Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRVβ6 CDR2 peptide

Journal of Neuroimmunology

Volumn 76, Issue 1-2, 1997, Pages 29-38

  Gold, Daniel P ^a   Smith, Richard A ^b   Golding, Anna B ^a   Morgan, Elizabeth E ^c   Dafashy, Tanya ^b   Nelson, James ^b   Smith, Larry ^c   Joji Diveley, ^c   Laxer, Julie A ^c   Richieri, Steven P ^c   Carlo, Dennis J ^c   Brostoff, Steven W ^c   Wilson, Darcy B ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b Neurology Center   (United States)

^c Orchestra Therapeutics Inc   (United States)

Author keywords

Multiple sclerosis; Regulatory immune response; T cell receptor peptide; T cells; Vaccination therapy

Indexed keywords

FREUND ADJUVANT; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR PEPTIDE VACCINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOREGULATION; INJECTION PAIN; INTRAMUSCULAR DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; MULTIPLE SCLEROSIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AMINO ACID SEQUENCE; FEMALE; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; VACCINATION;

EID: 0031007205     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00029-5     Document Type: Article

References (30)

1. Begovich, A.B., McClure, G.R., Suraj, V.C., Helmuth, R.C., Fildes, N., Bugawan, T.L., Erlich, H.A. and Klitz, W. (1992) Polymorphism, recombination and linkage disequilibrium within the HLA class II region. J. Immunol. 148, 249-258.
2. Ben-Nun, A., Wekerle, H. and Cohen, I.R. (1981) Vaccination against EAE with T-lymphocyte lines and cells reactive against myelin basic protein. Nature 292, 60-61.
3. Bourdette, D.N., Whitham, R.H., Chou, Y.K., Morrison, W.J., Atherton, J., Kenny, C., Liefeld, D., Hashim, G.A., Offner, H. and Vandenbark, A.A. (1994) Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides. J. Immunol. 152, 2510-2519.
4. Burns, F.R., Li, X., Shen, N., Offner, H., Chou, Y., Vandenbark, A.A. and Heber-Katz, E. (1989) Both rat and mouse T-cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα- and Vβ-chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 169, 27-39.
5. Chluba, J., Steeg, C., Becker, A., Wekerle, H. and Epplen, J.T. (1989) T-cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol. 19, 279-284.
6. Chou, Y.K., Morrison, W.J., Weinberg, A.D., Dedrick, R., Whitham, R., Bourdette, D.N., Hashim, G., Offner, H. and Vandenbark, A.A. (1994b) Immunity to TCR peptides in multiple sclerosis. II. T-cell recognition of Vβ5.2 and Vβ6.1 CDR2 peptides. J. Immunol. 152, 2520-2529.
7. Ellerman, K.E., Powers, J.M. and Brostoff, S.W. (1988) A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis. Nature 331, 265-267.
8. Erlich, H., Bugawan, T., Begovich, A.B., Scharf, S., Griffity, R., Saiki, R., Higuchi, R. and Walsh, P.S. (1991) HLA-DR, -DQ and -DP typing using PCR amplification and immobilized probes. Eur. J. Immunogenet. 18, 33-55.
9. Gaur, A., Haspel, R., Mayer, J.P. and Fathman, C.G. (1993) Requirement for CD8+ cells in T-cell receptor peptide-induced clonal unresponsiveness. Science 259, 91-94.
10. Gold, D.P., Offner, H., Sun, D., Wiley, S., Vandenbark, A.A. and Wilson, D.B. (1991) Analysis of T-cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: Conserved CDR3 regions. J. Exp. Med. 174, 1467-1476.
11. Howell, M.D., Winters, S.T., Olee, T., Powell, H.C., Carlo, D.J. and Brostoff, S.W. (1989) Vaccination against experimental allergic encephalomyelitis with T-cell receptor peptides. Science 246, 668-669.
12. Imrich, H., Kugler, C., Torres-Nagel, N., Durries, R. and Hunig, T. (1995) Prevention and treatment of Lewis rat experimental allergic encephalomyelitis with a monoclonal antibody to the T-cell receptor Vβ8.2 segment. Eur. J. Immunol. 25, 1960-1964.
13. Karpus, W.J., Gould, K.E. and Swanborg, R.H. (1992) CD4+ suppressor cells of autoimmune encephalomyelitis respond to T-cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur. J. Immunol. 22, 1757-63.
14. Kumar, V. and Sercarz, E. (1995) Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyelitis. J. Immunol. 154, 1941-1950.
15. Lider, O., Rashef, T., Beraud, E., Ben-Nun, A. and Cohen, I.R. (1988) Anti-idiotypic network induced by T-cell vaccination against experimental autoimmune encephalomyelitis. Science 239, 181-183.
16. Margalit, H., Sprouge, J.L., Cornette, J.L., Cease, K.P., Delisi, C. and Berzofsky, J. (1987) Prediction of immunodominant T-cell antigenic sites from the primary sequence. J. Immunol. 138, 2213-2224.
17. Merrifield, R.B. (1978) Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85, 2149-2154.
18. Mitchell, A.R., Kent, S.B.H., Englehard, M. and Merrifield, R.B. (1978). A new synthetic route to tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenyl-acetamidomethyl-resin, an improved support for solid-phase peptide synthesis. J. Org. Chem. 43, 2845-2852.
19. Offner, H., Buenafe, A.C., Vainiene, M., Celnik, B., Weinberg, A.D., Gold, D.P., Hashim, G. and Vandenbark, A.A. (1993) Where, when and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis. J. Immunol. 151, 506-517.
20. Oksenberg, J.R., Panzara, M.A., Begovich, A.B., Mitchell, D., Erlich, H.A., Murray, R.S., Shimonkevitz, R., Sherritt, R.M., Rothbard, J., Bernard, C.C.A. and Steinman, L. (1993). Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362, 68-70.
21. Poser, C.M., Paty, D.W., Scheinberg, L., MacDonald, W.I., Davis, F.A., Ebers, G.C., Johnson, K.P., Sibley, W.A., Silberberg, D.H. and Tourtellotte, W.W. (1983) New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann. Neurol. 13, 227-231.
22. Qin, Y, Sun, D. and Wekerle, H. (1992). Immune regulation in self tolerance: Functional elimination of a self-reactive, counterregulatory CD8+ T-lymphocyte circuit by neonatal transfer of encephalitogenic CD4+ T-cell lines. Eur. J. Immunol. 22, 1193-1198.
23. Rothbard, J.B. and Taylor, W.R. (1988). A sequence pattern common to T-cell epitopes. EMBO J. 7, 93-100.
24. Seboun, E, Robinson, M.A., Doolittle, T.H., Ciulla, T.A., Kindt, J.J. and Hauser, S.J. (1989). A susceptibility locus for multiple sclerosis is linked to the T-cell receptor β chain complex. Cell 57, 1095-1100.
25. Sun, D., Qin, Y., Chluba, J., Epplen, J.T. and Wekerle, H. (1988) Suppression of experimentally induced autoimmune encephalomyelitis by cytotoxic T-T interactions. Nature 332, 843-845.
26. Vandenbark, A.A., Hashim, G. and Offner, H. (1989) Immunization with a synthetic T-cell receptor V region peptide protects against EAE. Nature 341, 541-544.
27. Waksman, B.H. and Reynolds, W.E. (1984) Multiple sclerosis as a disease of immune regulation. Proc. Soc. Exp. Biol. Med. 175, 282-294.
28. Weiner, H.L., Friedman, A., Miller, A., Khoury, S.J., Al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E. and Haffler, D.A. (1994) Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12, 809-837.
29. Wilson, D.B., Steinman, L. and Gold, D.P. (1993) The V-region disease hypothesis: New evidence suggests it is probably wrong. Immunol. Today 14, 376-80.
30. Wilson, D.B., Golding, A.B., Smith, R.A., Dafashy, T., Nelson, J., Smith, L., Carlo, D.J., Brostoff, S.T. and Gold, D.P. (1997) Results of a phase I clinical trial of a T-cell receptor peptide vaccine in patients with multiple sclerosis. I. Analysis of T-cell receptor utilization in CSF cell populations. J. Neuroimmunol. 76, 15-28.