Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

Journal of the American Chemical Society

Volumn 126, Issue 45, 2004, Pages 14740-14745

  Kim, Young Kwon ^a   Arai, Midori A ^a   Arai, Takayoshi ^a   Lamenzo, Julia O ^a   Dean III, Elton F ^a   Patterson, Nick ^a   Clemons, Paul A ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATES; CONFORMATIONS; STATISTICAL METHODS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

BICYCLIC PRODUCTS; CONFORMATIONAL RESTRICTIONS; MONOCYCLIC PRECURSORS; SKELETAL DIVERSITY;

MOLECULAR DYNAMICS;

BICYCLO COMPOUND;

ARTICLE; CARBOHYDRATE ANALYSIS; CELL BASED ASSAY; CLUSTER ANALYSIS; MOLECULAR BIOLOGY; MOLECULAR MODEL; OUTCOMES RESEARCH; QUANTITATIVE ANALYSIS; QUANTITATIVE DIAGNOSIS; RING CLOSING METATHESIS; SCREENING TEST; SKELETON DEPENDENT CONFORMATIONAL RESTRICTION; STATISTICAL ANALYSIS; STEREOCHEMISTRY; SYNTHESIS; TAXONOMY;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CLUSTER ANALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; DRUG EVALUATION, PRECLINICAL; ESTERASES; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8844221233     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja048170p     Document Type: Article

References (22)

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18. See Supporting Information (Section VI) for a detailed description of the Gamma-Poisson model fit and the likelihood ratio test.
19. Molecular descriptor values were calculated using Pipeline Pilot (Scitegic, Inc.; San Diego, CA).
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