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Volumn 76, Issue 1-2, 1997, Pages 15-28

Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations

Author keywords

Multiple sclerosis; Regulatory immune response; T cell receptor peptide; T cells; Vaccination therapy

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR PEPTIDE VACCINE; UNCLASSIFIED DRUG;

EID: 0031007204     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00028-3     Document Type: Article
Times cited : (41)

References (38)
  • 1
    • 0021784619 scopus 로고
    • The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: Evidence for a key role of activated lymphocytes
    • Bellamy, A.S., Calder, V.L., Feldmann, M. and Davison, A.N. (1985) The distribution of interleukin-2 receptor bearing lymphocytes in multiple sclerosis: Evidence for a key role of activated lymphocytes. Clin. Exp. Immunol. 61, 248-256.
    • (1985) Clin. Exp. Immunol. , vol.61 , pp. 248-256
    • Bellamy, A.S.1    Calder, V.L.2    Feldmann, M.3    Davison, A.N.4
  • 2
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T-lymphocyte lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun, A., Wekerle, H. and Cohen, I.R. (1981a) The rapid isolation of clonable antigen-specific T-lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11, 195-199.
    • (1981) Eur. J. Immunol. , vol.11 , pp. 195-199
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 3
    • 0019487117 scopus 로고
    • Vaccination against EAE with T-lymphocyte lines and cells reactive against myelin basic protein
    • Ben-Nun, A., Wekerle, H. and Cohen, I.R. (1981b) Vaccination against EAE with T-lymphocyte lines and cells reactive against myelin basic protein. Nature 292, 60-61.
    • (1981) Nature , vol.292 , pp. 60-61
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 4
    • 0028955369 scopus 로고
    • T-cell receptor repertoire in polymyositis: Clonal expansion of autoaggressive CD8+ T-cells
    • Bender, A., Ernst, N., Inflesias, A., Dornmair, K., Wekerle, H. and Hohfeld, R. (1995) T-cell receptor repertoire in polymyositis: Clonal expansion of autoaggressive CD8+ T-cells. J. Exp. Med. 181, 1863-1868.
    • (1995) J. Exp. Med. , vol.181 , pp. 1863-1868
    • Bender, A.1    Ernst, N.2    Inflesias, A.3    Dornmair, K.4    Wekerle, H.5    Hohfeld, R.6
  • 6
    • 0024530958 scopus 로고
    • Both rat and mouse T-cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα- And Vβ-chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different
    • Burns, F.R., Li, X., Shen, N., Offner, H., Chou, Y., Vandenbark, A.A. and Heber-Katz, E. (1989) Both rat and mouse T-cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα- and Vβ-chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 169, 27-39.
    • (1989) J. Exp. Med. , vol.169 , pp. 27-39
    • Burns, F.R.1    Li, X.2    Shen, N.3    Offner, H.4    Chou, Y.5    Vandenbark, A.A.6    Heber-Katz, E.7
  • 8
    • 0024603242 scopus 로고
    • T-cell receptor β chain usage in myelin basic protein-specific rat T-lymphocytes
    • Chluba, J., Steeg, C., Becker, A., Wekerle, H. and Epplen, J.T. (1989) T-cell receptor β chain usage in myelin basic protein-specific rat T-lymphocytes. Eur. J. Immunol. 19, 279-284.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 279-284
    • Chluba, J.1    Steeg, C.2    Becker, A.3    Wekerle, H.4    Epplen, J.T.5
  • 9
    • 0026556063 scopus 로고
    • Frequency of T-cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis
    • Chou, Y.K., Bourdette, D.N., Offner, H., Whitham, R., Wang, R.Y., Hashim, G.A. and Vandenbark, A.A. (1992) Frequency of T-cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J. Neuroimmunol. 38, 105-114.
    • (1992) J. Neuroimmunol. , vol.38 , pp. 105-114
    • Chou, Y.K.1    Bourdette, D.N.2    Offner, H.3    Whitham, R.4    Wang, R.Y.5    Hashim, G.A.6    Vandenbark, A.A.7
  • 12
    • 0027459879 scopus 로고
    • Requirement for CD8+ cells in T-cell receptor peptide-induced clonal unresponsiveness
    • Gaur, A., Haspel, R., Mayer, J.P. and Fathman, C.G. (1993) Requirement for CD8+ cells in T-cell receptor peptide-induced clonal unresponsiveness. Science 259, 91-94.
    • (1993) Science , vol.259 , pp. 91-94
    • Gaur, A.1    Haspel, R.2    Mayer, J.P.3    Fathman, C.G.4
  • 13
    • 0025721125 scopus 로고
    • Analysis of T-cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: Conserved CDR3 regions
    • Gold, D.P., Offner, H., Sun, D., Wiley, S., Vandenbark, A.A. and Wilson, D.B. (1991) Analysis of T-cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: Conserved CDR3 regions. J. Exp. Med. 174, 1467-1476.
    • (1991) J. Exp. Med. , vol.174 , pp. 1467-1476
    • Gold, D.P.1    Offner, H.2    Sun, D.3    Wiley, S.4    Vandenbark, A.A.5    Wilson, D.B.6
  • 14
    • 0031007205 scopus 로고    scopus 로고
    • Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCR Vβ6 CDR2 peptide
    • Gold, D.P., Smith, R.A., Golding, A.B., Morgan E.E., Dafashy, T., Nelson J., Diveley, J., Laxer, J.A., Richieri, S.P., Carlo, D.J., Brostoff, S.W. and Wilson, D.B. (1997) Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCR Vβ6 CDR2 peptide. J. Neuroimmunol. 76, 29-38.
    • (1997) J. Neuroimmunol. , vol.76 , pp. 29-38
    • Gold, D.P.1    Smith, R.A.2    Golding, A.B.3    Morgan, E.E.4    Dafashy, T.5    Nelson, J.6    Diveley, J.7    Laxer, J.A.8    Richieri, S.P.9    Carlo, D.J.10    Brostoff, S.W.11    Wilson, D.B.12
  • 15
    • 0027448731 scopus 로고
    • Dominant T-cell receptor β chain variable region Vβ14+ clones in juvenile rheumatoid arthritis
    • Grom, A., Thompson, S.D., Luyrink, L., Passo, M., Choi, E. and Glass, D.N. (1993) Dominant T-cell receptor β chain variable region Vβ14+ clones in juvenile rheumatoid arthritis. Proc. Nat. Acad. Sci. USA 90, 11104-11108.
    • (1993) Proc. Nat. Acad. Sci. USA , vol.90 , pp. 11104-11108
    • Grom, A.1    Thompson, S.D.2    Luyrink, L.3    Passo, M.4    Choi, E.5    Glass, D.N.6
  • 17
    • 0021889168 scopus 로고
    • In vivo activated T-lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Hafler, D.A., Fox, D.A., Manning, M.E., Schlossman, S.F., Reinherz, E.L. and Weiner, H.L. (1985) In vivo activated T-lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N. Engl. J. Med. 312, 1405-1411.
    • (1985) N. Engl. J. Med. , vol.312 , pp. 1405-1411
    • Hafler, D.A.1    Fox, D.A.2    Manning, M.E.3    Schlossman, S.F.4    Reinherz, E.L.5    Weiner, H.L.6
  • 18
    • 0024468234 scopus 로고
    • Vaccination against experimental allergic encephalomyelitis with T-cell receptor peptides
    • Howell, M.D., Winters, S.T., Olee, T., Powell, H.C., Carlo, D.J. and Brostoff, S.W. (1989) Vaccination against experimental allergic encephalomyelitis with T-cell receptor peptides. Science 246, 668-669.
    • (1989) Science , vol.246 , pp. 668-669
    • Howell, M.D.1    Winters, S.T.2    Olee, T.3    Powell, H.C.4    Carlo, D.J.5    Brostoff, S.W.6
  • 19
    • 0028887507 scopus 로고
    • Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyelitis
    • Kumar, V. and Sercarz, E. (1995) Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyelitis. J. Immunol. 154, 1941-1950.
    • (1995) J. Immunol. , vol.154 , pp. 1941-1950
    • Kumar, V.1    Sercarz, E.2
  • 20
    • 0025790454 scopus 로고
    • The genomic structure of human Vβ6 T-cell antigen receptor genes
    • Li, Y., Szabo, P. and Posnett, D.N. (1991) The genomic structure of human Vβ6 T-cell antigen receptor genes. J. Exp. Med. 174, 1537-1547.
    • (1991) J. Exp. Med. , vol.174 , pp. 1537-1547
    • Li, Y.1    Szabo, P.2    Posnett, D.N.3
  • 23
    • 0025969733 scopus 로고
    • T-cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis
    • Offner, H., Hashim, G. and Vandenbark, A.A. (1991) T-cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251, 430-432.
    • (1991) Science , vol.251 , pp. 430-432
    • Offner, H.1    Hashim, G.2    Vandenbark, A.A.3
  • 24
    • 0027293755 scopus 로고
    • Where, when and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis
    • Offner, H., Buenafe, A.C., Vainiene, M., Celnik, B., Weinberg, A.D., Gold, D.P., Hashim, G. and Vandenbark, A.A. (1993) Where, when and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis. J. Immunol. 151, 506-517.
    • (1993) J. Immunol. , vol.151 , pp. 506-517
    • Offner, H.1    Buenafe, A.C.2    Vainiene, M.3    Celnik, B.4    Weinberg, A.D.5    Gold, D.P.6    Hashim, G.7    Vandenbark, A.A.8
  • 26
    • 0001370778 scopus 로고
    • Experimental autoimmune (allergic) encephalomyelitis: Induction, pathogenesis and suppression
    • In: P.A. Miescher and H.J. Müller-Eberhard (Eds.), Grune and Stratton, New York
    • Paterson, P.Y. (1976) Experimental autoimmune (allergic) encephalomyelitis: Induction, pathogenesis and suppression. In: P.A. Miescher and H.J. Müller-Eberhard (Eds.), Textbook of Immunopathology, 2nd Ed. Grune and Stratton, New York, p. 179.
    • (1976) Textbook of Immunopathology, 2nd Ed. , pp. 179
    • Paterson, P.Y.1
  • 27
    • 0001917043 scopus 로고
    • In: M. Samter, D.W. Talmage, M.M. Frank, K.F. Austin and H.N. Claman (Eds.), Little Brown & Co., Boston, MA
    • Paterson, P.Y. and Swanborg, R.H. (1988) In: M. Samter, D.W. Talmage, M.M. Frank, K.F. Austin and H.N. Claman (Eds.), Immunological Diseases, 4th Ed. Little Brown & Co., Boston, MA, p. 1877.
    • (1988) Immunological Diseases, 4th Ed. , pp. 1877
    • Paterson, P.Y.1    Swanborg, R.H.2
  • 30
    • 0024406282 scopus 로고
    • A susceptibility locus for multiple sclerosis is linked to the T-cell receptor β chain complex
    • Seboun, E, Robinson, M.A., Doolittle, T.H., Ciulla, T.A., Kindt, J.J. and Hauser, S.J. (1989). A susceptibility locus for multiple sclerosis is linked to the T-cell receptor β chain complex. Cell 57, 1095-1100.
    • (1989) Cell , vol.57 , pp. 1095-1100
    • Seboun, E.1    Robinson, M.A.2    Doolittle, T.H.3    Ciulla, T.A.4    Kindt, J.J.5    Hauser, S.J.6
  • 31
    • 0023904339 scopus 로고
    • Suppression of experimentally induced autoimmune encephalomyelitis by cytotoxic T-T interactions
    • Sun, D., Qin, Y., Chluba, J., Epplen, J.T. and Wekerle, H. (1988) Suppression of experimentally induced autoimmune encephalomyelitis by cytotoxic T-T interactions. Nature 332, 843-845.
    • (1988) Nature , vol.332 , pp. 843-845
    • Sun, D.1    Qin, Y.2    Chluba, J.3    Epplen, J.T.4    Wekerle, H.5
  • 32
    • 1842340825 scopus 로고
    • Organization and sequences of the diversity, joining and constant region genes of the human T-cell receptor β chain
    • Toyonaga, B., Yoshikai, Y., Vadasz, V., Chin, B. and Mak, T.W. (1985) Organization and sequences of the diversity, joining and constant region genes of the human T-cell receptor β chain. Proc. Natl. Acad. Sci. USA 82, 8624-8628.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 8624-8628
    • Toyonaga, B.1    Yoshikai, Y.2    Vadasz, V.3    Chin, B.4    Mak, T.W.5
  • 33
    • 0024425273 scopus 로고
    • Immunization with a synthetic T-cell receptor V region peptide protects against EAE
    • Vandenbark, A.A., Hashim, G. and Offner, H. (1989) Immunization with a synthetic T-cell receptor V region peptide protects against EAE. Nature 341, 541-544.
    • (1989) Nature , vol.341 , pp. 541-544
    • Vandenbark, A.A.1    Hashim, G.2    Offner, H.3
  • 34
    • 0021636525 scopus 로고
    • Multiple sclerosis as a disease of immune regulation
    • Waksman, B.H. and Reynolds, W.E. (1984) Multiple sclerosis as a disease of immune regulation. Proc. Soc. Exp. Biol. Med. 175, 282-294.
    • (1984) Proc. Soc. Exp. Biol. Med. , vol.175 , pp. 282-294
    • Waksman, B.H.1    Reynolds, W.E.2
  • 36
    • 0024477135 scopus 로고
    • Idiotypic regulation of T-cells in graft-versus-host disease and autoimmunity
    • Wilson, D.B. (1989) Idiotypic regulation of T-cells in graft-versus-host disease and autoimmunity. Immunol. Rev. 107, 159-177.
    • (1989) Immunol. Rev. , vol.107 , pp. 159-177
    • Wilson, D.B.1
  • 37
    • 0028238201 scopus 로고
    • Clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide
    • Wucherpfennig, K.W., Zhang, J., Witek, C., Matsui, M., Modabber, Y., Ota, K. and Hafler, D.A. (1994) Clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152, 5581-5592.
    • (1994) J. Immunol. , vol.152 , pp. 5581-5592
    • Wucherpfennig, K.W.1    Zhang, J.2    Witek, C.3    Matsui, M.4    Modabber, Y.5    Ota, K.6    Hafler, D.A.7
  • 38
    • 0027957780 scopus 로고
    • Increased frequency of interleukin-2 responsive T-cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Zhang, J., Markovic-Plese, S., Lacet, B., Raus, J., Weiner, H.L. and Hafler, D.A. (1994) Increased frequency of interleukin-2 responsive T-cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179, 973-984.
    • (1994) J. Exp. Med. , vol.179 , pp. 973-984
    • Zhang, J.1    Markovic-Plese, S.2    Lacet, B.3    Raus, J.4    Weiner, H.L.5    Hafler, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.