The role of CpG motifs in immunostimulation and gene therapy

Advanced Drug Delivery Reviews

Volumn 44, Issue 2-3, 2000, Pages 119-134

  Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Bacterial DNA; CpG Motif; Gene Therapy; Immunostimulation

Indexed keywords

BACTERIA; DNA; GENETIC ENGINEERING; PATIENT TREATMENT;

ADAPTIVE IMMUNE RESPONSE; CYTOKINES; DINUCLEOTIDE MOTIFS; GENE THERAPY; IMMUNOSTIMULATION;

IMMUNOLOGY;

ADJUVANT; BACTERIAL DNA; CATION; CYTOKINE; DRUG VEHICLE; LIPID; OLIGODEOXYNUCLEOTIDE; PLASMID DNA; VACCINE;

B LYMPHOCYTE; BACTERIUM; CANCER IMMUNOTHERAPY; CLONING VECTOR; CPG ISLAND; DENDRITIC CELL; DNA FLANKING REGION; DRUG DELIVERY SYSTEM; GENE TARGETING; GENE THERAPY; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOSTIMULATION; INFLAMMATION; MACROPHAGE; MAMMAL; MONOCYTE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TH1 CELL;

EID: 0034670157     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00090-9     Document Type: Article

References (71)

1. Bacterial CpG DNA activates immune cells to signal infectious danger
2. The role of CpG motifs in innnate immunity
3. Consequences of bacterial CpG DNA-driven activation of antigen-presenting cells
4. Signal transduction pathways activated by CpG-DNA
5. Macrophage activation by immunostimulatory DNA
6. Mechanism of action of CpG DNA
7. Bacterial DNA as an evolutionary conserved ligand signaling danger of infection to immune cells
8. Bacterial DNA as immune cell activator
9. BCG immunotherapy of rat tumours in athymic nude mice
10. BCG in tumor immunotherapy
11. Activation of peritoneal lymphocyte cytotoxicity in patients with ovarian cancer by intraperitoneal treatment with Corynebacterium parvum
12. Treatment of inoperable malignant tumors with toxins of erysipelas and the Bacillus prodigiosus
13. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
14. CpG motifs in bacterial DNA trigger direct B-cell activation
15. Regulation and function of DNA methylation in vertebrates
16. CpG islands
17. A chronicle of DNA methylation (1948-1975)
18. Competition - a common motif for the imprinting mechanism?
19. Effect of DNA methylation on the binding of vertebrate and plant proteins to DNA
20. Gene number, noise reduction and biological complexity
21. DNA methylation and its possible biological roles
22. The immune system evolved to discriminate infectious nonself from noninfectious self
23. Tolerance, danger, and the extended family
24. Innate immunity: impact on the adaptive immune response
25. Mitogenicity of DNA from different organisms for murine B cells
26. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
27. Direct immunologic activities of CpG DNA and implications for gene therapy
28. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides
29. Mechanisms and therapeutic applications of immune stimulatory CpG DNA
30. Phosphorodithioate DNA as a potential therapeutic drug
31. Characterization and modulation of immune stimulation by modified oligonucleotides
32. Oligodeoxynucleotide modifications determine the magnitude of B cell stimulation by CpG motifs
33. Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides
34. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
35. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
36. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
37. Immunostimulatory properties of genomic DNA from different bacterial species
38. Induction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteria
39. CpG oligodeoxynucleotides down-regulate macrophage class II antigen processing
40. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides
41. Macrophages ingest and are activated by bacterial DNA
42. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells
43. DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen
44. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
45. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
46. CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells
47. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors
48. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo
49. Promoter attenuation in gene therapy: interferon-γ and tumor necrosis factor-squaresign squaresign inhibit transgene expression
50. In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complex
51. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
52. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration
53. Activation of host antitumoral responses by cationic lipid/DNA complexes
54. Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when adminstered intravenously
55. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth
56. Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs
57. Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung
58. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes
59. Interleukin 12, interferon γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction
60. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock
61. Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases
62. Intratracheal administration of interleukin 12 plasmid-cationic lipid complexes inhibits murine lung metastases
63. Plasmid DNA gene therapy: studies with the human interleukin-12 gene in tumor cells in vitro and in the murine B16 model in vivo
64. Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal models
65. Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12
66. The role of CXC chemokines as regulators of angiogenesis
67. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes
68. Towards gene therapy for cystic fibrosis: A clinical progress report
69. Transcriptional repression by methylation of CpG
70. Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs
71. Depression of human polymorphonuclear leucocyte function by anti-malarial drugs