SCOPUS 정보 검색 플랫폼

Organic and Biomolecular Chemistry

Volumn 6, Issue 7, 2008, Pages 1149-1158

Diversity-oriented synthesis; A spectrum of approaches and results

(3) Spandl, Richard J a Bender, Andreas b,c Spring, David R a

a UNIVERSITY OF CAMBRIDGE (United Kingdom)

b LEIDEN UNIVERSITY (Netherlands)

c LEIDEN UNIVERSITY (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; LEAD COMPOUNDS; SPECTRUM ANALYSIS; SYNTHESIS (CHEMICAL);

DIVERSITY-ORIENTED SYNTHESIS (DOS);

MOLECULAR STRUCTURE;

EID: 41149097628 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b719372f Document Type: Article

Times cited : (270)

References (59)

1
- 0344515366
- -3870
- D. R. Spring Org. Biomol. Chem. 2003 1 3867 3870
- (2003) Org. Biomol. Chem. , vol.1 , pp. 3867
- Spring, D.R.¹

2
- 0032130279
- -1152
- S. L. Schreiber Bioorg. Med. Chem. 1998 6 1127 1152
- (1998) Bioorg. Med. Chem. , vol.6 , pp. 1127
- Schreiber, S.L.¹

3
- 21144440283
- -482
- D. R. Spring Chem. Soc. Rev. 2005 34 472 482
- (2005) Chem. Soc. Rev. , vol.34 , pp. 472
- Spring, D.R.¹

4
- 0037416141
- -61
- S. L. Schreiber Chem. Eng. News 2003 81 51 61
- (2003) Chem. Eng. News , vol.81 , pp. 51
- Schreiber, S.L.¹

5
- 33745726644
- -2530
- D. P. Walsh Y. T. Chang Chem. Rev. 2006 106 2476 2530
- (2006) Chem. Rev. , vol.106 , pp. 2476
- Walsh, D.P.¹ Chang, Y.T.²

6
- 0034920256
- G. MacBeath, Genome Biol., 2001, 2, 2005.2001-2005.2006
- (2001) Genome Biol. , vol.2 , pp. 20052001-20052006
- MacBeath, G.¹

7
- 26644444285
- The number of 324 validated biological targets is derived from a consensus set of small molecule drugs compiled from the FDA Orange Book, as well as biological drugs listed by the website of the Center for Biological Evaluation and Research. Those sources list 1204 distinct small molecule drugs as well as 166 distinct biologics, respectively. For 1065 of the total number of compounds a 'strong evidence of cell-based and/or in vivo evidence linking the target (and specific target sub-type) to the effect of the drug [...] alongside binding data' could be established, leading to a list of 324 distinct molecular targets with strong evidence of being implicated in the mechanism of action of those drugs. See: -202
- M. Welch H. Mikkelsen J. E. Swatton D. S. Smith G. L. Thomas F. G. Glansdorp D. R. Spring Mol. BioSyst. 2005 1 196 202
- (2005) Mol. BioSyst. , vol.1 , pp. 196
- Welch, M.¹ Mikkelsen, H.² Swatton, J.E.³ Smith, D.S.⁴ Thomas, G.L.⁵ Glansdorp, F.G.⁶ Spring, D.R.⁷

8
- 33751547539
- -996
- J. P. Overington B. Al-Lazikani A. L. Hopkins Nat. Rev. Drug Discovery 2006 5 993 996
- (2006) Nat. Rev. Drug Discovery , vol.5 , pp. 993
- Overington, J.P.¹ Al-Lazikani, B.² Hopkins, A.L.³

9
- 0036717194
- -730
- A. L. Hopkins C. R. Groom Nat. Rev. Drug Discovery 2002 1 727 730
- (2002) Nat. Rev. Drug Discovery , vol.1 , pp. 727
- Hopkins, A.L.¹ Groom, C.R.²

10
- 11144320699
- -861
- C. Lipinski A. Hopkins Nature 2004 432 855 861
- (2004) Nature , vol.432 , pp. 855
- Lipinski, C.¹ Hopkins, A.²

11
- 3042799070
- -58
- M. D. Burke S. L. Schreiber Angew. Chem., Int. Ed. 2004 43 46 58
- (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 46
- Burke, M.D.¹ Schreiber, S.L.²

12
- 35248817286
- -880
- K. Azzaoui J. Hamon B. Faller S. Whitebread E. Jacoby A. Bender J. L. Jenkins L. Urban ChemMedChem 2007 2 874 880
- (2007) ChemMedChem , vol.2 , pp. 874
- Azzaoui, K.¹ Hamon, J.² Faller, B.³ Whitebread, S.⁴ Jacoby, E.⁵ Bender, A.⁶ Jenkins, J.L.⁷ Urban, L.⁸

13
- 0035324944
- -864
- M. M. Hann A. R. Leach G. Harper J. Chem. Inf. Comput. Sci. 2001 41 856 864
- (2001) J. Chem. Inf. Comput. Sci. , vol.41 , pp. 856
- Hann, M.M.¹ Leach, A.R.² Harper, G.³

14
- 33646237094
- -535
- A. Schuffenhauer N. Brown P. Selzer P. Ertl E. Jacoby J. Chem. Inf. Model. 2006 46 525 535
- (2006) J. Chem. Inf. Model. , vol.46 , pp. 525
- Schuffenhauer, A.¹ Brown, N.² Selzer, P.³ Ertl, P.⁴ Jacoby, E.⁵

15
- 20444378945
- -303
- S. J. Haggarty Curr. Opin. Chem. Biol. 2005 9 296 303
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 296
- Haggarty, S.J.¹

16
- 20444383539
- -309
- S. Fergus A. Bender D. R. Spring Curr. Opin. Chem. Biol. 2005 9 304 309
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 304
- Fergus, S.¹ Bender, A.² Spring, D.R.³

17
- 14644431061
- -152
- J. J. Perez Chem. Soc. Rev. 2005 34 143 152
- (2005) Chem. Soc. Rev. , vol.34 , pp. 143
- Perez, J.J.¹

18
- 0033779243
- -372
- L. Xue J. Bajorath Comb. Chem. High Throughput Screening 2000 3 363 372
- (2000) Comb. Chem. High Throughput Screening , vol.3 , pp. 363
- Xue, L.¹ Bajorath, J.²

19
- 10344230435
- -3218
- A. Bender R. C. Glen Org. Biomol. Chem. 2004 2 3204 3218
- (2004) Org. Biomol. Chem. , vol.2 , pp. 3204
- Bender, A.¹ Glen, R.C.²

20
- 0342645323
- -584
- R. D. Brown Y. C. Martin J. Chem. Inf. Comput. Sci. 1996 36 572 584
- (1996) J. Chem. Inf. Comput. Sci. , vol.36 , pp. 572
- Brown, R.D.¹ Martin, Y.C.²

21
- 0028496956
- -1102
- G. M. Downs P. Willett W. Fisanick J. Chem. Inf. Comput. Sci. 1994 34 1094 1102
- (1994) J. Chem. Inf. Comput. Sci. , vol.34 , pp. 1094
- Downs, G.M.¹ Willett, P.² Fisanick, W.³

22
- 0035159445
- -1588
- E. Estrada E. Uriarte Curr. Med. Chem. 2001 8 1573 1588
- (2001) Curr. Med. Chem. , vol.8 , pp. 1573
- Estrada, E.¹ Uriarte, E.²

23
- 11144341956
- -828
- C. M. Dobson Nature 2004 432 824 828
- (2004) Nature , vol.432 , pp. 824
- Dobson, C.M.¹

24
- 34547236043
- -734
- S. H. Fitzgerald M. Sabat M. Geysen J. Comb. Chem. 2007 9 724 734
- (2007) J. Comb. Chem. , vol.9 , pp. 724
- Fitzgerald, S.H.¹ Sabat, M.² Geysen, M.³

25
- 17844399025
- -195
- M. S. Butler Nat. Prod. Rep. 2005 22 162 195
- (2005) Nat. Prod. Rep. , vol.22 , pp. 162
- Butler, M.S.¹

26
- 34249811180
- -289
- K. S. Lam Trends Microbiol. 2007 15 279 289
- (2007) Trends Microbiol. , vol.15 , pp. 279
- Lam, K.S.¹

27
- 0034237264
- -293
- M. J. Valler D. Green Drug Discovery Today 2000 5 286 293
- (2000) Drug Discovery Today , vol.5 , pp. 286
- Valler, M.J.¹ Green, D.²

28
- 0031024171
- -25
- C. A. Lipinski F. Lombardo B. W. Dominy P. J. Feeney Adv. Drug Delivery Rev. 1997 23 3 25
- (1997) Adv. Drug Delivery Rev. , vol.23 , pp. 3
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

29
- 33746071900
- -361
- T. H. Keller A. Pichota Z. Yin Curr. Opin. Chem. Biol. 2006 10 357 361
- (2006) Curr. Opin. Chem. Biol. , vol.10 , pp. 357
- Keller, T.H.¹ Pichota, A.² Yin, Z.³

30
- 36549024945
- -997
- C. Abad-Zapatero Drug Discovery Today 2007 12 995 997
- (2007) Drug Discovery Today , vol.12 , pp. 995
- Abad-Zapatero, C.¹

31
- 0037208308
- -227
- M. Feher J. M. Schmidt J. Chem. Inf. Comput. Sci. 2003 43 218 227
- (2003) J. Chem. Inf. Comput. Sci. , vol.43 , pp. 218
- Feher, M.¹ Schmidt, J.M.²

32
- 33751060195
- -712
- G. L. Thomas E. E. Wyatt D. R. Spring Curr. Opin. Drug Discovery Dev. 2006 9 700 712
- (2006) Curr. Opin. Drug Discovery Dev. , vol.9 , pp. 700
- Thomas, G.L.¹ Wyatt, E.E.² Spring, D.R.³

33
- 0142147275
- -618
- M. D. Burke E. M. Berger S. L. Schreiber Science 2003 302 613 618
- (2003) Science , vol.302 , pp. 613
- Burke, M.D.¹ Berger, E.M.² Schreiber, S.L.³

34
- 7444242717
- -14104
- M. D. Burke E. M. Berger S. L. Schreiber J. Am. Chem. Soc. 2004 126 14095 14104
- (2004) J. Am. Chem. Soc. , vol.126 , pp. 14095
- Burke, M.D.¹ Berger, E.M.² Schreiber, S.L.³

35
- 33746720909
- -3298
- E. E. Wyatt S. Fergus W. Galloway A. Bender D. J. Fox A. T. Plowright A. S. Jessiman M. Welch D. R. Spring Chem. Commun. 2006 3296 3298
- (2006) Chem. Commun. , pp. 3296
- Wyatt, E.E.¹ Fergus, S.² Galloway, W.³ Bender, A.⁴ Fox, D.J.⁵ Plowright, A.T.⁶ Jessiman, A.S.⁷ Welch, M.⁸ Spring, D.R.⁹

36
- 20444420189
- -247
- A. Reayi P. Arya Curr. Opin. Chem. Biol. 2005 9 240 247
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 240
- Reayi, A.¹ Arya, P.²

37
- 11144311139
- -837
- J. Clardy C. Walsh Nature 2004 432 829 837
- (2004) Nature , vol.432 , pp. 829
- Clardy, J.¹ Walsh, C.²

38
- 33745862400
- -2964
- S. K. Ko H. J. Jang E. Kim S. B. Park Chem. Commun. 2006 2962 2964
- (2006) Chem. Commun. , pp. 2962
- Ko, S.K.¹ Jang, H.J.² Kim, E.³ Park, S.B.⁴

39
- 33644499135
- -1632
- C. X. Zhou A. V. Dubrovsky R. C. Larock J. Org. Chem. 2006 71 1626 1632
- (2006) J. Org. Chem. , vol.71 , pp. 1626
- Zhou, C.X.¹ Dubrovsky, A.V.² Larock, R.C.³

40
- 20444400874
- -265
- R. Messer C. A. Fuhrer R. H. Iner R. Haner Curr. Opin. Chem. Biol. 2005 9 259 265
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 259
- Messer, R.¹ Fuhrer, C.A.² Iner, R.H.³ Haner, R.⁴

41
- 33746047675
- -10611
- A. Noren-Muller I. Reis-Correa H. Prinz C. Rosenbaum K. Saxena H. J. Schwalbe D. Vestweber G. Cagna S. Schunk O. Schwarz H. Schiewe H. Waldmann Proc. Natl. Acad. Sci. USA 2006 103 10606 10611
- (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10606
- Noren-Muller, A.¹ Reis-Correa, I.² Prinz, H.³ Rosenbaum, C.⁴ Saxena, K.⁵ Schwalbe, H.J.⁶ Vestweber, D.⁷ Cagna, G.⁸ Schunk, S.⁹ Schwarz, O.¹⁰ Schiewe, H.¹¹ Waldmann, H.¹²

42
- 33646456511
- -5403
- B. C. Goess R. N. Hannoush L. K. Chan T. Kirchhausen M. D. Shair J. Am. Chem. Soc. 2006 128 5391 5403
- (2006) J. Am. Chem. Soc. , vol.128 , pp. 5391
- Goess, B.C.¹ Hannoush, R.N.² Chan, L.K.³ Kirchhausen, T.⁴ Shair, M.D.⁵

43
- 33644839988
- -84
- D. S. Tan Nat. Chem. Biol. 2005 1 74 84
- (2005) Nat. Chem. Biol. , vol.1 , pp. 74
- Tan, D.S.¹

44
- 20444409179
- -239
- F. J. Dekker M. A. Koch H. Waldmann Curr. Opin. Chem. Biol. 2005 9 232 239
- (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 232
- Dekker, F.J.¹ Koch, M.A.² Waldmann, H.³

45
- 28444498830
- -17277
- M. A. Koch A. Schuffenhauer M. Scheck S. Wetzel M. Casaulta A. Odermatt P. Ertl H. Waldmann Proc. Natl. Acad. Sci. USA 2005 102 17272 17277
- (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 17272
- Koch, M.A.¹ Schuffenhauer, A.² Scheck, M.³ Wetzel, S.⁴ Casaulta, M.⁵ Odermatt, A.⁶ Ertl, P.⁷ Waldmann, H.⁸

46
- 0034678033
- -1969
- S. L. Schreiber Science 2000 287 1964 1969
- (2000) Science , vol.287 , pp. 1964
- Schreiber, S.L.¹

47
- 29844455070
- A further example of this strategy has been published recently: -2538
- N. Kumar M. Kiuchi J. A. Tallarico S. L. Schreiber Org. Lett. 2005 7 2535 2538
- (2005) Org. Lett. , vol.7 , pp. 2535
- Kumar, N.¹ Kiuchi, M.² Tallarico, J.A.³ Schreiber, S.L.⁴

48
- 42249095476
- 10.1002/anie.200705415
- G. L. Thomas R. J. Spandl F. G. Glansdorp M. Welch A. Bender J. Cockfield J. A. Lindsay C. Bryant D. F. J. Brown O. Loiseleur H. Rudyk M. Ladlow D. R. Spring Angew. Chem., Int. Ed. 2008 10.1002/anie.200705415
- (2008) Angew. Chem., Int. Ed.
- Thomas, G.L.¹ Spandl, R.J.² Glansdorp, F.G.³ Welch, M.⁴ Bender, A.⁵ Cockfield, J.⁶ Lindsay, J.A.⁷ Bryant, C.⁸ Brown, D.F.J.⁹ Loiseleur, O.¹⁰ Rudyk, H.¹¹ Ladlow, M.¹² Spring, D.R.¹³

49
- 37549020046
- -56
- T. E. Nielsen S. L. Schreiber Angew. Chem., Int. Ed. 2008 47 48 56
- (2008) Angew. Chem., Int. Ed. , vol.47 , pp. 48
- Nielsen, T.E.¹ Schreiber, S.L.²

50
- 33746272686
- -3638
- N. Kumagai G. Muncipinto S. L. Schreiber Angew. Chem., Int. Ed. 2006 45 3635 3638
- (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 3635
- Kumagai, N.¹ Muncipinto, G.² Schreiber, S.L.³

51
- 33846579646
- -1209
- D. Tejedor A. Sántos-Expósito F. García-Tellado Chem.-Eur. J. 2007 13 1201 1209
- (2007) Chem.-Eur. J. , vol.13 , pp. 1201
- Tejedor, D.¹ Sántos-Expósito, A.² García-Tellado, F.³

52
- 34250673184
- -2126
- E. Comer E. Rohan L. Deng J. A. Porco Org. Lett. 2007 9 2123 2126
- (2007) Org. Lett. , vol.9 , pp. 2123
- Comer, E.¹ Rohan, E.² Deng, L.³ Porco, J.A.⁴

53
- 33847274696
- -491
- D. Tejedor F. García-Tellado Chem. Soc. Rev. 2007 36 484 491
- (2007) Chem. Soc. Rev. , vol.36 , pp. 484
- Tejedor, D.¹ García-Tellado, F.²

54
- 12344293904
- -50
- H. Oguri S. L. Schreiber Org. Lett. 2005 7 47 50
- (2005) Org. Lett. , vol.7 , pp. 47
- Oguri, H.¹ Schreiber, S.L.²

55
- 0344514145
- -4127
- J. K. Sello P. R. Andreana D. S. Lee S. L. Schreiber Org. Lett. 2003 5 4125 4127
- (2003) Org. Lett. , vol.5 , pp. 4125
- Sello, J.K.¹ Andreana, P.R.² Lee, D.S.³ Schreiber, S.L.⁴

56
- 8844221233
- -14745
- Y. K. Kim M. A. Arai T. Arai J. O. Lamenzo E. F. Dean N. Patterson P. A. Clemons S. L. Schreiber J. Am. Chem. Soc. 2004 126 14740 14745
- (2004) J. Am. Chem. Soc. , vol.126 , pp. 14740
- Kim, Y.K.¹ Arai, M.A.² Arai, T.³ Lamenzo, J.O.⁴ Dean, E.F.⁵ Patterson, N.⁶ Clemons, P.A.⁷ Schreiber, S.L.⁸

57
- 0038713943
- -8421
- A. N. Koehler A. F. Shamji S. L. Schreiber J. Am. Chem. Soc. 2003 125 8420 8421
- (2003) J. Am. Chem. Soc. , vol.125 , pp. 8420
- Koehler, A.N.¹ Shamji, A.F.² Schreiber, S.L.³

58
- 0037138650
- -1363
- D. R. Spring S. Krishnan H. E. Blackwell S. L. Schreiber J. Am. Chem. Soc. 2002 124 1354 1363
- (2002) J. Am. Chem. Soc. , vol.124 , pp. 1354
- Spring, D.R.¹ Krishnan, S.² Blackwell, H.E.³ Schreiber, S.L.⁴

59
- 0037061492
- -657
- F. G. Kuruvilla A. F. Shamji S. M. Sternson P. J. Hergenrother S. L. Schreiber Nature 2002 416 653 657
- (2002) Nature , vol.416 , pp. 653
- Kuruvilla, F.G.¹ Shamji, A.F.² Sternson, S.M.³ Hergenrother, P.J.⁴ Schreiber, S.L.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.