-
1
-
-
19744372388
-
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
-
Akinc A, Thomas M, Klibanov AM, and Langer R (2005) Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 7:657-663.
-
(2005)
J Gene Med
, vol.7
, pp. 657-663
-
-
Akinc, A.1
Thomas, M.2
Klibanov, A.M.3
Langer, R.4
-
2
-
-
0030615201
-
Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes PJ and Karin M (1997) Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071.
-
(1997)
N Engl J Med
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
3
-
-
0030825116
-
Nonviral gene delivery to the rat kidney with polyethylenimine
-
Boletta A, Benigni A, Lutz J, Remuzzi G, Soria MR, and Monaco L (1997) Nonviral gene delivery to the rat kidney with polyethylenimine. Hum Gene Ther 8:1243-1251.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 1243-1251
-
-
Boletta, A.1
Benigni, A.2
Lutz, J.3
Remuzzi, G.4
Soria, M.R.5
Monaco, L.6
-
4
-
-
0029160083
-
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
-
Boussif O, Lezoualc HF, Zanta AM, Mergny DM, Scherman D, Demeneix B, and Behr JP (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 92:7297-7301.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7297-7301
-
-
Boussif, O.1
Lezoualc, H.F.2
Zanta, A.M.3
Mergny, D.M.4
Scherman, D.5
Demeneix, B.6
Behr, J.P.7
-
5
-
-
0033758920
-
Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs
-
Bragonzi A, Dina G, Villa A, Calori G, Biffi A, Bordignon C, Assael BM, and Conese M (2000) Biodistribution and transgene expression with nonviral cationic vector/DNA complexes in the lungs. Gene Ther 7:1753-1760.
-
(2000)
Gene Ther
, vol.7
, pp. 1753-1760
-
-
Bragonzi, A.1
Dina, G.2
Villa, A.3
Calori, G.4
Biffi, A.5
Bordignon, C.6
Assael, B.M.7
Conese, M.8
-
6
-
-
0036371914
-
Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
-
Chollet P, Favrot MC, Hurbin A, and Coll JL (2002) Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med 4:84-91.
-
(2002)
J Gene Med
, vol.4
, pp. 84-91
-
-
Chollet, P.1
Favrot, M.C.2
Hurbin, A.3
Coll, J.L.4
-
7
-
-
0034667770
-
Phosphorothioate backbone modification modulates macrophage activation by CpG DNA
-
David PS, Shalin N, Shannon JB, David AH, and Katryn JS (2000) Phosphorothioate backbone modification modulates macrophage activation by CpG DNA. J Immunol 165:4165-4173.
-
(2000)
J Immunol
, vol.165
, pp. 4165-4173
-
-
David, P.S.1
Shalin, N.2
Shannon, J.B.3
David, A.H.4
Katryn, J.S.5
-
8
-
-
0032080647
-
Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: Cationic lipid complexes
-
Freimark BD, Blezinger HP, Florack VJ, Nordstrom JL, Long SD, Deshpande DS, Nochumson S, and Petrak KL (1998) Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes. J Immunol 160:4580-4586.
-
(1998)
J Immunol
, vol.160
, pp. 4580-4586
-
-
Freimark, B.D.1
Blezinger, H.P.2
Florack, V.J.3
Nordstrom, J.L.4
Long, S.D.5
Deshpande, D.S.6
Nochumson, S.7
Petrak, K.L.8
-
9
-
-
27144475378
-
Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex
-
Fumoto S, Kawakami S, Shigeta K, Higuchi Y, Yamashita F, and Hashida M (2005) Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex. J Pharmacol Exp Ther 315:484-493.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 484-493
-
-
Fumoto, S.1
Kawakami, S.2
Shigeta, K.3
Higuchi, Y.4
Yamashita, F.5
Hashida, M.6
-
10
-
-
0031720533
-
Polyethylenimine-based intravenous delivery of transgenes to mouse lung
-
Goula D, Benoist C, Mantero S, Merlo G, Levi G, and Demeneix BA (1998) Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther 5:1291-1295.
-
(1998)
Gene Ther
, vol.5
, pp. 1291-1295
-
-
Goula, D.1
Benoist, C.2
Mantero, S.3
Merlo, G.4
Levi, G.5
Demeneix, B.A.6
-
11
-
-
0030950392
-
In vivo Gene transfer by intravenous administration of stable cationic lipid/DNA complex
-
Hofland HEJ, Nagy D, Liu JJ, Spratt K, Lee YL, Danos O, and Sullivan SM (1997) In vivo Gene transfer by intravenous administration of stable cationic lipid/DNA complex. Pharm Res (N Y) 14:742-749.
-
(1997)
Pharm Res (N Y)
, vol.14
, pp. 742-749
-
-
Hofland, H.E.J.1
Nagy, D.2
Liu, J.J.3
Spratt, K.4
Lee, Y.L.5
Danos, O.6
Sullivan, S.M.7
-
12
-
-
0034000572
-
In vivo gene delivery to the liver using novel galactosylated cationic liposomes
-
Kawakami S, Fumoto S, Nishikawa M, Yamashita F, and Hashida M (2000a) In vivo gene delivery to the liver using novel galactosylated cationic liposomes. Pharm Res (N Y) 17:306-313.
-
(2000)
Pharm Res (N Y)
, vol.17
, pp. 306-313
-
-
Kawakami, S.1
Fumoto, S.2
Nishikawa, M.3
Yamashita, F.4
Hashida, M.5
-
13
-
-
0033995526
-
Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes
-
Kawakami S, Sato A, Nishikawa M, Yamashita F, and Hashida M (2000b) Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes. Gene Ther 7:292-299.
-
(2000)
Gene Ther
, vol.7
, pp. 292-299
-
-
Kawakami, S.1
Sato, A.2
Nishikawa, M.3
Yamashita, F.4
Hashida, M.5
-
14
-
-
0035131596
-
Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application
-
Kircheis R, Wightman L, Schreiber A, Robitza B, Rossler V, Kursa M, and Wagner E (2001) Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Ther 8:28-40.
-
(2001)
Gene Ther
, vol.8
, pp. 28-40
-
-
Kircheis, R.1
Wightman, L.2
Schreiber, A.3
Robitza, B.4
Rossler, V.5
Kursa, M.6
Wagner, E.7
-
15
-
-
0035286969
-
Polyethylenimine-mediated gene delivery: A mechanistic study
-
Kichler A, Leborgne C, Coeytaux E, and Danos O (2001) Polyethylenimine-mediated gene delivery: a mechanistic study. J Gene Med 3:135-144.
-
(2001)
J Gene Med
, vol.3
, pp. 135-144
-
-
Kichler, A.1
Leborgne, C.2
Coeytaux, E.3
Danos, O.4
-
16
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
Klinman DM (2004) Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 4:1-10.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 1-10
-
-
Klinman, D.M.1
-
17
-
-
0029100239
-
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
-
Knowles MR, Hohneker KW, Zhou Z, Olsen JC, Noah TL, Hu PC, Leigh MW, and Boucher RC (1995) A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med 333:823-831.
-
(1995)
N Engl J Med
, vol.333
, pp. 823-831
-
-
Knowles, M.R.1
Hohneker, K.W.2
Zhou, Z.3
Olsen, J.C.4
Noah, T.L.5
Hu, P.C.6
Leigh, M.W.7
Boucher, R.C.8
-
18
-
-
0028931102
-
CpG motif in bacterial DNA trigger direct B-cell activation
-
Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, and Klinman DM (1995) CpG motif in bacterial DNA trigger direct B-cell activation. Nature (Lond) 374:546-549.
-
(1995)
Nature (Lond)
, vol.374
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
19
-
-
0024475227
-
NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
-
Lenardo MJ and Baltimore D (1989) NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227-229.
-
(1989)
Cell
, vol.58
, pp. 227-229
-
-
Lenardo, M.J.1
Baltimore, D.2
-
20
-
-
0033005285
-
Effect of immune response on gene transfers to the lung via systemic administration of cationic vectors
-
Li S, Wu SP, Whitmore M, Loeffert EJ, Wang L, Watkins SC, Pitt BR, and Huang L (1999) Effect of immune response on gene transfers to the lung via systemic administration of cationic vectors. Am J Physiol 276:L796-L804.
-
(1999)
Am J Physiol
, vol.276
-
-
Li, S.1
Wu, S.P.2
Whitmore, M.3
Loeffert, E.J.4
Wang, L.5
Watkins, S.C.6
Pitt, B.R.7
Huang, L.8
-
21
-
-
0030813879
-
Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration
-
Liu F, Qi H, Huang L, and Liu D (1997) Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Ther 6:517-523.
-
(1997)
Gene Ther
, vol.6
, pp. 517-523
-
-
Liu, F.1
Qi, H.2
Huang, L.3
Liu, D.4
-
22
-
-
0035831629
-
Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes
-
Loisel S, Le Gall C, Doucet L, Ferec C, and Floch V (2001) Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes. Hum Gene Ther 12:685-696.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 685-696
-
-
Loisel, S.1
Le Gall, C.2
Doucet, L.3
Ferec, C.4
Floch, V.5
-
23
-
-
19444372923
-
A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy
-
Moghimi SM, Symonds P, Murray JC, Hunter AC, Debska G, and Szewczyk A (2005) A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Mol Ther 11:990-995.
-
(2005)
Mol Ther
, vol.11
, pp. 990-995
-
-
Moghimi, S.M.1
Symonds, P.2
Murray, J.C.3
Hunter, A.C.4
Debska, G.5
Szewczyk, A.6
-
24
-
-
0037301583
-
Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethylenimine on hepatoma cells and mouse liver
-
Morimoto K, Nishikawa M, Kawakami S, Nakano T, Hattori Y, Fumoto S, Yamashita F, and Hashida M (2003) Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethylenimine on hepatoma cells and mouse liver. Mol Ther 7:254-261.
-
(2003)
Mol Ther
, vol.7
, pp. 254-261
-
-
Morimoto, K.1
Nishikawa, M.2
Kawakami, S.3
Nakano, T.4
Hattori, Y.5
Fumoto, S.6
Yamashita, F.7
Hashida, M.8
-
25
-
-
23944464631
-
Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives
-
Neu M, Fischer D, and Kissel T (2005) Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med 7:992-1009.
-
(2005)
J Gene Med
, vol.7
, pp. 992-1009
-
-
Neu, M.1
Fischer, D.2
Kissel, T.3
-
26
-
-
0029799638
-
Gene therapy in the United States: A five-year status report
-
Ross G, Erickson R, Knorr D, Motulsky AG, Parkman R, Samulski J, Straus SE, and Smith BR (1996) Gene therapy in the United States: a five-year status report. Hum Gene Ther 7:1781-1790.
-
(1996)
Hum Gene Ther
, vol.7
, pp. 1781-1790
-
-
Ross, G.1
Erickson, R.2
Knorr, D.3
Motulsky, A.G.4
Parkman, R.5
Samulski, J.6
Straus, S.E.7
Smith, B.R.8
-
27
-
-
17844401203
-
Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: The role of the neutral helper lipid
-
Sakurai F, Nishioka T, Saito H, Baba T, Okuda A, Matsumoto O, Taga T, Yamashita F, Takakura Y, and Hashida M (2001) Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid. Gene Ther 8:677-686.
-
(2001)
Gene Ther
, vol.8
, pp. 677-686
-
-
Sakurai, F.1
Nishioka, T.2
Saito, H.3
Baba, T.4
Okuda, A.5
Matsumoto, O.6
Taga, T.7
Yamashita, F.8
Takakura, Y.9
Hashida, M.10
-
28
-
-
0036060566
-
The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes
-
Sakurai F, Terada T, Yasuda K, Yamashita F, Takakura Y, and Hashida M (2002) The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes. Gene Ther 9:1120-1126.
-
(2002)
Gene Ther
, vol.9
, pp. 1120-1126
-
-
Sakurai, F.1
Terada, T.2
Yasuda, K.3
Yamashita, F.4
Takakura, Y.5
Hashida, M.6
-
29
-
-
0030668116
-
Characterization of cationic liposomemediated gene transfer in vivo by intravenous administration
-
Song YK, Liu F, Chu SY, and Liu D (1997) Characterization of cationic liposomemediated gene transfer in vivo by intravenous administration. Hum Gene Ther 8:1585-1594.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 1585-1594
-
-
Song, Y.K.1
Liu, F.2
Chu, S.Y.3
Liu, D.4
-
30
-
-
0034991899
-
Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity
-
Tan Y, Liu F, Li Z, Li S, and Huang L (2001) Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity. Mol Ther 3:673-682.
-
(2001)
Mol Ther
, vol.3
, pp. 673-682
-
-
Tan, Y.1
Liu, F.2
Li, Z.3
Li, S.4
Huang, L.5
-
31
-
-
0036936852
-
Codelivery of NF-κB decoy-related oligodeoxynucleotide improves LPD-mediated systemic gene transfer
-
Tan Y, Zhang JS, and Huang L (2002) Codelivery of NF-κB decoy-related oligodeoxynucleotide improves LPD-mediated systemic gene transfer. Mol Ther 6:804-812.
-
(2002)
Mol Ther
, vol.6
, pp. 804-812
-
-
Tan, Y.1
Zhang, J.S.2
Huang, L.3
-
32
-
-
0034634861
-
Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid: Plasmid DNA complexes in mice
-
Tousignant JD, Gates AL, Ingram LA, Johnson CL, Nietupski JB, Cheng SH, Eastman SJ, and Scheule RK (2000) Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid: plasmid DNA complexes in mice. Hum Gene Ther 11:2493-2513.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 2493-2513
-
-
Tousignant, J.D.1
Gates, A.L.2
Ingram, L.A.3
Johnson, C.L.4
Nietupski, J.B.5
Cheng, S.H.6
Eastman, S.J.7
Scheule, R.K.8
-
33
-
-
3242746274
-
Physicochemical optimisation of plasmid delivery by cationic lipids
-
Tranchant I, Thompson B, Nicolazzi C, Mignet N, and Scherman D (2004) Physicochemical optimisation of plasmid delivery by cationic lipids. J Gene Med 6:24-35.
-
(2004)
J Gene Med
, vol.6
, pp. 24-35
-
-
Tranchant, I.1
Thompson, B.2
Nicolazzi, C.3
Mignet, N.4
Scherman, D.5
-
34
-
-
0032732516
-
LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth
-
Whitmore M, Li S, and Huang L (1999) LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther 6:1867-1875.
-
(1999)
Gene Ther
, vol.6
, pp. 1867-1875
-
-
Whitmore, M.1
Li, S.2
Huang, L.3
-
35
-
-
0035408714
-
Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo
-
Wightman L, Kircheis R, Rossler V, Carotta S, Ruzicka R, Kursa M, and Wagner E (2001) Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med 3:362-372.
-
(2001)
J Gene Med
, vol.3
, pp. 362-372
-
-
Wightman, L.1
Kircheis, R.2
Rossler, V.3
Carotta, S.4
Ruzicka, R.5
Kursa, M.6
Wagner, E.7
-
36
-
-
0030759050
-
Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA
-
Yang JP and Huang L (1997) Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA. Gene Ther 4:950-960.
-
(1997)
Gene Ther
, vol.4
, pp. 950-960
-
-
Yang, J.P.1
Huang, L.2
-
37
-
-
0028328261
-
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
-
Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, and Wilson JM (1994) Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91:4407-4411.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4407-4411
-
-
Yang, Y.1
Nunes, F.A.2
Berencsi, K.3
Furth, E.E.4
Gonczol, E.5
Wilson, J.M.6
-
38
-
-
0033585425
-
Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid: PDNA complexes
-
Yew NS, Wang KX, Przybylska M, Bagley RG, Stedman M, Marshall J, Scheule RK, and Cheng SH (1999) Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid: pDNA complexes. Hum Gene Ther 10:223-234.
-
(1999)
Hum Gene Ther
, vol.10
, pp. 223-234
-
-
Yew, N.S.1
Wang, K.X.2
Przybylska, M.3
Bagley, R.G.4
Stedman, M.5
Marshall, J.6
Scheule, R.K.7
Cheng, S.H.8
-
39
-
-
0034149827
-
Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs
-
Yew NS, Zhao H, Wu IH, Song A, Tousignant JD, Przybylska M, and Cheng SH (2000) Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs. Mol Ther 1:255-262.
-
(2000)
Mol Ther
, vol.1
, pp. 255-262
-
-
Yew, N.S.1
Zhao, H.2
Wu, I.H.3
Song, A.4
Tousignant, J.D.5
Przybylska, M.6
Cheng, S.H.7
-
40
-
-
0032525023
-
CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
-
Yi AK, Tuetken R, Redford T, Waldschmidt M, Kirsch J, and Krieg AM (1998) CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J Immunol 160:4755-4761.
-
(1998)
J Immunol
, vol.160
, pp. 4755-4761
-
-
Yi, A.K.1
Tuetken, R.2
Redford, T.3
Waldschmidt, M.4
Kirsch, J.5
Krieg, A.M.6
-
41
-
-
0034152683
-
Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
-
Zou SM, Erbacher P, Remy JS, and Behr JP (2000) Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J Gene Med 2:128-134.
-
(2000)
J Gene Med
, vol.2
, pp. 128-134
-
-
Zou, S.M.1
Erbacher, P.2
Remy, J.S.3
Behr, J.P.4
|