How does blood oxygen level-dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors?

Magnetic Resonance in Medicine

Volumn 48, Issue 6, 2002, Pages 980-986

  Baudelet, Christine ^a   Gallez, Bernard ^a,b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b Laboratory of Medicinal Chemistry   (Belgium)

Author keywords

BOLD; Correlation; pO2; T2*; Tumor

Indexed keywords

CORRELATION METHODS; IMAGING TECHNIQUES; MERCURY COMPOUNDS; OXYGEN; OXYGENATION; PARTIAL PRESSURE; TUMORS;

BLOOD OXYGEN LEVEL DEPENDENTS; BOLD; FIBER-OPTIC MICROPROBES; FUNCTIONAL MRI (FMRI); GRADIENT ECHO IMAGING; HIGH SPATIAL RESOLUTION; OXYGEN PARTIAL PRESSURE; TRANSVERSE RELAXATION TIME;

BLOOD;

DEOXYHEMOGLOBIN; OXYGEN;

ARTICLE; BLOOD FLOW; CONTRAST; HUMAN; HYPEROXIA; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL RESOLUTION; OXYGEN BLOOD LEVEL; OXYGEN TENSION; PROVOCATION TEST; SIGNAL PROCESSING; TECHNIQUE; TISSUE OXYGENATION; TUMOR;

EID: 0036893483     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.10318     Document Type: Article

References (34)

1. Thomlinson RH, Gray LH. The histological structure of some human cancers and the possible implications for radiotherapy. Br J Cancer 1955;9:539-549.
2. Molls M, Vaupel P. The impact of the tumor microenvironment on experimental and clinical radiation oncology and other therapeutic modalities. In: Molls M, Vaupel P, editors. Blood Perfusion and Microenvironment of Human Tumors: Implications for Clinical Radiooncology. Berlin: Springer; 2000. p 1-4.
3. Ogawa S, Lee TM, Nayak AS, Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 1990;14:68-78.
4. 2* and resonance frequency weighted magnetic resonance images of rodent tumours. NMR Biomed 1994;7:3-11.
5. Robinson SP, Howe FA, Griffiths JR. Noninvasive monitoring of carbogen-induced changes in tumor blood flow and oxygenation by functional magnetic resonance imaging. Int J Radiat Oncol Biol Phys 1995;33:855-859.
6. Griffiths JR, Taylor NJ, Howe FA, Saunders MI, Robinson SP, Hoskin PJ, Powell ME, Thoumine M, Caine LA, Baddeley H. The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging. Int J Radiat Oncol Biol Phys 1997;39:697-701.
7. Peller M, Weissfloch L, Stehling MK, Weber J, Bruening R, Senekowitsch-Schmidtke R, Molls M, Reiser M. Oxygen-induced MR signal changes in murine tumors. Magn Reson Imaging 1998;16:799-809.
8. Jordan BF, Misson P-D, Demeure R, Baudelet C, Beghein N, Gallez B. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI. Int J Radiat Oncol Biol Phys 2000;48:565-570.
9. van Zijl PC, Eleff SM, Ulatowski JA, Oja JM, Ulug AM, Traystman RJ, Kauppinen RA. Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 1998;4:159-167.
10. Cheng YC, Haacke EM. Predicting BOLD signal changes as a function of blood volume fraction and resolution. NMR Biomed 2001;14:468-477.
11. Diemling M, Barth M, Moser E. Quantification of signal changes in gradient recalled echo FMRI. Magn Reson Imaging 1997;15:753-762.
12. Weisskoff RM. Basic theoretical model of BOLD signal change. In: Moonen CTW, Bandettini PA, editors. Functional MRI. Berlin: Springer-Verlag; 2000. p 115-123.
13. Howe FA, Robinson SP, Rodrigues LM, Griffiths JR. Flow and oxygenation dependent (FLOOD) contrast MR imaging to monitor the response of rat tumors to carbogen breathing. Magn Reson Imaging 1999;17:1307-1318.
14. Al-Hallaq HA, River JN, Zamora M, Oikawa H, Karczmar GS. Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation. Int J Radiat Oncol Biol Phys 1998;41:151-159.
15. 2 using a fiber-optic oxygen sensor in rodent tumours and their response to carbogen breathing. In: Proceedings of the 6th Annual Meeting of ISMRM, Sydney, Australia, 1998. p 1665.
16. Lebon V, Carlier PG, Brillault-Salvat C, Leroy-Willig A. Simultaneous measurement of perfusion and oxygenation changes using a multiple gradient-echo sequence: Application to human muscle study. Magn Reson Imaging 1998;16:721-729.
17. Howe FA, Robinson SP, McIntyre DJ, Stubbs M, Griffiths JR. Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours. NMR Biomed 2001;14:497-506.
18. Milas L, Hunter N, Mason K, Withers HR. Immunological resistance to pulmonary metastases in C3Hf/Bu mice bearing syngeneic fibrosarcoma of different sizes. Cancer Res 1974;34:61-71.
19. Griffiths JR, Robinson SP. The OxyLite: A fibre-optic oxygen sensor [commentary]. Br J Radiol 1999;72:627-630.
20. Hunjan S, Zhao D, Constantinescu A, Hahn EW, Antich PP, Mason RP. Tumor oximetry: Demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. Int J Radiat Oncol Biol Phys 2001;49:1097-1108.
21. Landuyt W, Hermans R, Bosmans H, Sunaert S, Beatse E, Farina D, Meijerink M, Zhang H, Van Den Bogaert W, Lambin P, Marchal G. BOLD contrast fMRI of whole rodent tumour during air or carbogen breathing using echo-planar imaging at 1.5 T, Eur Radiol 2001;11:2332-2340.
22. Thulborn KR, Waterton JC, Matthews PM, Radda GK. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 1982;714:265-270.
23. Dunn JF, Swartz HM. Blood oxygenation. Heterogeneity of hypoxic tissues monitored using bold MR imaging. Adv Exp Med Biol 1997;428:645-650.
24. 2* estimation, Magn Reson Med 1998;39:685-690.
25. Fenton BM, Raubertas RF, Boyce DJ. Quantification of micro-regional heterogeneities in tumor oxygenation using intravascular HbO2 saturations. Radiat Res 1995;141:49-56.
26. Maseide K, Rofstad EK. Intratumour heterogeneity in microvessel oxyhaemoglobin saturations. Cancer Lett 2001;162:245-251.
27. Prasad PV, Edelman RR, Epstein FH. Noninvasive evaluation of intrarenal oxygenation with BOLD MRI. Circulation 1996;94:3271-3275.
28. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, Ugurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 1993;64:803-812.
29. Lai S, Glover GH, Haacke EM. Spatial selectivity of BOLD contrast: Effects in and around draining veins. In: Moonen CTW, Bandettini PA, editors. Functional MRI. Berlin: Springer-Verlag; 2000. p 221-231.
30. Cheng YC, Haacke EM. Predicting BOLD signal changes as a function of blood volume fraction and resolution. NMR Biomed 2001;14:468-477.
31. Swartz HM, Clarkson RB. The measurement of oxygen in vivo using EPR techniques. Phys Med Biol 1998;43:1957-1975.
32. Gallez B, Jordan BF, Baudelet C, Misson PD. Pharmacological modifications of the partial pressure of oxygen in murine tumors: Evaluation using in vivo EPR oximetry. Magn Reson Med 1999;42:627-630.
33. Velan SS, Spencer RGS, Zweier JL, Kuppusamy P. Electron paramagnetic resonance oxygen mapping (EPROM): Direct visualization of oxygen concentration in tissue. Magn Reson Med 2000;43:804-809.
34. Golman K, Petersson JS, Ardenkjaer-Larsen JH, Leunbach I, Wistrand LG, Ehnholm G, Liu K. Dynamic in vivo oxymetry using Overhauser enhanced MR imaging. J Magn Reson Imaging 2000;12:929-938.