Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:Plasmid DNA complexes in mice

Human Gene Therapy

Volumn 11, Issue 18, 2000, Pages 2493-2513

  Tousignant, Jennifer D ^a   Gates, Amy L ^a   Ingram, Laurie A ^a   Johnson, Carrie L ^a   Nietupski, Jennifer B ^a   Cheng, Seng H ^a   Eastman, Simon J ^a   Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 6; LIPID; LIPOSOME; PLASMID DNA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE TOXICITY; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENE EXPRESSION; INFLAMMATION; LEUKOPENIA; LIVER NECROSIS; MOUSE; NONHUMAN; THROMBOCYTOPENIA; TRANSGENE;

ANIMALS; BLOOD PLATELETS; CATIONS; COMPLEMENT SYSTEM PROTEINS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE THERAPY; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-6; KINETICS; LEUKOCYTES; LEUKOPENIA; LIPIDS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NECROSIS; PLASMIDS; THROMBOCYTOPENIA; TIME FACTORS; TRANSAMINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034634861     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340050207984     Document Type: Article

References (74)

1. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
2. Effects of complement depletion on the pharmacokinetics and gene delivery mediated by cationic lipid-DNA complexes
3. DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA
4. The biology of cachectin/TNF-A primary mediator of the host response
5. Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol)-lipids
6. No lung toxicity after repeated aerosol or intravenous delivery of plasmid-cationic liposome complexes
7. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12
8. The role of surface charge in the activation of the classical and alternative path ways of complement by liposomes
9. The clearance and localization of nucleic acids by New Zealand rabbits and normal mice
10. Binding of deoxyribonucleic acid to the surface of human platelets
11. Depletion of plasma complement in vivo by a protein of cobra venom: Its effects on various immunologic reactions
12. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
13. Membrane defense against complement lysis: The structure and biological properties of CD59
14. Intravenous cytokine gene delivery by lipid-DNA complexes and controls the growth of established lung metastases
15. Lipid-DNA complexes induce potent activation of innate immune responses antitumor activity when administered intravenously
16. Kinetics and mechanisms for removal of circulating single-stranded DNA in mice
17. Active translocation of platelets into sinusoidal and Disse spaces in the liver in response to lipopolysaccharides, interleukin-1 and tumor necrosis factor
18. Modulation of platelet aggregation by native DNA-Initial description of platelet receptor type, number and discrimination for native DNA
19. Modulation of platelet activation by native DNA
20. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
21. Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes
22. Neutrophil depletion protects against liver injury from bacterial endotoxin
23. In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complex
24. Mechanisms of inflammatory liver injury: Adhesion molecules and cytotoxicity of neutrophils
25. Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse serum
26. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
27. Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA
28. CpG motifs in bacterial DNA trigger direct B-cell activation
29. Sinusoidal lining cells and hepatoxocity
30. Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
31. Hepatic changes produced by a single dose of endotoxin in the germfree mouse. Histochemistry, light microscopy, fluorescence microscopy, and electron microscopy
32. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
33. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors
34. Fate of cationic liposomes and their complex with oligonucleotide in vivo
35. Cationic liposome-mediated gene delivery via systemic administration
36. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration
37. Cationic liposome-mediated intravenous gene delivery
38. Biodistribution and gene expression of lipid/plasmid complexes after systemic administration
39. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice
40. Regulation of the complement membrane attack pathway
41. Protective role of complement in the development of experimental pneumococcal pneumonia in mice
42. Translocation of platelets into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides, interleukin-1 and tumour necrosis factor: The role of Kupffer cells
43. Complement-mediated early clearance of Haemophilus influenzae type b from blood is independent of serum lytic activity
44. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction
45. Cancer gene therapy using plasmid DNA: Safety evaluation in rodents and non-human primates
46. Tissue distribution of the cytofectin component of a plasmid-DNA/cationic lipid complex following intravenous administration in mice
47. Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat
48. Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration
49. Mice deficient for the 55 kD tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
50. Immune activation by bacterial DNA: A new genetic code
51. Activation of the alternate pathway of human complements by rabbit cells
52. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
53. Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy
54. Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung
55. Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia
56. Sinusoidal circulatory disturbance by microthrombosis as a cause of endotoxin-induced hepatic injury
57. Role of neutrophils and platelets in the pathogenesis of focal hepatocellular necrosis in endotoxaemia
58. Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharides
59. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
60. Macrophages ingest and are activated by bacterial DNA
61. Gene transfer in vivo with DNA-liposome complexes: Safety and acute toxicity in mice
62. Inhibition of the classical and alternative pathways by amino acids and their derivatives
63. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo
64. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions
65. Tumor necrosis factor in sepsis: Mediator of multiple organ failure or essential part of host defense?
66. Neutrophil migration during endotoxemia
67. Complement and complement deficiencies
68. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth
69. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid: pDNA complexes
70. IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
71. Systemic gene expression after intravenous DNA delivery into adult mice