Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators

British Journal of Pharmacology

Volumn 120, Issue 4, 1997, Pages 681-689

  Mülsch, Alexander ^a   Bauersachs, Johann ^a   Schäfer, Andreas ^a   Stasch, Johannes Peter ^b   Kast, Raimund ^b   Busse, Rudi ^a  

^a GOETHE UNIVERSITY   (Germany)

^b BAYER AG   (Germany)

Author keywords

Nitric oxide; NS 2028 (1H (1,2,4) oxdiazolo (4,3 a) 6 bromo quinoxazin 1 one); Oxygen radicals; Relaxation; Soluble guanylyl cyclase; Vascular smooth muscle; YC 1 (3 (5' hydroxymethyl 2'furyl) 1 benzyl indazole)

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; CYCLIC GMP; ENZYME ACTIVATOR; GLYCERYL TRINITRATE; GUANOSINE TRIPHOSPHATE; GUANYLATE CYCLASE; NITROPRUSSIDE SODIUM; NS 2028; PHENYLEPHRINE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VASODILATOR AGENT; XANTHINE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; CELLS, CULTURED; CYCLIC GMP; ENZYME ACTIVATION; GUANYLATE CYCLASE; INDAZOLES; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; RABBITS; RATS; RATS, INBRED WKY; SUPEROXIDES; VASODILATOR AGENTS;

EID: 0031046943     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0700982     Document Type: Article

References (38)

1. BILLIAR, T.R. (1995). Nitric oxide. Novel biology with clinical relevance. Annal. Surg., 4, 339-349.
2. BRÜNE, B., SCHMIDT, K.U. & ULLRICH, V. (1990). Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion. Eur. J. Biochem., 192, 683-688.
3. CHERRY, P.D., OMAR, H.A., FARRELL, K.A., STUART, J.S. & WOLIN, M.S. (1990). Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation. Am. J. Physiol., 259, H1056-H1062.
4. DERUBERTIS, F.R., CRAVEN, P.A. & PRATT, D.W. (1978). Electron spin resonance study of the role of nitrosyl-heme in the activation of guanylate cyclase by nitrosoguanidine and related agonists. Biochem. Biophys. Res. Commun., 83, 158-167.
5. ESUMI, H. & TANNENBAUM, S.R. (1994). U.S.-Japan cooperative cancer research progam: Seminar on nitric oxide synthase and carcinogenesis. Cancer Res., 54, 297-301.
6. GARTHWAITE, J., SOUTHAM, E., BOULTON, C.L., NIELSEN, E.B., SCHMIDT, K. & MAYER, B. (1995). Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one. Mol. Pharmacol., 48, 184-188.
7. GERZER, R., BÖHME, E., HOFMANN, F. & SCHULTZ, G. (1981). Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett., 132, 71-74.
8. GERZER, R., HAMET, P., ROSS, A.H., LAWSON, J.A. & HARDMAN, J.G. (1983). Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. J. Pharmacol. Exp. Ther., 226, 180-186.
9. GRAFF, G., STEPHENSON, J.H., GLASS, D.B., HADDOX, M.K. & GOLDBERG, N.D. (1978). Activation of soluble splenic cell guanylate cyclase by prostaglandin endoperoxides and fatty acid hydroperoxides. J. Biol. Chem., 253, 7662-7676.
10. 15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138.
11. HECKER, M., PREIß, C., SCHINI-KERTH, V.B. & BUSSE, R. (1996). Antioxidants differentially affect nuclear factor κB-mediated nitric oxide synthase expression in vascular smooth muscle cells. FEBS Lett., 380, 224-228.
12. IGNARRO, L.J. (1990). Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: A unique transduction mechanism for transcellular signalling. Pharmacol. Toxicol., 67, 1-7.
13. IGNARRO, L.J., WOOD, K.S. & WOLIN, M.S. (1982). Activation of purified soluble guanylate cyclase by protoporphyrin IX. Proc. Natl. Acad. Sci. U.S.A., 79, 2870-2873.
14. KO, F.N., WU, C.C., LEE, F.Y. & TENG, C.M. (1994). YC-1, a novel activator of platelet guanylate cyclase. Blood, 84, 4226-4233.
15. KÖSSLING, D., HERZ, J., GAUSEPOHL, H., NIROOMAND, F., HINSCH, K.D., MÜLSCH, A., BÖHME, E., SCHULTZ, G. & FRANK, R. (1988). The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. FEBS Lett., 239, 29-34.
16. KÖSSLING, D., HARTENECK, C., HUMBERT, P., BOSSERHOFF, A., FRANK, R., SCHULTZ, G. & BÖHME, E. (1990). The primary structure of the larger subunit of soluble guanylyl cyclase from bovine lung. FEBS Lett., 266, 128-132.
17. LAURSEN, J.B., MÜLSCH, A., BOESGARD, S., MORDVINTCEV, P.I., TRAUTNER, S., GRUHN, N., NIELSEN-KUDSK, J.E., BUSSE, R. & ALDERSHVILE, J. (1996). Nitrate tolerance in vivo is not associated with reduced bioconversion of nitroglycerin to nitric oxide. Circulation, 94, 2241-2247.
18. LINCOLN, T.M. & CORNWELL, T.L. (1993). Intracellular cyclic GMP receptor proteins. FASEB J., 7, 328-338.
19. MÜLSCH, A. (1986). Untersuchungen zur Regulation der löslichen Guanylat-Cyclase. Doctoral thesis, University of Heidelberg, Germany.
20. MÜLSCH, A., BARA, A., MORDVINTCEV, P., VANIN, A. & BUSSE, R. (1995a). Specificity of different organic nitrates to elicit NO formation in vascular tissues and organs of living rabbits. Br. J. Pharmacol., 116, 2743-2749.
21. MÜLSCH, A. & BÖHME, E. (1984). UV/VIS- and EPR-spectroscopic investigation of soluble guanylate cyclase. Activation by NO and sydnonimines. Naunyn-Schmiedeberg's Arch. Pharmacol., 325, R31.
22. MÜLSCH, A., BUSSE, R., LIEBAU, S. & FÖRSTERMANN, U. (1988). LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J. Pharmacol. Exp. Ther., 247, 283-288.
23. MÜLSCH, A. & GERZER, R. (1991). Purification of heme-containing soluble guanylyl cyclase. In Methods Enzymol., Vol. 195, Adenyl Cyclase, G Proteins, and Guanylyl Cyclase. ed. Johnson, J.A. & Corbin, J.D. pp. 377-383. San Diego: Academic Press.
24. MÜLSCH, A., LÜCKHOFF, A., POHL, U., BUSSE, R. & BASSENGE, E. (1989). LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 119-125.
25. MÜLSCH, A., MORDVINTCEV, P., BARA, A., JUNG, F., CLEMENT, B. & BUSSE, R. (1995b). In vivo spin trapping of glycerol trinitrate-derived nitric oxide in blood vessels and organs. Circulation, 92, 1876-1882.
26. MÜNZEL, T., SAYEGH, H., FREEMAN, B.A., TARPEY, M. & HARRISON, D.G. (1995). Evidence for enhanced vascular superoxide anion production in nitrate tolerance. J. Clin. Invest., 95, 187-194.
27. OHARA, Y., PETERSON, T.E. & HARRISON, D.G. (1993). Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest., 91, 2546-2551.
28. OLESEN, S.P., DREJER, J., AXELSSON, O., MOLDT, P., BANG, L., MÜLSCH, A., NIELSEN-KUDSK, J.E. & BUSSE, R. (1996). NS 2028, a novel inhibitor of the NO sensitive guanylyl cyclase. 2nd Intern. Conf. Biochemistry & Molecular Biology of Nitric Oxide, Los Angeles.
29. SCHINI, J.B., JUNQUERO, D.C., SCOTT-BURDEN, T. & VANHOUTTE, P.M. (1991). Interleukin-1β induces the production of an L-arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta. Biochem. Biophys. Res. Commun., 176, 114-121.
30. SENTER, P.D., ECKSTEIN, F.E., MÜLSCH, A. & BÖHME, E. (1983). The stereochemical course of the reaction catalyzed by soluble bovine lung guanylate cyclase. J. Biol. Chem., 258, 6741-6745.
31. STADLER, J., TROCKFELD, J., SCHMALIX, W.A., BRILL, T., SIEWERT, J.R., GREIM, H. & DOEHMER, J. (1994). Inhibition of cytochromes P4501A by nitric oxide. Proc. Natl. Acad. Sci. U.S.A., 91, 3559-3563.
32. STONE, J.R., SANDS, R.H., DUNHAM, W.R. & MARLETTA, M.A. (1995). Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase. Biochem. Biophvs. Res. Commun., 207, 572-577.
33. 1 subunit yields a nitric-oxide-insensitive form of soluble guanylyl cyclase. Proc. Natl. Acad. Sci. U.S.A., 91, 2592-2596.
34. WU, C.C., KO, F.N., KUO, S.C., LEE, F.Y. & TENG, C.M. (1995). YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. Br. J. Pharmacol., 116, 1973-1978.
35. WU, X.B., BRÜNE, B., VON APPEN, F. & ULLRICH, V. (1992). Reversible activation of soluble guanylate cyclase by oxidizing agents. Arch. Biochem. Biophys., 294, 75-82.
36. YOSHINA, S. & KUO, S.C. (1978). Studies on heterocyclic compounds XXXV. Synthesis of furo[3,2-C]pyrazole derivatives. (2) electrophilic substitution of 1,3-diphenylfuro[3,2-C]pyrazole. Yakugaku Zasshi, 98, 204-208.
37. YU, A.E., HU, S., SPIRO, T.G. & BURSTYN, J.N. (1994). Resonance Raman spectroscopy of soluble guanylyl cyclase reveals displacement of distal and proximal heme ligands by NO. J. Am. Chem. Soc., 116, 4117-4118.
38. YU, S.M., CHENG, Z.J., GUH, J.H., LEE, F.Y. & KUO, S.C. (1995). Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth muscle cells. Biochem. J., 306, 787-792.