Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine

Cancer Chemotherapy and Pharmacology

Volumn 39, Issue 4, 1997, Pages 361-366

  Doric, Mary Jo ^a   Brown, J Martin ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 Fluorouracil; Carboplatin; Cyclophosphamide; Doxorubicin; Etoposide; Navelbine; Taxol; Tirapazamine

Indexed keywords

ANTIINFECTIVE AGENT; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; NAVELBINE; TIRAPAZAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENTIATION; FIBROSARCOMA; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ETOPOSIDE; FLUOROURACIL; MICE; MICE, INBRED C3H; PACLITAXEL; RADIATION-SENSITIZING AGENTS; TRIAZINES;

EID: 0031023702     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050584     Document Type: Article

References (20)

1. Ashizawa T, Asada M, Kobayashi E, Okabe M, Gomi K, Hirata T (1993) Combination effect of navelbine (vinorelbine ditartrate) with cisplatin against murine P388 leukemia and human lung carcinoma xenografts in mice. Anticancer Drugs 4:577
2. Brown JM (1993) SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br J Cancer 67: 1163
3. Brown JM, Lemmon MJ (1990) Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res 50:7745
4. Brown JM, Lemmon MJ (1991) Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation. Int J Radiat Oncol Biol Phys 20:457
5. Brown JM, Lemmon MJ (1991) SR 4233: a tumor specific radiosensitizer active in fractionated radiation regimes. Radiother Oncol 20:151
6. Dische S, Anderson PJ, Sealy R, Watson ER (1983) Carcinoma of the cervix anaemia, radiotherapy and hyperbaric oxygen. Br J Radiol 56:251
7. Doric MJ, Brown JM (1993) Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res 53:4633
8. Dorie MJ, Brown JM (1995) Potentiation of the anticancer effect of cisplatin by the hypoxic cytotoxin tirapazamine. In: Vaupel PW, Kellerer DK, Gunderoth M (eds) Tumor oxygenation. Fischer, Stuttgart, p 125
9. Durand RE, Olive PL (1996) Physiological and cytotoxic effects of tirapazamine in tumour-bearing mice. Br J Cancer (in press)
10. Grau C, Overgaard J (1988) Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay. Radiother Oncol 13:301
11. Hockel M, Knoop C, Schlenger K, Vorndran B, BauBmann E, Mitze M, Knapstein PG, Vaupel P (1993) Intratumoral pOpredicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26:45
12. Kennedy KA (1987) Hypoxic cells as specific drug targets for chemotherapy. Anticancer Drug Des 2:181
13. Langmuir VK, Rooker JA, Osen M, Mendonca HL, Laderoute KR (1994) Synergistic interaction between tirapazamine and cyclophosphamide in human breast cancer xenografts. Cancer Res 54:2845
14. Moulder JE, Rockwell S (1984) Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10:695
15. Overguard J, Hansen HS, Jorgensen K, Hansen MH (1986) Primary radiotherapy of larynx and pharynx carcinoma - an analysis of some factors influencing local control and survival. Int J Radiat Oncol Biol Phys 12:515
16. Sartorelli AC (1988) Therapeutic attack of hypoxic cells of solid tumors (Presidential address). Cancer Res 48:775
17. Tannock I, Guttman P (1981) Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions. Br J Cancer 42:245
18. Twenty-man PR, Brown JM, Gray JW, Franko AJ, Scoles MA, Kallman RF (1980) A new mouse tumor model system (RIF-1) for comparison of end-point studies. J Natl Cancer Inst 64:595
19. 2 histography. In: Vaupel PW, Kellerer DK, Gunderoth M (eds) Tumor oxygenation. Fischer, Stuttgart, p 219
20. Zeman EM, Hirst VK, Lemmon MJ, Brown JM (1988) Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233. Radiother Oncol 12:209