Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia

Radiotherapy and Oncology

Volumn 44, Issue 2, 1997, Pages 163-169

  Lyng, Heidi ^a   Sundfør, Kolbein ^a   Rofstad, Einar K ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cervix carcinoma; Hypoxia; Melanoma; Necrosis; Oxygen tension; Vascular density

Indexed keywords

OXYGEN; PIMONIDAZOLE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; ELECTRODE; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; MELANOMA; MOUSE; NEEDLE; NONHUMAN; NUDE MOUSE; OXYGEN TENSION; POLAROGRAPHY; PRIORITY JOURNAL; TUMOR NECROSIS; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA;

ADULT; AGED; ANIMALS; CELL HYPOXIA; ELECTRODES; FEMALE; HUMANS; MELANOMA; MICE; MICE, INBRED BALB C; MIDDLE AGED; NECROSIS; OXYGEN; POLAROGRAPHY; UTERINE CERVICAL NEOPLASMS;

EID: 0030825252     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(97)01920-8     Document Type: Article

References (35)

1. Arteel, G.E., Thurman, R.G., Yates, J.M. and Raleigh, J.A. Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer 79: 889-895, 1995.
2. 2. In: Clinical Oxygen Pressure Measurement, pp. 17-42. Editors: A.M. Ehrly, L. Hauss and R. Huch. Springer-Verlag, Berlin, 1987.
3. Brizel, D.M., Rosner, G.L., Harrelson, J., Prosnitz, L.R. and Dewhirst, M.W. Pretreatment oxygenation profiles of human soft tissue sarcomas. Int. J. Radiat. Biol. Oncol. Phys. 30: 635-642, 1994.
4. 2 histography. Br. J. Cancer 66: 919-924, 1992.
5. Fenton, B.M. Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int. J. Radiat. Oncol. Biol. Phys. 33: 365-373, 1995.
6. Ferenczy, A. Carcinoma and other malignant tumors of the cervix. In: Pathology of the Female Genital Tract, 2nd edn., pp. 184-222. Editor: A. Blaustein. Springer-Verlag, New York, 1982.
7. 2 histograms from rabbit hind-limb muscles obtained by simultaneous measurements with hypodermic needle electrodes and with surface electrodes. Adv. Exp. Med. Biol. 169: 447-455, 1984.
8. Fowler, J.F. The influence of recovery, repopulation and reoxygenation on radiosensitivity of tumors and normal tissues. In: The Biological and Clinical Basis of Radiosensitivity, pp. 373-388. Editor: M. Friedman. Charles C Thomas, Springfield, IL, 1974.
9. Hirst, D.G., Hirst, V.K., Joiner, B., Prise, V. and Shaffi, K.M. Changes in tumour morphology with alteration in oxygen availability: further evidence for oxygen as a limiting substrate. Br. J. Cancer 64: 54-58, 1991.
10. Höckel, M., Schlenger, K., Aral, B., Mitze, M, Schäffer, U. and Vaupel, P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56: 4509-4515, 1996.
11. 2 tension measurements. Cancer Res. 51: 6098-6102, 1991.
12. Kallinowski, F., Schlenger, K.H., Runkel, S., Kloes, M., Stohrer, M., Okunieff, P. and Vaupel, P. Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Res. 49: 3759-3764, 1989.
13. 2-histography. Int. J. Radiat. Oncol. Biol. Phys. 19: 953-961, 1990.
14. Khalil, A.A., Horsman, M.R. and Overgaard, J. The importance of determining necrotic fraction when studying the effect of tumour volume on tissue oxygenation. Acta Oncol. 34: 297-300, 1995.
15. Lartigau, E., Le Ridant, A.M., Lambin, P., Weeger, P., Martin, L., Sigal, R., Lusinchi, A., Luboinski, B., Eschwege, F. and Guichard, M. Oxygenation of head and neck tumors. Cancer 71: 2319-2325, 1993.
16. Lyng, H., Monge, O.R., Bøhler, P.J. and Rofstad, E.K. Temperature distribution in locally advanced breast carcinoma during hyperthermic treatment: relationship to perfusion, vascular density, and histology. Int. J. Radiat. Oncol. Biol. Phys. 21: 423-430, 1991.
17. 2 and histological appearance in human cervix carcinoma. In: Tumor Oxygenation, pp. 249-257. Editors: P.W. Vaupel, O.K. Kelleher and M. Günderoth. Gustav Fischer Verlag, New York, 1995.
18. Lyng, H., Sundfør, K., Trope, C. and Rofstad, E.K. Oxygen tension and vascular density in human cervix carcinoma. Br. J. Cancer 74: 1559-1563, 1996.
19. Nordsmark, M., Bentzen, S. and Overgaard, J. Measurement of human tumour oxygenation status by a polarographic needle electrode: an analysis of inter- and intratumour heterogeneity. Acta Oncol. 33: 383-389, 1994.
20. Nordsmark, M., Overgaard, M. and Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41: 31-39, 1996.
21. Rofstad, E.K. Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern. Br. J. Cancer 70: 804-812, 1994.
22. 2 measurements with hypodermic needle probes. In: Clinical Oxygen Pressure Measurement II. Tissue Oxygen Pressure and Transcutaneous Oxygen Pressure, pp. 38-50. Editors: A.M. Ehrly, W. Fleckenstein, J. Hauss and R. Huch. Blackwell Ueberreuter Wissenschaft, Berlin, 1990.
23. Steinberg, F., Hildenhagen-Brüggemann, E. and Konerding, M.A. Oxygen electrode injury in tumour tissue. In: Tumor Oxygenation, pp. 185-193. Editors: P.W. Vaupel, D.K. Kelleher and M. Günderoth. Gustav Fischer Verlag, New York, 1995.
24. Steinberg, F., Konerding, M.A., Sander, A. and Streffer, C. Vascularization, proliferation and necrosis in untreated human primary tumours and untreated human xenografts. Int. J. Radiat. Biol. 60: 161-168, 1991.
25. Stone, H.B., Brown, J.M., Phillips, T.L. and Sutherland, R.M. Oxygen in human tumors: correlations between methods of measurement and response to therapy. Radiat. Res. 136: 422-434, 1993.
26. 2 in cervix carcinoma. Gynecol. Oncol. 64: 230-236, 1997.
27. Tannock, I.F. Oxygen diffusion and the distribution of cellular radiosensitivity in tumours. Br. J. Radiol. 45: 515-524, 1972.
28. Teicher, B.A., Lazo, J.S. and Sartorelli, A.C. Classification of antineoplastic agents by their selective toxicities towards oxygenated and hypoxic tumor cells. Cancer Res. 41: 73-81, 1981.
29. 2 measurement in vitro and in vivo. Int. J. Radiat. Biol. 69: 205-211, 1996.
30. Thomlinson, R.H. and Gray, L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer 9: 539-549, 1955.
31. Vaupel, P. Oxygenation of human tumors. Strahlenther. Onkol. 166: 377-386, 1990.
32. Vaupel, P. Oxygenation of solid tumors. In: Drug Resistance in Oncology, pp. 53-85. Editor: B.A. Teicher. Marcel Dekker, New York, 1993.
33. Vaupel, P., Fortmeyer, H.P., Runkel, S. and Kallinowski, F. Blood flow, oxygen consumption and tissue oxygenation of human breast cancer xenografts in nude rats. Cancer Res. 47: 3496-3503, 1987.
34. 2 tension measurements. Cancer Res. 51: 3316-3322, 1991.
35. Zanelli, G.D. and Fowler, J.F. Anaesthetics in the study of the microcirculation of tumours: pitfalls and uses. Bibl. Anat. 15: 249-254, 1977.