A common TCR V-D-J sequence in Vβ13.1 T cells recognizing an immunodominant peptide of myelin basic protein in multiple sclerosis

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 3530-3538

  Hong, Jian ^a,b   Zang, Ying C Q ^a,b   Tejada Simon, Maria V ^a,b   Kozovska, Milena ^a,b   Li, Sufang ^a,b   Singh, Rana A K ^a   Yang, Deye ^a   Rivera, Victor M ^a   Killian, James K ^a   Zhang, Jingwu Z ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EPITOPE; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DNA DETERMINATION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE CLONE; MOLECULAR CLONING; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; T LYMPHOCYTE SUBPOPULATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CLONE CELLS; CLONING, MOLECULAR; DNA PRIMERS; DNA, RECOMBINANT; EPITOPES, T-LYMPHOCYTE; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; IMMUNODOMINANT EPITOPES; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 0033568626     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Ota, K., M. Matsui, E. L. Milford, G. A. Mackin, H. L. Weiner, and D. A. Hafler. 1990. T cell recognition of an immunodominant MBP epitope in multiple sclerosis. Nature 346:183.
2. Martin, R., M. D. Howell, D. Jaraquemada, M. Flerlage, J. Richert, S. Brostoff, E. O. Long, D. E. McFarlin, and H. F. McFarland. 1991. A MBP peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med. 173:19.
3. Pette, M., K. Fujita, D. Wilkinson, D. M Altmann, J. Trowsdale, G. Giegerich, A. Hinkkanen, J. T. Epplen, L. Kappos, and H. Wekerle. 1990. Myelin autoreactivity in multiple sclerosis: recognition of MBP in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA 87:7968.
4. Zhang, J., S. Markovic, B. Lacet, J. Raus, H. L. Weiner, and D. A. Hafler. 1994. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179:973.
5. Valli, A., A. Sette, L. Kappos, C. Oseroff, J. Sidney, G. Miescher, M. Hochberger, E. D. Albert, and L. Adorini. 1993. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cell from multiple sclerosis patients. J. Clin. Invest. 91:616.
6. Zhang, J., R. Medaer, G. Hashim, C. Ying, E. van den Berg-Loonen, and J. Raus. 1992. Myelin basic protein-specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity, and cytotoxicity. Ann. Neurol. 32:330.
7. Wucherpfennig, K. W., J. Zhang, C. Wilek, M. Matsui, Y. Modabber, K. Ota, and D. A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152:5581.
8. Vandevyver, C., N. Mertens, P. van de Elsen, R. Medaer, J. Raus, and J. Zhang. 1995. Clonal expansion of myelin basic protein-reactive T cells in patients with multiple sclerosis: restricted T cell receptor V gene rearrangements and CDR3 sequence. Eur. J. Immunol. 25:958.
9. Chou, Y. K., D. N. Bourdette, H. Offner, and A. A. Vandenbark. 1992. Frequency ofT cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J. Neuroimmunol. 38:105.
10. Zhang, J., R. Medaer, P. Stinissen, D. A. Hafler, and J. Raus. 1993. MHC restricted depletion of human myelin basic protein reactive T cells by T cell vaccination. Science 261:1451.
11. Vandenbark, A. A., Y. K. Chou, R. Whitham, M. Mass, A. Buenafe, D. Liefeld, D. Kavanagh, S. Cooper, G. A. Hashim, and H. Offner. 1996. Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nat. Med. 10:1109.
12. Johnson, K. P., B. R. Brooks, J. A. Cohen, C. C. Ford, J. Goldstein, R. P. Lisak, L. W. Myers, H. S. Panitch, J. W. Rose, R. B. Schiffer, and the Copolymer 1 Multiple Sclerosis Study Group. 1995. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial Neurology 45:1268.
13. Ben-Nun, A., R. S. Liblau, L. Cohen, D. Lehmann, E. Tournier-Lasserve, A. Rosenzweig, J. W. Zhang, J. Raus, and M.-A. Bach. 1991. Restricted T-cell receptor Vβ gene usage by myelin basic protein-specific T cell clones in multiple sclerosis: predominant genes vary in individuals. Proc. Natl. Acad. Sci. USA 88:2466.
14. Wucherpfennig, K. W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J. L. Strominger, and D. A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279.
15. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science 274:209.
16. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
17. Zang, Y. C. Q., M. Kozovska, I. Aebischer, S. Li, S. Boehme, P. Crowe, V. M. Rivera, and J. Zhang. 1998. Restricted TCR Vα gene rearrangement in T cells recognizing an immunodominant peptide of myelin basic protein in DR2 patients with multiple sclerosis. Int. Immunol. 10:991.
18. Hafler, D. A., M. G. Saadeh, V. K. Kuchroo, E. Milford, and L. Steinman. 1996. TCR usage in human and experimental demyelinating disease. Immunol. Today 17:152.
19. Wucherpfennig, K. W., K. Ota, N. Endo, J. G. Seidman, A. Rosenzweig, H. L. Weiner, D. H. Hafler. 1990. Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248:1016.
20. Oksenberg, J. R., M. A. Panzara, A. B. Begovich, D. Mitchell, H. A. Erlich, R. S. Murray, R. Shimonkevitz, M. Sherritt, J. Rothbard, C. C. Bernard, and L. Steinman. 1993. Selection for T cell receptor V-D-J gene rearrangements with specificity for a myelin basic protein peptide in the brain lesions of multiple sclerosis. Nature 362:68.
21. Poser, C. M. 1983. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:227.
22. Sanger, F., and A. R. Coulson. 1975. A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J. Mol. Biol. 94:441.
23. Salvetti, M., G. Ristori, M. D'Amato, C. Buttinelli, M. Falcone, C. Fieschi, H. Wekerle, and C. Pozzilli. 1993. Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Eur. J. Immnuol. 23:1232.
24. Kozovska, M., Y. C. Q. Zang, I. Aebischer, S. Lnu, V. M. Rivera, P. D. Crowe, S. A. Boehme, and J. Z. Zhang. 1998. T cell receptor recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications. Eur. J. Immunol. 28:1894.
25. Allegretta, M., R. J. Albertini, M. D. Howell, L. R. Smith, R. Martin, H. F. McFarland, S. Sriram, S. Brostoff, and L. Steinman. 1994. Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J. Clin. Invest. 94:105.
26. Zhang, J., S. Markovic-Plese, B. Lacet, J. Raus, H. L. Weiner, D. A. Hafler. 1994. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179:973.
27. Pelfrey, C. M., L. R. Tranquill, S. A. Boehme, H. F. McFarland, and M. J. Lenardo. 1995. Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from patients with multiple sclerosis and normal individuals. J. Immunol. 154:6191.
28. Lasalle, J. M., P. J. Tolentino, G. J. Freeman, L. M. Nadler, and D. A. Hafler. 1992. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J. Exp. Med. 76:177.
29. Bieganowska, K. D., L. J. Ausubel, Y. Modabber, E. Slovik, W. Messersmith, and D. A. Hafler. 1997. Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease. J. Exp. Med 185:1585.
30. Chou, Y. K., W. J. Morrison, A. D. Weinberg, R. Dedrick, R. Whitham, D. N. Bourdette, G. Hashim, H. Offner, and A. A. Vandenbark. 1994. Immunity to TCR peptides in multiple sclerosis. II. T cell recognition of Vβ5.2 and Vβ6.1 CDR2 peptides. J. Immunol. 152:2520.