Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus

Annals of the New York Academy of Sciences

Volumn 967, Issue , 2002, Pages 363-378

  Ravussin, Eric ^a   Smith, Steven R ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Acquired lipodystrophy; Adiponectin; Ectopic fat storage syndrome; Endocrine paradigm; Resistin

Indexed keywords

ADIPONECTIN; ANGIOTENSIN; FAT; INSULIN; INTERLEUKIN 6; LEPTIN;

ADIPOCYTE; CELL PROLIFERATION; CONFERENCE PAPER; DIABETIC OBESITY; FAT INTAKE; FATTY ACID OXIDATION; HORMONAL REGULATION; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; LIPODYSTROPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY;

EID: 0036299262     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04292.x     Document Type: Conference Paper

References (117)

1. Science, medicine, and the future: Non-insulin dependent diabetes mellitus - The gathering storm
2. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
3. Impaired glucose tolerance as a disorder of insulin action: Longitudinal and cross-sectional studies in Pima Indians
4. Banting lecture: Role of insulin resistance in human disease
5. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: The Third National Health and Nutrition Examination Survey, 1988-1994
6. Diabetes incidence in Pima Indians: Contributions of obesity and parental diabetes
7. Lilly lecture 1980: Insulin resistance and insulin action - An in vitro and in vivo perspective
8. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
9. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: Prospective studies of Pima Indians
10. Forearm metabolism in obesity and its response to intraarterial insulin: Characterization of insulin resistance and evidence for adaptive hyperinsulinism
11. Splanchnic glucose and amino acid metabolism in obesity
12. Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes
13. Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians: Analysis of the impact of gender, body fat, physical fitness, and life-style factors
14. Biology of regional body fat distribution: Relationship to non-insulin-dependent diabetes mellitus
15. The insulin resistance-dyslipidemic syndrome: Contribution of visceral obesity and therapeutic implications
16. Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?
17. Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women
18. Fat distribution and health in obesity
19. The glucose fatty acid cycle: Its role in insulin sensitivity and metabolic disturbances of diabetes mellitus
20. Fuel selection in human skeletal muscle in insulin resistance: A reexamination
21. Free fatty acids and pathogenesis of type 2 diabetes mellitus
22. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
23. Relationships of generalized and regional adiposity to insulin sensitivity in men
24. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
25. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity
26. Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM
27. Insulin sensitivity and serum triglyceride level in obese white and black women: Relationship to visceral and truncal subcutaneous fat
28. Role of muscle in triglyceride metabolism
29. Skeletal muscle triglyceride levels are inversely related to insulin action
30. Skeletal muscle density: Effects of obesity and non-insulin-dependent diabetes mellitus
31. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
32. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
33. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity
34. Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo
35. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
36. 1H NMR spectroscopy study
37. The effect of diet on thermogenesis in acquired lipodystrophy
38. Familial partial lipodystrophy: Complications of obesity in the non-obese?
39. Transgenic mice lacking white fat: Models for understanding human lipoatrophic diabetes
40. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
41. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice
42. Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene
43. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
44. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
45. Subcutaneous lipectomy causes a metabolic syndrome in hamsters
46. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
47. Cellular mechanisms of insulin resistance
48. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation
49. Efficacy of troglitazone on body fat distribution in type 2 diabetes
50. Insulin secretion in relation to adipose tissue in men
51. Effects of altered adipose tissue morphology on plasma insulin levels in the rat
52. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance
53. Cellular basis of insulin insensitivity in large rat adipocytes
54. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
55. Transcriptional control of adipogenesis
56. Insights into the transcriptional control of adipocyte differentiation
57. Multilineage potential of adult human mesenchymal stem cells
58. Transcriptional regulation of adipogenesis
59. Please pass the chips: Genomic insights into obesity and diabetes
60. Molecular regulation of adipogenesis
61. The molecular mechanism of the stimulation of adipocyte differentiation by a glucocorticoid
62. PPARγ, the ultimate thrifty gene
63. Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade
64. Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by antagonists of adipogenesis
65. The common PPAR-gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
66. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
67. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: Study of 24-h RQ
68. Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: The Baltimore Longitudinal Study on Aging
69. The respiratory quotient as a prognostic factor in weight-loss rebound
70. Fat and carbohydrate balances during adaptation to a high-fat diet
71. Human skeletal muscle carnitine palmitoyltransferase I activity determined in isolated intact mitochondria
72. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
73. Lower activity of oxidative key enzymes and smaller fiber areas in skeletal muscle of postobese women
74. 1H-MRS)
75. Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
76. Demonstration of an in vivo functional beta3-adrenoceptor in man
77. Dobutamine as selective beta(1)-adrenoceptor agonist in in vivo studies on human thermogenesis and lipid utilization
78. A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men
79. Respiratory quotient is inversely associated with muscle sympathetic nerve activity
80. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
81. Peripheral administration of human corticotropin-releasing hormone: A novel method to increase energy expenditure and fat oxidation in man
82. Leptin directly alters lipid partitioning in skeletal muscle
83. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor
84. Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle
85. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
86. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
87. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
88. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
89. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
90. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
91. Abnormal A1 adenosine receptor function in genetic obesity
92. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
93. The acylation stimulating protein-adipsin system
94. 2+-dependent mechanism
95. Angiotensinogen, angiotensin II, and adipose tissue development
96. Upregulation of bone morphogenetic protein GDF-3/Vgr-2 expression in adipose tissue of FABP4/aP2 null mice
97. Endocrine and paracrine negative regulators of adipose differentiation
98. De novo formation of adipose tissue by controlled release of basic fibroblast growth factor
99. Insulin-like growth factor 1 induction of differentiation of porcine preadipocytes
100. IGF-I- and IGFBP-3-expression in cultured human preadipocytes and adipocytes
101. Interleukin-8 production in human adipose tissue: Inhibitory effects of anti-diabetic compounds, the thiazolidinedione ciglitazone, and the biguanide metformin
102. Lactate production in adipose tissue: A regulated function with extra-adipose implications
103. Positional cloning of the mouse obese gene and its human homologue
104. Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes: A paracrine signal for preadipocyte growth
105. Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes: A paracrine signal for preadipocyte growth
106. Elaboration of type-1 plasminogen activator inhibitor from adipocytes: A potential pathogenetic link between obesity and cardiovascular disease
107. Function of pref-1 as an inhibitor of adipocyte differentiation
108. Differentiation of preadipose cells: Paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II
109. Resistin: A new hormone that links obesity with type 2 diabetes
110. Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue
111. Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice
112. A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model
113. Tissue-specific regulation of fat cell lipolysis by NPY in 6-OHDA-treated rats
114. The role of melanocortins in adipocyte function
115. A role for preadipocytes as macrophage-like cells
116. Inhibition of adipogenesis by Wnt signaling