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A planning strategy for diversity-oriented synthesis
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M.D. Burke, and S.L. Schreiber A planning strategy for diversity-oriented synthesis Angew Chem Int Ed Engl 43 2004 46 58 This review describes the design of structural diversity and complexity in the context of chemical genetics and is highly recommended as an excellent introduction to the field.
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Burke, M.D.1
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S.L. Schreiber Target-oriented and diversity-oriented organic synthesis in drug discovery Science 287 2000 1964 1969
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D.R. Spring Diversity-oriented synthesis; a challenge for synthetic chemists Org Biomol Chem 1 2003 3867 3870
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J.Y. Ortholand, and A. Ganesan Natural products and combinatorial chemistry: back to the future Curr Opin Chem Biol 8 2004 271 280
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Rescuing Combichem diversity-oriented synthesis aims to pick up where traditional combinatorial chemistry left off
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S. Borman Rescuing Combichem diversity-oriented synthesis aims to pick up where traditional combinatorial chemistry left off Chem Eng News 82 2004 32 40 This recent article highlights the advent of DOS to counter the negative press that combinatorial chemistry had received. Comments from many big players in the field are included.
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Chemical genetics resulting from a passion for synthetic organic chemistry
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S.L. Schreiber Chemical genetics resulting from a passion for synthetic organic chemistry Bioorg Med Chem 6 1998 1127 1152
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The small molecule approach to biology
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S.L. Schreiber The small molecule approach to biology Chem Eng News 81 2003 51 61
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P.J. Alaimo, M.A. Shogren-Knaak, and K.M. Shokat Chemical genetic approaches for the elucidation of signalling pathways Curr Opin Chem Biol 5 2001 360 367
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G. MacBeath Chemical genomics: what will it take and who gets to play? Genome Biol 2 2001 2005.1 2005.6
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Synthesis and optimization of a new family of type 3 17β- hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry
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R. Maltais, V. Luu-The, and D. Poirier Synthesis and optimization of a new family of type 3 17β-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry J Med Chem 45 2002 640 653
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Identification from a combinatorial library of a small molecule that selectively induces apoptosis in cancer cells
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V. Nesterenko, K.S. Putt, and P.J. Hergenrother Identification from a combinatorial library of a small molecule that selectively induces apoptosis in cancer cells J Am Chem Soc 125 2003 14672 14673 An elegant use of combinatorial chemistry to generate small molecules to probe biology.
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Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-α release on mouse macrophages in vitro
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L. Zhang, G. Liu, S.-D. Zhang, H.-Z. Yang, L. Li, X.-H. Wu, J. Yu, B.-B. Kou, S. Xu, and J. Li Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-α release on mouse macrophages in vitro J Comb Chem 6 2004 431 436
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Rapid diversity-oriented synthesis in microtitre plates for in situ screening: Discovery of potent and selective α-fucosidase inhibitors
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C.Y. Wu, C.F. Chang, J.S.Y. Chen, C.H. Wong, and C.H. Lin Rapid diversity-oriented synthesis in microtitre plates for in situ screening: discovery of potent and selective α-fucosidase inhibitors Angew Chem Int Ed Engl 42 2003 4661 4664
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Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform
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D.R. Spring, S. Krishnan, H.E. Blackwell, and S.L. Schreiber Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform J Am Chem Soc 124 2002 1354 1363
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Spring, D.R.1
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Diversity-oriented synthesis of tamoxifen-type tetrasubstituted olefins
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K. Itami, T. Kamei, and J. Yoshida Diversity-oriented synthesis of tamoxifen-type tetrasubstituted olefins J Am Chem Soc 125 2003 14670 14671
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Macrolactones in diversity-oriented synthesis: Preparation of a pilot library and exploration of factors controlling macrocyclization
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D.R. Schmidt, O. Kwon, and S.L. Schreiber Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization J Comb Chem 6 2004 286 292
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J Comb Chem
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Schmidt, D.R.1
Kwon, O.2
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Skeletal diversity via a folding pathway: Synthesis of indole alkaloid-like skeletons
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H. Oguri, and S.L. Schreiber Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons Org Lett 7 2005 47 50 Inspired by the skeletal diversity of indole alkaloids, the authors exploited Padwa intramolecular cyclizations in three out of six possible modes. The paper illustrates a conceptually simple and general approach to folding substrates to give different molecular frameworks.
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Org Lett
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Oguri, H.1
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Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates
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S.J. Taylor, A.M. Taylor, and S.L. Schreiber Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates Angew Chem Int Ed Engl 43 2004 1681 1685
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Taylor, S.J.1
Taylor, A.M.2
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Diversity-oriented synthesis of azaspirocycles
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P. Wipf, C.R.J. Stephenson, and M.A.A. Walczak Diversity-oriented synthesis of azaspirocycles Org Lett 6 2004 3009 3012
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Generating diverse skeletons of small molecules combinatorially
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M.D. Burke, E.M. Berger, and S.L. Schreiber Generating diverse skeletons of small molecules combinatorially Science 302 2003 613 618 The authors outline the approach of using appendages to pre-encode substrates to undergo different folding pathways to different molecular frameworks using the same reaction conditions. This is the first paper to describe this approach.
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Science
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A synthesis strategy yielding skeletally diverse small molecules combinatorially
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M.D. Burke, E.M. Berger, and S.L. Schreiber A synthesis strategy yielding skeletally diverse small molecules combinatorially J Am Chem Soc 126 2004 14095 14104
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Molecular descriptors in chemoinformatics, computational combinatorial chemistry and virtual screening
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M.D. Burke, and G. Lalic Teaching target-oriented and diversity-oriented organic synthesis at Harvard University Chem Biol 9 2002 535 541 This article is a comprehensive, useful guide to the comparison of target-oriented and diversity-oriented synthesis.
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J.J. Perez Managing molecular diversity Chem Soc Rev 34 2005 143 152 An excellent general introduction to computational molecular diversity has appeared, describing four steps for diverse compound selection. Approaches to describe molecular structures are followed by methods to establish their similarities. Next, partitioning/clustering methods are described for diversity-oriented compound selection, accompanied by their validations.
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Perez, J.J.1
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