A Sorcerer's apprentice and The Rule of Five: from rule-of-thumb to commandment and beyond

Drug Discovery Today

Volumn 12, Issue 23-24, 2007, Pages 995-997

  Abad Zapatero, Cele ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN;

DRUG RESEARCH; HEALTH PRACTITIONER; MEDICAL RESEARCH; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; SHORT SURVEY;

CHEMISTRY, PHARMACEUTICAL; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; PHARMACEUTICAL PREPARATIONS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 36549024945     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.10.022     Document Type: Short Survey

References (8)

1. Lipinski C.A., et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug. Deliv. Rev. 23 (1997) 3-25
2. Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 44 (2000) 235-249
3. Veber, et al. J. Med. Chem. 45 (2002) 2615-2623
4. Congreve M., et al. Drug Discov. Today 8 (2003) 876-877
5. Taleb, N.N. (2007) The Black Swan. The Impact of the Highly Improbable, Random House
6. Hajduk P., and Greer J. Nature reviews. Drug Discov. 6 (2007) 211-219
7. Brown D., and Superti-Furga G. Drug Discov. Today 8 (2003) 1067-1077
8. Gould S.J. The Rule of Five in The Flamingo Smile (1985), W.W. Norton & Company, New York pp. 199-211