Cationic compounds used in lipoplexes and polyplexes for gene delivery

Journal of Controlled Release

Volumn 100, Issue 2, 2004, Pages 165-180

  Zhang, Shubiao ^a   Xu, Yingmei ^a   Wang, Bing ^a   Qiao, Weihong ^b   Liu, Dongliang ^b   Li, Zongshi ^b  

^a DALIAN NATIONALITIES UNIVERSITY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Cationic compounds; Lipoplexes; Polyplexes

Indexed keywords

CATIONIC LIPIDS; CATIONIC POLYMERS; GENETIC DISEASES;

DISEASE CONTROL; IMMUNOLOGY; LIPIDS; POLYPEPTIDES; POSITIVE IONS; TOXIC MATERIALS;

GENE TRANSFER;

CATION; CHITOSAN; CHOLESTEROL; GUANIDINE DERIVATIVE; LIPID; PEPTIDE DERIVATIVE; POLYETHYLENEIMINE; POLYLYSINE; POLYMER; PROTAMINE;

COVALENT BOND; CYTOTOXICITY; DISULFIDE BOND; DRUG SYNTHESIS; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; MACROMOLECULE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; VIRAL GENE DELIVERY SYSTEM;

CATIONS; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; LIPIDS; LIPOSOMES; POLYMERS;

EID: 8544230612     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.08.019     Document Type: Review

References (109)

1. F. Liu, and L. Huang Development of non-viral vectors for systemic gene delivery J. Control. Release 78 2002 259 266
2. I.M. Verma, and N. Somia Gene therapy-promises, problems and prospects Nature 389 1997 239 242
3. D. Ferber Gene therapy: safer and virus-free? Science 294 2001 1638 1642
4. K.K. Hunt, and S.A. Vorburger Hurdles and hopes for cancer treatment Science 297 2002 415 416
5. D.D. Lasic, and N.S. Templeton Liposomes in gene therapy Adv. Drug Deliv. Rev. 20 1996 221 266
6. O. Meyer, D. Kirpotin, K. Hong, B. Sternberg, J.W. Park, M.C. Woodle, and D. Papahadjopoulos Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides J. Biol. Chem. 273 1998 15621 15627
7. F.L. Sorgi, S. Bhattacharya, and L. Huang Protamine sulfate enhances lipid-mediated gene transfer Gene Ther. 4 1997 961 968
8. N. Zhu, D. Liggitt, Y. Liu, and R. Debs Systemic gene expression after intravenous DNA delivery in adult mice Science 261 1993 209 211
9. M. Tsukamoto, T. Ochiya, S.T. Sugimura, and M. Terada Gene transfer and expression in progeny after intravenous DNA injection into pregnant mice Nat. Genet. 9 1995 243 248
10. M.C. Woodle, and P. Scaria Cationic liposomes and nucleic acids Curr. Opin. Colloid and Interface Sci. 6 2001 78 84
11. J. Zabner Cationic lipids used in gene transfer Adv. Drug Deliv. Rev. 27 1997 17 28
12. R.I. Zhdanov, O.V. Podobed, and V.V. Vlassov Cationic lipid-DNA complexes-lipoplexes for gene transfer and therapy Bioelectrochemistry 58 2002 53 64
13. 14C]-DNA tissue distribution following intraperitoneal administration of new pH-sensitive lipoplexes in mice Cytobios 106 S1 2001 7 14
14. Fillion Patrick, Annie Desjardins, Khampoune Sayasith, and Jacqueline Lagace Encapsulation of DNA in negatively charged liposomes and inhibition of bacterial gene expression with fluid liposome-encapsulated antisense oligonucleotides Biochim. Biophys. Acta 1515 2001 44 54
15. K.K. Son, D. Tkach, and K.J. Hall Efficient in vivo gene delivery by the negatively charged complexes of cationic liposomes and plasmid DNA Biochim. Biophys. Acta 1468 2000 6 10
16. J.H. Felgner, R. Kumar, C.N. Sridhar, C.J. Wheeler, Y.J. Tsai, R. Border, P. Ramsey, M. Martin, and P.L. Felgner Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations J. Biol. Chem. 269 1994 2550 2561
17. H. Farhood, N. Serbina, and L. Huang The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer Biochim. Biophys. Acta 1235 1995 289 295
18. N.S. Tempelton, D.D. Lasic, P.M. Frederik, H.H. Strey, D.D. Roberts, and G.N. Palvakis Improved DNA:liposomes complexes for increased systemic delivery and gene expression Nat. Biotechnol. 15 1997 647 652
19. K. Hong, W. Zheng, A. Baker, and D. Papahadjopoulos Stabilisation of cationic liposome/DNA complexes by polyamines and polyethylenglycol-phospholipid conjugates for efficient in vivo gene delivery FEBS Lett. 414 1997 187 192
20. D.D. Lasic Liposomes in Gene Delivery 1997 CRC Press Boca Raton
21. M.J. Bennet, M.H. Nantz, R.P. Balasubramanian, D.C. Gruenert, and R.W. Malone Cholesterol enhances cationic liposome-mediated DNA transfection of human respiratory epithelial cells Biosci. Rep. 15 1995 47 53
22. S. Kawakami, F. Yamashita, M. Nishikawa, Y. Takakura, and M. Hashida Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes Biochem. Biophys. Res. Commun. 252 1998 78 83
23. D.D. Lasic Recent developments in medical applications of liposomes: sterically stabilized liposomes in cancer therapy and gene delivery in vivo J. Control. Release 48 1997 203 222
24. Otmane Boussif, Jérôme Gaucheron, Catherine Santaella Hanno V.J. Kolbe, and Pierre Vierling Enhanced in vitro and in vivo cationic lipid-mediated gene delivery with a fluorinated glycerophosphoethanolamine helper lipid J. Gene Med. 3 2001 109 114
25. P.L. Felgner, T.R. Gadek, M. Holm, R. Roman, H.W. Chan, M. Wenz, J.P. Northrop, G.M. Ringold, and M. Danielsen Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc. Natl. Acad. Sci. U. S. A. 84 21 1987 7413 7427
26. A.J. Fasbender, J. Zabner, and M.J. Welsh Optimization of cationic lipid-mediated gene transfer to airway epithelia Am. J. Physiol. 269 1, Pt. 1 1995 L45 L51
27. N.J. Caplen, E. Kinrade, F. Sorgi, X. Gao, D. Gruenert, D. Geddes, C. Coutelle, L. Huang, E.W. Alton, and R. Williamson In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE Gene Ther. 2 9 1995 603 613
28. X. Gao, and L. Huang Potentiation of cationic liposome-mediated gene delivery by polycations Biochemistry 35 3 1996 1027 1036
29. I.S. Kikuchi, and A.M. Carmona-Ribeiro Interactions between DNA and synthetic cationic liposomes J. Phys. Chem., B 104 2000 2829 2835
30. P. Pinnaduwage, L. Schmitt, and L. Huang Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse l-cells Biochim. Biophys. Acta 985 1 1989 33 37
31. Fuxing Tang, and Jeffrey A. Hughes Synthesis of a single-tailed cationic lipid and investigation of its transfection J. Control. Release 62 1999 345 358
32. Y. Liu, D. Liggit, N. Zhou, K. Gaensler, and R. Debs Cationic liposome mediated intravenous gene delivery J. Biol. Chem. 270 1995 24864 24870
33. A. Kim, E.H. Lee, S.H. Choi, and C.K. Kim In vitro and in vivo transfection efficiency of a novel ultradeformable cationic liposome Biomaterials 25 2004 305 313
34. Fuminori Sakurai, Rui Inoue, Yasunobu Nishino, Ayumu Okuda, Osamu Matsumoto, Tooru Taga, Fumiyoshi Yamashita, Yoshinobu Takakura, and Mitsuru Hashida Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression J. Control. Release 66 2000 255 269
35. Armandodoriano Bianco, Francesco Bonadies, Raffaella Napolitano, Giancarlo Ortaggi, Claudio Esposito, Giuseppe Mossa, and Cesare Cametti Synthesis of novel cationic lipids for preparation of liposomes to be used in gene therapy of glioma C. R., Chimie 6 2003 589 595
36. Mohamad Radwan Almofti, Hideyoshi Harashima, Yasuo Shinohar, Ammar Almofti, Yoshinobu Baba, and Hiroshi Kiwada Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization Arch. Biochem. Biophys. 410 2003 246 253
37. A. Kikuchi, Y. Aoki, S. Sugaya, T. Serikawa, K. Takakuwa, K. Tanaka, N. Suzuki, and H. Kikuchi Development of novel cationic liposomes for efficient gene transfer into peritoneal disseminated tumor Hum. Gene Ther. 10 1999 947 955
38. Hideki Ishiwata, Norio Suzuki, Shuichi Ando, Hiroshi Kikuchi, and Takayuki Kitagawa Characteristics and biodistribution of cationic liposomes and their DNA complexes J. Control. Release 69 2000 139 148
39. R. Fraley, R.M. Straubinger, G. Rule, E.L. Springer, and D. Papahadjopoulos Liposome-mediated delivery of deoxyribonucleic acid to cells: enhanced efficiency of delivery related to lipid composition and incubation Biochemistry 20 24 1981 6978 6987
40. Satoshi Obika, Wei Yu, Atsuko Shimoyama, Takeshi Uneda, Kazuyuki Miyashita, Takefumi Doi, and Takeshi Imanishi Symmetrical cationic triglycerides: an efficient synthesis and application to gene transfer Bioorg. Med. Chem. 9 2001 245 254
41. Marappan Subramanian, Juha M. Holopainen, Tommi Paukku, Ove Eriksson, Ilpo Huhtaniemi, and Paavo K.J. Kinnunen Characterisation of three novel cationic lipids as liposomal complexes with DNA1 Biochim. Biophys. Acta 1466 2000 289 305
42. M.A. Ilies, W.A. Seitz, M.T. Caproiu, M. Wentz, R.E. Garfield, and A.T. Balaban Pyridinium-based cationic lipids as gene-transfer agents Eur. J. Org. Chem. 2003 2645 2655
43. J.P. Berh, B. Demeneix, J.P. Loeffler, and J.P. Mutul Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine coated DNA Proc. Natl. Acad. Sci. U. S. A. 86 1989 6982 6986
44. Elisabetta Fortunati, Abraham Bout, Maria Antonia Zanta, Dinko Valerio, and Maurizio Scarpa In vitro and in vivo gene transfer to pulmonary cells mediated by cationic liposomes Biochim. Biophys. Acta 1306 1996 55 62
45. Takashi Imaoka, Isao Date, Takashi Ohmoto, Tatsuji Yasuda, and Masaaki Tsuda In vivo gene transfer into the adult mammalian central nervous system by continuous injection of plasmid DNA-cationic liposome complex Brain Res. 780 1998 119 128
46. David Gilot, Marie-Laure Miramon, Thierry Benvegnu, Vincent Ferrieres, Olivier Loreal, Christiane Guguen-Guillouzo, Daniel Plusquellec, and Pascal Loyer Cationic lipids derived from glycine betaine promote efficient and non-toxic gene transfection in cultured hepatocytes J. Gene Med. 4 2002 415 427
47. David Lleres, Emmanuel Dauty, Jean-Paul Behr, Yves Mély, and Guy Duportail DNA condensation by an oxidizable cationic detergent. Interactions with lipid vesicles Chem. Phys. Lipids 111 2001 59 71
48. Kai Ewert, Ayesha Ahmad, Heather M. Evans, Hans-Werner Schmidt, and Cyrus R. Safinya Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery J. Med. Chem. 45 2002 5023 5029
49. Boon-ek Yingyongnarongkul, Mark Howarth, Tim Elliott, and Mark Bradley Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells Chem. Eur. J. 10 2004 463 473
50. Jean Herscovici, Marie José Egron, Alain Quenot, Françoise Leclercq, Nicolas Leforestier, Nathalie Mignet, Barbara Wetzer, and Daniel Scherman Synthesis of new cationic lipids from an unsaturated glycoside scaffold Org. Lett. 3 2001 1893 1896
51. Marc Frederic, Daniel Scherman, and Gerardo Byk Introduction of cyclic guanidines into cationic lipids for non-viral gene delivery Tetrahedron Lett. 41 2000 675 679
52. P. Belmont, A. Aissaoui, M. Hauchecorne, N. Oudrhiri, L. Petit, J.P. Vigneron, J.M. Lehn, and P. Lehn Aminoglycoside-derived cationic lipids as efficient vectors for gene transfection in vitro and in vivo J. Gene Med. 4 2002 517 526
53. A. Noguchi, T. Furuno, C. Kawaura, and M. Nakanishi Membrane fusion plays an important role in gene transfection mediated by cationic liposomes FEBS Lett. 433 1998 169 173
54. R.I. Zhdanov, N.G. Kutsenko, O.V. Podobed, O.A. Buneeva, T.A. Tsvetkova, D.N. Konevets, and V.V. Vlassov Cholesterol polyethylen/propylen/imines as mediators of transfection of eukaryotic cells for gene therapy Dokl. Akad. Nauk 361 1998 695 699
55. L.V. Kozlov, R.I. Zhdanov, V.A. Guzova, O.V. Podobed, Yu. V. Sviridov, E.V. Bogdanenko, V.I. Shvets, O.S. Dyabina, and A.S. Ermakov Action of non-viral gene delivery vectors on human complement system: low anticomplementary activity of lipoplexes based on LacZ plasmid and phospholipid/oligocation liposomes Cytobios 106 Suppl. 1 2001 67 74
56. Shigeru Kawakami, Fumiyoshi Yamashita, Makiya Nishikawa, Yoshinobu Takakura, and Mitsuru Hashida Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes Biochem. Biophys. Res. Commun. 252 1998 78 83
57. A.E. Smith Viral vectors in gene therapy Annu. Rev. Microbiol. 4 1995 807 838
58. L.C. Smith, J. Duguid, M.S. Wadhwa, M.J. Logan, C.H. Tung, Vince Edwards, and James T. Sparrow Synthetic peptide-based DNA complexes for nonviral gene delivery Adv. Drug Deliv. Rev. 30 1998 115 131
59. T.B. Wyman, F. Nicol, O. Zelphati, P.V. Scaria, C. Plank, and F.C. Szoka Jr. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers Biochemistry 36 1997 3008 3017
60. T. Niidome, K. Takaji, M. Urakawa, N. Ohmori, A. Wada, T. Hirayama, and H. Aoyagi Chain length of cationic alpha-helical peptide sufficient for gene delivery into cells Bioconjug. Chem. 10 1999 773 780
61. Anas El-Aneed An overview of current delivery systems in cancer gene therapy J. Control. Release 94 2004 1 14
62. A.M. Haines, A.S. Irvine, A. Mountain, J. Charlesworth, N.A. Farrow, R.D. Husain, H. Hyde, H. Ketteringham, R.H. McDermott, A.F. Mulcahy, T.L. Mustoe, S.C. Reid, M. Rouquette, J.C. Shaw, D.R. Thatcher, J.H. Welsh, D.E. Williams, W. Zauner, and R.O. Phillips CL22-a novel cationic peptide for efficient transfection of mammalian cells Gene Ther. 8 2001 99 110
63. N. Ohmori, T. Niidome, T. Kiyota, S. Lee, G. Sugihara, A. Wada, T. Hirayama, and H. Aoyagi Importance of hydrophobic region in amphiphilic structures of alpha-helical peptides for their gene transferability into cells Biochem. Biophys. Res. Commun. 245 1998 259 265
64. H.H. Kim, W.S. Lee, J.M. Yang, and S. Shin Basic peptide system for efficient delivery of foreign genes Biochim. Biophys. Acta 1640 2003 129 136
65. K. Rittner, A. Benavente, A. Bompard-Sorlet, F. Heitz, G. Divita, R. Brasseur, and E. Jacobs New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo Molec. Ther. 5 2002 104 114
66. Masaki Tokunaga, Norio Hazemoto, Toshihisa Yotsuyanagi, Masaki Tokunaga, Norio Hazemoto, and Toshihisa Yotsuyanagi Effect of oligopeptides on gene expression: comparison of DNA/peptide and DNA/peptide/liposome complexes Int. J. Pharm. 269 2004 71 80
67. P.L. Felgner, and G.M. Ringold Cationic liposome mediated transfection Nature 337 1989 387 388
68. S. Li, and L. Huang In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes Gene Ther. 4 1997 891 900
69. O. Boussif, F. Lezoualc'h, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and J.P. Behr Versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U. S. A. 92 1995 7297 7301
70. D.D. Dunlap, A. Maggi, M.R. Soria, and L. Monaco Nanoscopic structure of DNA condensed for gene delivery Nucleic Acids Res. 25 1997 3095 3101
71. H. Pollard, J.S. Remy, G. Loussouarn, S. Demolombe, J.P. Behr, and D. Escande Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells J. Biol. Chem. 273 1998 7507 7511
72. D. Fischer, T. Bieber, Y. Li, H.P. Elsasser, and T. Kissel A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity Pharm. Res. 16 1999 1273 1279
73. W.T. Godbey, K.K. Wu, and A.G. Mikos Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle J. Biomed. Mater. Res. 45 1999 268 275
74. A. Sato, S. Kawakami, M. Yamada, F. Yamashita, and M. Hashida Enhanced gene transfection in macrophages using mannosylated cationic liposome-polyethylenimine-plasmid DNA complexes J. Drug Target. 9 2001 201 207
75. P. Lampela, J. Raisanen, P.T. Mannisto, S. Yla-Herttuala, and A. Raasmaja The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures J. Gene Med. 4 2002 205 214
76. K. Kunath, A. von Harpe, D. Fischer, H. Petersen, U. Bickel, K. Voigt, and T. Kissel Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine J. Control Release 89 2003 113 125
77. P. Chollet, M.C. Favrot, A. Hurbin, and J.L. Coll Side-effects of a systemic injection of linear polyethylenimine-DNA complexes J. Gene Med. 4 2002 84 91
78. R. Kircheis, S. Schuller, S. Brunner, M. Ogris, K.H. Heider, W. Zauner, and E. Wagner Polycation-based DNA complexes for tumor-targeted gene delivery in vivo J. Gene Med. 1 1999 111 120
79. Chien-Hsin Lee, Yen-Hsuan Ni, Chia-Chi Chen, Chen-Kung Chou, and Fu-Hsiung Chang Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells Biochim. Biophys. Acta 1611 2003 55 62
80. Pasi Lampel, Matti Eloma, Marika Ruponen, Arto Urtti, Pekka T. Männistö, and Atso Raasmaja Different synergistic roles of small polyethylenimine and Dosper in gene delivery J. Control. Release 88 2003 173 183
81. G.Y. Wu, and C.H. Wu Receptor-mediated in vitro gene transformation by a soluble DNA carrier system J. Biol. Chem. 262 1987 4429 4432
82. C.M. Ward, M.L. Read, and L.W. Seymour Systemic circulation of poly(l-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy Blood 97 2001 2221 2229
83. C.W. Pouton, P. Lucas, B.J. Thomas, A.N. Uduehi, D.A. Milroy, and S.H. Moss Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids J. Control Release 53 1998 289 299
84. M.D. Brown, A. Schatzlein, A. Brownlie, V. Jack, W. Wang, L. Tetley, A.I. Gray, and I.F. Uchegbu Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents Bioconjug. Chem. 11 2000 880 891
85. C.M. Ward, M. Pechar, D. Oupicky, K. Ulbrich, and L.W. Seymour Modification of pLL/DNA complexes with a multivalenthydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo J. Gene Med. 4 2002 536 547
86. C. Pichon, C. Goncalves, and P. Midoux Histidine-rich peptides and polymers for nucleic acids delivery Adv. Drug Deliv. Rev. 53 2001 75 94
87. A. Shibata, M. Yamamoto, T. Yamashita, J.S. Chiou, H. Kamaya, and I. Ueda Biphasic effects of alcohols on the phase transition of poly(l-lysine) between α-helix and b-sheet conformations Biochemistry 31 1992 5728 5733
88. F.L. Sorgi, S. Bhattacharya, and L. Huang Protamine sulfate enhances lipid-mediated gene transfer Gene Ther. 4 9 1997 961 968
89. S. Li, M.A. Rizzo, S. Bhattacharya, and L. Huang Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery Gene Ther. 5 7 1998 930 937
90. R.W. Warrant, and S.H. Kim Alpha-helix-double helix interaction shown in the structure of a protamine-transfer RNA complex and a nucleoprotamine model Nature 271 5641 1978 130 135
91. A. Ziemienowicz, D. Gorlich, E. Lanka, B. Hohn, and L. Rossi Import of DNA into mammalian nuclei by proteins originating from a plant pathogenic bacterium Proc. Natl. Acad. Sci. U. S. A. 96 7 1999 3729 3733
92. R.J. Mumper, J. Wang, J.M. Claspell, and A.P. Rolland Novel polymeric condensing carriers for gene delivery Proc. Int. Symp. Control. Release Bioact. Mater. 22 1995 178 179
93. T. Sato, T. Ishii, and Y. Okahata In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency Biomaterials 22 2001 2075 2080
94. T. Ishii, Y. Okahata, and T. Sato Mechanism of cell transfection with plasmid/chitosan complexes Biochim. Biophys. Acta 1514 2001 51 64
95. W.G. Liu, and K.D. Yao Chitosan and its derivatives-a promising non-viral vector for gene transfection J. Control. Release 83 2002 1 11
96. P.J. Flory Molecular size distribution in three dimensional polymers: I. Gelation J. Am. Chem. Soc. 63 1941 3083 3090
97. L. Vincent, J. Varet, J.Y. Pille, H. Bompais, P. Opolon, A. Maksimenko, C. Malvy, M. Mirshahi, H. Lu, J.P. Vannier, C. Soria, and H. Li Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth andangiogenesis: in vitro and in vivo studies Int. J. Cancer 105 2003 419 429
98. Toshinari Takahashi, Kenji Kono, Toshihide Itoh, Nobuhiko Emi, and Toru Takagishi Synthesis of novel cationic lipids having polyamidoamine dendrons and their transfection activity Bioconjug. Chem. 14 2003 764 773
99. M.L. Read, K.H. Bremner, D. Oupick, N.K. Green, P.F. Searle, and L.W. Seymour Vectors based on reducible polycations facilitate intracellular release of nucleic acids J. Gene Med. 5 2003 232 245
100. A.V. Kabanov, P. Lemieux, S. Vinogradov, and V. Alakhov Pluronic block copolymers: novel functional molecules for gene therapy Adv. Drug Deliv. Rev. 54 2002 223 233
101. B.R. Twaites, C. de las Heras Alarcon, D. Cunliffe, M. Lavigne, S. Pennadam, J.R. Smith, D.C. Gorecki, C. Alexander, Thermo and pH responsive polymers as gene delivery vectors: effect of polymer architecture on DNA complexation in vitro, 97 (2004) 551-566.
102. Michel Bessodes, Catherine Dubertret, Gabrielle Jaslin, and Daniel Scherman Synthesis and biological properties of new glycosidic cationic lipids for DNA delivery Bioorganic Med. Chem. Letters 10 2000 1393 1395
103. B. Santanu, and P.V. Dileep Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone Tetrahedron Lett. 40 1999 8167 8171
104. J.A. Heyes, D. Niculescu-Duvaz, R.G. Cooper, and C.J. Springer Synthesis of novel cationic lipids: effect of structural modification on the efficiency of gene transfer J. Med. Chem. 45 2002 99 114
105. T. Ren, and D.X. Liu Synthesis of diether-linked cationic lipids for gene delivery Bioorganic Med. Chem. Letters 9 1999 1247 1250
106. T. Ren, and D.X. Liu Synthesis of cationic lipids from 1,2,4-butanetriol Tetrahedron Lett. 40 1999 209 212
107. F.X. Tang, and J.A. Hughes Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA Biochem. Biophys. Res. Commun. 242 1998 141 145
108. J. Gaucheron, T. Wong, K.F. Wong, N. Maurer, and P.R. Cullis Synthesis and properties of novel tetraalkyl cationic lipids Bioconjug. Chem. 13 2002 671 675
109. D.B. Fenske, L.R. Palmer, T. Chen, K.F. Wong, and P.R. Cullis Cationic poly(ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells Biochim. Biophys. Acta 1512 2001 259 272