Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA

International Journal of Cancer

Volumn 121, Issue 2, 2007, Pages 401-406

  Kawano, Hiroki ^a   Nishikawa, Makiya ^a   Mitsui, Masaru ^a   Takahashi, Yuki ^a   Kako, Keiko ^a   Yamaoka, Kiyoshi ^a   Watanabe, Yoshihiko ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Cancer gene therapy; CpG dinucleotides; Hydrodynamics; Interferon; Pulmonary metastasis

Indexed keywords

BETA INTERFERON; DINUCLEOTIDE; GAMMA INTERFERON; PLASMID DNA; SODIUM CHLORIDE; VIRUS VECTOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; GENE CONSTRUCT; GENE EXPRESSION; GENE TRANSFER; GENETIC CODE; HYDRODYNAMICS; LUNG METASTASIS; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME;

ANIMALS; AREA UNDER CURVE; CELL LINE, TUMOR; COLONIC NEOPLASMS; CPG ISLANDS; GENE EXPRESSION; GENE THERAPY; INJECTIONS, INTRAVENOUS; INTERFERON TYPE II; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PLASMIDS; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME;

EID: 34250315361     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22636     Document Type: Article

References (40)

1. Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 2001;12:861-70.
2. Nishikawa M, Hashida M. Nonviral approaches satisfying various requirements for effective in vivo gene therapy. Biol Pharm Bull 2002;25:275-83.
3. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999;6:1258-66.
4. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999;10:1735-7.
5. Song YK, Liu F, Zhang G, Liu D. Hydrodynamics-based transfection: simple and efficient method for introducing and expressing transgenes in animals by intravenous injection of DNA. Methods Enzymol 2002;346:92-105.
6. Kobayashi N, Nishikawa M, Takakura Y. The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels. Adv Drug Deliv Rev 2005; 57:713-31.
7. Eastman SJ, Baskin KM, Hodges BL, Chu Q, Gates A, Dreusicke R, Anderson S, Scheule RK. Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA. Hum Gene Ther 2002;13:2065-77.
8. Gansbacher B, Bannerji R, Daniels B, Zier K, Cronin K, Gilboa E. Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res 1990;50:7820-5.
9. Yanagihara K, Seyama T, Watanabe Y. Antitumor potential of interferon-γ: retroviral expression of mouse interferon-γ cDNA in two kinds of highly metastatic mouse tumor lines reduces their tumorigenicity. Nat Immun 1994;13:102-12.
10. Singh RK, Gutman M, Bucana CD, Sanchez R, Llansa N, Fidler IJ. Interferons α and β down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 1995;92:4562-6.
11. Albini A, Marchisone C, Del Grosso F, Benelli R, Masiello L, Tacchetti C, Bono M, Ferrantini M, Rozera C, Truini M, Belardelli F, Santi L et al. Inhibition of angiogenesis and vascular tumor growth by interferon-producing cells: a gene therapy approach. Am J Pathol 2000;156:1381-93.
12. Kobayashi N, Kuramoto T, Chen S, Watanabe Y, Takakura Y. Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models. Mol Ther 2002;6:737-44.
13. Li S, Wu SP, Whitmore M, Loeffert EJ, Wang L, Watkins SC, Pitt BR, Huang L. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors. Am J Physiol 1999;276:L796-L804.
14. Whitmore M, Li S, Huang L. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther 1999;6: 1867-75.
15. Kuramoto T, Nishikawa M, Thanaketpaisarn O, Okabe T, Yamashita F, Hashida M. Use of lipoplex-induced nuclear factor-κB activation to enhance transgene expression by lipoplex in mouse lung. J Gene Med 2006;8:53-62.
16. Tan Y, Li S, Pitt BR, Huang L. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo. Hum Gene Ther 1999;10:2153-61.
17. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408:740-5.
18. Hsieh CL. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol Cell Biol 1999;19:8211-18.
19. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet 2000;9:2395-402.
20. Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol 1998;18: 6538-47.
21. Fujita N, Shimotake N, Ohki I, Chiba T, Saya H, Shirakawa M, Nakao M. Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Mol Cell Biol 2000;20:5107-18.
22. Hofman CR, Dileo JP, Li Z, Li S, Huang L. Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity. Gene Ther 2001;8:71-4.
23. Reyes-Sandoval A, Ertl HC. CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses. Mol Ther 2004;9:249-61.
24. Yew N, Cheng SH. Reducing the inflammatory activity of CpG-containing plasmid DNA vectors for non-viral gene therapy. Expert Opin Drug Deliv 2004;1:115-25.
25. Yew NS, Wang KX, Przybylska M, Bagley RG, Stedman M, Marshall J, Scheule RK, Cheng SH. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes. Hum Gene Ther 1999;10:223-34.
26. Yew NS, Zhao H, Wu IH, Song A, Tousignam JD, Przybylska M, Cheng SH. Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs. Mol Ther 2000;1:255-62.
27. Yew NS, Zhao H, Przybylska M, Wu IH, Tousignant JD, Scheule RK, Cheng SH. CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo. Mol Ther 2002;5:731-8.
28. Kawabata K, Takakura Y, Hashida M. The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake. Pharm Res 1995;12:825-30.
29. Nomura T, Yasuda K, Yamada T, Okamoto S, Mahato RI, Watanabe Y, Takakura Y, Hashida M. Gene expression and antitumor effects following direct interferon (IFN)-γ gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice. Gene Ther 1999;6:121-9.
30. Watanabe Y, Kawade Y. Induction, production, and purification of natural mouse IFN-α and -β. In: Clemens MJ, Morris AG, Gearing AJH, eds. Lymphokines and interferons: A practical approach. Oxford: IRL Press, 1987. p. 1-14.
31. Yamaoka K, Nakagawa T, Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 1978;6:547-58.
32. Bailer AJ. Testing for the equality of area under the curves when using destructive measurement techniques. J Pharmacokinet Biopharm 1988;16:303-9.
33. Hodges BL, Taylor KM, Joseph MF, Bourgeois SA, Scheule RK. Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides. Mol Ther 2004;10:269-78.
34. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet 2000;1:11-9.
35. Ballestar E, Wolffe AP. Methyl-CpG-binding proteins. Targeting specific gene repression. Eur J Biochem 2001;268:1-6.
36. Sutter D, Doerfler W. Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression. Proc Natl Acad Sci USA 1980;77:253-6.
37. Doerfler W. DNA methylation: eukuryotic defense against the transcription of foreign genes? Microb Pathog 1992;12:1-8.
38. Sellins K, Fradkin L, Liggitt D, Dow S. Type I interferons potently suppress gene expression following gene delivery using liposome-DNA complexes. Mol Ther 2005;12:451-9.
39. Esumi N, Hunt B, Itaya T, Frost P. Reduced tumorigenicity of murine tumor cells secreting gainma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression. Cancer Res 1991;51:1185-9.
40. Xie K, Bielenberg D, Huang S, Xu L, Salas T, Juang SH, Dong Z, Fidler IJ. Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-β gene: possible role of nitric oxide. Clin Cancer Res 1997;3:2283-94.