T cell receptor peptides in treatment of autoimmune disease: Rationale and potential

Journal of Neuroscience Research

Volumn 43, Issue 4, 1996, Pages 391-402

  Vandenbark, A A ^a,b   Hashim, G A ^c   Offner, H ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Department of Molecular Microbiology Oregon Health Sciences University ^*  (United States)

Author keywords

EAE; MS; TCR

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; AUTOIMMUNITY; AUTOREGULATION; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; SCREENING TEST; SHORT SURVEY; TARGET CELL;

EID: 0029930328     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960215)43:4<391::AID-JNR1>3.0.CO;2-A     Document Type: Short Survey

References (86)

1. Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GW, Waldor MK, Zamvil SS, McDevitt HO, Steinman L (1988): Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263-273.
2. Alvord EC, Jr (1984): Species-restricted encephalitogenic determinants. In Alvord, EC Jr, Kies MW, Suckling AJ (eds): "Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis," Vol. 146. New York: Alan R. Liss, Inc., pp 523-537.
3. Bell RB, Lindsey JW, Sobel RA, Hodgkinson S, Steinman L (1993): Diverse T cell receptor Vβ gene usage in the central nervous system in experimental allergic encephalomyelitis. J Immunol 150:4085-4092.
4. Ben-Nun A, Liblau RS, Cohen L, Lehmann D, Tournier-Lasserve E, Rosenzweig A, Jingwu Z, Raus JCM, Bach MA (1991): Restricted T-cell receptor Vβ gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals. Proc Natl Acad Sci USA 88:2466-2470.
5. Beraud E, Reshef T, Vandenbark AA, Offner H, Fritz R, Chou C-HJ, Bernard D, Cohen ER (1986): Experimental autoimmune encephalomyelitis mediated by T lymphocyte lines: genotype of antigen presenting cells influences immunodominant epitope of basic protein. J Immunol 136:511-515.
6. Bourdette DN, Whitham RH, Chou YK, Morrison WJ, Atherton J, Kenny C, Liefeld D, Hashim GA, Offner H, Vandenbark AA (1994a): Immunity to T cell receptor peptides in multiple sclerosis. I. Successful immunization of patients with synthetic Vβ5.2 and Vβ6.1 CDR2 peptides. J Immunol 152:2510-2519.
7. Bourdette DN, Whitham RH, Chou YK, Buenafe A, Hashim GA, Offner H, Vandenbark AA (1994b): Successful immunization of multiple sclerosis patients with synthetic TCR Vβ peptides. J Neuroimmunol (Abstr) 54:154.
8. Broeren CPM, Lucassen MA, van Stipdonk MJB, van der Zee R, Boog CJP, Kusters JG, van Eden W (1994): CDR1 T-cell receptor β-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions. Proc Natl Acad Sci USA 91:5997-6001.
9. Buenafe AC, Vainieae M, Celnik B, Vandenbark AA, Offner H (1994): Analysis of Vβ8-CDR3 sequences derived from the CNS of Lewis rats with experimental autoimmune encephalomyelitis. J Immunol 153:386-394.
10. Burns FR, Li X, Shen N, Offner H, Chou Y, Vandenbark AA, Heber-Katz E (1989): Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 169:27-39.
11. Burns J, Littlefield K, Gomez C, Kumar V (1991): Assessment of antigenic determinants for the human T cell response against myelin basic protein using overlapping synthetic peptides. J Neuroimmunol 31:105.
12. Chou YK, Henderikx P, Vainiene M, Whitham R, Bourdette D, Chou C-HJ, Hashim GA, Offner H, Vandenbark AA (1991): Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein. J Neurosci Res 28:280-290.
13. Chou YK, Bourdette DM, Offner H, Whitham R, Wang R, Hashim GA, Vandenbark AA (1992): Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J Neuroimmunol 38:105-114.
14. Chou YK, Morrison WJ, Weinberg AD, Dedrick R, Whitham R, Bourdette DN, Hashim G, Offner H, Vandenbark AA (1994a): Immunity to T cell receptor peptides in multiple sclerosis. II. T cell recognition of Vβ5.2 and Vβ6.1 CDR2 peptides. J Immunol 152:2520-2529.
15. Chou YK, Buenafe AC, Dedrick R, Morrison WJ, Bourdette DN, Whitham R, Atherton J, Lane J, Spoor E, Hashim GA, Offner H, Vandenbark AA (1994b): T cell receptor Vβ gene usage in the recognition of myelin basic protein by cerebrospinal fluid- and blood-derived T cells from patients with multiple sclerosis. J Neurosci Res 37:169-181.
16. Cohen IR (1991): T-cell vaccination in immunological disease. J Intern Med 230:471-477.
17. Desquenne-Clark L, Esch TR, Otvos Jr. L, Heber-Katz E (1991): T cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc Natl Acad Sci USA 88:7219-7223.
18. Fritz RB, Chou C-HJ, McFarlin DE (1983): Induction of EAE in PL/J and (SJL/JxPL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant. J Immunol 130:191.
19. Gaur A, Haspel R, Mayer JP, Fathman CG (1993): Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness. Science 259:91-94.
20. Giegerich G, Pette M, Mainl E, Epplen JT, Wekerle H, Hinkkanen A (1992): Diversity of T cell receptor a and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes. Eur J Immunol 22:753-758
21. Gold DP (1994): TCR V gene usage in autoimmunity. Curr Opin Immunol 6:907-912.
22. Gold DP, Offner H, Sun D, Wilery S, Vandenbark AA, Wilson DB (1991): Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med 174:1467-1476.
23. Goss JA, Alexander-Miller MA, Gorka J, Rye MW, Connolly JM, Hansen TH (1993): Specific prolongation of allograft survival by a T-cell-receptor-derived peptide. Proc Natl Acad Sci USA 90:9872-9876.
24. Gould KE, Stepaniak JA, Swanborg RH (1994): Variable susceptibility of Lewis rats to experimental autoimmune encephalomyelitis. J Neuroimmunol 54:145-146.
25. Goverman J, Woods A, Larson L, Weinver LP, Hood L, Zaller DM (1993): Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551-560.
26. Gregorian SK, Lee WP, Doudikian N, Amento EP (1993): Two distinct T cell receptor peptides independently regulate experimental autoimmune neuritis. Am Assoc Immunol 150:28A.
27. Haqqi TM, Qu X-M, Ma J, Sy MS (1995): Immunization with TCR Vβ region peptides completely prevents the induction of collagen induced arthritis. 9th Int Congress Immunol Abstr 5014:845.
28. Hashim GA, Vandenbark AA, Galang AB, Diamanduros T, Carvalho E, Srinivasan J, Jones R, Vainiene M, Morrison WJ, Offner H (1990): Antibodies specific for a Vβ8 T cell receptor peptide suppress experimental autoimmune encephalomyelitis. J Immunol 144:4621-4627.
29. Hawes GE, Struyk L, Godthelp BC, van den Elsen PJ (1995): Limited restriction in the TCR-αβ V region usage of antigen-specific clones. J Immunol 154:555-566.
30. Heber-Katz E, Acha-Orbea H (1989): The V-region disease hypothesis: evidence from autoimmune encephalomyelitis. Immunol Today 10:164-169.
31. Howell MD, Winters ST, Olee T, Powell HC, Carlo DJ, Brostoff SW (1989): Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246:668-670.
32. Jiang H, Sercarz E, Nitecki D, Pernis B (1991): The problem of presentation of T cell receptor peptides by activated T cells. Ann NY Acad Sci 636:28-32.
33. Joshi N, Usuku K, Hauser SL (1993): The T-cell response to myelin basic protein in familial multiple sclerosis: diversity of fine specificity, restricting elements, and T-cell receptor usage. Ann Neurol 34:385-393.
34. Jung S, Schluesener HJ, Toyka KV, Hartung H-P (1993): Modulation of EAE by vaccination with T cell receptor peptides: Vβ8 T cell receptor peptide-specific CD4+ lymphocytes lack direct immunoregulatory activity. J Neuroimmunol 45:15-22.
35. Kawano YI, Sasamoto Y, Kotake S, Thurau SR, Wiggert B, Gery I (1991): Trial of vaccination against experimental autoimmune uveoretinitis with a T-cell receptor peptide. Curr Eye Res 10:789-795.
36. Klausner RD, Lippincott-Schwartz J, Bonifacino JS (1990): The T cell antigen receptor: insights into organelle biology. Annu Rev Cell Biol 6:403-431.
37. Konat G, Offner H (1982): Density distribution of myelin fragments isolated from control and multiple sclerosis brains. Neurochem Int 4:241-246.
38. Kotzin BL, Karuturi S, Chou YK, Lafferty J, Forrester JM, Better M, Nedwin GE, Offner H, Vandenbark AA (1991): Preferential T cell receptor Vβ gene usage in myelin basic protein reactive T cell clones from patients with multiple sclerosis. Proc Natl Acad Sci USA 88:9161-9165.
39. Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB (1991): Induction of experimental allergic encephalomyelitis by myelin proteolipid protein specific T cell clones and synthetic peptides. Pathobiology 59:305-312.
40. Kuchroo VK, Sobel RA, Laning JC, Martin CA, Greenfield E, Dorf ME, Lees MB (1992): Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myefin proteolipid protein. Fine specificity and T cell receptor Vβ usage. J Immunol 148:3776-3782.
41. Kuhrober A, Schirmbeck R, Reimann J (1994): Vaccination with T cell receptor peptides primes anti-receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL. Eur J Immunol 24:1172-1180.
42. Kumar V, Sercarz EE (1993): The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med 178:909-916.
43. Kumar V, Sercarz E (1995): Self-determinant selection and selective regulation. In Adorini L (ed): "Selective Immunosuppression: Basic Concepts and Clinical Applications." Basel: Karger pp 1-19.
44. Lehmann PV, Forsthuber T, Miller A, Sercarz EE (1992): Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155-157.
45. Marchalonis JJ, Kaymaz H, Dedeoglu F, Schluter SF, Yocum DE, Edmundson AB (1992): Human autoantibodies reactive with synthetic autoantigens from T-cell receptor β chain. Proc Natl Acad Sci USA 89:3325-3329.
46. Marchalonis JJ, Deghanpisheh K, Huang D, Schluter SF, Watson RR (1994): Autoantibodies to T-cell receptors following infection by murine retrovirus. Lymphology 275:853.
47. Margalit H, Spouge JL, Cornette JL, Ease KB, DeLisi C, Bersofsky JA (1987): Prediction of immunodominant helper T cell antigenic sites from the primary sequence. J Immunol 138:2213-2229.
48. Martin R, Howell MD, Jaraquemada D, Flerlage M, Richert J, Brostoff S, Long EO, McFarlin DE, McFarland HF (1991): A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J Exp Med 172:19-24.
49. Martin R, Utz U, Coligan JE, Richert JR, Flerlage M, Robinson E, Stone R, Biddison WE, McFarlin DE, McFarland HF (1992): Diversity in fine specificity and T cell receptor usage of the human CD4 + cytotoxic T cell response specific for the immunodominant myelia basic protein peptide 87-106. J Immunol 148:1359-1366.
50. Matsumoto Y, Tsuchida M, Hanawa H, Abo T (1994): T cell receptor peptide therapy for autoimmune encephalomyelitis: stronger immunization is necessary for effective vaccination. Cell Immunol 153:468-478.
51. McCarron RM, Fallis RJ, McFarlin DE (1990): Alterations in T cell antigen specificity and class U restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J Neuroimmunol 29:73.
52. Meinl E, Weber F, Drexler K, Morelle C, Ott M, Saruhan-Direskeneli G, Goebels N, Ertl B, Jechart G, Giegerich G, Schonbeck S, Bannwarth W, Wekerle H, Hohlfeld R (1993): Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. J Clin Invest 92:2633-2643.
53. Mokhtarian F, McFarlin DE, Raine CS (1984): Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309:356.
54. Offner H, Hashim GA, Vandenbark AA (1991): T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251:430-432.
55. Offner H, Vainiene M, Gold DP, Celnik B, Wang R, Hashim GA, Vandenbark A (1992): Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. I. T cell receptor peptide regulation of T cell clones expressing cross-reactive Vβ genes. J Immunol 148:1706-1711.
56. Offner H, Hashim G, Chou YK, Bourdette D, Vandenbark AA (1993): Prevention, suppression and treatment of EAE with a synthetic T cell receptor V region peptide. In Alt FW, Vogel MG (eds): "Molecular Mechanisms of Immunological Self-Recognition." San Diego: Academic Press, pp 199-230.
57. Offner H, Vainiene M, Celnik B, Weinberg AD, Buenafe A, Vandenbark AA (1994): Co-culture of TCR peptide-specific T cells with basic protein-specific T cells inhibits proliferation, IL-3 mRNA, and transfer of experimental autoimmune encephalomyelitis. J Immunol 153:4988-4996.
58. Offner H, Malotky MKH, Pope L, Vainiene M, Celnik B, Miller SD, Vandenbark AA (1995): Increased severity of experimental autoimmune encephalomyelitis in rats tolerized as adults but not neonatally to protective TCR Vβ8 CDR2 idiotope. J Immunol 154:928-935,
59. Offner H, Vainiene M, Vandenbark AA (1995): Immunoregulatory determinants on rat TCR Vβ8.2. 9th Int Congress Immunol Abstr 2350:397.
60. Oksenberg JR, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CCA, Steinman L (1993): Selection of T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362:68-70.
61. Olsson T, Wane WZ, Hojeberg B, Kostulas V, Yu-Ping J, Anderson G, Ekre H-P, Link H (1990): Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferonγ. J Clin Invest 86:981-985.
62. Ota K, Matsui M, Milford EL, Macklin GA, Weiner HL, Hafler DA (1990): T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346:183-185.
63. Pelfrey T, Trotter J, Rhame L, McFarland H (1993): Myelin proteolipid protein (PLP) peptide reactivity in multiple sclerosis. J Immunol 150:174A.
64. Raine CS, Scheinberg LC (1988): On the immunopathology of plaque development and repair in multiple sclerosis. J Neuroimmunol 20:189-193.
65. Richert J, Robinson ED, Deibler GE, Martenson RE, Dragovic LJ, Kies MW (1989): Evidence for multiple human T cell recognition sites on myelin basic protein. J Neuroimmunol 23:55.
66. Richert JR, Robinson ED, Johnson AH, Bergman CA, Dragovic LJ, Reinsmoen NL, Hurley CK (1991): Heterogeneity of the T cell receptor β gene rearrangements generated in myelin basic protein-specific T cell clones isolated from a patient with multiple sclerosis. Ann Neurol 29:299-306.
67. Rothbard JB, Taylor WR (1988): A sequence pattern common to T cell epitopes. EMBO J 7:93-100.
68. Satyanarayana K, Chou YK, Bourdette D, Whitham R, Hashim GA, Offner H, Vandenbark AA (1993): Epitope specificity and V gene expression of cerebrospinal fluid T cells specific for intact versus cryptic epitopes of myelin basic protein. J Neuroimmunol 44:57-68.
69. Stevens DB, Karpus WJ, Gould KE, Swanborg RH (1991): Studies of Vβ8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis. J Neuroimmunol 37:123-129.
70. Sun D (1992): Synthetic peptides representing sequence 39 to 59 of rat Vβ8 TCR fail to elicit regulatory T cells reactive with Vβ8 TCR on rat encephalitogenic T cells. Cell Immunol 141:200-210.
71. Sun JB, Olsson T, Wang WZ, Xiao BG, Kostulas V, Fredrikson S, Ekre HP, Link H (1991): Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 21:1461-1468.
72. Traugott U (1985): Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoim-mune demyelinating lesions. Springer Semin Immunopathol 8(1-2):71.
73. Urban JL, Kumar V, Kono DH, Gomez C, Horvath SJ, Clayton J, Ando DG, Sercarz EE, Hood L (1988): Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577-592.
74. Vainiene M, Gold DP, Celnik B, Hashim GA, Vandenbark AA, Offner H (1992): Common sequence on distinct Vβ genes defines a protective idiotope in experimental encephalomyelitis. J Neurosci Res 31:413-420.
75. Vainiene M, Celnik B, Hashim GA, Vandenbark AA, Offner H (1996): Natural immunodominant and EAE-protective determinants within the Lewis rat Vβ8.2 sequence include CDR2 and framework 3 idiotopes. J Neurosci Res (in press).
76. Vandenbark AA, Hashim G, Offner H (1989): Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541-544.
77. Vandenbark AA, Vainiene M, Celnik B, Hashim G, Offner H (1992): TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system. J Neuroimmunol 39:251-260.
78. Vandenbark AA, Bourdette DN, Whitham R, Hashim GA, Chou YK, Offner H (1993): Episodic changes in T cell frequencies to myelin basic protein in patients with multiple sclerosis. Neurology 43:2416-2417.
79. Vandenbark AA, Chou YK, Offner H (1995): TCR peptide-specific human Th2 cells inhibit BP-specific Th1 effector cells. 9th Int Congress Immunol Abstr 1061:179.
80. Watson RR, Wang JY, Dehghanpisheh K, Huang DS, Wood S, Ardestani SK, Liang B, Marchalonis JJ (1995): T cell receptor Vβ complementarity-determining region 1 peptide administration moderates immune dysfunction and cytokine dysregulation induced by murine retrovirus infection. J Immunol 155:2282-2291.
81. Weinberg AD, Celnik B, Vainiene M, Buenafe AC, Vandenbark AA, Offner H (1994): The effect of TCR Vβ8 peptide therapy on T cell populations isolated from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. J Neuroimmunol 49:161-170.
82. Whitham RH, Bourdette DN, Hashim G A, Herndon RM, Ilg RC, Vandenbark AA, Offner H (1991): Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating EAE. J Immunol 146:101-107.
83. Whitham RH, Kotzin BL, Buenafe AC, Weinberg AD, Jones RE, Hashim GA, Hoy CM, Vandenbark AA, Offner H (1993): Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides. J Neurosci Res 35:115-128.
84. Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HS, Haffler DA (1990): Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein. Science 248:1016-1019.
85. Zamvil SS, Nelson P, Trotter J, Mitchell D, Knobler R, Fritz R, Steinman L (1985): T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 317:355-358.
86. Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA (1994): Increased frequency of Interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med 179:973-984.