메뉴 건너뛰기




Volumn 34, Issue 12, 2004, Pages 3572-3581

Development of an anti-IL-12 p40 auto-vaccine: Protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection

Author keywords

Autoimmunity; IL 12; Vaccination

Indexed keywords

AUTOANTIBODY; EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 23; LEISHMANIA VACCINE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; OVALBUMIN; PEPTIDE DERIVATIVE; PROTEIN P40; PROTEIN SUBUNIT; PROTEOLIPID PROTEIN;

EID: 10944221275     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425443     Document Type: Article
Times cited : (35)

References (47)
  • 1
    • 0030457726 scopus 로고    scopus 로고
    • Breaking of B cell tolerance toward a highly conserved self protein
    • Dalum, I., Jensen, M. R., Hindersson, P., Elsner, H. I. and Mouritsen, I., Breaking of B cell tolerance toward a highly conserved self protein. J. Immunol. 1996. 157: 4796-4804.
    • (1996) J. Immunol. , vol.157 , pp. 4796-4804
    • Dalum, I.1    Jensen, M.R.2    Hindersson, P.3    Elsner, H.I.4    Mouritsen, I.5
  • 2
    • 0345404156 scopus 로고    scopus 로고
    • Induction of cross-reactive antibodies against a self protein by immunization with a modified self protein containing a foreign T helper epitope
    • Dalum, I., Jensen, M. R., Gregorius, K., Thomasen, K. M., Elsner, H. I. and Mouritsen, S., Induction of cross-reactive antibodies against a self protein by immunization with a modified self protein containing a foreign T helper epitope. Mol. Immunol. 1997. 34: 1113-1120.
    • (1997) Mol. Immunol. , vol.34 , pp. 1113-1120
    • Dalum, I.1    Jensen, M.R.2    Gregorius, K.3    Thomasen, K.M.4    Elsner, H.I.5    Mouritsen, S.6
  • 3
    • 0023971475 scopus 로고
    • Active immunization of heifers against luteinizing hormone-releasing hormone, human chorionic gonadotropin and bovine luteinizing hormone
    • Johnson, H. E., DeAvila, D. M., Chang, C. F. and Reeves, J. J., Active immunization of heifers against luteinizing hormone-releasing hormone, human chorionic gonadotropin and bovine luteinizing hormone. J. Anim. Sci. 1988. 66: 719-726.
    • (1988) J. Anim. Sci. , vol.66 , pp. 719-726
    • Johnson, H.E.1    DeAvila, D.M.2    Chang, C.F.3    Reeves, J.J.4
  • 8
    • 0034681145 scopus 로고    scopus 로고
    • Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice
    • Richard, M., Grencis, R. K., Humphreys, N. E., Renauld, J.-C. and Van Snick, J., Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proc. Natl. Acad. Sci. USA 2000. 97: 767-772.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 767-772
    • Richard, M.1    Grencis, R.K.2    Humphreys, N.E.3    Renauld, J.-C.4    Van Snick, J.5
  • 10
    • 0242500350 scopus 로고    scopus 로고
    • Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: Correlation with worm expulsion in murine nematode infections
    • Khan, W. I., Richard, M., Akiho, H., Blennerhasset, P. A., Humphreys, N. E., Grencis, R. K., Van Snick, J. and Collins, S. M., Modulation of intestinal muscle contraction by interleukin-9 (IL-9) or IL-9 neutralization: correlation with worm expulsion in murine nematode infections. Infect. Immun. 2003. 71: 2430-2438.
    • (2003) Infect. Immun. , vol.71 , pp. 2430-2438
    • Khan, W.I.1    Richard, M.2    Akiho, H.3    Blennerhasset, P.A.4    Humphreys, N.E.5    Grencis, R.K.6    Van Snick, J.7    Collins, S.M.8
  • 12
    • 0034898470 scopus 로고    scopus 로고
    • Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies
    • Chackerian, B., Lowy, D. R. and Schiller, J. T., Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J. Clin. Invest. 2001. 108: 415-423.
    • (2001) J. Clin. Invest. , vol.108 , pp. 415-423
    • Chackerian, B.1    Lowy, D.R.2    Schiller, J.T.3
  • 13
    • 0031826252 scopus 로고    scopus 로고
    • Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice
    • Matthys, P., Vermeire, K., Mitera, T., Heremans, H., Huang, S. and Billiau, A., Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice. Eur. J. Immunol. 1998. 28: 2143-2151.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2143-2151
    • Matthys, P.1    Vermeire, K.2    Mitera, T.3    Heremans, H.4    Huang, S.5    Billiau, A.6
  • 15
    • 0033564323 scopus 로고    scopus 로고
    • IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder
    • Hong, K., Chu, A., Ludviksson, B. R., Berg, E. L. and Ehrhardt, R. O., IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder. J. Immunol. 1999. 162: 7480-7491.
    • (1999) J. Immunol. , vol.162 , pp. 7480-7491
    • Hong, K.1    Chu, A.2    Ludviksson, B.R.3    Berg, E.L.4    Ehrhardt, R.O.5
  • 16
    • 0029880442 scopus 로고    scopus 로고
    • The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lprlpr mice
    • Huang, F. P., Feng, G. J., Lindop, G., Stott, D. I. and Liew, F. Y., The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lprlpr mice. J. Exp. Med. 1996. 183: 1447-1459.
    • (1996) J. Exp. Med. , vol.183 , pp. 1447-1459
    • Huang, F.P.1    Feng, G.J.2    Lindop, G.3    Stott, D.I.4    Liew, F.Y.5
  • 17
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E. and Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995. 182: 1281-1290.
    • (1995) J. Exp. Med. , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 18
  • 19
    • 0032528896 scopus 로고    scopus 로고
    • Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
    • Comabella, M., Balashov, K., Issazadeh, S., Smith, D., Weiner, H. L. and Khoury, S. J., Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J. Clin. Invest. 1998. 102: 671-678.
    • (1998) J. Clin. Invest. , vol.102 , pp. 671-678
    • Comabella, M.1    Balashov, K.2    Issazadeh, S.3    Smith, D.4    Weiner, H.L.5    Khoury, S.J.6
  • 21
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T. et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6    Lucian, L.7    To, W.8    Kwan, S.9    Churakova, T.10
  • 22
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher, B., Durell, B. G. and Noelle, R. J., Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 2002. 110: 493-497.
    • (2002) J. Clin. Invest. , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 23
    • 0032775094 scopus 로고    scopus 로고
    • Role of endogenous interleukin-12 (IL-12) in induced and spontaneous relapses of experimental autoimmune encephalomyelitis in mice
    • Heremans, H., Dillen, C., Groenen, M., Matthys, P. and Billiau, A., Role of endogenous interleukin-12 (IL-12) in induced and spontaneous relapses of experimental autoimmune encephalomyelitis in mice. Eur. Cytokine Netw. 1999. 10: 171-180.
    • (1999) Eur. Cytokine Netw. , vol.10 , pp. 171-180
    • Heremans, H.1    Dillen, C.2    Groenen, M.3    Matthys, P.4    Billiau, A.5
  • 24
    • 0032211092 scopus 로고    scopus 로고
    • Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
    • Constantinescu, C. S., Wysocka, M., Hilliard, B., Ventura, E. S., Lavi, E., Trinchieri, G. and Rostami, A., Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J. Immunol. 1998. 161: 5097-5104.
    • (1998) J. Immunol. , vol.161 , pp. 5097-5104
    • Constantinescu, C.S.1    Wysocka, M.2    Hilliard, B.3    Ventura, E.S.4    Lavi, E.5    Trinchieri, G.6    Rostami, A.7
  • 26
    • 10944230573 scopus 로고    scopus 로고
    • Anti-Interleukin-9 vaccination: A new tool to dissect IL-9 activities in vivo
    • PhD thesis, U.C.L, Brussels, Belgium
    • Richard, M., Anti-Interleukin-9 vaccination: a new tool to dissect IL-9 activities in vivo.PhD thesis, U.C.L, Brussels, Belgium. 2002
    • (2002)
    • Richard, M.1
  • 27
    • 0030002111 scopus 로고    scopus 로고
    • Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
    • Mattner, F., Magram, J., Ferrante, J., Launois, P., Di Padova, K., Behin, R., Gately, M. K., Louis, J. A. and Alber, G., Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 1996. 26: 1553-1559.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1553-1559
    • Mattner, F.1    Magram, J.2    Ferrante, J.3    Launois, P.4    Di Padova, K.5    Behin, R.6    Gately, M.K.7    Louis, J.A.8    Alber, G.9
  • 29
    • 2342486903 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
    • Su, C. G. and Lichtenstein, G. R., Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. Gastroenterology 2003. 125: 1544-1546.
    • (2003) Gastroenterology , vol.125 , pp. 1544-1546
    • Su, C.G.1    Lichtenstein, G.R.2
  • 30
    • 0028209541 scopus 로고
    • Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma
    • Tripp, C. S., Gately, M. K., Hakimi, J., Ling, P. and Unanue, E. R., Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. J. Immunol. 1994. 152: 1883-1887.
    • (1994) J. Immunol. , vol.152 , pp. 1883-1887
    • Tripp, C.S.1    Gately, M.K.2    Hakimi, J.3    Ling, P.4    Unanue, E.R.5
  • 31
    • 0029162723 scopus 로고
    • Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice
    • Castro, A. G., Silva, R. A. and Appelberg, R., Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice. J. Immunol. 1995. 155: 2013-2019.
    • (1995) J. Immunol. , vol.155 , pp. 2013-2019
    • Castro, A.G.1    Silva, R.A.2    Appelberg, R.3
  • 32
    • 0028947010 scopus 로고
    • The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection
    • Cooper, A. M., Roberts, A. D., Rhoades, E. R., Callahan, J. E., Getzy, D. M. and Orme, I. M., The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 1995. 84: 423-432.
    • (1995) Immunology , vol.84 , pp. 423-432
    • Cooper, A.M.1    Roberts, A.D.2    Rhoades, E.R.3    Callahan, J.E.4    Getzy, D.M.5    Orme, I.M.6
  • 33
    • 0030970867 scopus 로고    scopus 로고
    • Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
    • Scharton-Kersten, T. M., Yap, G., Magram, J. and Sher, A., Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 1997. 185: 1261-1273.
    • (1997) J. Exp. Med. , vol.185 , pp. 1261-1273
    • Scharton-Kersten, T.M.1    Yap, G.2    Magram, J.3    Sher, A.4
  • 34
    • 0037450808 scopus 로고    scopus 로고
    • Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: Medical and immunological implications
    • Fieschi, C., Dupuis, S., Catherinot, E., Feinberg, J., Bustamante, J., Breiman, A., Altare, F., Baretto, R., Le Deist, F., Kayal, S. et al., Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J. Exp. Med. 2003. 197: 527-535.
    • (2003) J. Exp. Med. , vol.197 , pp. 527-535
    • Fieschi, C.1    Dupuis, S.2    Catherinot, E.3    Feinberg, J.4    Bustamante, J.5    Breiman, A.6    Altare, F.7    Baretto, R.8    Le Deist, F.9    Kayal, S.10
  • 37
    • 0032976126 scopus 로고    scopus 로고
    • The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice
    • Lee, T. S., Yen, H. C., Pan, C. C. and Chau, L. Y., The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 1999. 19: 734-742.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 734-742
    • Lee, T.S.1    Yen, H.C.2    Pan, C.C.3    Chau, L.Y.4
  • 38
    • 0030051657 scopus 로고    scopus 로고
    • Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo
    • Fallarino, F., Uyttenhove, C., Boon, T. and Gajewski, T. F., Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J. Immunol. 1996. 156: 1095-1100.
    • (1996) J. Immunol. , vol.156 , pp. 1095-1100
    • Fallarino, F.1    Uyttenhove, C.2    Boon, T.3    Gajewski, T.F.4
  • 41
    • 0033083303 scopus 로고    scopus 로고
    • Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
    • Weinberg, A. D., Wegmann, K. W., Funatake, C. and Whitham, R. H., Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 1999. 162: 1818-1826.
    • (1999) J. Immunol. , vol.162 , pp. 1818-1826
    • Weinberg, A.D.1    Wegmann, K.W.2    Funatake, C.3    Whitham, R.H.4
  • 42
    • 0000337323 scopus 로고    scopus 로고
    • Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein
    • Slavin, A., Ewing, C., Liu, J., Ichikawa, M., Slavin, J. and Bernard, C. C., Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity 1998. 28: 109-120.
    • (1998) Autoimmunity , vol.28 , pp. 109-120
    • Slavin, A.1    Ewing, C.2    Liu, J.3    Ichikawa, M.4    Slavin, J.5    Bernard, C.C.6
  • 43
    • 0023739985 scopus 로고
    • Functional and structural characterization of P40, a mouse glycoprotein with T cell growth factor activity
    • Uyttenhove, C., Simpson, R. and Van Snick, J., Functional and structural characterization of P40, a mouse glycoprotein with T cell growth factor activity. Proc. Natl. Acad. Sci. USA 1988. 85: 6934-6938.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6934-6938
    • Uyttenhove, C.1    Simpson, R.2    Van Snick, J.3
  • 44
    • 0022972464 scopus 로고
    • A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
    • Espevik, T. and Nissen-Meyer, J., A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods 1986. 95: 99-105.
    • (1986) J. Immunol. Methods , vol.95 , pp. 99-105
    • Espevik, T.1    Nissen-Meyer, J.2
  • 45
    • 0033564686 scopus 로고    scopus 로고
    • Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
    • Mohrs, M., Ledermann, B., Kohler, G., Dorfmuller, A., Gessner, A. and Brombacher, F., Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J. Immunol. 1999. 162: 7302-7308.
    • (1999) J. Immunol. , vol.162 , pp. 7302-7308
    • Mohrs, M.1    Ledermann, B.2    Kohler, G.3    Dorfmuller, A.4    Gessner, A.5    Brombacher, F.6
  • 46
    • 0031913243 scopus 로고    scopus 로고
    • Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
    • Holscher, C., Kohler, G., Muller, U., Mossmann, H., Schaub, G. A. and Brombacher, F., Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect. Immun. 1998. 66: 1208-1215.
    • (1998) Infect. Immun. , vol.66 , pp. 1208-1215
    • Holscher, C.1    Kohler, G.2    Muller, U.3    Mossmann, H.4    Schaub, G.A.5    Brombacher, F.6
  • 47
    • 0027934360 scopus 로고
    • Determination of arginase activity in macrophages: A micro-method
    • Corraliza, I. M., Campo, M. L., Soler, G. and Modolell, M., Determination of arginase activity in macrophages: a micro-method. J. Immunol. Methods 1994. 174: 231-235.
    • (1994) J. Immunol. Methods , vol.174 , pp. 231-235
    • Corraliza, I.M.1    Campo, M.L.2    Soler, G.3    Modolell, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.