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Volumn 22, Issue 3, 2008, Pages 175-198

Vaccines for multiple sclerosis: Progress to date

Author keywords

Multiple sclerosis vaccine, therapeutic use; Multiple sclerosis, treatment; Research and development; T cell replacement therapy, therapeutic use

Indexed keywords

CYTOKINE; DENDRITIC CELL VACCINE; DNA VACCINE; FAS LIGAND; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN FC FRAGMENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCLONAL ANTIBODY; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NEUTRALIZING ANTIBODY; PEPTIDE VACCINE; PLACEBO; PLASMID DNA; PROTEOLIPID PROTEIN; T CELL RECEPTOR PEPTIDE VACCINE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE VACCINE; TIPLIMOTIDE; TRIPLE VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACCINE;

EID: 39349098254     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200822030-00001     Document Type: Review
Times cited : (30)

References (164)
  • 1
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: Results of an international survey
    • Apr;
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996 Apr; 46 (4): 907-11
    • (1996) Neurology , vol.46 , Issue.4 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 2
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 3
    • 0032772860 scopus 로고    scopus 로고
    • Immunopathogenesis of multiple sclerosis: The role of T cells
    • Jun;
    • Martino G, Hartung HP. Immunopathogenesis of multiple sclerosis: the role of T cells. Curr Opin Neurol 1999 Jun; 12 (3): 309-21
    • (1999) Curr Opin Neurol , vol.12 , Issue.3 , pp. 309-321
    • Martino, G.1    Hartung, H.P.2
  • 4
    • 0023948785 scopus 로고
    • Mutual cell interactions and the selection of immune repertoires: Implication in autoimmunity
    • Jul-Aug;
    • Marcos MA, Toribio ML, de la Hera A, et al. Mutual cell interactions and the selection of immune repertoires: implication in autoimmunity. Immunol Today 1988 Jul-Aug; 9 (7-8): 204-7
    • (1988) Immunol Today , vol.9 , Issue.7-8 , pp. 204-207
    • Marcos, M.A.1    Toribio, M.L.2    de la Hera, A.3
  • 5
    • 33745098092 scopus 로고    scopus 로고
    • Molecular mimicry in multiple sclerosis
    • Feb;
    • Sospedra M, Martin R. Molecular mimicry in multiple sclerosis. Autoimmunity 2006 Feb; 39 (1): 3-8
    • (2006) Autoimmunity , vol.39 , Issue.1 , pp. 3-8
    • Sospedra, M.1    Martin, R.2
  • 6
    • 0034773019 scopus 로고    scopus 로고
    • Mechanisms for induction of autoimmunity by infectious agents
    • Oct 15;
    • Wucherpfening KW. Mechanisms for induction of autoimmunity by infectious agents. J Clin Invest 2001 Oct 15; 108 (8): 1097-104
    • (2001) J Clin Invest , vol.108 , Issue.8 , pp. 1097-1104
    • Wucherpfening, K.W.1
  • 7
    • 26844499037 scopus 로고    scopus 로고
    • How can the innate immune system influence autoimmunity in type 1 diabetes and other autoimmune disorders?
    • Wen L, Wong FS. How can the innate immune system influence autoimmunity in type 1 diabetes and other autoimmune disorders? Crit Rev Immunol 2005; 25 (3): 225-50
    • (2005) Crit Rev Immunol , vol.25 , Issue.3 , pp. 225-250
    • Wen, L.1    Wong, F.S.2
  • 8
    • 33750435941 scopus 로고    scopus 로고
    • Physiologic regulation of central and peripheral tolerance: Lessons for therapeutic applications
    • Nov;
    • Li L, Boussiotis VA. Physiologic regulation of central and peripheral tolerance: lessons for therapeutic applications. J Mol Med 2006 Nov; 84 (11): 887-99
    • (2006) J Mol Med , vol.84 , Issue.11 , pp. 887-899
    • Li, L.1    Boussiotis, V.A.2
  • 9
    • 20444485767 scopus 로고    scopus 로고
    • Goodnow CC, Sprent J, Fazekas de St Groth b, et al. Cellular and genetic mechanisms of self-tolerance and autoimmunity. Nature 2005 Jun 2; 435 (7042): 590-7
    • Goodnow CC, Sprent J, Fazekas de St Groth b, et al. Cellular and genetic mechanisms of self-tolerance and autoimmunity. Nature 2005 Jun 2; 435 (7042): 590-7
  • 10
    • 0021647194 scopus 로고
    • The current status of multiple sclerosis intra-blood-brain-barrier IgG synthesis
    • Tourtellotte WW, Walsh MJ, Baumhefner RW, et al. The current status of multiple sclerosis intra-blood-brain-barrier IgG synthesis. Ann N Y Acad Sci 1984; 436: 52-67
    • (1984) Ann N Y Acad Sci , vol.436 , pp. 52-67
    • Tourtellotte, W.W.1    Walsh, M.J.2    Baumhefner, R.W.3
  • 11
    • 0024561002 scopus 로고
    • B cells antibodies in MS
    • Link H, Baig S, Jiang YP, et al. B cells antibodies in MS. Res Immunol 1989; 140 (2): 219-26
    • (1989) Res Immunol , vol.140 , Issue.2 , pp. 219-226
    • Link, H.1    Baig, S.2    Jiang, Y.P.3
  • 12
    • 0017572709 scopus 로고
    • Principles of albumin and IgG analyses in neurological disorders: III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis
    • Sep;
    • Link H, Tibbling G. Principles of albumin and IgG analyses in neurological disorders: III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis. Scand J Clin Lab Invest 1977 Sep; 37 (5): 397-401
    • (1977) Scand J Clin Lab Invest , vol.37 , Issue.5 , pp. 397-401
    • Link, H.1    Tibbling, G.2
  • 13
    • 0021670537 scopus 로고
    • Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labelling, and avidinbiotin amplification
    • Jul;
    • Olsson T, Kostulas V, Link H. Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labelling, and avidinbiotin amplification. Clin Chem 1984 Jul; 30 (7): 1246-9
    • (1984) Clin Chem , vol.30 , Issue.7 , pp. 1246-1249
    • Olsson, T.1    Kostulas, V.2    Link, H.3
  • 14
    • 0028037604 scopus 로고
    • Cerebrospinal fluid in the diagnosis of multiple sclerosis: A consensus report
    • Aug;
    • Andersson M, Alvarez-Cermeno J, Bernardi G, et al. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J Neurol Neurosurg Psychiatry 1994 Aug; 57 (8): 897-902
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , Issue.8 , pp. 897-902
    • Andersson, M.1    Alvarez-Cermeno, J.2    Bernardi, G.3
  • 15
    • 33750604563 scopus 로고    scopus 로고
    • Oligoclonal bands in multiple sclerosis cerebrospinal fluid: An update on methodology and clinical usefulness
    • Nov;
    • Link H, Huang YM. Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness. J Neuroimmunol 2006 Nov; 180 (1-2): 17-28
    • (2006) J Neuroimmunol , vol.180 , Issue.1-2 , pp. 17-28
    • Link, H.1    Huang, Y.M.2
  • 16
    • 0036223573 scopus 로고    scopus 로고
    • Oligoclonal bands and antibodies responses in multiple sclerosis
    • Apr;
    • Correale J, Bassani Molinas M. Oligoclonal bands and antibodies responses in multiple sclerosis. J Neurol 2002 Apr; 249 (4): 375-89
    • (2002) J Neurol , vol.249 , Issue.4 , pp. 375-389
    • Correale, J.1    Bassani Molinas, M.2
  • 17
    • 33750627447 scopus 로고    scopus 로고
    • Roles of immunoglobulins and B cells in multiple sclerosis: From pathogenesis to treatment
    • Nov;
    • Antel J, Bar-Or A. Roles of immunoglobulins and B cells in multiple sclerosis: from pathogenesis to treatment. J Neuroimmunol 2006 Nov; 180 (1-2): 3-8
    • (2006) J Neuroimmunol , vol.180 , Issue.1-2 , pp. 3-8
    • Antel, J.1    Bar-Or, A.2
  • 18
    • 34249687536 scopus 로고    scopus 로고
    • B cells: No longer the nondominant arm of multiple sclerosis
    • May;
    • Klawiter EC, Cross AH. B cells: no longer the nondominant arm of multiple sclerosis. Curr Neurol Neeurosci Rep 2007 May; 7 (3): 231-8
    • (2007) Curr Neurol Neeurosci Rep , vol.7 , Issue.3 , pp. 231-238
    • Klawiter, E.C.1    Cross, A.H.2
  • 19
    • 0000361150 scopus 로고
    • Histologie de le sclerose en plaques.
    • Charcot JM. Histologie de le sclerose en plaques. Gaz Hop 1868; 41: 554-66
    • (1868) Gaz Hop , vol.41 , pp. 554-566
    • Charcot, J.M.1
  • 20
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transection in the lesions of multiple sclerosis
    • Jan 29;
    • Trapp BD, Peterson J, Ransoohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998 Jan 29; 338 (5): 278-85
    • (1998) N Engl J Med , vol.338 , Issue.5 , pp. 278-285
    • Trapp, B.D.1    Peterson, J.2    Ransoohoff, R.M.3
  • 21
    • 0032796747 scopus 로고    scopus 로고
    • Axonal pathology in multiple sclerosis: Relationship to neurologic disability
    • Jun;
    • Trapp BD, Ransohoff R, Rudick R. Axonal pathology in multiple sclerosis: relationship to neurologic disability. Curr Opin Neurol 1999 Jun; 12 (3): 295-302
    • (1999) Curr Opin Neurol , vol.12 , Issue.3 , pp. 295-302
    • Trapp, B.D.1    Ransohoff, R.2    Rudick, R.3
  • 22
    • 84879150116 scopus 로고    scopus 로고
    • Cohen JA, Rudick RA, editors, 2nd ed. London: Martin Dunitz Ltd
    • Cohen JA, Rudick RA, editors. Multiple sclerosis therapeutics. 2nd ed. London: Martin Dunitz Ltd, 2003
    • (2003) Multiple sclerosis therapeutics
  • 23
    • 0020551984 scopus 로고
    • Isolation of myelin basic protein-reactive T-cell lines from normal human blood
    • Oct;
    • Burns J, Rosenzweig A, Zweiman B, et al. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell Immunol 1983 Oct; 81 (2): 435-40
    • (1983) Cell Immunol , vol.81 , Issue.2 , pp. 435-440
    • Burns, J.1    Rosenzweig, A.2    Zweiman, B.3
  • 24
    • 0029086439 scopus 로고
    • Isolation and characterization of autoreactive proteolipid protein-peptide specific T cell-clones from multiple sclerosis patients
    • Jul;
    • Correale J, McMillan M, McCarthy K, et al. Isolation and characterization of autoreactive proteolipid protein-peptide specific T cell-clones from multiple sclerosis patients. Neurology 1995 Jul; 45 (7): 1370-8
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1370-1378
    • Correale, J.1    McMillan, M.2    McCarthy, K.3
  • 25
    • 0032879769 scopus 로고    scopus 로고
    • Autoreactivity to myelin antigens: Myelin/oligodendrocyte glycoprotein is a prevalent autoantigen
    • Sep;
    • Diaz-Villoslada P, Shih A, Shao L, et al. Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. J Neuroimmunol 1999 Sep; 99 (1): 36-43
    • (1999) J Neuroimmunol , vol.99 , Issue.1 , pp. 36-43
    • Diaz-Villoslada, P.1    Shih, A.2    Shao, L.3
  • 26
    • 0019487117 scopus 로고
    • Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein
    • Jul 2;
    • Ben-Nun A, Wekerle H, Cohen I. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 1981 Jul 2; 292: 60-1
    • (1981) Nature , vol.292 , pp. 60-61
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.3
  • 27
    • 0024952631 scopus 로고
    • Physiological basis of T-cell vaccination against autoimmune disease
    • Cohen I. Physiological basis of T-cell vaccination against autoimmune disease. Cold Spring Harb Symp Quant Biol 1989; 54 (Pt 2): 879-84
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , Issue.PART 2 , pp. 879-884
    • Cohen, I.1
  • 28
    • 0023864061 scopus 로고
    • Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis
    • Jan 8;
    • Lider O, Reshef T, Beraud E, et al. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 1988 Jan 8; 239: 181-3
    • (1988) Science , vol.239 , pp. 181-183
    • Lider, O.1    Reshef, T.2    Beraud, E.3
  • 29
    • 0012825298 scopus 로고
    • Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure
    • Jul;
    • Lider O, Karin N, Shinitzky M, et al. Therapeutic vaccination against adjuvant arthritis using autoimmune T cells treated with hydrostatic pressure. Proc Natl Acad Sci U S A 1987 Jul; 84: 4577-80
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 4577-4580
    • Lider, O.1    Karin, N.2    Shinitzky, M.3
  • 30
    • 0026378547 scopus 로고
    • T cell vaccination in autoimmune diseases
    • Dec 30;
    • Beraud E. T cell vaccination in autoimmune diseases. Ann N Y Acad Sci 1991 Dec 30; 636: 124-34
    • (1991) Ann N Y Acad Sci , vol.636 , pp. 124-134
    • Beraud, E.1
  • 31
    • 0020684764 scopus 로고
    • Lines of T lymphocytes induce or vaccinate against autoimmune artritis
    • Jan 7;
    • Holoshitz J, Naparstek Y, Ben-Nun A, et al. Lines of T lymphocytes induce or vaccinate against autoimmune artritis. Science 1983 Jan 7; 219: 56-8
    • (1983) Science , vol.219 , pp. 56-58
    • Holoshitz, J.1    Naparstek, Y.2    Ben-Nun, A.3
  • 32
    • 0021038257 scopus 로고
    • T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice
    • Nov;
    • Maron R, Zerubavel R, Friedman A, et al. T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J Immunol 1983 Nov; 131 (5): 2316-22
    • (1983) J Immunol , vol.131 , Issue.5 , pp. 2316-2322
    • Maron, R.1    Zerubavel, R.2    Friedman, A.3
  • 33
    • 0026322837 scopus 로고
    • Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDA heat shock protein
    • Apr 15;
    • Elias D, Reshef T, Birk OS, et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDA heat shock protein. Proc Natl Acad Sci U S A 1991 Apr 15; 88 (8): 3088-91
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.8 , pp. 3088-3091
    • Elias, D.1    Reshef, T.2    Birk, O.S.3
  • 34
    • 0024614915 scopus 로고
    • Vaccination against experimental autoimmune encephalomyelitis using a subencepahlitogenic dose of autoimmune effector T cells: (II). Induction of a protective anti-idiotypic response
    • Feb;
    • Lider O, Beraud E, Reshef T, et al. Vaccination against experimental autoimmune encephalomyelitis using a subencepahlitogenic dose of autoimmune effector T cells: (II). Induction of a protective anti-idiotypic response. J Autoimmun 1989 Feb; 2 (1): 87-99
    • (1989) J Autoimmun , vol.2 , Issue.1 , pp. 87-99
    • Lider, O.1    Beraud, E.2    Reshef, T.3
  • 35
    • 0002646925 scopus 로고
    • Natural Id-anti-Id networks and the immunological homunculus
    • Atlan H, Cohen IR, editors, Berlin: Springer-Verlag
    • Cohen IR. Natural Id-anti-Id networks and the immunological homunculus. In: Atlan H, Cohen IR, editors. Theories of immune networks. Berlin: Springer-Verlag, 1989: 6-12
    • (1989) Theories of immune networks , pp. 6-12
    • Cohen, I.R.1
  • 36
    • 0028875204 scopus 로고
    • In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination
    • Dec 15;
    • Zhang J, Vandevyver C, Stinissen P, et al. In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination. J Immunol 1995 Dec 15; 155 (12): 5868-77
    • (1995) J Immunol , vol.155 , Issue.12 , pp. 5868-5877
    • Zhang, J.1    Vandevyver, C.2    Stinissen, P.3
  • 37
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Sep 10;
    • Zhang J, Medaer R, Stinissen P, et al. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 1993 Sep 10; 261: 1451-4
    • (1993) Science , vol.261 , pp. 1451-1454
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3
  • 38
    • 0034710361 scopus 로고    scopus 로고
    • T cell vaccination in secondary progressive multiple sclerosis
    • Jul;
    • Correale J, Lund B, McMillan M, et al. T cell vaccination in secondary progressive multiple sclerosis. J Neuroimmunol 2000 Jul; 107 (2): 130-9
    • (2000) J Neuroimmunol , vol.107 , Issue.2 , pp. 130-139
    • Correale, J.1    Lund, B.2    McMillan, M.3
  • 39
    • 0034655088 scopus 로고    scopus 로고
    • Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination
    • Apr 15;
    • Zang YC, Hong J, Rivera VM, et al. Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination. J Immunol 2000 Apr 15; 164 (8): 4011-7
    • (2000) J Immunol , vol.164 , Issue.8 , pp. 4011-4017
    • Zang, Y.C.1    Hong, J.2    Rivera, V.M.3
  • 40
    • 33645525544 scopus 로고    scopus 로고
    • Hong J, Zang YC, Nie H, et al. CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis. Proc Natl Acad Sci U S A 2006 Mar 28; 103 (13): 5024-9
    • Hong J, Zang YC, Nie H, et al. CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis. Proc Natl Acad Sci U S A 2006 Mar 28; 103 (13): 5024-9
  • 41
    • 0034002679 scopus 로고    scopus 로고
    • Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis
    • Mar;
    • Zang YC, Hong J, Tejada-Simon MV, et al. Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis. Eur J Immunol 2000 Mar; 30 (3): 908-13
    • (2000) Eur J Immunol , vol.30 , Issue.3 , pp. 908-913
    • Zang, Y.C.1    Hong, J.2    Tejada-Simon, M.V.3
  • 42
    • 0022931255 scopus 로고
    • Regulation of autoimmune disease physiological and therapeutic
    • Dec;
    • Cohen IR. Regulation of autoimmune disease physiological and therapeutic. Immunol Rev 1986 Dec; 94: 5-21
    • (1986) Immunol Rev , vol.94 , pp. 5-21
    • Cohen, I.R.1
  • 43
    • 0020529974 scopus 로고
    • T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE): Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells
    • May;
    • Naparstek Y, Ben-Nun A, Holoshitz J, et al. T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE): functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells. Eur J Immunol 1983 May; 13 (5): 418-23
    • (1983) Eur J Immunol , vol.13 , Issue.5 , pp. 418-423
    • Naparstek, Y.1    Ben-Nun, A.2    Holoshitz, J.3
  • 44
    • 0024363480 scopus 로고
    • Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells
    • May 19;
    • Lohse AW, Mor F, Karin N, et al. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science 1989 May 19; 244: 820-2
    • (1989) Science , vol.244 , pp. 820-822
    • Lohse, A.W.1    Mor, F.2    Karin, N.3
  • 45
    • 33747038380 scopus 로고    scopus 로고
    • Anti-ergotypic immunoregulation
    • Sep;
    • Quintana FJ, Cohen IR. Anti-ergotypic immunoregulation. Scand J Immunol 2006 Sep; 64 (3): 205-10
    • (2006) Scand J Immunol , vol.64 , Issue.3 , pp. 205-210
    • Quintana, F.J.1    Cohen, I.R.2
  • 46
    • 0032881571 scopus 로고    scopus 로고
    • Cellular and humoral immune responses against autoreactive T cells in multiple sclerosis patients after T cell vaccination
    • Sep;
    • Hermans G, Denzer U, Lohse A, et al. Cellular and humoral immune responses against autoreactive T cells in multiple sclerosis patients after T cell vaccination. J Autoimmun 1999 Sep; 13 (2): 233-46
    • (1999) J Autoimmun , vol.13 , Issue.2 , pp. 233-246
    • Hermans, G.1    Denzer, U.2    Lohse, A.3
  • 47
    • 0031127366 scopus 로고    scopus 로고
    • Humoral mechanisms in T cell vaccination: Induction and functional characterization of anti-lymphocytic autoantibodies
    • Apr;
    • Herkel J, Brunner S, Meyer zum Büschenfelde KH, et al. Humoral mechanisms in T cell vaccination: induction and functional characterization of anti-lymphocytic autoantibodies. J Autoimmun 1997 Apr; 10 (2): 137-46
    • (1997) J Autoimmun , vol.10 , Issue.2 , pp. 137-146
    • Herkel, J.1    Brunner, S.2    Meyer zum Büschenfelde, K.H.3
  • 48
    • 0034671943 scopus 로고    scopus 로고
    • Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T cell vaccination
    • Dec 15;
    • Hong J, Zang YC, Tejada-Simon MV, et al. Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T cell vaccination. J Immunol 2000 Dec 15; 165 (12): 6858-64
    • (2000) J Immunol , vol.165 , Issue.12 , pp. 6858-6864
    • Hong, J.1    Zang, Y.C.2    Tejada-Simon, M.V.3
  • 49
    • 11144356793 scopus 로고    scopus 로고
    • Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants
    • Apr 1;
    • Buenafe AC, Tsaknaridis L, Spencer L, et al. Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants. J Neurosci Res 2004 Apr 1; 76 (1): 129-40
    • (2004) J Neurosci Res , vol.76 , Issue.1 , pp. 129-140
    • Buenafe, A.C.1    Tsaknaridis, L.2    Spencer, L.3
  • 50
    • 27944499757 scopus 로고    scopus 로고
    • Reduced suppressive effect of CD4+CD25 high regulatory T cells on the T cell immune response against myelin oligodendrocyte protein in patients with multiple sclerosis
    • Nov;
    • Haas JA, Hug A, Viehöver B, et al. Reduced suppressive effect of CD4+CD25 high regulatory T cells on the T cell immune response against myelin oligodendrocyte protein in patients with multiple sclerosis. Eur J Immunol 2005 Nov; 35 (11): 3343-52
    • (2005) Eur J Immunol , vol.35 , Issue.11 , pp. 3343-3352
    • Haas, J.A.1    Hug, A.2    Viehöver, B.3
  • 51
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Apr 5;
    • Viglietta V, Baecher-Allan C, Weiner HL, et al. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004 Apr 5; 199 (7): 971-9
    • (2004) J Exp Med , vol.199 , Issue.7 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3
  • 52
    • 33751113922 scopus 로고    scopus 로고
    • CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis
    • Nov;
    • Kumar M, Putzki N, Limmroth V, et al. CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis. J Neuroimmunol 2006 Nov; 180 (1-2): 178-84
    • (2006) J Neuroimmunol , vol.180 , Issue.1-2 , pp. 178-184
    • Kumar, M.1    Putzki, N.2    Limmroth, V.3
  • 53
    • 0032881571 scopus 로고    scopus 로고
    • Cellular and humoral immune responses against autoreactive T cells in multiple sclerosis patients after T cell vaccination
    • Sep;
    • Hermans G, Denzer U, Lohse A, et al. Cellular and humoral immune responses against autoreactive T cells in multiple sclerosis patients after T cell vaccination. J Autoimmun 1999 Sep; 13 (2): 233-46
    • (1999) J Autoimmun , vol.13 , Issue.2 , pp. 233-246
    • Hermans, G.1    Denzer, U.2    Lohse, A.3
  • 54
    • 0032105479 scopus 로고    scopus 로고
    • Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination
    • Jul;
    • Stinissen P, Zhang J, Vandevyver C, et al. Gammadelta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination. J Neuroimmunol 1998 Jul; 87 (1-2): 94-104
    • (1998) J Neuroimmunol , vol.87 , Issue.1-2 , pp. 94-104
    • Stinissen, P.1    Zhang, J.2    Vandevyver, C.3
  • 55
    • 0026536020 scopus 로고
    • T cell vaccination in multiple sclerosis: A preliminary report
    • Mar;
    • Hafler DA, Cohen IR, Benjamin DS, et al. T cell vaccination in multiple sclerosis: a preliminary report. Clin Immunol Immunopathol 1992 Mar; 62 (3): 307-13
    • (1992) Clin Immunol Immunopathol , vol.62 , Issue.3 , pp. 307-313
    • Hafler, D.A.1    Cohen, I.R.2    Benjamin, D.S.3
  • 56
    • 0029167057 scopus 로고
    • Depletion of myelin-basic-protein autoreactive T cells by T cell vaccination: Pilot trial in multiple sclerosis
    • Sep 23;
    • Medaer R, Stinissen P, Truyen L, et al. Depletion of myelin-basic-protein autoreactive T cells by T cell vaccination: pilot trial in multiple sclerosis. Lancet 1995 Sep 23; 346: 807-8
    • (1995) Lancet , vol.346 , pp. 807-808
    • Medaer, R.1    Stinissen, P.2    Truyen, L.3
  • 57
    • 0036169323 scopus 로고    scopus 로고
    • T cell vaccination in multiple sclerosis: Results of a preliminary study
    • Feb;
    • Zhang JZ, Rivera VM, Tejada-Simon MV, et al. T cell vaccination in multiple sclerosis: results of a preliminary study. J Neurol 2002 Feb; 249 (2): 212-8
    • (2002) J Neurol , vol.249 , Issue.2 , pp. 212-218
    • Zhang, J.Z.1    Rivera, V.M.2    Tejada-Simon, M.V.3
  • 58
    • 0037235010 scopus 로고    scopus 로고
    • T cell vaccination in multiple sclerosis patients with autologous CSF-derived activated T cells: Results from a pilot study
    • Jan;
    • Van der Aa A, Hellings N, Medaer R, et al. T cell vaccination in multiple sclerosis patients with autologous CSF-derived activated T cells: results from a pilot study. Clin Exp Immunol 2003 Jan; 131 (1): 155-68
    • (2003) Clin Exp Immunol , vol.131 , Issue.1 , pp. 155-168
    • Van der Aa, A.1    Hellings, N.2    Medaer, R.3
  • 59
    • 4644338002 scopus 로고    scopus 로고
    • T cell vaccination in multiple sclerosis relapsing-remitting non responders patients
    • Nov;
    • Achiron A, Lavie G, Kishner I, et al. T cell vaccination in multiple sclerosis relapsing-remitting non responders patients. Clin Immunol 2004 Nov; 113 (2): 155-60
    • (2004) Clin Immunol , vol.113 , Issue.2 , pp. 155-160
    • Achiron, A.1    Lavie, G.2    Kishner, I.3
  • 60
    • 39349103342 scopus 로고    scopus 로고
    • National MS Society, online, Available from URL:, Accessed 2008 Jan 28
    • National MS Society. Clinical trials in MS 2007: planned, in progress, recently completed [online]. Available from URL: http://www.nationalmssociety. org/docs/HOM/clinical trials.pdf [Accessed 2008 Jan 28]
    • Clinical trials in MS 2007: Planned, in progress, recently completed
  • 61
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33 (11): 1444-52
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 62
    • 33749059726 scopus 로고    scopus 로고
    • The neurobiology of multiple sclerosis: Genes, inflammation and neurodegeneration
    • Oct 5;
    • Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation and neurodegeneration. Neuron 2006 Oct 5; 52 (1): 61-76
    • (2006) Neuron , vol.52 , Issue.1 , pp. 61-76
    • Hauser, S.L.1    Oksenberg, J.R.2
  • 63
    • 0024530958 scopus 로고
    • Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different
    • Jan 1;
    • Burns FR, Li XB, Shen N, et al. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 1989 Jan 1; 169 (1): 27-39
    • (1989) J Exp Med , vol.169 , Issue.1 , pp. 27-39
    • Burns, F.R.1    Li, X.B.2    Shen, N.3
  • 64
    • 45149146393 scopus 로고
    • The V-region hypothesis: Evidence for autoimmune encephalomyelitis
    • May;
    • Heber-Katz E, Acha-Orbea H. The V-region hypothesis: evidence for autoimmune encephalomyelitis. Immunol Today 1989 May; 10 (5): 164-9
    • (1989) Immunol Today , vol.10 , Issue.5 , pp. 164-169
    • Heber-Katz, E.1    Acha-Orbea, H.2
  • 65
    • 0025328989 scopus 로고    scopus 로고
    • Zaller DM, Osman G, Kanagawa O, et al. Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies. J Exp Med 1990 Jun 1; 171 (6): 1943-55
    • Zaller DM, Osman G, Kanagawa O, et al. Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies. J Exp Med 1990 Jun 1; 171 (6): 1943-55
  • 66
    • 0029930328 scopus 로고    scopus 로고
    • T cell receptor peptides in treatment of autoimmune disease: Rationale and potential
    • Feb 15;
    • Vandenbark AA, Hashim GA, Offner H. T cell receptor peptides in treatment of autoimmune disease: rationale and potential. J Neurosc Res 1996 Feb 15; 43 (4): 391-402
    • (1996) J Neurosc Res , vol.43 , Issue.4 , pp. 391-402
    • Vandenbark, A.A.1    Hashim, G.A.2    Offner, H.3
  • 67
    • 0026396782 scopus 로고
    • Immunoregulation of autoimmune disease by vaccination with T cell receptor peptides
    • Dec 30;
    • Brostoff SW, Howell MD. Immunoregulation of autoimmune disease by vaccination with T cell receptor peptides. Ann N Y Acad Sci 1991 Dec 30; 636: 71-8
    • (1991) Ann N Y Acad Sci , vol.636 , pp. 71-78
    • Brostoff, S.W.1    Howell, M.D.2
  • 68
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
    • Oct 12;
    • Vandenbark AA, Hashim G, Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 1989 Oct 12; 341: 541-4
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 69
    • 0024468234 scopus 로고
    • Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
    • Nov 3;
    • Howell MD, Winster ST, Olee T, et al. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 1989 Nov 3; 246: 668-70
    • (1989) Science , vol.246 , pp. 668-670
    • Howell, M.D.1    Winster, S.T.2    Olee, T.3
  • 70
    • 0025339288 scopus 로고
    • Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis
    • Jun 15;
    • Hashim GA, Vandenbark AA, Galang AB, et al. Antibodies specific for VB8 receptor peptide suppress experimental autoimmune encephalomyelitis. J Immunol 1990 Jun 15; 144 (12): 4621-7
    • (1990) J Immunol , vol.144 , Issue.12 , pp. 4621-4627
    • Hashim, G.A.1    Vandenbark, A.A.2    Galang, A.B.3
  • 71
    • 0032168560 scopus 로고    scopus 로고
    • Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice
    • Sep 1;
    • Offner H, Adlard K, Bebo Jr BF, et al. Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice. J Immunol 1998 Sep 1; 161 (5): 2178-86
    • (1998) J Immunol , vol.161 , Issue.5 , pp. 2178-2186
    • Offner, H.1    Adlard, K.2    Bebo Jr, B.F.3
  • 72
    • 0034176818 scopus 로고    scopus 로고
    • Reduced chemokine and chemokine receptor expression in spinal cord of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein
    • Apr 1;
    • Matejuk A, Vandenbark AA, Burrows GG, et al. Reduced chemokine and chemokine receptor expression in spinal cord of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein. J Immunol 2000 Apr 1; 164 (7): 3924-31
    • (2000) J Immunol , vol.164 , Issue.7 , pp. 3924-3931
    • Matejuk, A.1    Vandenbark, A.A.2    Burrows, G.G.3
  • 73
    • 0028221789 scopus 로고
    • Immunity to TCR peptides in multiple sclerosis: I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides
    • Mar 1;
    • Bourdette DN, Whitham RH, Chou YK, et al. Immunity to TCR peptides in multiple sclerosis: I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides. J Immunol 1994 Mar 1; 152 (5): 2510-9
    • (1994) J Immunol , vol.152 , Issue.5 , pp. 2510-2519
    • Bourdette, D.N.1    Whitham, R.H.2    Chou, Y.K.3
  • 74
    • 0028221790 scopus 로고
    • Immunity to TCR peptides in multiple sclerosis: II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides
    • Mar 1;
    • Chou YK, Morrison WJ, Weinberg AD, et al. Immunity to TCR peptides in multiple sclerosis: II. T cell recognition of V beta 5.2 and V beta 6.1 CDR2 peptides. J Immunol 1994 Mar 1; 152 (5): 2520-9
    • (1994) J Immunol , vol.152 , Issue.5 , pp. 2520-2529
    • Chou, Y.K.1    Morrison, W.J.2    Weinberg, A.D.3
  • 75
    • 16044361810 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial
    • Oct;
    • Vandenbark AA, Chou YK, Whitham R, et al. Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nat Med 1996 Oct; 2 (10): 1109-15
    • (1996) Nat Med , vol.2 , Issue.10 , pp. 1109-1115
    • Vandenbark, A.A.1    Chou, Y.K.2    Whitham, R.3
  • 76
    • 0031007204 scopus 로고    scopus 로고
    • Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis: I. Analysis of T-cell receptor utilization in CSF cell populations
    • Jun;
    • Wilson DB, Golding AB, Smith RA, et al. Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis: I. Analysis of T-cell receptor utilization in CSF cell populations. J Neuroimmunol 1997 Jun; 76 (1-2): 15-28
    • (1997) J Neuroimmunol , vol.76 , Issue.1-2 , pp. 15-28
    • Wilson, D.B.1    Golding, A.B.2    Smith, R.A.3
  • 77
    • 0031007205 scopus 로고    scopus 로고
    • Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis: II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCR Vβ6 CDR2 peptide
    • Jun;
    • Gold DP, Smith RA, Golding AB, et al. Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis: II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCR Vβ6 CDR2 peptide. J Neuroimmunol 1997 Jun; 76 (1-2): 29-38
    • (1997) J Neuroimmunol , vol.76 , Issue.1-2 , pp. 29-38
    • Gold, D.P.1    Smith, R.A.2    Golding, A.B.3
  • 78
    • 0033568626 scopus 로고    scopus 로고
    • A common T cell receptor V-D-J séquense in Vβ 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis
    • Sep 15;
    • Hong J, Zang Y, Tejada-Simoón MV, et al. A common T cell receptor V-D-J séquense in Vβ 13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis. J Immunol 1999 Sep 15; 163 (6): 3530-8
    • (1999) J Immunol , vol.163 , Issue.6 , pp. 3530-3538
    • Hong, J.1    Zang, Y.2    Tejada-Simoón, M.V.3
  • 79
    • 37149039794 scopus 로고    scopus 로고
    • Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis
    • Vandenbark AA, Culberston NE, Bartholomew, et al. Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis. Immunology 2008; 123 (1): 66-78
    • (2008) Immunology , vol.123 , Issue.1 , pp. 66-78
    • Vandenbark, A.A.1    Culberston, N.E.2    Bartholomew3
  • 80
    • 0026068885 scopus 로고
    • Restricted T-cell receptor Vβ gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: Predominant genes vary in individuals
    • Mar 15;
    • Ben-Nun A, Liblau RS, Cohen L, et al. Restricted T-cell receptor Vβ gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals. Proc Natl Acad Sci U S A 1991 Mar 15; 88 (6): 2466-70
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.6 , pp. 2466-2470
    • Ben-Nun, A.1    Liblau, R.S.2    Cohen, L.3
  • 81
    • 0029431617 scopus 로고
    • Diversity of T cell receptor V alpha, V beta and CDR3 expression by myelin basic protein-specific human T-cell clones
    • Oct;
    • Richert JR, Robinsosn ED, Camphausen K, et al. Diversity of T cell receptor V alpha, V beta and CDR3 expression by myelin basic protein-specific human T-cell clones. Neurology 1995 Oct; 45 (10): 1919-22
    • (1995) Neurology , vol.45 , Issue.10 , pp. 1919-1922
    • Richert, J.R.1    Robinsosn, E.D.2    Camphausen, K.3
  • 82
    • 0029991959 scopus 로고    scopus 로고
    • TCR usage in human and experimental demyelinating disease
    • Apr;
    • Hafler DA, Saadeh MG, Kuchroo VK, et al. TCR usage in human and experimental demyelinating disease. Immunol Today 1996 Apr; 17 (4): 152-9
    • (1996) Immunol Today , vol.17 , Issue.4 , pp. 152-159
    • Hafler, D.A.1    Saadeh, M.G.2    Kuchroo, V.K.3
  • 83
    • 0030989875 scopus 로고    scopus 로고
    • Biotechnological agents for the immunotherapy of multiple sclerosis: Principles, problems and perspectives
    • May;
    • Hohlfeld R. Biotechnological agents for the immunotherapy of multiple sclerosis: principles, problems and perspectives. Brain 1997 May; 120 (5): 865-916
    • (1997) Brain , vol.120 , Issue.5 , pp. 865-916
    • Hohlfeld, R.1
  • 84
    • 0031853145 scopus 로고    scopus 로고
    • Diversity of the anti-T cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis
    • Aug;
    • Zipp F, Kerschensteiner M, Dornmair K, et al. Diversity of the anti-T cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis. Brain 1998 Aug; 121 (8): 1395-407
    • (1998) Brain , vol.121 , Issue.8 , pp. 1395-1407
    • Zipp, F.1    Kerschensteiner, M.2    Dornmair, K.3
  • 85
    • 0034871273 scopus 로고    scopus 로고
    • TCR peptide therapy in human autoimmune diseases
    • Jun;
    • Vandenbark AA, Morgan E, Bartholomew R, et al. TCR peptide therapy in human autoimmune diseases. Neurochem Res 2001 Jun; 26 (6): 713-30
    • (2001) Neurochem Res , vol.26 , Issue.6 , pp. 713-730
    • Vandenbark, A.A.1    Morgan, E.2    Bartholomew, R.3
  • 86
    • 0025231388 scopus 로고
    • Direct gene transfer into mouse muscle in vivo
    • Mar 23;
    • Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990 Mar 23; 247: 1465-8
    • (1990) Science , vol.247 , pp. 1465-1468
    • Wolff, J.A.1    Malone, R.W.2    Williams, P.3
  • 87
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Mar 19;
    • Ulmer JB, Donnelly JJ, Parker SE, et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993 Mar 19; 59: 1745-9
    • (1993) Science , vol.59 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3
  • 88
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: Immunology, application, and optimization
    • Gurunathan S, Klinman DM, Seder RA. DNA vaccines: immunology, application, and optimization. Annu Rev Immunol 2000; 18: 927-74
    • (2000) Annu Rev Immunol , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 89
    • 33750966758 scopus 로고    scopus 로고
    • DNA vaccines: Recent developments and future possibilities
    • Nov;
    • Liu MA, Wahren B, Hedestam GB. DNA vaccines: recent developments and future possibilities. Hum Gene Ther 2006 Nov; 17 (11): 1051-61
    • (2006) Hum Gene Ther , vol.17 , Issue.11 , pp. 1051-1061
    • Liu, M.A.1    Wahren, B.2    Hedestam, G.B.3
  • 90
    • 0034900849 scopus 로고    scopus 로고
    • Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice
    • Aug;
    • Urbanek-Ruiz I, Ruiz PJ, Paragas V, et al. Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice. Clin Immunol 2001 Aug; 100 (2): 164-71
    • (2001) Clin Immunol , vol.100 , Issue.2 , pp. 164-171
    • Urbanek-Ruiz, I.1    Ruiz, P.J.2    Paragas, V.3
  • 91
    • 0141920623 scopus 로고    scopus 로고
    • DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: Identification of a regulatory HSP60 peptide
    • Oct 1;
    • Quintana FJ, Carmi P, Mor F, et al. DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide. J Immunol. 2003 Oct 1; 171 (7): 3533-41
    • (2003) J Immunol , vol.171 , Issue.7 , pp. 3533-3541
    • Quintana, F.J.1    Carmi, P.2    Mor, F.3
  • 92
    • 0029796099 scopus 로고    scopus 로고
    • Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity
    • Aug;
    • Waisman A, Ruiz PJ, Hirschberg DL, et al. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med 1996 Aug; 2 (8): 899-905
    • (1996) Nat Med , vol.2 , Issue.8 , pp. 899-905
    • Waisman, A.1    Ruiz, P.J.2    Hirschberg, D.L.3
  • 93
    • 0034575336 scopus 로고    scopus 로고
    • Plasmid DNA vaccines: Assay for integration into host genomic DNA
    • Ledwith BJ, Manam S, Troilo PJ, et al. Plasmid DNA vaccines: assay for integration into host genomic DNA. Dev Biol 2000; 104: 33-43
    • (2000) Dev Biol , vol.104 , pp. 33-43
    • Ledwith, B.J.1    Manam, S.2    Troilo, P.J.3
  • 94
    • 0031870767 scopus 로고    scopus 로고
    • Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA
    • Aug;
    • Tsunoda I, Kuang LQ, Tolley ND, et al. Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA. J Neuropathol Exp Neurol 1998 Aug; 57 (8): 758-67
    • (1998) J Neuropathol Exp Neurol , vol.57 , Issue.8 , pp. 758-767
    • Tsunoda, I.1    Kuang, L.Q.2    Tolley, N.D.3
  • 95
    • 0034847380 scopus 로고    scopus 로고
    • Immunological capabilities of skeletal muscle cells
    • Mar;
    • Nagaraju K. Immunological capabilities of skeletal muscle cells. Acta Physiol Scand 2001 Mar; 171 (3): 215-23
    • (2001) Acta Physiol Scand , vol.171 , Issue.3 , pp. 215-223
    • Nagaraju, K.1
  • 96
    • 0037388738 scopus 로고    scopus 로고
    • DNA vaccines: A review
    • Apr;
    • Liu MA. DNA vaccines: a review. J Intern Med 2003 Apr; 253 (4): 402-10
    • (2003) J Intern Med , vol.253 , Issue.4 , pp. 402-410
    • Liu, M.A.1
  • 97
    • 0034985055 scopus 로고    scopus 로고
    • Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis
    • Jun;
    • Kumar V, Maglione J, Thatte J, et al. Induction of a type 1 regulatory CD4 T cell response following V beta 8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis. Int Immunol 2001 Jun; 13 (6): 835-41
    • (2001) Int Immunol , vol.13 , Issue.6 , pp. 835-841
    • Kumar, V.1    Maglione, J.2    Thatte, J.3
  • 98
    • 0037438597 scopus 로고    scopus 로고
    • Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10
    • Jan 15;
    • Braciak TA, Pedersen B, Chin J, et al. Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10. J Immunol 2003 Jan 15; 170 (2): 765-74
    • (2003) J Immunol , vol.170 , Issue.2 , pp. 765-774
    • Braciak, T.A.1    Pedersen, B.2    Chin, J.3
  • 99
    • 0032534725 scopus 로고    scopus 로고
    • Induction or protection from experimental autoimmune encepahlomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells
    • Dec 15;
    • Kumar V, Sercarz E. Induction or protection from experimental autoimmune encepahlomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells. J Immunol 1998 Dec 15; 161 (12): 6585-91
    • (1998) J Immunol , vol.161 , Issue.12 , pp. 6585-6591
    • Kumar, V.1    Sercarz, E.2
  • 100
    • 0027274058 scopus 로고
    • Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein
    • Apr;
    • Barnett LA, Whitton JL, Wada Y, et al. Enhancement of autoimmune disease using recombinant vaccinia virus encoding myelin proteolipid protein. J Neuroimmunol 1993 Apr; 44 (1): 15-25
    • (1993) J Neuroimmunol , vol.44 , Issue.1 , pp. 15-25
    • Barnett, L.A.1    Whitton, J.L.2    Wada, Y.3
  • 101
    • 0029912167 scopus 로고    scopus 로고
    • Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis
    • Feb;
    • Barnett LA, Whitton JL, Wang LY, et al. Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis. J Neuroimmunol 1996 Feb; 64 (2): 163-73
    • (1996) J Neuroimmunol , vol.64 , Issue.2 , pp. 163-173
    • Barnett, L.A.1    Whitton, J.L.2    Wang, L.Y.3
  • 102
    • 0029665430 scopus 로고    scopus 로고
    • Exploitation of the Vbeta8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector
    • Jun 15;
    • Chunduru SK, Sutherland RM, Stewart GA, et al. Exploitation of the Vbeta8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector. J Immunol 1996 Jun 15; 156 (12): 4940-5
    • (1996) J Immunol , vol.156 , Issue.12 , pp. 4940-4945
    • Chunduru, S.K.1    Sutherland, R.M.2    Stewart, G.A.3
  • 103
    • 0030941033 scopus 로고    scopus 로고
    • Enhancement of EAE and induction of autoantibodies to T-cell epitopes in mice infected with a recombinant vaccinia virus encoding myelin proteolipid protein
    • May;
    • Wang LY, Fujinami RS. Enhancement of EAE and induction of autoantibodies to T-cell epitopes in mice infected with a recombinant vaccinia virus encoding myelin proteolipid protein. J Neuroimmunol 1997 May; 75 (1-2): 75-83
    • (1997) J Neuroimmunol , vol.75 , Issue.1-2 , pp. 75-83
    • Wang, L.Y.1    Fujinami, R.S.2
  • 104
    • 0030781981 scopus 로고    scopus 로고
    • Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein
    • Nov;
    • Genain CP, Gritz L, Joshi N, et al. Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. J Neuroimmunol 1997 Nov; 79 (2): 119-28
    • (1997) J Neuroimmunol , vol.79 , Issue.2 , pp. 119-128
    • Genain, C.P.1    Gritz, L.2    Joshi, N.3
  • 105
    • 0032794139 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines
    • Aug;
    • Youssef S, Wildbaum G, Karin N. Prevention of experimental autoimmune encephalomyelitis by MIP-1alpha and MCP-1 naked DNA vaccines. J Autoimmun 1999 Aug; 13 (1): 21-9
    • (1999) J Autoimmun , vol.13 , Issue.1 , pp. 21-29
    • Youssef, S.1    Wildbaum, G.2    Karin, N.3
  • 106
    • 0032482187 scopus 로고    scopus 로고
    • Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis
    • May 4;
    • Lobell A, Weissert R, Storch MK, et al. Vaccination with DNA encoding an immunodominant myelin basic protein peptide targeted to Fc of immunoglobulin G suppresses experimental autoimmune encephalomyelitis. J Exp Med 1998 May 4; 187 (9): 1543-8
    • (1998) J Exp Med , vol.187 , Issue.9 , pp. 1543-1548
    • Lobell, A.1    Weissert, R.2    Storch, M.K.3
  • 107
    • 0033519264 scopus 로고    scopus 로고
    • Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis
    • May;
    • Wang LY, Theil DJ, Whitton JL, et al. Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis. J Neuroimmunol 1999 May; 96 (2): 148-57
    • (1999) J Neuroimmunol , vol.96 , Issue.2 , pp. 148-157
    • Wang, L.Y.1    Theil, D.J.2    Whitton, J.L.3
  • 108
    • 0033559521 scopus 로고    scopus 로고
    • Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: Modulation of T cell costimulation
    • Mar 15;
    • Ruiz PJ, Garren H, Ruiz IU, et al. Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. J Immunol 1999 Mar 15; 162 (6): 3336-41
    • (1999) J Immunol , vol.162 , Issue.6 , pp. 3336-3341
    • Ruiz, P.J.1    Garren, H.2    Ruiz, I.U.3
  • 109
    • 0032735735 scopus 로고    scopus 로고
    • Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis
    • Nov 1;
    • Lobell A, Weissert R, Eltayeb S, et al. Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis. J Immunol 1999 Nov 1; 163 (9): 4754-62
    • (1999) J Immunol , vol.163 , Issue.9 , pp. 4754-4762
    • Lobell, A.1    Weissert, R.2    Eltayeb, S.3
  • 110
    • 0033818187 scopus 로고    scopus 로고
    • A targeted DNA vaccine encoding Fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis
    • Sep;
    • Wildbaum G, Westermann J, Maor G, et al. A targeted DNA vaccine encoding Fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis. J Clin Invest 2000 Sep; 106 (5): 671-9
    • (2000) J Clin Invest , vol.106 , Issue.5 , pp. 671-679
    • Wildbaum, G.1    Westermann, J.2    Maor, G.3
  • 111
    • 0034332960 scopus 로고    scopus 로고
    • Naked DNA vaccination differentially modulates autoimmune responses in experimental autoimmune encephalomyelitis
    • Nov 1;
    • Selmaj K, Kowal C, Walczak A, et al. Naked DNA vaccination differentially modulates autoimmune responses in experimental autoimmune encephalomyelitis. J Neuroimmunol 2000 Nov 1; 111 (1-2): 34-44
    • (2000) J Neuroimmunol , vol.111 , Issue.1-2 , pp. 34-44
    • Selmaj, K.1    Kowal, C.2    Walczak, A.3
  • 112
    • 0034532892 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-DNA vaccination induces antibody-mediated autoaggression in experimental autoimmune encephalomyelitis
    • Dec;
    • Bourquin C, Iglesias A, Berger T, et al. Myelin oligodendrocyte glycoprotein-DNA vaccination induces antibody-mediated autoaggression in experimental autoimmune encephalomyelitis. Eur J Immunol 2000 Dec; 30 (12): 3663-71
    • (2000) Eur J Immunol , vol.30 , Issue.12 , pp. 3663-3671
    • Bourquin, C.1    Iglesias, A.2    Berger, T.3
  • 113
    • 0034897403 scopus 로고    scopus 로고
    • Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
    • Jul;
    • Garren H, Ruiz PJ, Watkins TA, et al. Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 2001 Jul; 15 (1): 15-22
    • (2001) Immunity , vol.15 , Issue.1 , pp. 15-22
    • Garren, H.1    Ruiz, P.J.2    Watkins, T.A.3
  • 114
    • 0037442140 scopus 로고    scopus 로고
    • Lobell A, Weissert R, Eltayeb S, et al. Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide induced experimental autoimmune encephalomyelitis involves a T1-biased immune response. J Immunol 2003 Feb 15; 170 (4): 1806-13
    • Lobell A, Weissert R, Eltayeb S, et al. Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide induced experimental autoimmune encephalomyelitis involves a T1-biased immune response. J Immunol 2003 Feb 15; 170 (4): 1806-13
  • 115
    • 1542500981 scopus 로고    scopus 로고
    • Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFN beta
    • Apr;
    • Wefer J, Harris RA, Lobell A. Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFN beta. J Neuroimmunol 2004 Apr; 149 (1-2): 66-76
    • (2004) J Neuroimmunol , vol.149 , Issue.1-2 , pp. 66-76
    • Wefer, J.1    Harris, R.A.2    Lobell, A.3
  • 116
    • 2642588817 scopus 로고    scopus 로고
    • Differential prevention of experimental autoimmune encephalomyelitis with antigen-specific DNA vaccination
    • Jun;
    • Walczak A, Szymanska B, Selmaj K. Differential prevention of experimental autoimmune encephalomyelitis with antigen-specific DNA vaccination. Clin Neurol Neurosurg 2004 Jun; 106 (3): 241-5
    • (2004) Clin Neurol Neurosurg , vol.106 , Issue.3 , pp. 241-245
    • Walczak, A.1    Szymanska, B.2    Selmaj, K.3
  • 117
    • 10744231057 scopus 로고    scopus 로고
    • Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis
    • Sep;
    • Robinson WH, Fontoura P, Lee BJ, et al. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol 2003 Sep; 21 (9): 1033-9
    • (2003) Nat Biotechnol , vol.21 , Issue.9 , pp. 1033-1039
    • Robinson, W.H.1    Fontoura, P.2    Lee, B.J.3
  • 118
    • 12344315245 scopus 로고    scopus 로고
    • Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis
    • Feb;
    • Mueller AM, Pedre X, Kleiter I, et al. Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 2005 Feb; 159 (1-2): 55-65
    • (2005) J Neuroimmunol , vol.159 , Issue.1-2 , pp. 55-65
    • Mueller, A.M.1    Pedre, X.2    Kleiter, I.3
  • 119
    • 27144453293 scopus 로고    scopus 로고
    • A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease
    • Nov 1;
    • Ho PP, Fontoura P, Platten M, et al. A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. J Immunol 2005 Nov 1; 175 (9): 6226-34
    • (2005) J Immunol , vol.175 , Issue.9 , pp. 6226-6234
    • Ho, P.P.1    Fontoura, P.2    Platten, M.3
  • 120
    • 33751580722 scopus 로고    scopus 로고
    • Coadministration of plasmid DNA constructs encoding an encephalitogenic determinant and IL-10 elicits regulatory T cell-mediated protective immunity in the central nervous system
    • Dec 1;
    • Schif-Zuck S, Wildbaum G, Karin N. Coadministration of plasmid DNA constructs encoding an encephalitogenic determinant and IL-10 elicits regulatory T cell-mediated protective immunity in the central nervous system. J Immunol 2006 Dec 1; 177 (11): 8241-7
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 8241-8247
    • Schif-Zuck, S.1    Wildbaum, G.2    Karin, N.3
  • 121
    • 0033010444 scopus 로고    scopus 로고
    • Non-coding plasmid DNA induces IFN-gamma in vivo and suppress autoimmune encephalomyelitis
    • Feb;
    • Boccaccio GL, Mor F, Steinman L. Non-coding plasmid DNA induces IFN-gamma in vivo and suppress autoimmune encephalomyelitis. Int Immunol 1999 Feb; 11 (2): 289-96
    • (1999) Int Immunol , vol.11 , Issue.2 , pp. 289-296
    • Boccaccio, G.L.1    Mor, F.2    Steinman, L.3
  • 122
    • 0036604393 scopus 로고    scopus 로고
    • Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis
    • Jun 1;
    • Wildbaum G, Netzer N, Karin N. Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. J Immunol 2002 Jun 1; 168 (1): 5885-92
    • (2002) J Immunol , vol.168 , Issue.1 , pp. 5885-5892
    • Wildbaum, G.1    Netzer, N.2    Karin, N.3
  • 123
    • 23244456102 scopus 로고    scopus 로고
    • DNA vaccines progress and challenges
    • Jul 15;
    • Donnelly JJ, Wahren B, Lio MA. DNA vaccines progress and challenges. J Immunol 2005 Jul 15; 175 (2): 633-9
    • (2005) J Immunol , vol.175 , Issue.2 , pp. 633-639
    • Donnelly, J.J.1    Wahren, B.2    Lio, M.A.3
  • 124
    • 33646147142 scopus 로고    scopus 로고
    • DNA vaccines:successes and limitations in cancer and infectious diseases
    • May 15;
    • Lowe DB, Shearer MH, Kennedy RC. DNA vaccines:successes and limitations in cancer and infectious diseases. J Cell Biochem 2006 May 15; 98 (2): 235-42
    • (2006) J Cell Biochem , vol.98 , Issue.2 , pp. 235-242
    • Lowe, D.B.1    Shearer, M.H.2    Kennedy, R.C.3
  • 125
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Jul 12;
    • Ota K, Matsui M, Milford EL, et al. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990 Jul 12; 346: 183-7
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3
  • 126
    • 0023236490 scopus 로고
    • Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope
    • Jun;
    • Allen PM, Matsueda GR, Evans RJ, et al. Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope. Nature 1987 Jun; 327: 713-5
    • (1987) Nature , vol.327 , pp. 713-715
    • Allen, P.M.1    Matsueda, G.R.2    Evans, R.J.3
  • 127
    • 0027409792 scopus 로고
    • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling
    • Apr 1;
    • Racioppi L, Ronchese F, Matis LA, et al. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J Exp Med 1993 Apr 1; 177 (4): 1047-60
    • (1993) J Exp Med , vol.177 , Issue.4 , pp. 1047-1060
    • Racioppi, L.1    Ronchese, F.2    Matis, L.A.3
  • 128
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster J, Allen PM. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu Rev Immunol 1996; 14: 1-27
    • (1996) Annu Rev Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 129
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Oct;
    • Nicholson LB, Greer JM, Sobel RA, et al. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995 Oct; 3 (4): 397-405
    • (1995) Immunity , vol.3 , Issue.4 , pp. 397-405
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3
  • 130
    • 0030973661 scopus 로고    scopus 로고
    • Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms
    • Apr;
    • Gaur A, Boehme SA, Chalmers D, et al. Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J Neuroimmunol 1997 Apr; 74 (1-2): 149-58
    • (1997) J Neuroimmunol , vol.74 , Issue.1-2 , pp. 149-158
    • Gaur, A.1    Boehme, S.A.2    Chalmers, D.3
  • 131
    • 0025190308 scopus 로고
    • Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis
    • Feb;
    • Kumar V, Urban JL, Horvath SJ, et al. Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis. Proc Natl Acad Sci U S A 1990 Feb; 87 (4): 1337-41
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.4 , pp. 1337-1341
    • Kumar, V.1    Urban, J.L.2    Horvath, S.J.3
  • 132
    • 0028326522 scopus 로고
    • T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis
    • Apr;
    • Franco A, Southwood S, Arrhenius T, et al. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur J Immunol 1994 Apr; 24 (4): 940-6
    • (1994) Eur J Immunol , vol.24 , Issue.4 , pp. 940-946
    • Franco, A.1    Southwood, S.2    Arrhenius, T.3
  • 133
    • 0027964523 scopus 로고
    • A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
    • Oct 1;
    • Kuchroo VK, Greer JM, Kaul D, et al. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J Immunol 1994 Oct 1; 153 (7): 3326-36
    • (1994) J Immunol , vol.153 , Issue.7 , pp. 3326-3336
    • Kuchroo, V.K.1    Greer, J.M.2    Kaul, D.3
  • 134
    • 0034177889 scopus 로고    scopus 로고
    • IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis
    • Apr 1;
    • Young DA, Lowe LD, Booth SS, et al. IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J Immunol 2000 Apr 1; 164 (7): 3563-72
    • (2000) J Immunol , vol.164 , Issue.7 , pp. 3563-3572
    • Young, D.A.1    Lowe, L.D.2    Booth, S.S.3
  • 135
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand NBI-6024, based on the immunodominant type 1 diabetes autologous insulin- B chain (9-23) peptide
    • Jul;
    • Alleva DG, Gaur A, Jin L, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand NBI-6024, based on the immunodominant type 1 diabetes autologous insulin- B chain (9-23) peptide. Diabetes 2002 Jul; 51 (7): 2126-34
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3
  • 136
    • 0031670931 scopus 로고    scopus 로고
    • Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells
    • Nov;
    • Crowe PD, Boehme SA, Wong T, et al. Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells. Hum Immunol 1998 Nov; 59 (11): 679-89
    • (1998) Hum Immunol , vol.59 , Issue.11 , pp. 679-689
    • Crowe, P.D.1    Boehme, S.A.2    Wong, T.3
  • 137
    • 0028902752 scopus 로고
    • Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Jan 27;
    • Madrenas J, Wange RL, Wang JL, et al. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 1995 Jan 27; 267: 515-8
    • (1995) Science , vol.267 , pp. 515-518
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3
  • 138
    • 0031808897 scopus 로고    scopus 로고
    • Altered peptide ligand modulation of experimental allergic encephalomyelitis: Immune responses within the CNS
    • Jan;
    • Santambrogio L, Lees MB, Sobel RA. Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS. J Neuroimmunol 1998 Jan; 81 (1-2): 1-13
    • (1998) J Neuroimmunol , vol.81 , Issue.1-2 , pp. 1-13
    • Santambrogio, L.1    Lees, M.B.2    Sobel, R.A.3
  • 139
    • 0033762708 scopus 로고    scopus 로고
    • NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients
    • Nov;
    • Crowe PD. Qin Y, Conlon PJ, et al. NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol 2000 Nov; 48 (5): 758-65
    • (2000) Ann Neurol , vol.48 , Issue.5 , pp. 758-765
    • Crowe, P.D.1    Qin, Y.2    Conlon, P.J.3
  • 140
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Oct;
    • Bielekova B, Goodwin B, Richert N, et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000 Oct; 6 (10): 1167-75
    • (2000) Nat Med , vol.6 , Issue.10 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3
  • 141
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
    • Oct;
    • Kappos L, Comi G, Panitch H, et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. Nat Med 2000 Oct; 6 (10): 1176-82
    • (2000) Nat Med , vol.6 , Issue.10 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3
  • 142
    • 0036046080 scopus 로고    scopus 로고
    • Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand
    • Aug;
    • Kim HJ, Antel JP, Duquette P, et al. Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand. Clin Immunol 2002 Aug; 104 (2): 105-14
    • (2002) Clin Immunol , vol.104 , Issue.2 , pp. 105-114
    • Kim, H.J.1    Antel, J.P.2    Duquette, P.3
  • 143
    • 2442693021 scopus 로고    scopus 로고
    • Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: Expression receptor signalling, and correlation with axon regeneration
    • May;
    • Sandvig A, Berry M, Barrett LB, et al. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression receptor signalling, and correlation with axon regeneration. Glia 2004 May; 46 (3): 225-51
    • (2004) Glia , vol.46 , Issue.3 , pp. 225-251
    • Sandvig, A.1    Berry, M.2    Barrett, L.B.3
  • 144
    • 3042701267 scopus 로고    scopus 로고
    • The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination
    • Jul;
    • Karnezis T, Mandemakers W, McQualter JL, et al. The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neurosci 2004 Jul; 7 (7): 736-44
    • (2004) Nat Neurosci , vol.7 , Issue.7 , pp. 736-744
    • Karnezis, T.1    Mandemakers, W.2    McQualter, J.L.3
  • 145
    • 20844458088 scopus 로고    scopus 로고
    • Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: A potential strategy for axonal regeneration
    • Nov;
    • Xu G, Nie DY, Chen JT, et al. Recombinant DNA vaccine encoding multiple domains related to inhibition of neurite outgrowth: a potential strategy for axonal regeneration. J Neurochem 2004 Nov; 91 (4): 1018-23
    • (2004) J Neurochem , vol.91 , Issue.4 , pp. 1018-1023
    • Xu, G.1    Nie, D.Y.2    Chen, J.T.3
  • 146
    • 9144268373 scopus 로고    scopus 로고
    • Immunity to extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis
    • Dec 1;
    • Fontoura P, Ho PP, DeVoss J, et al. Immunity to extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J Immunol 2004 Dec 1; 173 (11): 6981-92
    • (2004) J Immunol , vol.173 , Issue.11 , pp. 6981-6992
    • Fontoura, P.1    Ho, P.P.2    DeVoss, J.3
  • 147
    • 0035283235 scopus 로고    scopus 로고
    • Vaccination with autologous dendritic cells: From experimental autoimmune encephalomyelitis to multiple sclerosis
    • Mar;
    • Link H, Huang YM, Masterman T, et al. Vaccination with autologous dendritic cells: from experimental autoimmune encephalomyelitis to multiple sclerosis. J Neuroimmunol 2001 Mar; 114 (1-2): 1-7
    • (2001) J Neuroimmunol , vol.114 , Issue.1-2 , pp. 1-7
    • Link, H.1    Huang, Y.M.2    Masterman, T.3
  • 148
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Mar 19;
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 Mar 19; 392: 245-52
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 149
    • 0036715411 scopus 로고    scopus 로고
    • Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity
    • Sep;
    • Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity. Trends Immunol 2002 Sep; 23 (9): 445-9
    • (2002) Trends Immunol , vol.23 , Issue.9 , pp. 445-449
    • Lutz, M.B.1    Schuler, G.2
  • 150
    • 0037099710 scopus 로고    scopus 로고
    • On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity
    • Jul 15;
    • Legge KL, Gregg RK, Maldonado-Lopez R, et al. On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity. J Exp Med 2002 Jul 15; 196 (2): 217-27
    • (2002) J Exp Med , vol.196 , Issue.2 , pp. 217-227
    • Legge, K.L.1    Gregg, R.K.2    Maldonado-Lopez, R.3
  • 151
    • 0033011514 scopus 로고    scopus 로고
    • Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFN-gamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice
    • Jul;
    • Shinomiya M, Fazle Akbar SM, Shinomiya H, et al. Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFN-gamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol 1999 Jul; 117 (1): 38-43
    • (1999) Clin Exp Immunol , vol.117 , Issue.1 , pp. 38-43
    • Shinomiya, M.1    Fazle Akbar, S.M.2    Shinomiya, H.3
  • 152
    • 0347359059 scopus 로고    scopus 로고
    • Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis
    • Jan;
    • Xiao BG, Wu XC, Yang JS, et al. Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis. Int Immunol 2004 Jan; 16 (1): 13-22
    • (2004) Int Immunol , vol.16 , Issue.1 , pp. 13-22
    • Xiao, B.G.1    Wu, X.C.2    Yang, J.S.3
  • 153
    • 0031573204 scopus 로고    scopus 로고
    • Induction of tolerance by IL-10-treated dendritic cells
    • Nov 15;
    • Steinbrink K, Wolfl M, Jonuleit H, et al. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997 Nov 15; 159 (10): 4772-80
    • (1997) J Immunol , vol.159 , Issue.10 , pp. 4772-4780
    • Steinbrink, K.1    Wolfl, M.2    Jonuleit, H.3
  • 154
    • 0032946720 scopus 로고    scopus 로고
    • Interferon-beta inhibits Th1 responses at the dendritic cell level: Relevance to multiple sclerosis
    • Mar;
    • Bartholome EJ, Willems F, Crusiaux A, et al. Interferon-beta inhibits Th1 responses at the dendritic cell level: relevance to multiple sclerosis. Acta Neurol Belg 1999 Mar; 99 (1): 44-52
    • (1999) Acta Neurol Belg , vol.99 , Issue.1 , pp. 44-52
    • Bartholome, E.J.1    Willems, F.2    Crusiaux, A.3
  • 155
    • 33745263083 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-κB enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis
    • Jul;
    • Iruretagoyena MI, Sepúlveda SE, Lezana JP, et al. Inhibition of nuclear factor-κB enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther 2006 Jul; 318 (1): 59-67
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.1 , pp. 59-67
    • Iruretagoyena, M.I.1    Sepúlveda, S.E.2    Lezana, J.P.3
  • 156
    • 0034881458 scopus 로고    scopus 로고
    • Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rat
    • Aug;
    • Xiao BG, Huang YM, Yang JS, et al. Bone marrow-derived dendritic cells from experimental allergic encephalomyelitis induce immune tolerance to EAE in Lewis rat. Clin Exp Immunol 2001 Aug; 125 (2): 300-9
    • (2001) Clin Exp Immunol , vol.125 , Issue.2 , pp. 300-309
    • Xiao, B.G.1    Huang, Y.M.2    Yang, J.S.3
  • 157
    • 0034655607 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
    • Apr 15;
    • Arpinati M, Green CL, Heimfeld S, et al. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000 Apr 15; 95 (8): 2484-90
    • (2000) Blood , vol.95 , Issue.8 , pp. 2484-2490
    • Arpinati, M.1    Green, C.L.2    Heimfeld, S.3
  • 158
    • 0037033427 scopus 로고    scopus 로고
    • Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    • Jan;
    • Menges M, Rossner S, Voigtlander C, et al. Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J Exp Med 2002 Jan; 195 (1): 15-21
    • (2002) J Exp Med , vol.195 , Issue.1 , pp. 15-21
    • Menges, M.1    Rossner, S.2    Voigtlander, C.3
  • 159
    • 0037135661 scopus 로고    scopus 로고
    • A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses
    • Aug 19;
    • Jegerlehner A, Tissot A, Lechner F, et al. A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses. Vaccine 2002 Aug 19; 20 (25-26): 3104-12
    • (2002) Vaccine , vol.20 , Issue.25-26 , pp. 3104-3112
    • Jegerlehner, A.1    Tissot, A.2    Lechner, F.3
  • 160
    • 0034898470 scopus 로고    scopus 로고
    • Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies
    • Aug;
    • Chakerian B, Lowy DR, Schiller JT. Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J Clin Invest 2001 Aug; 108 (3): 415-23
    • (2001) J Clin Invest , vol.108 , Issue.3 , pp. 415-423
    • Chakerian, B.1    Lowy, D.R.2    Schiller, J.T.3
  • 161
    • 33751254750 scopus 로고    scopus 로고
    • Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
    • Nov;
    • Röhn TA, Jennings GT, Hernandez M, et al. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur J Immunol 2006 Nov; 36 (11): 2857-67
    • (2006) Eur J Immunol , vol.36 , Issue.11 , pp. 2857-2867
    • Röhn, T.A.1    Jennings, G.T.2    Hernandez, M.3
  • 162
    • 35748966435 scopus 로고    scopus 로고
    • Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis
    • Uyttenhove C, Sommereyens C, Théate I, et al. Anti-IL-17A autovaccination prevents clinical and histological manifestations of experimental autoimmune encephalomyelitis. Ann N Y Acad Sci 2007; 1110: 330-6
    • (2007) Ann N Y Acad Sci , vol.1110 , pp. 330-336
    • Uyttenhove, C.1    Sommereyens, C.2    Théate, I.3
  • 163
    • 10944221275 scopus 로고    scopus 로고
    • Development of an anti-IL-12 p40 auto-vaccine: Protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection
    • Dec;
    • Uyttenhove C, Arendse B, Stroobant V, et al. Development of an anti-IL-12 p40 auto-vaccine: protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection. Eur J Immunol 2004 Dec; 34 (12): 3572-81
    • (2004) Eur J Immunol , vol.34 , Issue.12 , pp. 3572-3581
    • Uyttenhove, C.1    Arendse, B.2    Stroobant, V.3
  • 164
    • 34848865834 scopus 로고    scopus 로고
    • Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial
    • Bar-Or A, Vollmer T, Antel J, et al. Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. Arch Neurol 2007; 64 (10): 1407-15
    • (2007) Arch Neurol , vol.64 , Issue.10 , pp. 1407-1415
    • Bar-Or, A.1    Vollmer, T.2    Antel, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.