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Volumn 12, Issue 3, 1999, Pages 309-321

Immunopathogenesis of multiple sclerosis: The role of T cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLYCOPROTEIN; MYELIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

EID: 0032772860     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199906000-00010     Document Type: Review
Times cited : (130)

References (145)
  • 1
    • 0029965137 scopus 로고    scopus 로고
    • A few autoreactive cells in an autoimmune infiltrate control a vast population of non specific cells: A tale of smart bombs and the infantry
    • Steinman L. A few autoreactive cells in an autoimmune infiltrate control a vast population of non specific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci U S A 1996; 93:2253-2256.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2253-2256
    • Steinman, L.1
  • 2
    • 0029034068 scopus 로고
    • Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
    • Martin R, McFarland HF. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit Rev Clin Lab Sci 1995; 32:121-182.
    • (1995) Crit Rev Clin Lab Sci , vol.32 , pp. 121-182
    • Martin, R.1    McFarland, H.F.2
  • 3
    • 0027457115 scopus 로고
    • The T-lymphocyte response against myelin-associated glycoprotein and myelin basic protein in patients
    • Zhang YD, Burger D, Saruhan M, Jeannet M, Steck AJ. The T-lymphocyte response against myelin-associated glycoprotein and myelin basic protein in patients. Neurology 1993; 43:403-407.
    • (1993) Neurology , vol.43 , pp. 403-407
    • Zhang, Y.D.1    Burger, D.2    Saruhan, M.3    Jeannet, M.4    Steck, A.J.5
  • 4
    • 0026521206 scopus 로고
    • Virus-specific and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis
    • Link H, Sun JB, Wang Z, Xu Z, Love A, Frederikson S, Olsson T. Virus-specific and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 1992; 38:63-74.
    • (1992) J Neuroimmunol , vol.38 , pp. 63-74
    • Link, H.1    Sun, J.B.2    Wang, Z.3    Xu, Z.4    Love, A.5    Frederikson, S.6    Olsson, T.7
  • 5
    • 0020551984 scopus 로고
    • Isolation of myelin basic protein-reactive T-cell lines from normal human blood
    • Burns J, Rosenzweig A, Zweiman B, Lisak RP. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell Immunol 1983; 81:435-440.
    • (1983) Cell Immunol , vol.81 , pp. 435-440
    • Burns, J.1    Rosenzweig, A.2    Zweiman, B.3    Lisak, R.P.4
  • 6
    • 0025370870 scopus 로고
    • T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
    • Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990; 346:183-187.
    • (1990) Nature , vol.346 , pp. 183-187
    • Ota, K.1    Matsui, M.2    Milford, E.L.3    Mackin, G.A.4    Weiner, H.L.5    Hafler, D.A.6
  • 8
    • 0025188659 scopus 로고
    • Myelin basic protein-specific T lymphocyte lines from multiple sclerosis patients and healthy individuals
    • Pette M, Fujita K, Kitze B, Whitaker JN, Albert E, Kappos L, Wekerle H. Myelin basic protein-specific T lymphocyte lines from multiple sclerosis patients and healthy individuals. Neurology 1990; 40:1770-1776.
    • (1990) Neurology , vol.40 , pp. 1770-1776
    • Pette, M.1    Fujita, K.2    Kitze, B.3    Whitaker, J.N.4    Albert, E.5    Kappos, L.6    Wekerle, H.7
  • 9
    • 0025013169 scopus 로고
    • Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-γ
    • Olsson T, Wei Zhi W, Hojeberg B, Kostulas V, Yu-Ping J, Anderson G, et al. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-γ. J Clin Invest 1990; 86:981-985.
    • (1990) J Clin Invest , vol.86 , pp. 981-985
    • Olsson, T.1    Wei Zhi, W.2    Hojeberg, B.3    Kostulas, V.4    Yu-Ping, J.5    Anderson, G.6
  • 10
    • 0026517943 scopus 로고
    • Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis
    • Olsson T, Sun J, Hillert J, Hojeberg B, Ekre HP, Andersson G, et al. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis. Eur J Immunol 1992; 22:1083-1087.
    • (1992) Eur J Immunol , vol.22 , pp. 1083-1087
    • Olsson, T.1    Sun, J.2    Hillert, J.3    Hojeberg, B.4    Ekre, H.P.5    Andersson, G.6
  • 11
    • 0030973104 scopus 로고    scopus 로고
    • Direct ex vivo analysis of activated Fas-sensitive autoreactive T cells in human autoimmune disease
    • Bieganowska KD, Ausbel LJ, Modaber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med 1997; 185:1585-1594.
    • (1997) J Exp Med , vol.185 , pp. 1585-1594
    • Bieganowska, K.D.1    Ausbel, L.J.2    Modaber, Y.3    Slovik, E.4    Messersmith, W.5    Hafler, D.A.6
  • 12
    • 0027170966 scopus 로고
    • The T-cell response to myelin basic protein in familial multiple sclerosis: Diversity of fine specificity, restricting elements, and T-cell receptor usage
    • Joshi N, Usuku K, Hauser SL. The T-cell response to myelin basic protein in familial multiple sclerosis: diversity of fine specificity, restricting elements, and T-cell receptor usage. Ann Neurol 1993; 34:385-393.
    • (1993) Ann Neurol , vol.34 , pp. 385-393
    • Joshi, N.1    Usuku, K.2    Hauser, S.L.3
  • 13
    • 0027486499 scopus 로고
    • Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis
    • Martin R, Voskuhl R, Flerlage M, McFarlin DE, McFarland HF. Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis. Ann Neurol 1993; 34:524-535.
    • (1993) Ann Neurol , vol.34 , pp. 524-535
    • Martin, R.1    Voskuhl, R.2    Flerlage, M.3    McFarlin, D.E.4    McFarland, H.F.5
  • 15
    • 0032521030 scopus 로고    scopus 로고
    • MHC class I-restricted of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes
    • + cytotoxic T cells can contribute to the tissue injury in multiple sclerosis.
    • (1998) J Immunol , vol.160 , pp. 3056-3059
    • Jurewicz, A.1    Biddison, W.E.2    Antel, J.P.3
  • 16
    • 0025138302 scopus 로고
    • T Cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta M, Nicklas JA, Sriram S, Albertini RJ. T Cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990; 247:718-721.
    • (1990) Science , vol.247 , pp. 718-721
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertini, R.J.4
  • 17
    • 0027957780 scopus 로고
    • Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 1994; 179:973-984.
    • (1994) J Exp Med , vol.179 , pp. 973-984
    • Zhang, J.1    Markovic-Plese, S.2    Lacet, B.3    Raus, J.4    Weiner, H.L.5    Hafler, D.A.6
  • 18
    • 0030973104 scopus 로고    scopus 로고
    • Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease
    • Bieganowska KD, Ausubel LJ, Modabber Y, Slovik E, Messersmith W, Hafler DA. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J Exp Med 1997; 185:1585-1594.
    • (1997) J Exp Med , vol.185 , pp. 1585-1594
    • Bieganowska, K.D.1    Ausubel, L.J.2    Modabber, Y.3    Slovik, E.4    Messersmith, W.5    Hafler, D.A.6
  • 19
    • 0032519421 scopus 로고    scopus 로고
    • Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients
    • Lovett-Racke AE, Trotter JL, Lauber J, Perrin PJ, June CH, Racke MK. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. J Clin Invest 1998; 101:725-730. The results obtained suggest that MBP-reactive T cells are more likely to have been activated in vivo or differentiated into memory T cells in multiple sclerosis patients compared with in control individuals.
    • (1998) J Clin Invest , vol.101 , pp. 725-730
    • Lovett-Racke, A.E.1    Trotter, J.L.2    Lauber, J.3    Perrin, P.J.4    June, C.H.5    Racke, M.K.6
  • 21
    • 0032902375 scopus 로고    scopus 로고
    • Isolation of myelin basic protein-specific T cells predominantly from the memory T-cell compartment in multiple sclerosis
    • Burns J, Bartholomew B, Lobo S. Isolation of myelin basic protein-specific T cells predominantly from the memory T-cell compartment in multiple sclerosis. Ann Neurol 1999; 45:33-39. These results suggest that a substantial proportion of MBP-reactive T cells from some patients with multiple sclerosis have been previously activated in vivo.
    • (1999) Ann Neurol , vol.45 , pp. 33-39
    • Burns, J.1    Bartholomew, B.2    Lobo, S.3
  • 22
    • 0023892492 scopus 로고    scopus 로고
    • Peptide specificities of myelin basic protein-reactive human T-cell clones
    • Richert JR, Reuben-Burnside CA, Deibler GE, Kies MW. Peptide specificities of myelin basic protein-reactive human T-cell clones. Neurology 1998; 38:739-742.
    • (1998) Neurology , vol.38 , pp. 739-742
    • Richert, J.R.1    Reuben-Burnside, C.A.2    Deibler, G.E.3    Kies, M.W.4
  • 23
    • 0025155486 scopus 로고
    • Myelin autoreactivity in multiple sclerosis: Recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors
    • Pette M, Fujita K, Wilkinson D, Altmann DM, Trowsdale J, Giegerich G, et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc Natl Acad Sci U S A 1990; 87:7968-7972.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 7968-7972
    • Pette, M.1    Fujita, K.2    Wilkinson, D.3    Altmann, D.M.4    Trowsdale, J.5    Giegerich, G.6
  • 24
    • 0025966510 scopus 로고
    • A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis
    • Martin R, Howell MD, Jaraquemada D, Flerlage M, Richert J, Brostoff S, et al. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J Exp Med 1991; 173:19-24.
    • (1991) J Exp Med , vol.173 , pp. 19-24
    • Martin, R.1    Howell, M.D.2    Jaraquemada, D.3    Flerlage, M.4    Richert, J.5    Brostoff, S.6
  • 25
    • 0027138878 scopus 로고
    • Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones
    • Meinl E, Weber F, Drexler K, Morelle C, Ott M, Saruhan-Direskeneli G, et al. Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. J Clin Invest 1993; 92:2633-2643.
    • (1993) J Clin Invest , vol.92 , pp. 2633-2643
    • Meinl, E.1    Weber, F.2    Drexler, K.3    Morelle, C.4    Ott, M.5    Saruhan-Direskeneli, G.6
  • 26
    • 18544397838 scopus 로고    scopus 로고
    • T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: Peptide binding, immunodominance and effector functions of T cells
    • Vergelli M, Kalbus M, Rojo SC, Hemmer B, Kalbacher H, Tranquill L, et al. T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells. J Neuroimmunol 1997; 77:195-203.
    • (1997) J Neuroimmunol , vol.77 , pp. 195-203
    • Vergelli, M.1    Kalbus, M.2    Rojo, S.C.3    Hemmer, B.4    Kalbacher, H.5    Tranquill, L.6
  • 27
    • 0030749517 scopus 로고    scopus 로고
    • Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell repertoire
    • Muraro PA, Vergelli M, Kalbus M, Banks DE, Nagle JW, Tranquill LR, et al. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell repertoire. J Clin Invest 1997; 100:339-349.
    • (1997) J Clin Invest , vol.100 , pp. 339-349
    • Muraro, P.A.1    Vergelli, M.2    Kalbus, M.3    Banks, D.E.4    Nagle, J.W.5    Tranquill, L.R.6
  • 28
    • 0002905451 scopus 로고
    • Major T-cell responses in multiple sclerosis
    • Steinman L, Waisman A, Altman D. Major T-cell responses in multiple sclerosis. Mol Med Today 1995; 1:79-83.
    • (1995) Mol Med Today , vol.1 , pp. 79-83
    • Steinman, L.1    Waisman, A.2    Altman, D.3
  • 29
    • 0027389119 scopus 로고
    • Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients
    • Valli A, Sette A, Kappos L, Oseroff C, Sidney J, Miescher G, et al. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J Clin Invest 1993; 91:616-628.
    • (1993) J Clin Invest , vol.91 , pp. 616-628
    • Valli, A.1    Sette, A.2    Kappos, L.3    Oseroff, C.4    Sidney, J.5    Miescher, G.6
  • 31
    • 0028120895 scopus 로고
    • Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
    • Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 1994; 179:279-290.
    • (1994) J Exp Med , vol.179 , pp. 279-290
    • Wucherpfennig, K.W.1    Sette, A.2    Southwood, S.3    Oseroff, C.4    Matsui, M.5    Strominger, J.L.6    Hafler, D.A.7
  • 32
    • 0027406406 scopus 로고
    • Selection for T-cell receptor Vb-Db-Jb gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
    • Oksenber JR, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, et al. Selection for T-cell receptor Vb-Db-Jb gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 1993; 362:68-70.
    • (1993) Nature , vol.362 , pp. 68-70
    • Oksenber, J.R.1    Panzara, M.A.2    Begovich, A.B.3    Mitchell, D.4    Erlich, H.A.5    Murray, R.S.6
  • 33
    • 0028242718 scopus 로고
    • Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis
    • Allegretta M, Albertini RJ, Howell MD, Smith LR, Martin R, McFarland HF, et al. Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J Clin Invest 1994; 94:105-109.
    • (1994) J Clin Invest , vol.94 , pp. 105-109
    • Allegretta, M.1    Albertini, R.J.2    Howell, M.D.3    Smith, L.R.4    Martin, R.5    McFarland, H.F.6
  • 34
    • 0031841212 scopus 로고    scopus 로고
    • T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: Structural requirements and clinical implications
    • Kozovska M, Zang YC, Aebischer I, Lnu S, Rivera VM, Crowe PD, et al. T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications. Eur J Immunol 1998; 28:1894-1901. This study shows that two central residues (Phe90 and Lys91) served as the critical TCR contact points for both DR2-restricted and DR4-restricted T-cell clones. A single alanine substitution at residue 90 or residue 91 abolished the responses of 81-95% of the TCCs, whereas a double alanine substitution rendered all TCCs unresponsive.
    • (1998) Eur J Immunol , vol.28 , pp. 1894-1901
    • Kozovska, M.1    Zang, Y.C.2    Aebischer, I.3    Lnu, S.4    Rivera, V.M.5    Crowe, P.D.6
  • 35
    • 0030701864 scopus 로고    scopus 로고
    • Human T-cell response to myelin basic protein peptide (83-99): Extensive heterogeneity in antigen recognition, function and phenotype
    • Hemmer B, Vergelli M, Tranquill L, Conlon P, Ling N, McFarland HF, Martin R. Human T-cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function and phenotype. Neurology 1997; 49:1116-1126.
    • (1997) Neurology , vol.49 , pp. 1116-1126
    • Hemmer, B.1    Vergelli, M.2    Tranquill, L.3    Conlon, P.4    Ling, N.5    McFarland, H.F.6    Martin, R.7
  • 37
    • 0026042680 scopus 로고
    • Preferential T-cell receptor Vb-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis
    • Kotzin BL, Karuturi S, Chou YK, Lafferty J, Forrester M, Better M, et al. Preferential T-cell receptor Vb-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis. Proc Natl Acad Sci U S A 1991; 88:9161-9165.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 9161-9165
    • Kotzin, B.L.1    Karuturi, S.2    Chou, Y.K.3    Lafferty, J.4    Forrester, M.5    Better, M.6
  • 38
    • 10244247768 scopus 로고    scopus 로고
    • Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)
    • Vergelli M, Hemmer B, Utz U, Vogt A, Kalbus M, Tranquill L, et al. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur J Immunol 1996; 26:2624-2634.
    • (1996) Eur J Immunol , vol.26 , pp. 2624-2634
    • Vergelli, M.1    Hemmer, B.2    Utz, U.3    Vogt, A.4    Kalbus, M.5    Tranquill, L.6
  • 39
    • 0028238201 scopus 로고
    • Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide
    • Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol 1994; 152:5581-5592.
    • (1994) J Immunol , vol.152 , pp. 5581-5592
    • Wucherpfennig, K.W.1    Zhang, J.2    Witek, C.3    Matsui, M.4    Modabber, Y.5    Ota, K.6    Hafler, D.A.7
  • 41
    • 0031596395 scopus 로고    scopus 로고
    • Restricted TCR Valpha gene rearrangements in T cells recognizing an immunodominant peptide of myelin basic protein in DR2 patients with multiple sclerosis
    • Zhang YC, Kozovska M, Aebischer I, Li S, Boehme S, Crowe P, et al. Restricted TCR Valpha gene rearrangements in T cells recognizing an immunodominant peptide of myelin basic protein in DR2 patients with multiple sclerosis. Intern Immunol 1998; 10:991-998.
    • (1998) Intern Immunol , vol.10 , pp. 991-998
    • Zhang, Y.C.1    Kozovska, M.2    Aebischer, I.3    Li, S.4    Boehme, S.5    Crowe, P.6
  • 42
    • 0026068885 scopus 로고
    • Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: Predominant genes vary in individuals
    • Ben-Nun A, Liblau RS, Cohen L, Lehmann D, Tournier-Lasserve E, Rosenzweig A, et al. Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals. Proc Natl Acad Sci U S A 1991; 88:2466-2470.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2466-2470
    • Ben-Nun, A.1    Liblau, R.S.2    Cohen, L.3    Lehmann, D.4    Tournier-Lasserve, E.5    Rosenzweig, A.6
  • 43
    • 0027222546 scopus 로고
    • Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis
    • Salvetti M, Ristori G, D'Amato M, Buttinelli C, Falcone M, Fieschi C, et al. Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Eur J Immuol 1993; 23:1232-1239.
    • (1993) Eur J Immuol , vol.23 , pp. 1232-1239
    • Salvetti, M.1    Ristori, G.2    D'Amato, M.3    Buttinelli, C.4    Falcone, M.5    Fieschi, C.6
  • 45
    • 0025044023 scopus 로고
    • HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals
    • Jaraquemada D, Martin R, Rosen-Bronson S, Flerlage M, McFarland HF, Long EO. HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals. J Immunol 1990; 145:2880-2685.
    • (1990) J Immunol , vol.145 , pp. 2880-2885
    • Jaraquemada, D.1    Martin, R.2    Rosen-Bronson, S.3    Flerlage, M.4    McFarland, H.F.5    Long, E.O.6
  • 46
    • 0024997357 scopus 로고
    • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
    • Martin R, Jaraquemada D, Flerlage M, Richert J, Whitaker J, Long EO, et al. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol. 1990; 145:540-548.
    • (1990) J Immunol , vol.145 , pp. 540-548
    • Martin, R.1    Jaraquemada, D.2    Flerlage, M.3    Richert, J.4    Whitaker, J.5    Long, E.O.6
  • 48
    • 0031569102 scopus 로고    scopus 로고
    • + T cell clones use perforin- or Fas Ligand-mediated pathways for target cell lysis
    • + TCCs specific for myelin basic protein, regardless of their cytokine phenotype, can be reither noncytotoxic or lyse target cells via either perforin- or Fas/Fas ligand-mediated cytotoxicity.
    • (1997) J Immunol , vol.158 , pp. 2756-2761
    • Vergelli, M.1    Hemmer, B.2    Muraro, P.3    Tranquill, L.4    Biddison, W.E.5    Sarin, A.6
  • 49
    • 0031966527 scopus 로고    scopus 로고
    • Probing degeneracy in T-cell recognition using peptide combinatorial libraries-importance for T-cell survival and autoimmunity
    • Hemmer B, Vergelli M, Pinilla C, Houghten RA, Martin R. Probing degeneracy in T-cell recognition using peptide combinatorial libraries-importance for T-cell survival and autoimmunity. Immunol Today 1998; 19:163-168.
    • (1998) Immunol Today , vol.19 , pp. 163-168
    • Hemmer, B.1    Vergelli, M.2    Pinilla, C.3    Houghten, R.A.4    Martin, R.5
  • 50
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • Mason D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol Today 1998; 19:395-404.
    • (1998) Immunol Today , vol.19 , pp. 395-404
    • Mason, D.1
  • 51
    • 0031569454 scopus 로고    scopus 로고
    • Modifications of peptide ligands enhancing T cell responsiveness suggest a broad spectrum of stimulatory ligands for autoreactive T cells
    • Vergelli M, Hemmer B, Kalbus M, Vogt AB, Ling N, Conlon P, et al. Modifications of peptide ligands enhancing T cell responsiveness suggest a broad spectrum of stimulatory ligands for autoreactive T cells. J Immunol 1997; 158:3746-3752.
    • (1997) J Immunol , vol.158 , pp. 3746-3752
    • Vergelli, M.1    Hemmer, B.2    Kalbus, M.3    Vogt, A.B.4    Ling, N.5    Conlon, P.6
  • 52
    • 0030925578 scopus 로고    scopus 로고
    • Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
    • Hemmer B, Fleckenstein BT, Vergelli M, Jung W, McFarland H, Martin R, Wiesmuller KH. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J Exp Med 1997; 185:1651-1659.
    • (1997) J Exp Med , vol.185 , pp. 1651-1659
    • Hemmer, B.1    Fleckenstein, B.T.2    Vergelli, M.3    Jung, W.4    McFarland, H.5    Martin, R.6    Wiesmuller, K.H.7
  • 53
    • 0031889913 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate antigen-independent T cell activation by two separate calcium signaling pathways in multiple sclerosis patients
    • + memory) from patients with multiple sclerosis can be activated by proinflammatory cytokines, bypassing the TCR engagment via two independent calcium-mediated intracellular pathways.
    • (1998) Ann Neurol , vol.43 , pp. 340-349
    • Martino, G.1    Grohovaz, F.2    Brambilla, E.3    Codazzi, F.4    Consiglio, A.5    Clementi, E.6
  • 54
    • 0027935476 scopus 로고
    • Antigen-independent activation of naive and memory resting T cells by a cytokine combination
    • Unutmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 1994; 180:1159-1164.
    • (1994) J Exp Med , vol.180 , pp. 1159-1164
    • Unutmaz, D.1    Pileri, P.2    Abrignani, S.3
  • 55
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type I interferon in vivo
    • Tough DF, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996; 272:1947-1950.
    • (1996) Science , vol.272 , pp. 1947-1950
    • Tough, D.F.1    Borrow, P.2    Sprent, J.3
  • 56
    • 0030945996 scopus 로고    scopus 로고
    • Bystander activation of cytotoxic T cells: Studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model
    • Ehl S, Hombach J, Aichele P, Hengartner H, Zinkernagel RM. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J Exp Med 1997; 185:1241-1251.
    • (1997) J Exp Med , vol.185 , pp. 1241-1251
    • Ehl, S.1    Hombach, J.2    Aichele, P.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 57
    • 0030030561 scopus 로고    scopus 로고
    • Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis
    • Talbot PJ, Paquette JS, Ciurli C, Antel JP, Ouellet F. Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis. Ann Neurol 1996; 39:233-240.
    • (1996) Ann Neurol , vol.39 , pp. 233-240
    • Talbot, P.J.1    Paquette, J.S.2    Ciurli, C.3    Antel, J.P.4    Ouellet, F.5
  • 58
    • 0029881371 scopus 로고    scopus 로고
    • Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2′, 3′ cyclic nucleotide' phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE
    • Birnbaum G, Kotilinek L, Schlievert P, Clark HB, Trotter J, Horvath E, et al. Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2′, 3′ cyclic nucleotide ' phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE. J Neurosci Res 1996; 44:381-396.
    • (1996) J Neurosci Res , vol.44 , pp. 381-396
    • Birnbaum, G.1    Kotilinek, L.2    Schlievert, P.3    Clark, H.B.4    Trotter, J.5    Horvath, E.6
  • 59
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfenning KW, Strominger JL. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995; 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfenning, K.W.1    Strominger, J.L.2
  • 60
    • 0032555419 scopus 로고    scopus 로고
    • Do micorbes with peptides mimicking myelin cause multiple sclerosis if the T cell response to their unique peptides is limited?
    • Kaufman MD. Do micorbes with peptides mimicking myelin cause multiple sclerosis if the T cell response to their unique peptides is limited? J Theor Biol 1998; 193:691-708. An hypothesis for the pathogenic mechanism of multiple sclerosis based upon assumptions about the response of the T-cell repertoire to pathogens is presented.
    • (1998) J Theor Biol , vol.193 , pp. 691-708
    • Kaufman, M.D.1
  • 61
    • 0025782929 scopus 로고
    • Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides
    • Trotter JL, Hickey WF, van der Veen RC, Sulze L. Peripheral blood mononuclear cells from multiple sclerosis patients recognize myelin proteolipid protein and selected peptides. J Neuroimmunol 1991; 33:55-62.
    • (1991) J Neuroimmunol , vol.33 , pp. 55-62
    • Trotter, J.L.1    Hickey, W.F.2    Van der Veen, R.C.3    Sulze, L.4
  • 62
    • 0025909739 scopus 로고
    • Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls
    • Sun JB, Olsson T, Wang WZ, Xiao BG, Kostulas V, Frederickson S, et al. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 1991; 21:1461-1468.
    • (1991) Eur J Immunol , vol.21 , pp. 1461-1468
    • Sun, J.B.1    Olsson, T.2    Wang, W.Z.3    Xiao, B.G.4    Kostulas, V.5    Frederickson, S.6
  • 65
    • 0028802217 scopus 로고
    • Analysis of proteolipid protein (PLP)-specific T cells in multiple sclerosis:identification of PLP 95-116 as an HLA-DR2, w15-associated determinant
    • Ohashi T, Yamamura T, Inobe J, Kondo T, Kunishita T, Tabira T. Analysis of proteolipid protein (PLP)-specific T cells in multiple sclerosis:identification of PLP 95-116 as an HLA-DR2, w15-associated determinant. Int Immunol 1995; 7:1771-1778.
    • (1995) Int Immunol , vol.7 , pp. 1771-1778
    • Ohashi, T.1    Yamamura, T.2    Inobe, J.3    Kondo, T.4    Kunishita, T.5    Tabira, T.6
  • 66
    • 0029019568 scopus 로고
    • T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans
    • Markovic-Plese S, Fukaura H, Zhang J, Al-Sabbagh A, Southwood S, Sette A, et al. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. J Immunol 1995; 155:982-992.
    • (1995) J Immunol , vol.155 , pp. 982-992
    • Markovic-Plese, S.1    Fukaura, H.2    Zhang, J.3    Al-Sabbagh, A.4    Southwood, S.5    Sette, A.6
  • 67
    • 0030861738 scopus 로고    scopus 로고
    • Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
    • Greer JM, Csurhes PA, Cameron KD, McCombe PA, Good MF, Pender MP. Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis. Brain 1997; 120:1447-1460.
    • (1997) Brain , vol.120 , pp. 1447-1460
    • Greer, J.M.1    Csurhes, P.A.2    Cameron, K.D.3    McCombe, P.A.4    Good, M.F.5    Pender, M.P.6
  • 68
    • 0032522194 scopus 로고    scopus 로고
    • T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects
    • Trotter JL, Pelfrey CM, Trotter AM, Selvidge JA, Gushleff KC, Mohanakumar T, McFarland HF. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects. J Neuroimmunol 1998; 84:172-178. TCLs from HLA-DR15 multiple sclerosis patients recognized peptide 95-117 significantly more often than TCLs from control individuals.
    • (1998) J Neuroimmunol , vol.84 , pp. 172-178
    • Trotter, J.L.1    Pelfrey, C.M.2    Trotter, A.M.3    Selvidge, J.A.4    Gushleff, K.C.5    Mohanakumar, T.6    McFarland, H.F.7
  • 70
    • 0030861738 scopus 로고    scopus 로고
    • Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
    • Greer JM, Csurhes PA, Cameron KD, McCombe PA, Good MF, Pender MP. Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis. Brain 1997; 120:1447-1460.
    • (1997) Brain , vol.120 , pp. 1447-1460
    • Greer, J.M.1    Csurhes, P.A.2    Cameron, K.D.3    McCombe, P.A.4    Good, M.F.5    Pender, M.P.6
  • 72
    • 0030899404 scopus 로고    scopus 로고
    • Diversity and plasticity of self recognition during the development of multiple sclerosis
    • Tuohy VK, Yu M, Weinstock-Guttman B, Kinkel RP. Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest 1997; 99:1682-1690.
    • (1997) J Clin Invest , vol.99 , pp. 1682-1690
    • Tuohy, V.K.1    Yu, M.2    Weinstock-Guttman, B.3    Kinkel, R.P.4
  • 73
    • 0032932360 scopus 로고    scopus 로고
    • The structure and function of myelin oligodendrocyte glycoprotein
    • Johns TG, Bernard CC. The structure and function of myelin oligodendrocyte glycoprotein. J Neurochem 1999; 72: 1-9.
    • (1999) J Neurochem , vol.72 , pp. 1-9
    • Johns, T.G.1    Bernard, C.C.2
  • 77
    • 0027144752 scopus 로고
    • Reactivity to myelin antigens in multiple sclerosis, Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
    • Kerlero de Rosbo N, Milo R, Lees MB, Burger D, Bernard CCA, Ben-Nun A. Reactivity to myelin antigens in multiple sclerosis, Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein. J Clin Invest 1993; 92:2602-2608.
    • (1993) J Clin Invest , vol.92 , pp. 2602-2608
    • Kerlero de Rosbo, N.1    Milo, R.2    Lees, M.B.3    Burger, D.4    Bernard, C.C.A.5    Ben-Nun, A.6
  • 78
    • 0025979945 scopus 로고
    • T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis
    • Sun J, Link H, Olsson T, Xiao BG, Andersson G, Ekre HP, et al. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J Immunol 1991; 146:1490-1495.
    • (1991) J Immunol , vol.146 , pp. 1490-1495
    • Sun, J.1    Link, H.2    Olsson, T.3    Xiao, B.G.4    Andersson, G.5    Ekre, H.P.6
  • 79
    • 0030697438 scopus 로고    scopus 로고
    • Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions
    • Kerlero de Rosbo N, Hoffman M, Mendel I, Yust I, Kaje J, Bakimer R, et al. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur J Immunol 1997; 27:3059-3069.
    • (1997) Eur J Immunol , vol.27 , pp. 3059-3069
    • Kerlero de Rosbo, N.1    Hoffman, M.2    Mendel, I.3    Yust, I.4    Kaje, J.5    Bakimer, R.6
  • 81
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffmann RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-2357.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffmann, R.L.5
  • 82
    • 0025807152 scopus 로고
    • Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
    • Del Prete G, De Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, et al. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991; 88:346-350.
    • (1991) J Clin Invest , vol.88 , pp. 346-350
    • Del Prete, G.1    De Carli, M.2    Mastromauro, C.3    Biagiotti, R.4    Macchia, D.5    Falagiani, P.6
  • 83
    • 0027164561 scopus 로고
    • Switch of CD8 T cells to noncytolytic CD8-CD4-cells that make TH2 cytokines and help B cells
    • Erard F, Wild M-T, Garcia-Sanz JA, Le Gros G. Switch of CD8 T cells to noncytolytic CD8-CD4-cells that make TH2 cytokines and help B cells. Science 1993; 260:1802-1805.
    • (1993) Science , vol.260 , pp. 1802-1805
    • Erard, F.1    Wild, M.-T.2    Garcia-Sanz, J.A.3    Le Gros, G.4
  • 84
    • 0025923025 scopus 로고
    • Human TH1 and TH2 subsets: Doubt no more
    • Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today 1991; 12:256-257.
    • (1991) Immunol Today , vol.12 , pp. 256-257
    • Romagnani, S.1
  • 85
    • 0027529932 scopus 로고
    • Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
    • Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA Jr. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med 1993; 177:57-68.
    • (1993) J Exp Med , vol.177 , pp. 57-68
    • Baron, J.L.1    Madri, J.A.2    Ruddle, N.H.3    Hashim, G.4    Janeway C.A., Jr.5
  • 86
    • 0025009870 scopus 로고
    • + islet-specific T cell clone
    • + islet-specific T cell clone. Science 1990; 249:1433-1436.
    • (1990) Science , vol.249 , pp. 1433-1436
    • Haskins, K.1    McDuffie, M.2
  • 87
    • 0025075218 scopus 로고
    • The effect of treatment with interferon-gamma on type II collagen-induced arthritis
    • Nakajima H, Takamori H, Hiyama Y, Tsukada W. The effect of treatment with interferon-gamma on type II collagen-induced arthritis. Clin Exp Immunol 1990; 81:441-445.
    • (1990) Clin Exp Immunol , vol.81 , pp. 441-445
    • Nakajima, H.1    Takamori, H.2    Hiyama, Y.3    Tsukada, W.4
  • 88
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383:787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 89
  • 90
    • 0029743819 scopus 로고    scopus 로고
    • Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99)
    • Hemmer B, Vergelli M, Calabresi P, Huang T, McFarland HF, Martin R. Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99). J Neurosci Res 1996; 45:852-862.
    • (1996) J Neurosci Res , vol.45 , pp. 852-862
    • Hemmer, B.1    Vergelli, M.2    Calabresi, P.3    Huang, T.4    McFarland, H.F.5    Martin, R.6
  • 91
    • 0030844435 scopus 로고    scopus 로고
    • Cytokine profile of myelin basic protein-reavtive T cells in multiple sclerosis and healthy individuals
    • Hermans G, Stinissen P, Hauben L, Van den Berg-Loonen E, Raus J, Zhang J. Cytokine profile of myelin basic protein-reavtive T cells in multiple sclerosis and healthy individuals. Ann Neurol 1997; 42:18-27.
    • (1997) Ann Neurol , vol.42 , pp. 18-27
    • Hermans, G.1    Stinissen, P.2    Hauben, L.3    Van den Berg-Loonen, E.4    Raus, J.5    Zhang, J.6
  • 92
    • 0028906889 scopus 로고
    • Patterns of Cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis
    • Correale J, Gilmore W, McMillan M, Li S, McCarthy K, Le T, Weiner LP. Patterns of Cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J Immunol 1995; 154:2959-2968.
    • (1995) J Immunol , vol.154 , pp. 2959-2968
    • Correale, J.1    Gilmore, W.2    McMillan, M.3    Li, S.4    McCarthy, K.5    Le, T.6    Weiner, L.P.7
  • 94
    • 0031012659 scopus 로고    scopus 로고
    • Antigen presentation by autoreactive proteolipid protein peptide-specific T cell clones from chronic progressive multiple sclerosis patients: Roles of co-stimulatory B7 molecules and IL-12
    • Correale J, McMillan M, Li S, McCarthy K, Le T, Weiner LP. Antigen presentation by autoreactive proteolipid protein peptide-specific T cell clones from chronic progressive multiple sclerosis patients: roles of co-stimulatory B7 molecules and IL-12. J Neuroimmunol 1997; 72:27-43.
    • (1997) J Neuroimmunol , vol.72 , pp. 27-43
    • Correale, J.1    McMillan, M.2    Li, S.3    McCarthy, K.4    Le, T.5    Weiner, L.P.6
  • 95
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch NL, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987; 1:893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, N.L.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 96
    • 0023221133 scopus 로고
    • Treatment of MS with gamma interferon: Exacerbations associated with activation of the immune system
    • Panitch NL, Hirsch RL, Schindler J, Johnson KP. Treatment of MS with gamma interferon: exacerbations associated with activation of the immune system. Neurology 1987; 37:1097-1102.
    • (1987) Neurology , vol.37 , pp. 1097-1102
    • Panitch, N.L.1    Hirsch, R.L.2    Schindler, J.3    Johnson, K.P.4
  • 97
    • 0025852567 scopus 로고
    • Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
    • Selmaj KW, Raine CS, Cannella B, Brosnan CF. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991; 87:949-954.
    • (1991) J Clin Invest , vol.87 , pp. 949-954
    • Selmaj, K.W.1    Raine, C.S.2    Cannella, B.3    Brosnan, C.F.4
  • 98
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H, Wietzerbin J. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol Scand 1988; 78:318-323.
    • (1988) Acta Neurol Scand , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3    Falcoff, E.4    Kirchner, H.5    Wietzerbin, J.6
  • 99
    • 0025247797 scopus 로고
    • Stress proteins and immunology
    • Young RA. Stress proteins and immunology. Annu Rev Immunol 1990; 8:401-420.
    • (1990) Annu Rev Immunol , vol.8 , pp. 401-420
    • Young, R.A.1
  • 100
    • 0027972656 scopus 로고
    • Cytokine induction of heat shock protein expression in human oligodendrocytes: An interleukin-1 mediated mechanism
    • DiSouza SD, Antel JP, Freedman MS. Cytokine induction of heat shock protein expression in human oligodendrocytes: an interleukin-1 mediated mechanism. J Neuroimmunol 1994; 50:17-24.
    • (1994) J Neuroimmunol , vol.50 , pp. 17-24
    • DiSouza, S.D.1    Antel, J.P.2    Freedman, M.S.3
  • 101
    • 0029070407 scopus 로고
    • Constitutive and inducible expression of heat shock protein HSP72 in oligodendrocytes in culture
    • Satoh J, Kim SU. Constitutive and inducible expression of heat shock protein HSP72 in oligodendrocytes in culture. NeuroReport 1995; 6:1081-1084.
    • (1995) NeuroReport , vol.6 , pp. 1081-1084
    • Satoh, J.1    Kim, S.U.2
  • 102
    • 0029953116 scopus 로고    scopus 로고
    • Antisense oilgonucleotide to the 70-kDa heat shock protein inhibits synthesis of myelin basic protein
    • Aquino DA, Lopez C, Farooq M. Antisense oilgonucleotide to the 70-kDa heat shock protein inhibits synthesis of myelin basic protein. Neurochem Res 1996; 21:417-422.
    • (1996) Neurochem Res , vol.21 , pp. 417-422
    • Aquino, D.A.1    Lopez, C.2    Farooq, M.3
  • 105
    • 0030612483 scopus 로고    scopus 로고
    • Expression of aB-crystallin in glia cells during lesional development in multiple sclerosis
    • Bajramovic JJ, Lassmann H, van Noort JM. Expression of aB-crystallin in glia cells during lesional development in multiple sclerosis. J Neuroimmunol 1997; 78:143-151.
    • (1997) J Neuroimmunol , vol.78 , pp. 143-151
    • Bajramovic, J.J.1    Lassmann, H.2    Van Noort, J.M.3
  • 106
    • 0029071796 scopus 로고
    • Increased frequency of γδ T cells in the cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: Reactivity, cytotoxicity and T cell receptor V gene rearrangements
    • Stinissen P, Vandevyver C, Medaer R, Vandegaer L, Nies J, Tuyls L, et al. Increased frequency of γδ T cells in the cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: reactivity, cytotoxicity and T cell receptor V gene rearrangements. J Immunol 1995; 154:4883-4894.
    • (1995) J Immunol , vol.154 , pp. 4883-4894
    • Stinissen, P.1    Vandevyver, C.2    Medaer, R.3    Vandegaer, L.4    Nies, J.5    Tuyls, L.6
  • 108
    • 0009575201 scopus 로고    scopus 로고
    • Epstein-Barr virus induced expression and HLA-DR restricted presentation of aB-crystallin, a major human myelin antigen
    • van Sechel AC, van Stipdonk MJB, Persoon-Deen C, van Noort JM. Epstein-Barr virus induced expression and HLA-DR restricted presentation of aB-crystallin, a major human myelin antigen [Abstract]. J Neuroimmunol 1998; 90:38.
    • (1998) J Neuroimmunol , vol.90 , pp. 38
    • Van Sechel, A.C.1    Van Stipdonk, M.J.B.2    Persoon-Deen, C.3    Van Noort, J.M.4
  • 109
    • 0027074381 scopus 로고
    • T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kD heat shock proteins in multiple sclerosis
    • Salvetti M, Buttinelli C, Ristori G, Carbonari M, Cherchi M, Fiorelli M, et al. T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kD heat shock proteins in multiple sclerosis. J Autoimmunity 1992; 5:691-702.
    • (1992) J Autoimmunity , vol.5 , pp. 691-702
    • Salvetti, M.1    Buttinelli, C.2    Ristori, G.3    Carbonari, M.4    Cherchi, M.5    Fiorelli, M.6
  • 110
    • 0029892540 scopus 로고    scopus 로고
    • The immune response to mycobacterial 70-kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis
    • Salvetti M, Ristori G, Buttinelli C, Fiori P, Falcone M, Britton W, et al. The immune response to mycobacterial 70-kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis. J Neuroimmunol 1996; 65:143-153.
    • (1996) J Neuroimmunol , vol.65 , pp. 143-153
    • Salvetti, M.1    Ristori, G.2    Buttinelli, C.3    Fiori, P.4    Falcone, M.5    Britton, W.6
  • 111
    • 0027988539 scopus 로고
    • Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis
    • Banki K, Colombo E, Sia F, Halladay D, Mattson DH, Tatum AH, et al. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J Exp Med 1994; 180:1649-1663.
    • (1994) J Exp Med , vol.180 , pp. 1649-1663
    • Banki, K.1    Colombo, E.2    Sia, F.3    Halladay, D.4    Mattson, D.H.5    Tatum, A.H.6
  • 112
    • 0030901670 scopus 로고    scopus 로고
    • Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis
    • Colombo E, Banki K, Tatum AH, Daucher J, Ferrante P, Murray RS, et al. Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis. J Clin Invest 1997; 99:1238-1250.
    • (1997) J Clin Invest , vol.99 , pp. 1238-1250
    • Colombo, E.1    Banki, K.2    Tatum, A.H.3    Daucher, J.4    Ferrante, P.5    Murray, R.S.6
  • 113
    • 0032080456 scopus 로고    scopus 로고
    • Dual implication of 2′,3′-cyclic nucleotide 3′ phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis
    • Walsh MJ, Murray JM. Dual implication of 2′,3′-cyclic nucleotide 3′ phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis. J Clin Invest 1998; 101:1923-1931.
    • (1998) J Clin Invest , vol.101 , pp. 1923-1931
    • Walsh, M.J.1    Murray, J.M.2
  • 114
    • 0343487828 scopus 로고    scopus 로고
    • 2′-3′-cyclic nucleotide 3′-phosphodiesterase: A novel candidate autoantigen in demyelinating diseases
    • Rosener M, Muraro PA, Riethmuller A, Kalbus M, Sappler G, Thompson RJ, et al. 2′-3′-cyclic nucleotide 3′-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases. J Neuroimmunol 1997; 75:28-34.
    • (1997) J Neuroimmunol , vol.75 , pp. 28-34
    • Rosener, M.1    Muraro, P.A.2    Riethmuller, A.3    Kalbus, M.4    Sappler, G.5    Thompson, R.J.6
  • 116
    • 0030861145 scopus 로고    scopus 로고
    • Multiple sclerosis: Comparison of the human T cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis
    • Schmidt S, Linnington C, Zipp F, Sotgiu S, de Waal Malefyt R, Wekerle H, Hohlfeld R. Multiple sclerosis: comparison of the human T cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis. Brain 1997; 120:1437-1445.
    • (1997) Brain , vol.120 , pp. 1437-1445
    • Schmidt, S.1    Linnington, C.2    Zipp, F.3    Sotgiu, S.4    De Waal Malefyt, R.5    Wekerle, H.6    Hohlfeld, R.7
  • 117
    • 0029987839 scopus 로고    scopus 로고
    • The instructive role of innate immunity in the acquired immune response
    • Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996; 272:50-53.
    • (1996) Science , vol.272 , pp. 50-53
    • Fearon, D.T.1    Locksley, R.M.2
  • 118
    • 0029122495 scopus 로고
    • + cells: New clues to their origin, specificity, and function
    • + cells: new clues to their origin, specificity, and function. J Exp Med 1995; 182:633-638.
    • (1995) J Exp Med , vol.182 , pp. 633-638
    • MacDonald, H.R.1
  • 119
    • 0028816354 scopus 로고
    • Multiple sclerosis: Limited diversity of the V delta 2-J delta 3 T-cell receptor in chronic active lesions
    • Battistini L, Selmaj K, Kowal C, Ohmen J, Modlin RL, Raince CS, Brosnan CF. Multiple sclerosis: limited diversity of the V delta 2-J delta 3 T-cell receptor in chronic active lesions. Ann Neurol 1995; 37:198-203.
    • (1995) Ann Neurol , vol.37 , pp. 198-203
    • Battistini, L.1    Selmaj, K.2    Kowal, C.3    Ohmen, J.4    Modlin, R.L.5    Raince, C.S.6    Brosnan, C.F.7
  • 120
    • 0026079842 scopus 로고
    • Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis
    • Selmaj K, Brosnan CF, Raine CS. Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc Natl Acad Sci U S A 1991; 88:6452-6456.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 6452-6456
    • Selmaj, K.1    Brosnan, C.F.2    Raine, C.S.3
  • 122
    • 0030924349 scopus 로고    scopus 로고
    • Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of V delta 2J delata 3 lineage in multiple sclerosis patients
    • Liedtke W, Meyer G, Faustmann PM, Warnatz H, Raine CS. Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of V delta 2J delata 3 lineage in multiple sclerosis patients. Int Immunol 1997; 9:1031-1041.
    • (1997) Int Immunol , vol.9 , pp. 1031-1041
    • Liedtke, W.1    Meyer, G.2    Faustmann, P.M.3    Warnatz, H.4    Raine, C.S.5
  • 123
    • 0025790237 scopus 로고
    • Peripheral blood gamma-delta T cells lyse fresh human brain-derived oligodendrocytes
    • Freedman MS, Ruijs TCG, Selin LK, Antel JP. Peripheral blood gamma-delta T cells lyse fresh human brain-derived oligodendrocytes. Ann Neurol 1991; 30:794-800.
    • (1991) Ann Neurol , vol.30 , pp. 794-800
    • Freedman, M.S.1    Ruijs, T.C.G.2    Selin, L.K.3    Antel, J.P.4
  • 124
    • 0032105478 scopus 로고    scopus 로고
    • Mechanism of gamma delta T cell-induced human oligodendrocyte cytotoxicity: Relevance to multiple sclerosis
    • Zeine R, Pon R, Ladiwala U, Antel JP, Filion LG, Freedman MS. Mechanism of gamma delta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis. J Neuroimmunol 1998; 87:49-61. The results of this study suggest that in multiple sclerosis γ/δ T cells may utilize either the Fas-mediated or perforin-based cell cytotoxicity pathways in exerting oligodendrocyte damage. Among them, the perforin pathway is predominant.
    • (1998) J Neuroimmunol , vol.87 , pp. 49-61
    • Zeine, R.1    Pon, R.2    Ladiwala, U.3    Antel, J.P.4    Filion, L.G.5    Freedman, M.S.6
  • 125
    • 0030210745 scopus 로고    scopus 로고
    • Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia
    • Boismenu R, Feng L, Xia YY, Chang JC, Havran WL. Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J Immunol 1996; 157:985-992.
    • (1996) J Immunol , vol.157 , pp. 985-992
    • Boismenu, R.1    Feng, L.2    Xia, Y.Y.3    Chang, J.C.4    Havran, W.L.5
  • 126
    • 0029901881 scopus 로고    scopus 로고
    • A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse
    • Rajan AJ, Gao Y-L, Raine CS, Brosnan CF. A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J Immunol 1996; 157:941-949.
    • (1996) J Immunol , vol.157 , pp. 941-949
    • Rajan, A.J.1    Gao, Y.-L.2    Raine, C.S.3    Brosnan, C.F.4
  • 127
    • 0030890603 scopus 로고    scopus 로고
    • Mouse CD1-specific NK1 T cells: Development, specificity, and function
    • Bendelac A, Rivera MN, Park SH, Roark JH. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol 1997; 15:535-562.
    • (1997) Annu Rev Immunol , vol.15 , pp. 535-562
    • Bendelac, A.1    Rivera, M.N.2    Park, S.H.3    Roark, J.H.4
  • 128
    • 0027178514 scopus 로고
    • Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain
    • Porcelli S, Yockey CE, Brenner MB, Balk SP. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J Exp Med 1993; 178:1-16.
    • (1993) J Exp Med , vol.178 , pp. 1-16
    • Porcelli, S.1    Yockey, C.E.2    Brenner, M.B.3    Balk, S.P.4
  • 129
    • 0028169443 scopus 로고
    • An invariant V alpha 24-J alpha O/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells
    • Dellabona P, Radovan E, Casorati G, Brockhaus M, Lanzavecchia A. An invariant V alpha 24-J alpha O/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J Exp Med 1994; 180:1171-1176.
    • (1994) J Exp Med , vol.180 , pp. 1171-1176
    • Dellabona, P.1    Radovan, E.2    Casorati, G.3    Brockhaus, M.4    Lanzavecchia, A.5
  • 131
    • 0028177589 scopus 로고
    • CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • Yoshimoto T, Paul WE. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994; 179:1285-1295.
    • (1994) J Exp Med , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 132
    • 0032547849 scopus 로고    scopus 로고
    • CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution
    • Brossay L, Chioda M, Burdin N, Koezuka Y, Casorati G, Dellabona P, Kronenberg M. CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med 1998; 188:1521-1528.
    • (1998) J Exp Med , vol.188 , pp. 1521-1528
    • Brossay, L.1    Chioda, M.2    Burdin, N.3    Koezuka, Y.4    Casorati, G.5    Dellabona, P.6    Kronenberg, M.7
  • 134
    • 0032495536 scopus 로고    scopus 로고
    • Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes
    • Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, et al. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 1998; 391:177-181.
    • (1998) Nature , vol.391 , pp. 177-181
    • Wilson, S.B.1    Kent, S.C.2    Patton, K.T.3    Orban, T.4    Jackson, R.A.5    Exley, M.6
  • 136
    • 0031572502 scopus 로고    scopus 로고
    • Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors
    • Battistini L, Borsellino G, Sawicki G, Poccia F, Salvetti M, Ristori G, Brosnan CF. Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors. J Immunol 1997; 159:3723-3730.
    • (1997) J Immunol , vol.159 , pp. 3723-3730
    • Battistini, L.1    Borsellino, G.2    Sawicki, G.3    Poccia, F.4    Salvetti, M.5    Ristori, G.6    Brosnan, C.F.7
  • 139
    • 0025955351 scopus 로고
    • Protection against experimental encephalomyelitis. Idiotypic autoregulation induced by a nonencephalitogenic T cell clone expressing a cross-reactive T cell receptor V gene
    • Offner H, Vainiene M, Gold DP, Morrison WJ, Wang RY, Hashim GA, Vandenbark AA. Protection against experimental encephalomyelitis. Idiotypic autoregulation induced by a nonencephalitogenic T cell clone expressing a cross-reactive T cell receptor V gene. J Immunol 1991; 146:4165-4172.
    • (1991) J Immunol , vol.146 , pp. 4165-4172
    • Offner, H.1    Vainiene, M.2    Gold, D.P.3    Morrison, W.J.4    Wang, R.Y.5    Hashim, G.A.6    Vandenbark, A.A.7
  • 140
    • 0026693811 scopus 로고
    • Spontaneous development of protective anti-T cell receptor autoimmunity targeted against a natural EAE-regulatory idiotope located within the 39-59 region of the TCR-V beta 8.2 chain
    • Hashim GA, Offner H, Wang RY, Shukla K, Carvalho E, Morrison WJ, Vandenbark AA. Spontaneous development of protective anti-T cell receptor autoimmunity targeted against a natural EAE-regulatory idiotope located within the 39-59 region of the TCR-V beta 8.2 chain. J Immunol 1992; 149:2803-2809.
    • (1992) J Immunol , vol.149 , pp. 2803-2809
    • Hashim, G.A.1    Offner, H.2    Wang, R.Y.3    Shukla, K.4    Carvalho, E.5    Morrison, W.J.6    Vandenbark, A.A.7
  • 141
    • 0027249369 scopus 로고
    • + T cells in recovery from antigen-induced autoimmune disease
    • + T cells in recovery from antigen-induced autoimmune disease. J Exp Med 1993; 178:909-916.
    • (1993) J Exp Med , vol.178 , pp. 909-916
    • Kumar, V.1    Sercarz, E.E.2
  • 142
    • 0030915318 scopus 로고    scopus 로고
    • Regulatory T cells specific for the same framework 3 region of the Vbeta8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis
    • Kumar V, Aziz F, Sercarz E, Miller A. Regulatory T cells specific for the same framework 3 region of the Vbeta8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis. J Exp Med 1997; 185:1725-1733.
    • (1997) J Exp Med , vol.185 , pp. 1725-1733
    • Kumar, V.1    Aziz, F.2    Sercarz, E.3    Miller, A.4
  • 145
    • 0031853145 scopus 로고    scopus 로고
    • Diversity of the anti-T cell receptor immune response and its implications for T cell vaccination therapy of multiple sclerosis
    • Zipp F, Kerschensteiner M, Dornmair K, Malotka J, Schmidt S, Bender A, et al. Diversity of the anti-T cell receptor immune response and its implications for T cell vaccination therapy of multiple sclerosis. Brain 1998; 121:1395-1407.
    • (1998) Brain , vol.121 , pp. 1395-1407
    • Zipp, F.1    Kerschensteiner, M.2    Dornmair, K.3    Malotka, J.4    Schmidt, S.5    Bender, A.6


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