Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor Vβ-specific antibodies

Journal of Experimental Medicine

Volumn 171, Issue 6, 1990, Pages 1943-1955

  Zaller, Dennis M ^a   Osman, Gamal ^a   Kanagawa, Osami ^b   Hood, Leroy ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CYTOCHEMISTRY; MOUSE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; THERAPY;

ANIMAL; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; CELL SEPARATION; ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE; FLOW CYTOMETRY; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MYELIN BASIC PROTEINS; PARALYSIS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SUPPORT, NON-U.S. GOV'T;

EID: 0025328989     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.171.6.1943     Document Type: Article

References (35)

1. Raine, C. S., D. H. Synder, M. P. Valsamis, and S. H. Stone. 1974. Chronic experimental allergic encephalomyelitis in guinea pigs. An ultrastructural study. Lab. Invest. 31:369.
2. Paterson, P. Y. 1976. Experimental autoimmune (allergic) encephalomyelitis: induction, pathogenesis, and suppression. In Textbook of Immunopathology. Second Edition. P. A. Miescher and H. J. Mueller-Eberhard, editors. Grune and Stratton, New York. 179-213.
3. Wisniewski, H. M., and H. B. Keith. 1977. Chronic relapsing experimental encephalomyelitis: an experimental model of multiple sclerosis. Ann. Neurol. 1:144.
4. Lassman, H. K., and H. M. Wisniewski. 1979. Chronic relapsing experimental allergic encephalomyelitis. Clinicopathological comparison with multiple sclerosis. Arch. Neurol. 36:490.
5. Traugott, U., E. Shevach, J. Chiba, S. H. Stone, and C. S. Raine. 1982. Autoimmune encephalomyelitis: simultaneous localization of T and B cells in the target organ. Science (Wash. DC). 214:1251.
6. Traugott, U., D. E. McFarlin, and C. S. Raine. 1986. Immunopathology of the lesion in chronic relapsing autoimmune encephalomyelitis in the mouse. Cell. Immunol. 99:395.
7. Brostoff, S. W., and D. W. Mason. 1984. Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J. Immunol. 133:1938.
8. Waldor, M. K., S. Sriram, R. Hardy, L. A. Herzenberg, L. A. Herzenberg, L. Lanier, M. Lim, and L. Steinman. 1985. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T cell subset marker. Science (Wash. DC). 227:415.
9. Paterson, P. Y. 1960. Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J. Exp. Med. 111:119.
10. Ortiz-Ortiz, L., and W. O. Weigle. 1976. Cellular events in the induction of experimental allergic encephalomyelitis in rats. J. Exp. Med. 144:604.
11. Richert, J. R., B. F. Driscoli, M. W. Keis, and E. C. Alvord, Jr. 1979. Adoptive transfer of experimental allergic encephalomyelitis: incubation of rat spleen cells with specific antigen. J. Immunol. 122:494.
12. Hold, J. H., A. M. Welch, and R. H. Swanborg. 1980. Autoimmune effector cells. I. Transfer of experimental allergic encephalomyelitis with lymphoid cells cultured with antigen. Eur. J. Immunol. 10:657
13. Ben-Nun, A., H. Wekerle, and J. R. Cohen. 1981. The rapid isolation of clonable antigen- " specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:195.
14. − lymphocytes. J. Immunol. 127:1420.
15. Mokhtarian, E, D. E. McFarlin, and C. S. Raine. 1984. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature (Land.). 309:356.
16. Zamvil, S., P. Nelson, J. Trotter, D. Mitchell, R. Knobler, R. Fritz, and L. Steinman. 1985. T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature (Lond.). 317:355.
17. Pettinelli, C. B., R. B. Fritz, C. H. Jen-Chou, and D. E. McFarlin. 1982. Encephalito-genic activity of guinea pig myelin basic protein. J. Immunol. 129:1209.
18. 1 mice by myelin basic protein and its peptides. Localization of a second encephalitogenic determinant. J. Immunol. 130:191.
19. Zamvil, S. S., D. J. Mitchel, A. C. Moore, K. Kitamura, L. Steinman, and J. B. Roth-bard. 1986. T cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature (Lond.). 324:258.
20. Kono, D. H., J. L. Urban, S. J. Horvath, D. G. Ando, R. A. Saavedra, and L. Hood. 1988. Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice. J. Exp. Med. 168:213.
21. Urban, J. L., V. K. Kumar, D. H. Kono, C. Gomez, S. J. Horvath, J. Clayton, D. G. Ando, E. E. Sercarz, and L. Hood. 1988. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibility for antibody therapy. Cell. 54:577.
22. Acha-Orbea, H., D.J. Mitchell, L. Timmermann, D. C. Wraith, G. S. Tausch, M. K. Waldor, S. S. Zamvil, H. O. McDevitt, and L. Steinman. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell. 54:263.
23. Hood, L., V. Kumar, G. Osman, S. S. Beall, C. Gomez, W. Funkhouser, D. H. Kono, D. Nickerson, D. M. Zaller, and J. L. Urban. 1989. Autoimmune disease and T cell immunologic recognition. Cold Spring Harbor Symp. Quant. Biol. In press.
24. Smith, M. E. 1969. An in vitro system for the study of myelin synthesis. J. Neurochem. 16:83.
25. Staerz, U., and M. Bevan. 1985. In Molecular Biology of the Immune System. J. Streilein, F. Ahmad, S. Black, B. Blomberg, and R. Voellmy, editors. Cambridge University Press, Cambridge. 61-64.
26. Urban, J. L., S.J. Horvath, and L. Hood. 1989. Autoimmune T cells: immune recognition of normal and variant epitopes and peptide-based therapy. Cell. 59:257.
27. McDuffie, M., W. Born, P. Marrack, and J. Kappler. 1986. The role of the T cell receptor in thymocyte maturation: effects in vivo of anti-receptor antibody. Proc. Natl. Acad. Sci. USA. 83:8728.
28. Wraith, D. C, D. E. Smilek, D.J. Mitchell, L. Steinman, and H. O. McDevitt. 1989. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide- o mediated immunotherapy. Cell. 59:247.
29. Steinman, L., J. T. Rosenbaum, S. Sriram, and H. O. McDevitt. 1981. In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA. 78:7111.
30. Sriram, S., and L. Steinman. 1983. Anti-I-A antibody suppresses active encephalomyelitis: treatment for Ir gene linked disease. J. Exp. Med. 158:1362
31. Ben-Nun, A., H. Wekerle, and I. R. Cohen. 1981. Vaccination against autoimmune en- " cephalomyelitis with T lymphocyte lines reactive against myelin basic protein. Nature (Lond.). 292:60.
32. Howell, M., S. T. Winters, O. Tsaiwei, H. C. Powell, D. J. Carlo, and S. W. Brostoff. 1989. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science (Wash. DC). 246:668.
33. Vandenbark, A. A., G. Hashim, and H. Offner. 1989. Immunization with a synthetic T cell receptor V region peptide protects against experimental autoimmune encephalomyelitis. Nature (Lond.). 341:541.
34. Behlke, M. A., H. S. Chou, K. Huppi, and D. Y. Loh. 1986. Murine T cell receptor mutants with deletions of β-chain variable region. Proc. Natl. Acad. Sci. USA. 83:767.
35. Owhashi, M., and E. Heber-Katz. 1988. Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein. J. Exp. Med. 168:2153.