Diversity screening versus focussed screening in drug discovery

Drug Discovery Today

Volumn 5, Issue 7, 2000, Pages 286-293

  Valler, Martin J ^a   Green, Darren ^b  

^a Molecular Discovery Department   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); SHIONOGI 50235; UNCLASSIFIED DRUG;

DRUG DEVELOPMENT; DRUG INDUSTRY; DRUG RESEARCH; DRUG SCREENING; DRUG SYNTHESIS; METHODOLOGY; SHORT SURVEY; TECHNOLOGY;

EID: 0034237264     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01517-8     Document Type: Review

References (9)

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2. 2 Marriott, D.P. et al. (1999) Lead generation using pharmacophore mapping and three-dimensional database searching: application to muscarinic M3 receptor antagonists. J. Med. Chem. 42, 3210-3216
3. 3 Walters, W.P. et al. (1998) Virtual screening - an overview. Drug Discovery Today 3, 160-178
4. 4 Gillet, V.J. et al. (1998) Identification of biological activity profiles using substructural analysis and genetic algorithms. J. Chem. Inf. Comput. Sci. 38, 165-179
5. 5 Ajay et al. (1999) Designing libraries with CNS activity. J. Med. Chem. 42, 4942-4951
6. 6 Willett, P. et al. (1998) Chemical similarity searching. J. Chem. Inf. Compta. Sci. 38, 983-996
7. 7 Young, S.S. et al. (1997) Optimum utilization of a compound collection or chemical library for drug discovery. J. Chem. Inf. Comput. Sci. 37, 892-899
8. 8 Rees, S. et al. (1999) Reporter gene systems for the study of G-protein coupled receptor signalling in mammalian cells. In Signal Transduction: A Practical Approach (Milligan, G., ed.), pp. 171-221, Oxford University Press
9. 9 Mere, L. et al. (1999) Miniaturized FRET assays and microfluidics: key components for ultra-high throughput screening. Drug Discovery Today 4, 363-369