Reduced Inflammatory Response to Plasmid DNA Vectors by Elimination and Inhibition of Immunostimulatory CpG Motifs

Molecular Therapy

Volumn 1, Issue 3, 2000, Pages 255-262

  Yew, Nelson S ^a   Zhao, Hongmei ^a   Wu, I Huan ^a   Song, Antonius ^a   Tousignant, Jennifer D ^a   Przybylska, Malgorzata ^a   Cheng, Seng H ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

CpG; immunostimulatory activity; cationic lipid; plasmid DNA; gene transfer; intravenous delivery; intranasal delivery

Indexed keywords

ANTIMALARIAL AGENT; BACTERIAL DNA; CHLOROQUINE; CYTOKINE; INTERLEUKIN 12; LIPID; MEPACRINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CPG ISLAND; DRUG ANTAGONISM; GENE DELETION; GENE TRANSFER; GENE VECTOR; GENETICS; IMMUNOLOGY; INFLAMMATION; INTRANASAL DRUG ADMINISTRATION; LUNG; LUNG LAVAGE; METABOLISM; MOUSE; PLASMID; SITE DIRECTED MUTAGENESIS; SPLEEN;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIMALARIALS; BRONCHOALVEOLAR LAVAGE FLUID; CHLOROQUINE; CPG ISLANDS; CYTOKINES; DNA, BACTERIAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; INFLAMMATION; INTERLEUKIN-12; LIPIDS; LUNG; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; QUINACRINE; SEQUENCE DELETION; SPLEEN;

EID: 0034149827     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2000.0036     Document Type: Article

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