Roles of immunoglobulins and B cells in multiple sclerosis: From pathogenesis to treatment

Journal of Neuroimmunology

Volumn 180, Issue 1-2, 2006, Pages 3-8

  Antel, Jack ^a   Bar Or, Amit ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

B cells; Immunoglobulins; Multiple sclerosis

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN;

ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL FUNCTION; CEREBROSPINAL FLUID; ENCEPHALOMYELITIS; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; MULTIPLE SCLEROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIBODY FORMATION; AUTOANTIBODIES; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CEREBROSPINAL FLUID PROTEINS; HUMANS; IMMUNOGLOBULINS; IMMUNOGLOBULINS, INTRAVENOUS; MULTIPLE SCLEROSIS; OLIGOCLONAL BANDS;

EID: 33750627447     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.06.032     Document Type: Review

References (66)

1. Alotaibi S., Kennedy J., Tellier R., Stephens D., and Banwell B. Epstein-Barr virus in pediatric multiple sclerosis. JAMA 291 15 (2004) 1875-1879
2. Antel J.P., and Bar-Or A. Do myelin antibodies predict the diagnosis of multiple sclerosis?. NEJM 349 2 (2003) 107-109
3. Alter A., Duddy M., Hebert S., Biernacki K., Prat A., Antel J.P., Yong V.W., Nuttall R.K., Pennington C.J., Edwards D.R., and Bar-Or A. Determinants of human B cell migration across brain endothelial cells. J. Immunol. 170 9 (2003) 4497-4505
4. Banwell B., Bar-Or A., Cheung R., Kennedy J., Krupp L.B., Becker D.J., and Dosch H.-M. On behalf of the Wadsworth Pediatric Multiple Sclerosis Study. Abnormal T cell reactivities to target-organ and environmental antigens in childhood multiple sclerosis and diabetes implicate both shared and distinct mechanisms in human autoimmune disease. Neurology 66 5 (2006) A310-A311 (Suppl 2)
5. Baranzini S.E., Jeong M.C., Butunoi C., Murray R.S., Bernard C.C., and Oksenberg J.R. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J. Immunol. 163 9 (1999) 5133-5144 (Nov. 1)
6. Bar-Or A., Oliveira E.M., Anderson D.E., Krieger J.I., Duddy M., O'Connor K.C., et al. Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state. J. Immunol. 167 10 (2001) 5669-5677
7. Bar-Or A., Nuttall R.K., Duddy M., Alter A., Kim H.J., Ifergan I., Pennington C.J., Bourgoin P., Edwards D.R., and Yong V.W. Analyses of all matrix metalloproteinase members in leukocytes: monocytes as major inflammatory mediators in Multiple Sclerosis. Brain 126 (2003) 2738-2749
8. Bar-Or A., Niino M., Duddy M., and Bodner C. Abnormal B cell cytokine response in multiple sclerosis points to distinct roles for naive and memory human B cells in immune regulation. Clin. Immunol. 119 (2006) S26-S27 (Suppl.)
9. Berger T., Rubner P., Schautzer F., Egg R., Ulmer H., Mayringer I., et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N. Engl. J. Med. 349 (2003) 139-145
10. Cepok S., Jacobsen M., Schock S., Omer B., Jaekel S., Boddeker I., et al. Patterns of cerebrospinal fluid pathology correlate with disease progression in multiple sclerosis. Brain 124 Pt. 11 (2001) 2169-2176
11. Cepok S., Rosche B., Grummel V., et al. Short lived plasma blasts are the main B cell effector subset during the course of MS. Brain 128 (2005) 1667-1676
12. Chan A., Weilbach F.X., Toyka K.V., and Gold R. Mitoxantrone induces cell death in peripheral blood leukocytes of multiple sclerosis patients. Clin. Exp. Immunol. 139 (2004) 152-158
13. Colombo M., Dono M., Gazzola P., Roncella S., Valetto A., Chiorazzi N., Mancardi G.L., and Ferrarini M. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of MS patients. J. Immunol. 164 (2000) 2782-2789
14. Corcione A., Casazza S., Ferretti E., Giunti D., Zappia E., Pistorio A., et al. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 101 30 (2004) 11064-11069
15. Corcione A., Aloisi F., Serafini B., Capello E., Mancardi G.L., Pistoia V., and Uccelli A. B-cell differentiation in the CNS of patients with multiple sclerosis. Autoimmun. Rev. 4 (2005) 549-554
16. Cree, et al. An open label study of the effects of rituximab in neuromyelitis optica. Neurology 64 (2005) 1270-1272
17. Cross A.H., and Stark J.L. Humoral immunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Immunol. Res. 32 1-3 (2005) 85-98
18. Cross, Trotter, and Lyons. B cells and antibodies in CNS demyelinating disease. J. Neuroimmunol. 112 (2001) 1-14
19. Cross A.H., Lauber J., and Lyons J. Preliminary results from a phase II trial of rituximab in MS. Eighth Annual Meeting of the Americas Committees for Research and Treatment in Multiple Sclerosis (2003) 20-21 abstract
20. Duddy M.E., Alter A., and Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation?. J. Immunol. 172 6 (2004) 3422-3427
21. Ebers G.C., and Paty D.W. CSF electrophoresis in one thousand patients. Can. J. Neurol. Sci. 7 4 (1980) 275-280
22. Fillatreau S., Sweenie C.H., McGeachy M.J., Gray D., and Anderton S.M. B cells regulate autoimmunity by provision of IL-10. Nat. Immunol. 3 (2002) 944-950
23. Fontoura P., Ho P.P., DeVoss J., Zheng B., Lee B.J., Kidd B.A., Garren H., Sobel R.A., Robinson W.H., Tessier-Lavigne M., and Steinman L. Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. J. Immunol. 173 11 (2004) 6981-6992
24. Genain C.P., Nguyen M.H., Letvin N.L., Pearl R., Davis R.L., Adelman M., Lees M.B., Linington C., and Hauser S.L. Antibody facilitation of multiple sclerosis-like lesions in nonhuman primate. J. Clin. Invest. 96 (1995) 2966-2974
25. Genain C.P., Cannella B., Hauser S.L., and Raine C.S. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5 (1999) 170-175 (comment)
26. Genc K., Dona D.L., and Reder A.T. Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy. J. Clin. Invest. 99 11 (1997) 2664-2671
27. Kanter J.L., Narayana S., Ho P.P., Catz I., Warren K.G., Sobel R.A., Steinman L., and Robinson W.H. Lipid microarrays identify key mediators of autoimmune brain inflammation. Nat. Med. 12 1 (2006) 138-143
28. Kappos L., Comi G., Panitch H., Oger J., Antel J., Conlon P., and Steinman L. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat. Med. 6 10 (2000) 1176-1182
29. Knezevic-Maramica I., and Kruskall M.S. Intravenous immune globulins: an update for clinicians. Review 43 10 (2003) 1460
30. Lapointe B.M., Herx L.M., Gill V., Metz L.M., and Kubes P. IVIg therapy in brain inflammation: etiology-dependent differential effects on leukocyte recruitment. Brain 127 Pt. 12 (2004) 2649-2656
31. Lemieux R., Bazin R., and Neron S. Therapeutic intravenous immunoglobulins. Mol. Immunol. 42 7 (2005) 839-848
32. Lennon V.A., Kryzer T.J., Pittock S.J., Verkman A.S., and Hinson S.R. IgG marker of optico-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med. 202 (2005) 473-477
33. Lim E.T., Berger T., Reindl M., Dalton C.M., Fernando K., Keir G., Thompson E.J., Miller D.H., and Giovannoni G. Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis. Mult. Scler. 11 4 (2005) 492-494
34. Lopez-Amaya C., O'Connor K., Kopel L., Fattahie R., Moore N., Gano D., Fournier A., Moscarello M., Banwell B., Kennedy J., Krupp L., Tenembaum S., Boiko A., Bykova O., Belman A., Mah J., Stoian C., Ness J., Rensel M., Hahn J., Weinstock-Guttman B., Yeh A., Waubant E., Farrell K., Freedman M., Bhan V., Dilenge M., Iivanainen M., Kremenchutzky M., Ruggieri M., and Bar-Or A. Anti-myelin antibodies in pediatric MS. Neurology 64 6 (2005) A194 (Suppl 1)
35. Lorenz R.G., Chaplin D.D., McDonald K.G., McDonough J.S., and Newberry R.D. Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin β receptor and TNF receptor I function. J. Immunol. 170 (2003) 5475-5482
36. Lucchinetti C.F., Bruck W., and Lassmann H. Evidence for pathogenic heterogeneity in multiple sclerosis. Ann. Neurol. 56 2 (2004) 308
37. Lund F.E., Garvy B.A., Randall T.D., and Harris D.P. Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr. Dir. Autoimmun. 8 (2005) 25-54
38. Mattson D.H., Roos R.P., and Arnason B.G. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains. Nature 287 5780 (1980) 335-337
39. Masjuan J., Alvarez-Cermeno J.C., Garcia-Barragan N., Diaz-Sanchez M., Espino M., Sadaba M.C., Gonzalez-Porque P., Martinez San Millan J., and Villar L.M. Clinically isolated syndromes: a new oligoclonal band test accurately predicts conversion to MS. Neurology 66 4 (2006) 576-578
40. Mauri C., Gray D., Mushtaq N., and Londei M. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 197 4 (2003) 489-501
41. Menge T., Lalive P.H., von Budingen H.C., Cree B., Hauser S.L., and Genain C.P. Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis. J. Allergy Clin. Immunol. 116 2 (2005) 453-459
42. Mizoguchi A., and Bhan A.K. A case for regulatory B cells. J. Immunol. 176 (2006) 705-710
43. Mizoguchi A., Mizoguchi E., Takedatsu H., Blumberg R.S., Bhan A.K., et al. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 16 (2002) 219-230
44. Monson, et al. Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis. Arch. Neurol. 62 2 (2005) 258-264
45. Neuhaus O., Wiendl H., Kieseier B.C., Archelos J.J., Hemmer B., Stüve O., and Hartung H.P. Multiple sclerosis: mitoxantrone promotes differential effects on immunocompetent cells in vitro. J. Neuroimmunol. 168 (2005) 128-137
46. Niehaus A., Shi J., Grzenkowski M., Diers-Fenger M., Archelos J., Hartung H.P., Toyka K., Bruck W., and Trotter J. Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination. Ann. Neurol. 48 3 (2000) 362-371
47. Niino N., Bodner C., Simard M.L., Alatab S., Gano G., Kim H.J., Trigueiro M., Racicot D., Guérette C., Antel J.P., Fournier A., Grand'Maison F., and Bar-Or A. Effects of natalizumab on immune responses in multiple sclerosis. Ann. Neurol. 59 5 (2006) 748-754
48. O'Connor K.C., Chitnis T., Griffin D.E., Piyasirisilp S., Bar-Or A., Khoury S., Wucherpfennig K.W., and Hafler D.A. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J. Neuroimmunol. 136 1-2 (2003) 140-148
49. O'Connor K.C., Appel H., Bregoli L., Call M.E., Catz I., Chan J.A., Moore N.H., Warren K.G., Wong S.J., Hafler D.A., and Wucherpfennig K.W. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J. Immunol. (2005)
50. Owens G.P., Kraus H., Burgoon M.P., Smith-Jensen T., Devlin M.T., and Gilden D.H. Restricted use of VH4 germline segments in an acute multiple sclerosis brain. Ann. Neurol. 43 (1998) 236-243
51. Petereit H.F., and Rubbert A. Effective suppression of cerebrospinal fluid B cells by rituximab and cyclophosphamide in progressive multiple sclerosis. Arch. Neurol. 62 10 (2005) 1641-1642
52. Prineas J.W. Multiple sclerosis: presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 203 4385 (1979) 1123-1125
53. Qin Y., Duquette P., Zhang Y., Talbot P., Poole R., and Antel J.P. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J. Clin. Invest. 102 5 (1998) 1045-1050
54. Randen I., Mellbye O.J., Forre O., and Natvig J.B. The identification of germinal centers and follicular dendritic cell networks in rheumatoid synovial tissue. Scand. J. Immunol. 41 (1995) 481-486
55. Robinson W.H., Steinman L., and Utz P.J. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics 3 11 (2003) 2077-2084
56. Rodriguez M., Miller D., and Lennon V. Immunoglobulins reactive with myelin basic protein promote CNS remyelination. Neurology 46 (1996) 538-545
57. Salmonsson S., Jonsson M.V., Skarstein K., Brokstad K.A., Hjelmstrom P., Wahren-Hernelius M., and Jonsson R. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome. Arthritis Rheum. 48 11 (2003) 3187-3201
58. Serafini B., Rosicarelli B., Magliozzi R., Stigliano E., and Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 14 2 (2004) 164-174
59. Shlomchik M.J., Craft J.E., and Mamula M.J. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev., Immunol. 1 2 (2001) 147-153
60. Stuve O., Cepok S., Elias B., Saleh A., Hartung H.P., Hemmer B., and Kieseier B. Clinical stabilization and effective B-lymphocyte depletion in the cerebrospinal fluid and peripheral blood of a patient with fulminant relapsing-remitting multiple sclerosis. Arch. Neurol. 62 (2005) 1620-1623
61. Uccelli A., Aloisi F., and Pistoia V. Unveiling the enigma of the CNS as a B-cell fostering environment. Trends Immunol. 26 5 (2005) 254-259
62. Villar L.M., Masjuan J., Gonzalez-Porque P., Plaza J., Sadaba M.C., Roldan E., et al. Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis. Ann. Neurol. 53 (2003) 222-226
63. Villar L.M., Masjuan J., Sadaba M.C., Gonzalez-Porque P., Plaza J., Bootello A., and Alvarez-Cermeno J.C. Early differential diagnosis of multiple sclerosis using a new oligoclonal band test. Arch. Neurol. 62 4 (2005) 574-577
64. Villar L.M., Sadaba M.C., Roldan E., Masjuan J., Gonzalez-Porque P., Villarrubia N., Espino M., Garcia-Trujillo J.A., Bootello A., and Alvarez-Cermeno J.C. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J. Clin. Invest. 115 1 (2005) 187-194
65. Walsh M.J., and Tourtelotte W.W. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA and IgM in multiple sclerosis. J. Exp. Med. 163 (1986) 41-53
66. Weinshenker B.G., O'Brien P.C., Petterson P.M., et al. A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann. Neurol. 46 (1999) 878-886