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Volumn 2, Issue 6, 2007, Pages 874-880

Modeling promiscuity based on in vitro safety pharmacology profiling data

(8) Azzaoui, Kamal a Hamon, Jacques a Faller, Bernard a Whitebread, Steven b Jacoby, Edgar a Bender, Andreas b Jenkins, Jeremy L b Urban, Laszlo b

a NOVARTIS PHARMA AG (Switzerland)

b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

Author keywords

Biological activity; Data analysis; Drug discovery; Promiscuity; Safety pharmacology

Indexed keywords

DRUG;

ARTICLE; BAYES THEOREM; CHEMICAL MODEL; CHEMISTRY; CLASSIFICATION; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG DESIGN; METABOLISM; METHODOLOGY; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION;

BAYES THEOREM; CLINICAL TRIALS AS TOPIC; DRUG DELIVERY SYSTEMS; DRUG DESIGN; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35248817286 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200700036 Document Type: Article

Times cited : (165)

References (31)

1
- 4644271084
- B. L. Roth, D. J. Sheffler, W. K. Kroeze, Nat. Rev. Drug Discovery 2004, 3, 353-359.
- (2004) Nat. Rev. Drug Discovery , vol.3 , pp. 353-359
- Roth, B.L.¹ Sheffler, D.J.² Kroeze, W.K.³

2
- 14244255403
- V. C. Stephenson, R. A. Heyding, D. F. Weaver, FEBS Lett. 2005, 579, 1338-1342.
- (2005) FEBS Lett , vol.579 , pp. 1338-1342
- Stephenson, V.C.¹ Heyding, R.A.² Weaver, D.F.³

3
- 3242802116
- T. Hampton, J. Am. Med. Assoc. 2004, 292, 419-422.
- (2004) J. Am. Med. Assoc , vol.292 , pp. 419-422
- Hampton, T.¹

4
- 32344446028
- A. L. Hopkins, J. S. Mason, J. P. Overington, Curr. Opin. Struct. Biol. 2006, 16, 127-136.
- (2006) Curr. Opin. Struct. Biol , vol.16 , pp. 127-136
- Hopkins, A.L.¹ Mason, J.S.² Overington, J.P.³

5
- 30344479953
- M. L. Espinoza-Fonseca, Bioorg. Med. Chem. 2006, 14, 896-897.
- (2006) Bioorg. Med. Chem , vol.14 , pp. 896-897
- Espinoza-Fonseca, M.L.¹

6
- 27544446579
- DOI: 10.1186/1472-6904-5-3
- S. K. Mencher, L. G. Wang, BMC Clin. Pharmacol. 2005, 5, 3; DOI: 10.1186/1472-6904-5-3.
- (2005) BMC Clin. Pharmacol , vol.5 , pp. 3
- Mencher, S.K.¹ Wang, L.G.²

7
- 33746088604
- J. Hamon, K. Azzaoui, S. Whitebread, L. Urban, B. Faller, Eur. Pharm. Rev. 2006, 1, 60-63.
- (2006) Eur. Pharm. Rev , vol.1 , pp. 60-63
- Hamon, J.¹ Azzaoui, K.² Whitebread, S.³ Urban, L.⁴ Faller, B.⁵

8
- 26944446576
- S. Whitebread, J. Hamon, D. Bojanic, L. Urban, Drug Discovery Today 2005, 10, 1421-1433.
- (2005) Drug Discovery Today , vol.10 , pp. 1421-1433
- Whitebread, S.¹ Hamon, J.² Bojanic, D.³ Urban, L.⁴

9
- 0034074402
- F. De Ponti, F. Poluzzi, N. Montanaro, Eur. J. Clin. Pharmacol. 2000, 56, 1-18.
- (2000) Eur. J. Clin. Pharmacol , vol.56 , pp. 1-18
- De Ponti, F.¹ Poluzzi, F.² Montanaro, N.³

10
- 0034610435
- R. B. Rothman, M. H. Baumann, S. J. Hufeisen, Circulation 2000, 102, 2836-2841.
- (2000) Circulation , vol.102 , pp. 2836-2841
- Rothman, R.B.¹ Baumann, M.H.² Hufeisen, S.J.³

11
- 33846876695
- M. J. Keiser, B. L. Roth, B. N. Armbruster, P. Ernsberger, J. J. Irwin, B. K. Shoichet, Nat. Biotechnol. 2007, 25, 197-206.
- (2007) Nat. Biotechnol , vol.25 , pp. 197-206
- Keiser, M.J.¹ Roth, B.L.² Armbruster, B.N.³ Ernsberger, P.⁴ Irwin, J.J.⁵ Shoichet, B.K.⁶

12
- 27144503431
- C. Rolland, R. Gozalbes, E. Nicolai, M. F. Paugam, L. Coussy, F. Barbosa, D. Horvath, F. Revah, J. Med. Chem. 2005, 48, 6563-6574.
- (2005) J. Med. Chem , vol.48 , pp. 6563-6574
- Rolland, C.¹ Gozalbes, R.² Nicolai, E.³ Paugam, M.F.⁴ Coussy, L.⁵ Barbosa, F.⁶ Horvath, D.⁷ Revah, F.⁸

13
- 32344440237
- A. F. Fliri, W. T. Loging, P. F. Thadeio, R. A. Volkmann, Nat. Chem. Biol. 2005, 1, 389-397.
- (2005) Nat. Chem. Biol , vol.1 , pp. 389-397
- Fliri, A.F.¹ Loging, W.T.² Thadeio, P.F.³ Volkmann, R.A.⁴

14
- 0037011890
- O. Roche, P. Schneider, J. Zuegge, W. Guba, M. Kansy, A. Alanine, K. Bleicher, F. Danel, E.-M. Gutknecht, M. Rogers-Evans, W. Neidhart, H. Stalder, M. Dillon, E. Sjögren, N. Fotouhi, P. Gillespie, R. Goodnow, W. Harris, P. Jones, M. Taniguchi, S. Tsujii, W. von der Saal, G. Zimmerman, G. Schneider, J. Med. Chem. 2002, 45, 137-142.
- (2002) J. Med. Chem , vol.45 , pp. 137-142
- Roche, O.¹ Schneider, P.² Zuegge, J.³ Guba, W.⁴ Kansy, M.⁵ Alanine, A.⁶ Bleicher, K.⁷ Danel, F.⁸ Gutknecht, E.-M.⁹ Rogers-Evans, M.¹⁰ Neidhart, W.¹¹ Stalder, H.¹² Dillon, M.¹³ Sjögren, E.¹⁴ Fotouhi, N.¹⁵ Gillespie, P.¹⁶ Goodnow, R.¹⁷ Harris, W.¹⁸ Jones, P.¹⁹ Taniguchi, M.²⁰ more..

15
- 40049100210
- A. Bender, J. Scheiber, M. Glick, J. W. Davies, K. Azzaoui, J. Hamon, L. Urban, S. Whitebread, J. L. Jenkins, ChemMedChem 2007, 2, 861-873.
- (2007) ChemMedChem , vol.2 , pp. 861-873
- Bender, A.¹ Scheiber, J.² Glick, M.³ Davies, J.W.⁴ Azzaoui, K.⁵ Hamon, J.⁶ Urban, L.⁷ Whitebread, S.⁸ Jenkins, J.L.⁹

16
- 0037061628
- S. L. McGovern, E. Caselli, N. Grigorieff, B. K. Shoichet, J. Med. Chem. 2002, 45, 1712-1722.
- (2002) J. Med. Chem , vol.45 , pp. 1712-1722
- McGovern, S.L.¹ Caselli, E.² Grigorieff, N.³ Shoichet, B.K.⁴

17
- 4143122120
- X. Xia, E. G. Maliski, P. Gallant, D. Rogers, J. Med. Chem. 2004, 47, 4463-4470.
- (2004) J. Med. Chem , vol.47 , pp. 4463-4470
- Xia, X.¹ Maliski, E.G.² Gallant, P.³ Rogers, D.⁴

18
- 33244482848
- M. Glick, J. L. Jenkins, J. H. Nettles, H. Hitchings, J. W. Davies, J. Chem. Inf. Model. 2006, 46, 193-200.
- (2006) J. Chem. Inf. Model , vol.46 , pp. 193-200
- Glick, M.¹ Jenkins, J.L.² Nettles, J.H.³ Hitchings, H.⁴ Davies, J.W.⁵

19
- 33745391215
- Nidhi, M. Glick, J. W. Davies, J. L. Jenkins, J. Chem. Inf. Model. 2006, 46, 1124-1133.
- (2006) J. Chem. Inf. Model , vol.46 , pp. 1124-1133
- Nidhi, M.¹ Glick, J.W.² Davies, J.L.J.³

20
- 33746156959
- G. V. Paolini, R. H. B. Shapland, W. P. van Hoorn, J. S. Mason, A. L. Hopkins, Nat. Biotechnol. 2006, 24, 805-815.
- (2006) Nat. Biotechnol , vol.24 , pp. 805-815
- Paolini, G.V.¹ Shapland, R.H.B.² van Hoorn, W.P.³ Mason, J.S.⁴ Hopkins, A.L.⁵

21
- 0035324944
- M. M. Hann, A. R. Leach, G. Harper, J. Chem. Inf. Model. 2001, 41, 856-864.
- (2001) J. Chem. Inf. Model , vol.41 , pp. 856-864
- Hann, M.M.¹ Leach, A.R.² Harper, G.³

22
- 19944422452
- E. Jacoby, A. Schuffenhauer, M. Popov, K. Azzaoui, B. Havill, U. Schopfer, C. Engeloch, J. Stanek, P. Acklin, P. Rigollier, F. Stoll, G. Koch, P. Meier, D. Orain, R. Giger, J. Hinrichs, K. Malagu, J. Zimmermann, H. J. Roth, Curr. Top. Med. Chem. 2005, 5, 397-411.
- (2005) Curr. Top. Med. Chem , vol.5 , pp. 397-411
- Jacoby, E.¹ Schuffenhauer, A.² Popov, M.³ Azzaoui, K.⁴ Havill, B.⁵ Schopfer, U.⁶ Engeloch, C.⁷ Stanek, J.⁸ Acklin, P.⁹ Rigollier, P.¹⁰ Stoll, F.¹¹ Koch, G.¹² Meier, P.¹³ Orain, D.¹⁴ Giger, R.¹⁵ Hinrichs, J.¹⁶ Malagu, K.¹⁷ Zimmermann, J.¹⁸ Roth, H.J.¹⁹

23
- 33645422011
- D. M. Schnur, M. A. Hermsmeier, A. J. Tebben, J. Med. Chem. 2006, 49, 2000-2009.
- (2006) J. Med. Chem , vol.49 , pp. 2000-2009
- Schnur, D.M.¹ Hermsmeier, M.A.² Tebben, A.J.³

24
- 33646715920
- R. Morphy, J. Med. Chem. 2006, 49, 2969-2978.
- (2006) J. Med. Chem , vol.49 , pp. 2969-2978
- Morphy, R.¹

25
- 33748770143
- B. Y. Zhu, Z. J. Jia, P. Zhang, T. Su, W. Huang, E. Goldman, D. Tumas, V. Kadambi, P. Eddy, U. Sinha, R. M. Scarborougha, Y. Songa, Bioorg. Med. Chem. Lett. 2006, 16, 5507-5512.
- (2006) Bioorg. Med. Chem. Lett , vol.16 , pp. 5507-5512
- Zhu, B.Y.¹ Jia, Z.J.² Zhang, P.³ Su, T.⁴ Huang, W.⁵ Goldman, E.⁶ Tumas, D.⁷ Kadambi, V.⁸ Eddy, P.⁹ Sinha, U.¹⁰ Scarborougha, R.M.¹¹ Songa, Y.¹²

26
- 54849410230
- Pipeline Pilot, SciTegic, Inc., 9665 Chesapeake Drive, Suite 401, San Diego, CA 92123.
- Pipeline Pilot, SciTegic, Inc., 9665 Chesapeake Drive, Suite 401, San Diego, CA 92123.

27
- 4344645978
- I. Kola, J. Landis, Nat. Rev. Drug Discovery 2004, 3, 711-715.
- (2004) Nat. Rev. Drug Discovery , vol.3 , pp. 711-715
- Kola, I.¹ Landis, J.²

28
- 54849428099
- Homepage:, accessed December
- Elsevier MDL Homepage: http://www.mdli.com (accessed December 2006).
- (2006)
- Elsevier, M.D.L.¹

29
- 10244222365
- J. Hert, P. Willett, D. J. Wilton, P. Acklin, K. Azzaoui, E. Jacoby, A. Schuffenhauer, Org. Biomol. Chem. 2004, 2, 3256-3266.
- (2004) Org. Biomol. Chem , vol.2 , pp. 3256-3266
- Hert, J.¹ Willett, P.² Wilton, D.J.³ Acklin, P.⁴ Azzaoui, K.⁵ Jacoby, E.⁶ Schuffenhauer, A.⁷

30
- 2942700377
- J. Hert, P. Willett, D. J. Wilton, P. Acklin, K. Azzaoui, E. Jacoby, A. Schuffenhauer, J. Chem. Inf. Model. 2004, 44, 1177-1185.
- (2004) J. Chem. Inf. Model , vol.44 , pp. 1177-1185
- Hert, J.¹ Willett, P.² Wilton, D.J.³ Acklin, P.⁴ Azzaoui, K.⁵ Jacoby, E.⁶ Schuffenhauer, A.⁷

31
- 0000293407
- H. L. Morgan, J. Chem. Doc. 1965, 5, 107-112.
- (1965) J. Chem. Doc , vol.5 , pp. 107-112
- Morgan, H.L.¹

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