Immune effects and mechanisms of action of CpG motifs

Vaccine

Volumn 19, Issue 6, 2000, Pages 618-622

  Krieg, Arthur M ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c PFIZER INC   (United States)

Author keywords

CpG motifs; Dendritic cell; DNA; Immunotherapy; Innate immunity

Indexed keywords

ADJUVANT; BACTERIAL DNA; DINUCLEOTIDE; OLIGODEOXYRIBONUCLEOTIDE; VACCINE;

ALLERGIC DISEASE; ARTICLE; CANCER; CANCER IMMUNOTHERAPY; CPG ISLAND; DENDRITIC CELL; HUMAN; IMMUNITY; IMMUNIZATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; VERTEBRATE;

EID: 0034623661     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00249-8     Document Type: Short Survey

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15. CpG motifs in bacterial DNA activates leukocytes through the pH-dependent generation of reactive oxygen species
16. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
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18. Macrophages ingest and are activated by bacterial DNA
19. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-a-mediated shock
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21. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
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23. CpG DNA is a potent adjuvant in mice immunized with recombinant hepatitis B surface antigen
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31. Bacterial DNA induces NK cells to produce interferon-γ in vivo and increases the toxicity of lipopolysaccharides
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36. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
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39. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
40. CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
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42. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
43. Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor
44. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
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46. CpG DNA: a pathogenic factor in systemic lupus erythematosus?
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49. Bacterial DNA causes septic shock