Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells

Human Immunology

Volumn 59, Issue 11, 1998, Pages 679-689

  Crowe, Paul D ^a   Boehme, Stefen A ^a   Wong, Tim ^a   Gaur, Amitabh ^a   Sidney, John ^b   Sette, Alessandro ^b   Conlon, Paul J ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

^b Epimmune   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MYELIN PROTEIN;

ANTIGEN RECOGNITION; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; B-LYMPHOCYTES; BINDING SITES; CELL DIVISION; CELL LINE; COCULTURE TECHNIQUES; CYTOKINES; GRB2 ADAPTOR PROTEIN; HLA-DR ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; T-LYMPHOCYTES, HELPER-INDUCER; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0031670931     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(98)00077-9     Document Type: Article

References (32)

1. Paul W.E., Seder R.A. Lymphocyte responses and cytokines. Cell. 76:(2):1994;241.
2. Mosmann T.R., Coffman R.L. TH1 and TH2 cells different patterns of lymphokine secretion lead to different functional properties . Annu Rev Immunol. 7:1989;145.
3. Kuchroo V.K., Sobel R.A., Laning J.C., Martin C.A., Greenfield E., Dorf M.E., Lees M.B. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein Fine specificity and T cell receptor V beta usage . J Immunol. 148:(12):1992;3776.
4. Karpus W.J., Gould K.E., Swanborg R.H. CD4+ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur J Immunol. 22:(7):1992;1757.
5. Racke M.K., Bonomo A., Scott D.E., Cannella B., Levine A., Raine C.S., Shevach E.M., Rocken M. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med. 180:(5):1994;1961.
6. Valitutti S., Muller S., Dessing M., Lanzavecchia A. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J Exp Med. 183:(4):1996;1917.
7. Itoh Y., Germain R.N. Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. J Exp Med. 186:(5):1997;757.
8. Racioppi L., Ronchese F., Matis L.A., Germain R.N. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J Exp Med. 177:(4):1993;1047.
9. Windhagen A., Scholz C., Hollsberg P., Fukaura H., Sette A., Hafler D.A. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity. 2:(4):1995;373.
10. Evavold B.D., Sloan-Lancaster J., Hsu B.L., Allen P.M. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J Immunol. 150:(8 Pt 1):1993;3131.
11. Tsitoura D.C., Verhoef A., Gelder C.M., O'Hehir R.E., Lamb J.R. Altered T cell ligands derived from a major house dust mite allergen enhance IFN-gamma but not IL-4 production by human CD4+ T cells. J Immunol. 157:(5):1996;2160.
12. Ausubel L.J., Krieger J.I., Hafler D.A. Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. J Immunol. 159:(5):1997;2502.
13. Combadiere B., Reis e Sousa C., Germain R.N., Lenardo M.J. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. J Exp Med. 187:(3):1998;349.
14. Madrenas J., Wange R.L., Wang J.L., Isakov N., Samelson L.E., Germain R.N. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 267:(5197):1995;515. [see comments].
15. Sloan-Lancaster J., Shaw A.S., Rothbard J.B., Allen P.M. Partial T cell signaling altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy . Cell. 79:(5):1994;913. [see comments].
16. Kersh G.J., Allen P.M. Structural basis for T cell recognition of altered peptide ligands a single T cell receptor can productively recognize a large continuum of related ligands . J Exp Med. 184:(4):1996;1259.
17. La Face D.M., Couture C., Anderson K., Shih G., Alexander J., Sette A., Mustelin T., Altman A., Grey H.M. Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J Immunol. 158:(5):1997;2057.
18. Ling N., Esch F., Bohlen P., Brazeau P., Wehrenberg W.B., Guillemin R. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin growth hormone-releasing factor . Proc Natl Acad Sci USA. 81:(14):1984;4302.
19. Martin R., Utz U., Coligan J.E., Richert J.R., Flerlage M., Robinson E., Stone R., Biddison W.E., McFarlin D.E., McFarland H.F. Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J Immunol. 148:(5):1992;1359.
20. O'Sullivan D., Sidney J., Appella E., Walker L., Phillips L., Colon S.M., Miles C., Chesnut R.W., Sette A. Characterization of the specificity of peptide binding to four DR haplotypes. J Immunol. 145:(6):1990;1799.
21. Sette A., Sidney J., Oseroff C., del Guercio M.F., Southwood S., Arrhenius T., Powell M.F., Colon S.M., Gaeta F.C., Grey H.M. HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions. J Immunol. 151:(6):1993;3163.
22. Sette A., Buus S., Colon S., Miles C., Grey H.M. Structural analysis of peptides capable of binding to more than one Ia antigen. J Immunol. 142:(1):1989;35.
23. Evavold B.D., Sloan-Lancaster J., Allen P.M. Tickling the TCR selective T-cell functions stimulated by altered peptide ligands . Immunol Today. 14:(12):1993;602.
24. Weiss A., Littman D.R. Signal transduction by lymphocyte antigen receptors. Cell. 76:(2):1994;263.
25. Chan A.C., Iwashima M., Turck C.W., Weiss A. ZAP-70 a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain . Cell. 71:(4):1992;649.
26. Sancho J., Peter M.E., Franco R., Danielian S., Kang J.S., Fagard R., Woods J., Reed J.C., Kamoun M., Terhorst C. Coupling of GTP-binding to the T cell receptor (TCR) zeta-chain with TCR-mediated signal transduction. J Immunol. 150:(8 Pt 1):1993;3230.
27. Garcia G.G., Miller R.A. Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes effect of age . Cell Immunol. 175:(1):1997;51.
28. Reis e Sousa C., Levine E.H., Germain R.N. Partial signaling by CD8+ T cells in response to antagonist ligands. J Exp Med. 184:(1):1996;149.
29. Qian D., Weiss A. T cell antigen receptor signal transduction. Curr Opin Cell Biol. 9:(2):1997;205.
30. Koretzky G.A. The role of Grb2-associated proteins in T-cell activation. Immunol Today. 18:(8):1997;401.
31. Sieh M., Batzer A., Schlessinger J., Weiss A. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol. 14:(7):1994;4435.
32. Zhang W., Sloan-Lancaster J., Kitchen J., Trible R.P., Samelson L.E. LAT The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation . Cell. 92:(1):1998;83.