiation
11. A convenient and reliable method for carbogen breathing in man
12. The response to carbogen breathing in experimental tumour models monitored by gradient-recalled echo magnetic resonance imaging
13. Effect of carbogen breathing on the physiological profile of human glioma xenografts
14. In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: Validation by intravital microscopy
15. Effect of carbogen breathing on tumour microregional blood flow in humans
16. Hemodynamic and biochemical effects of 100% oxygen breathing in humans
17. The effect of hyperoxia on cerebral blood flow: A study in healthy volunteers using magnetic resonance phase-contrast angiography
18. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields
19. The response of human tumours to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging
20. MRI measurements of cerebral deoxyhaemoglobin concentration [dHb] - Correlation with near infrared spectroscopy (NIRS)
21. Non-invasive vascular imaging: Assessing tumour vascularity
22. Mapping pathophysiological features of breast tumours by MRI at high spatial resolution
23. Fast dynamic gadolinium-enhanced MR imaging of urinary bladder and prostate cancer
24. MR microcirculation assessment in cervical cancer: Correlations with histomorphological tumour markers and clinical outcome
25. Modification of tumour perfusion and oxygenation monitored by gradient recalled echo MRI and 31P MRS
26. MRI measurements correctly predict the relative effects of tumour oxygenating agents on hypoxic fraction in rodent BA1112 tumours
27. Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels
28. Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumour oxygenation
29. 2 and radiation response in an experimental tumour model
30. Radiotherapy with carbogen breathing and nicotinamide in head and neck cancer: Feasibility and toxicity
31. Breath-hold R2* mapping with a multiple gradient-recalled echo sequence: Application to the evaluation of intrarenal oxygenation
32. Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumours
33. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: Standardized quantities and symbols
34. Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumours
35. Effects of different levels of hypercapnic hyperoxia on tumour R(2)* and arterial blood gases
36. 2, microcirculatory function and radiosensitivity
37. Inflow versus deoxyhemoglobin effects in BOLD functional MRI using gradient echoes at 1.5 T
38. Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging
39. Flow and oxygenation dependent (FLOOD) contrast MR imaging to monitor the response of rat tumours to carbogen breathing
40. Simultaneous measurement of perfusion and oxygenation changes using a multiple gradient-echo sequence: Application to human muscle study
41. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
42. Association between tumour hypoxia and malignant progression in advanced cancer of the uterine cervix
43. Effect of oxygen inhalation on relaxation times in various tissues
44. Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: Separation of blood volume and magnetic susceptibility effects
45. In vivo measurement of T*2 and field inhomogeneity maps in the human heart at 1.5 T
46. Intracapillary oxyhemoglobin saturation of malignant tumours in humans
47. Dynamic contrast enhanced magnetic resonance scanning as a predictor of response to accelerated radiotherapy for advanced head and neck cancer
48. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
49. The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation
50. The effects of hyperoxic and hypercarbic gases on tumour blood flow
51. ARCON: Accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas: The experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer (EORTC)
52. Tumour radiosensitization by nicotinamide: A result of improved perfusion and oxygenation
53. Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumour
54. Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumours
55. Human tumour blood flow is enhanced by nicotinamide and carbogen breathing
56. 2) during accelerated radiotherapy of head and neck carcinoma
57. A pilot study comparing intratumoural oxygenation using the comet assay following 2.5% and 5% carbogen and 100% oxygen
58. Clinical outcome and tumour microenvironmental effects of accelerated radiotherapy with carbogen and nicotinamide