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Volumn 32, Issue 1-2, 2006, Pages 19-37

Pathogenesis of type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN RECEPTOR 2; CALPAIN 10; INSULIN; INSULIN RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR 7 LIKE 2;

EID: 40449118639     PISSN: 07435800     EISSN: 15324206     Source Type: Journal    
DOI: 10.1080/07435800701743810     Document Type: Review
Times cited : (51)

References (91)
  • 1
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ, Van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 2005; 365:1333-1346.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Van Haeften, T.W.3
  • 2
    • 0024834748 scopus 로고
    • Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimalmodel approach
    • Bergman RN. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimalmodel approach. Diabetes 1989; 38:1512-1527.
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 3
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104:787-794.
    • (1999) J Clin Invest , vol.104 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 5
    • 0026795010 scopus 로고
    • Carbohydrate metabolism in non-insulin-dependent diabetes mellitus
    • Dinneen S, Gerich J, Rizza R. Carbohydrate metabolism in non-insulin-dependent diabetes mellitus. N Engl J Med 1992; 327:707-713.
    • (1992) N Engl J Med , vol.327 , pp. 707-713
    • Dinneen, S.1    Gerich, J.2    Rizza, R.3
  • 6
    • 0032710789 scopus 로고    scopus 로고
    • Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance
    • Weyer C, Bogardus C, Pratley RE. Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. Diabetes 1999; 48:2197-2203.
    • (1999) Diabetes , vol.48 , pp. 2197-2203
    • Weyer, C.1    Bogardus, C.2    Pratley, R.E.3
  • 8
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46:3-10.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 9
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning JC, Michael MD, Winnay IN, et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 1998; 2:559-569.
    • (1998) Mol Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1    Michael, M.D.2    Winnay, I.N.3
  • 10
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 299:572-574.
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 11
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, Kulkarni RN, Postic C, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000; 6:87-97.
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 12
    • 0033524937 scopus 로고    scopus 로고
    • Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    • Kulkarni RN, Bruning JC, Winnay IN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999; 96:329-339.
    • (1999) Cell , vol.96 , pp. 329-339
    • Kulkarni, R.N.1    Bruning, J.C.2    Winnay, I.N.3    Postic, C.4    Magnuson, M.A.5    Kahn, C.R.6
  • 13
    • 0035044213 scopus 로고    scopus 로고
    • Clinical review 125: The insulin receptor and its cellular targets
    • Kido Y, Nakae J, Accili D. Clinical review 125: the insulin receptor and its cellular targets. J Clin Endocrinol Metab 2001; 86:972-979.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 972-979
    • Kido, Y.1    Nakae, J.2    Accili, D.3
  • 14
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White ME. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002; 283:E413-22.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • White, M.E.1
  • 15
    • 0035500813 scopus 로고    scopus 로고
    • Insulin resistance: A phosphorylation-based uncoupling of insulin signaling
    • Zick Y. Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol 2001; 11:437-4411.
    • (2001) Trends Cell Biol , vol.11 , pp. 437-4411
    • Zick, Y.1
  • 16
    • 0003175629 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatases and the regulation of insulin action
    • LeRoith D, Taylor SI, Olefsky JM, eds, Philadelphia: Lippincott
    • Goldstein BJ. Protein-tyrosine phosphatases and the regulation of insulin action. In: LeRoith D, Taylor SI, Olefsky JM, eds. Diabetes mellitus: A Fundamental and Clinical Text. Philadelphia: Lippincott, 2003:255-268.
    • (2003) Diabetes mellitus: A Fundamental and Clinical Text , pp. 255-268
    • Goldstein, B.J.1
  • 17
    • 0036149984 scopus 로고    scopus 로고
    • Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
    • Zhande R, Mitchell JJ, Wu J, Sun XJ. Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1. Mol Cell Biol 2002; 22:1016-1026.
    • (2002) Mol Cell Biol , vol.22 , pp. 1016-1026
    • Zhande, R.1    Mitchell, J.J.2    Wu, J.3    Sun, X.J.4
  • 18
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • Rui L, Yuan M, Frantz D, Shoelson S, White ME SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 2002; 277:42394-42398.
    • (2002) J Biol Chem , vol.277 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.E.5
  • 19
    • 0042330251 scopus 로고    scopus 로고
    • Mini review: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis
    • Rajala MW, Scherer PE. Mini review: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144:3765-3773.
    • (2003) Endocrinology , vol.144 , pp. 3765-3773
    • Rajala, M.W.1    Scherer, P.E.2
  • 20
    • 0036299262 scopus 로고    scopus 로고
    • Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus
    • Ravussin E, Smith SR. Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann NY Acad Sci 2002; 967:363-378.
    • (2002) Ann NY Acad Sci , vol.967 , pp. 363-378
    • Ravussin, E.1    Smith, S.R.2
  • 21
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and b-cell dysfunction
    • Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and b-cell dysfunction. Eur J Clin Invest 2002; 32(Suppl. 3):14-23.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 3 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 22
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2002; 106:171-176.
    • (2002) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 23
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999; 48:1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 24
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I kappa B-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and I kappa B-alpha. Diabetes 2002; 51:2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 25
    • 3442895916 scopus 로고    scopus 로고
    • Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
    • Gao Z, Zhang X, Zuberi A, et al. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 2004; 18:2024-2034.
    • (2004) Mol Endocrinol , vol.18 , pp. 2024-2034
    • Gao, Z.1    Zhang, X.2    Zuberi, A.3
  • 26
    • 0033694663 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance and the role of the adipocyte
    • Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes Relat Metab Disord 2000; 24(Suppl. 4):S23-S27.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.SUPPL. 4
    • Hotamisligil, G.S.1
  • 27
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
    • Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 2000; 11:212-217.
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 212-217
    • Moller, D.E.1
  • 28
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 2003; 278: 13740-13746.
    • (2003) J Biol Chem , vol.278 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3
  • 29
    • 17044451410 scopus 로고    scopus 로고
    • A new role for SOCS in insulin action. Suppressor of cytokine signaling
    • Krebs DL, Hilton DJ. A new role for SOCS in insulin action. Suppressor of cytokine signaling. Sci STKE 2003:E6.
    • (2003) Sci STKE
    • Krebs, D.L.1    Hilton, D.J.2
  • 30
    • 2942687834 scopus 로고    scopus 로고
    • Adiponectin: A novel adipokine linking adipocytes and vascular function
    • Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 2004; 89:2563-2568.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2563-2568
    • Goldstein, B.J.1    Scalia, R.2
  • 31
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8:1288-1295.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 32
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
    • Tomas E, Tsao TS, Saha AK, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002; 99:16309-16313.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3
  • 33
    • 0037983775 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    • Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 2003; 52:1355-1363.
    • (2003) Diabetes , vol.52 , pp. 1355-1363
    • Wu, X.1    Motoshima, H.2    Mahadev, K.3    Stalker, T.J.4    Scalia, R.5    Goldstein, B.J.6
  • 34
    • 0037328928 scopus 로고    scopus 로고
    • Malonyl-CoA and AMP-activated protein kinase (AMPK): Possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
    • Ruderman NB, Cacicedo JM, Itani S, et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans 2003; 31:202-206.
    • (2003) Biochem Soc Trans , vol.31 , pp. 202-206
    • Ruderman, N.B.1    Cacicedo, J.M.2    Itani, S.3
  • 35
    • 0033996762 scopus 로고    scopus 로고
    • The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
    • Karin M, Delhase M. The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling. Semin Immunol 2000; 12:85-98.
    • (2000) Semin Immunol , vol.12 , pp. 85-98
    • Karin, M.1    Delhase, M.2
  • 36
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa) B kinase-beta
    • Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa) B kinase-beta. Nature 1998; 396:77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 37
    • 0034903710 scopus 로고    scopus 로고
    • Prevention of fat-induced insulin resistance by salicylate
    • Kim JK, Kim YJ, Fillmore JJ, et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 2001; 108:437-446.
    • (2001) J Clin Invest , vol.108 , pp. 437-446
    • Kim, J.K.1    Kim, Y.J.2    Fillmore, J.J.3
  • 38
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001; 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 39
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance
    • Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord 2003; 27(Suppl. 3):S49-S52.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.SUPPL. 3
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 40
    • 0036177867 scopus 로고    scopus 로고
    • Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein, and adiponectin
    • Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 2002; 13:51-59.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 51-59
    • Havel, P.J.1
  • 41
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112:1785-1788.
    • (2003) J Clin Invest , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 42
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51:2944-2950.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 43
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004; 350:664-671.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 44
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003; 100:8466-8471.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3
  • 45
    • 0038054341 scopus 로고    scopus 로고
    • PGC-lalpha-responsive genes involved in oxidative phosphorylation are coordinately down regulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-lalpha-responsive genes involved in oxidative phosphorylation are coordinately down regulated in human diabetes. Nat Genet 2003; 34:267-273.
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 46
    • 0031454481 scopus 로고    scopus 로고
    • Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity
    • Hopkins DF, Williams G. Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity. Diab Med 1997; 14:1044-1050.
    • (1997) Diab Med , vol.14 , pp. 1044-1050
    • Hopkins, D.F.1    Williams, G.2
  • 47
    • 0022371436 scopus 로고
    • Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain
    • Boyd FT, Clarke DW, Muther TF, Raizada MK. Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain. J Biol Chem 1985; 15:15880-15881.
    • (1985) J Biol Chem , vol.15 , pp. 15880-15881
    • Boyd, F.T.1    Clarke, D.W.2    Muther, T.F.3    Raizada, M.K.4
  • 48
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • Woods S, Letter E, McKay L, Porte DJ. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 1979; 282:503-505.
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.1    Letter, E.2    McKay, L.3    Porte, D.J.4
  • 50
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 52
    • 33747058235 scopus 로고    scopus 로고
    • The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magneto encephalographic study
    • USA
    • Tschritter O, Preissl H, Hennige AM, et al. The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magneto encephalographic study. Proc Natl Acad Sci USA 2006.
    • (2006) Proc Natl Acad Sci
    • Tschritter, O.1    Preissl, H.2    Hennige, A.M.3
  • 53
    • 0032449219 scopus 로고    scopus 로고
    • The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
    • Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 1998; 19:491-503.
    • (1998) Endocr Rev , vol.19 , pp. 491-503
    • Gerich, J.E.1
  • 54
    • 0029022819 scopus 로고
    • Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM
    • Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. JAMA 1995; 273:1855-1861.
    • (1995) JAMA , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3
  • 55
    • 0026731869 scopus 로고
    • Glucose toxicity
    • Yki-Jarvinen H. Glucose toxicity. Endocr Rev 1992; 13:415-431.
    • (1992) Endocr Rev , vol.13 , pp. 415-431
    • Yki-Jarvinen, H.1
  • 56
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003; 52:581-587.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 57
    • 0036724133 scopus 로고    scopus 로고
    • Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition
    • Patane G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM. Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition. Diabetes 2002; 51:2749-2756.
    • (2002) Diabetes , vol.51 , pp. 2749-2756
    • Patane, G.1    Anello, M.2    Piro, S.3    Vigneri, R.4    Purrello, F.5    Rabuazzo, A.M.6
  • 58
    • 0842284799 scopus 로고    scopus 로고
    • Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson RP, Harmon J, Tran PO, Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004; 53(Suppl. l):S119-S124.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. L
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Poitout, V.4
  • 59
    • 0032488968 scopus 로고    scopus 로고
    • Troglitazone lowers islet fat and restores beta cell function of diabetic fatty rats
    • Shimabukuro M, Zhou YT, Lee Y, Unger RH. Troglitazone lowers islet fat and restores beta cell function of diabetic fatty rats. J Biol Chem 1998; 273:3547-3550.
    • (1998) J Biol Chem , vol.273 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.T.2    Lee, Y.3    Unger, R.H.4
  • 60
    • 21244442275 scopus 로고    scopus 로고
    • Acid ceramidase over expression prevents the inhibitory effects of saturated fatty acids on insulin signaling
    • Chavez JA, Holland WL, Bar J, Sandhoff K, Summers SA. Acid ceramidase over expression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem 2005; 280:20148-20153.
    • (2005) J Biol Chem , vol.280 , pp. 20148-20153
    • Chavez, J.A.1    Holland, W.L.2    Bar, J.3    Sandhoff, K.4    Summers, S.A.5
  • 61
    • 0042531617 scopus 로고    scopus 로고
    • Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
    • Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem 2003; 278:30015-30021.
    • (2003) J Biol Chem , vol.278 , pp. 30015-30021
    • Kelpe, C.L.1    Moore, P.C.2    Parazzoli, S.D.3    Wicksteed, B.4    Rhodes, C.J.5    Poitout, V.6
  • 63
    • 0034632806 scopus 로고    scopus 로고
    • Islet amyloid and type 2 diabetes mellitus
    • Hoppener JW, Ahren B, Lips CJ. Islet amyloid and type 2 diabetes mellitus. N Engl J Med 2000; 343:411-419.
    • (2000) N Engl J Med , vol.343 , pp. 411-419
    • Hoppener, J.W.1    Ahren, B.2    Lips, C.J.3
  • 65
    • 0036483682 scopus 로고    scopus 로고
    • Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes
    • Knowles NG, Landchild MA, Fujimoto WY, Kahn SE. Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 2002; 25:292-297.
    • (2002) Diabetes Care , vol.25 , pp. 292-297
    • Knowles, N.G.1    Landchild, M.A.2    Fujimoto, W.Y.3    Kahn, S.E.4
  • 66
    • 0028813310 scopus 로고
    • Risk of diabetes in offspring of parents with non-insulin-dependent diabetes
    • Pierce M, Keen H, Bradley C. Risk of diabetes in offspring of parents with non-insulin-dependent diabetes. Diabet Med 1995; 12:6-13.
    • (1995) Diabet Med , vol.12 , pp. 6-13
    • Pierce, M.1    Keen, H.2    Bradley, C.3
  • 67
    • 0016688099 scopus 로고
    • Prevalence of diabetes and glucose intolerance in 199 offspring of thirtyseven conjugal diabetic parents
    • Tattersal RB, Fajans SS. Prevalence of diabetes and glucose intolerance in 199 offspring of thirtyseven conjugal diabetic parents. Diabetes 1975; 24:452-462.
    • (1975) Diabetes , vol.24 , pp. 452-462
    • Tattersal, R.B.1    Fajans, S.S.2
  • 68
    • 0026641354 scopus 로고
    • Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
    • Kaprio J, Tuomilehto J, Koskenvuo M, et al. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 1992; 35:1060-1067.
    • (1992) Diabetologia , vol.35 , pp. 1060-1067
    • Kaprio, J.1    Tuomilehto, J.2    Koskenvuo, M.3
  • 70
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis
    • Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35:595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barker, D.J.2
  • 71
    • 0033594787 scopus 로고    scopus 로고
    • The fetal insulin hypothesis: An alternative explanation of the association of low birth weight with diabetes and vascular disease
    • Hattersley AT, Tooke JE. The fetal insulin hypothesis: an alternative explanation of the association of low birth weight with diabetes and vascular disease. Lancet 1999; 353:1789-1792.
    • (1999) Lancet , vol.353 , pp. 1789-1792
    • Hattersley, A.T.1    Tooke, J.E.2
  • 73
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003; 33:177-182.
    • (2003) Nat Genet , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 74
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 2000; 106:467-472.
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 75
    • 0034681773 scopus 로고    scopus 로고
    • Thiazolidinediones: An update
    • Schoonjans K, Auwerx J. Thiazolidinediones: an update. Lancet 2000; 355:1008-1010.
    • (2000) Lancet , vol.355 , pp. 1008-1010
    • Schoonjans, K.1    Auwerx, J.2
  • 76
    • 0032588487 scopus 로고    scopus 로고
    • PPAR gamma, the ultimate thrifty gene
    • Auwerx J. PPAR gamma, the ultimate thrifty gene. Diabetologia 1999; 42:1033-1049.
    • (1999) Diabetologia , vol.42 , pp. 1033-1049
    • Auwerx, J.1
  • 77
    • 0141781066 scopus 로고    scopus 로고
    • Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes
    • Memisoglu A, Hu FB, Hankinson SE, et al. Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes. Diabetes Care 2003; 26:2915-7.
    • (2003) Diabetes Care , vol.26 , pp. 2915-2917
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3
  • 78
    • 12144291217 scopus 로고    scopus 로고
    • Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes
    • Silander K, Mohlke KL, Scott LJ, et al. Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes 2004; 53:1141-1149.
    • (2004) Diabetes , vol.53 , pp. 1141-1149
    • Silander, K.1    Mohlke, K.L.2    Scott, L.J.3
  • 79
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003; 52:568-572.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3
  • 80
    • 0035475967 scopus 로고    scopus 로고
    • Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: Examples from studies of the calpain-10 gene
    • Cox NJ. Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene. Hum Mol Genet 2001; 10:2301-2305.
    • (2001) Hum Mol Genet , vol.10 , pp. 2301-2305
    • Cox, N.J.1
  • 81
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 2000; 26:163-75.
    • (2000) Nat Genet , vol.26 , pp. 163-175
    • Horikawa, Y.1    Oda, N.2    Cox, N.J.3
  • 82
    • 33746943663 scopus 로고    scopus 로고
    • Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses
    • Tsuchiya T, Schwarz PE, Bosque-Plata LD, et al. Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab 2006.
    • (2006) Mol Genet Metab
    • Tsuchiya, T.1    Schwarz, P.E.2    Bosque-Plata, L.D.3
  • 83
    • 0033797241 scopus 로고    scopus 로고
    • A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    • Baier LJ, Permana PA, Yang X, et al. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest 2000; 106:R69-R73.
    • (2000) J Clin Invest , vol.106
    • Baier, L.J.1    Permana, P.A.2    Yang, X.3
  • 84
    • 0035458548 scopus 로고    scopus 로고
    • Calpains play a role in insulin secretion and action
    • Sreenan SK, Zhou YP, Otani K, et al. Calpains play a role in insulin secretion and action. Diabetes 2001; 50:2013-2020.
    • (2001) Diabetes , vol.50 , pp. 2013-2020
    • Sreenan, S.K.1    Zhou, Y.P.2    Otani, K.3
  • 85
    • 33845337981 scopus 로고    scopus 로고
    • Calpain 10: A mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction
    • Arrington D, Van Vleet T, Schnellmann R. Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction. Am J Physiol Cell Physiol 2006.
    • (2006) Am J Physiol Cell Physiol
    • Arrington, D.1    Van Vleet, T.2    Schnellmann, R.3
  • 86
    • 23044493861 scopus 로고    scopus 로고
    • Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes
    • Meyre D, Bouatia-Naji N, Tounian A, et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005; 37:863-867.
    • (2005) Nat Genet , vol.37 , pp. 863-867
    • Meyre, D.1    Bouatia-Naji, N.2    Tounian, A.3
  • 87
    • 15944371462 scopus 로고    scopus 로고
    • ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes
    • Abate N, Chandalia M, Satija P, et al. ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes. Diabetes 2005; 54:1207-1213.
    • (2005) Diabetes , vol.54 , pp. 1207-1213
    • Abate, N.1    Chandalia, M.2    Satija, P.3
  • 88
    • 32544443794 scopus 로고    scopus 로고
    • Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults
    • Matsuoka N, Patki A, Tiwari HK, et al. Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults. Int J Obes (Lond) 2006; 30:233-237.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 233-237
    • Matsuoka, N.1    Patki, A.2    Tiwari, H.K.3
  • 89
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38:320-323.
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 90
    • 33746075560 scopus 로고    scopus 로고
    • TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    • Florez JC, Jablonski KA, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 2006; 355:241-250.
    • (2006) N Engl J Med , vol.355 , pp. 241-250
    • Florez, J.C.1    Jablonski, K.A.2    Bayley, N.3
  • 91
    • 33644784937 scopus 로고    scopus 로고
    • Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population
    • Vaxillaire M, Dechaume A, Vasseur-Delannoy V, et al. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes 2006; 55:856-861.
    • (2006) Diabetes , vol.55 , pp. 856-861
    • Vaxillaire, M.1    Dechaume, A.2    Vasseur-Delannoy, V.3


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