Induction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6585-6591

  Kumar, Vipin ^a,b   Sercarz, Eli ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LYMPHOKINE; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, INTRANASAL; ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNIZATION; LYMPHOCYTE ACTIVATION; LYMPHOKINES; MICE; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS;

EID: 0032534725     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Weiner, H. L., A. Friedman, A. Miller, S. J. Khoury, A. al-Sabbagh, L. Santos, M. Sayegh, R. B. Nussenblatt, D. E. Trentham, and D. A. Hafler. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organspecific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12:809.
2. Rocken, M., M. Racke, and E. M. Shevach. 1996. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17:225.
3. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16: 34.
4. Paterson, P. Y. 1980. Autoimmune diseases of myelin. Prog. Clin. Biol. Res. 49:19.
5. Acha-Orbea, H., D. J. Mitchell, L. Timmermann, D. C. Wraith, G. S. Tausch, M. K. Waldor, S. S. Zamvil, H. O. McDevitt, and L. Steinman. 1988. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263.
6. Urban, J. L., V. Kumar, D. H. Kono, C. Gomez, S. J. Horvath, J. Clayton, D. G. Ando, E. E. Sercarz, and L. Hood. 1988. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577.
7. Ando, D. G., J. Clayton, D. Kono, J. L. Urban, and E. E. Sercarz. 1989. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:132.
8. Powell, M. B., D. Mitchell, J. Lederman, J. Buckmeier, S. S. Zamvil, M. Graham, N. H. Ruddle, and L. Steinman. 1990. Lymphotoxin and tumor necrosis factor-α production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2:539.
9. Zamvil, S. S., and L. Steinman. 1990. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:579.
10. Baron, J. L., J. A. Madri, N. H. Ruddle, G. Hashim, and C. A. Janeway, Jr. 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57.
11. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
12. Brocke, S., K. Gijbels, M. Allegretta, I. Ferber, C. Piercy, T. Blankenstein, R. Martin, U. Utz, N. Karin, D. Mitchell, and et al. 1996. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379:343.
13. Nicholson, L. B., J. M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
14. Kennedy, M. K., D. S. Torrance, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.
15. Lafaille, J. J., F. V. Keere, A. L. Hsu, J. L. Baron, W. Haas, C. S. Raine, and S. Tonegawa. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186:307.
16. Kumar, V., and E. Sercarz. 1993. T cell regulatory circuitry: antigen-specific and TCR-idiopeptide-specific T cell interactions in EAE. Int. Rev. Immunol. 9:287.
17. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:909.
18. Kumar, V., R. Tabibiazar, H. M. Geysen, and E. Sercarz. 1995. Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyelitis. J. Immunol. 154:1941.
19. Kumar, V., K. Stellrecht, and E. Sercarz. 1996. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J. Exp. Med. 184:1609.
20. + T cells in murine experimental allergic encephalomyelitis. Science 256:1211.
21. -/- mice. Science 256:1210.
22. Ben-Nun, A., H. Wekerle, and I. R. Cohen. 1981. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 292:60.
23. Broeren, C. P., M. A. Lucassen, M. J. van Stipdonk, R. van der Zee, C. J. Boog, J. G. Kusters, and W. van Eden. 1994. CDR1 T-cell receptor β-chain peptide induces major histocompatibility complex class II-restricted T-T cell interactions. Proc. Natl. Acad. Sci. USA 91:5997.
24. Howell, M. D., S. T. Winters, T. Olee, H. C. Powell, D. J. Carlo, and S. W. Brostoff. 1989. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246:668.
25. Kumar, V., F. Aziz, E. Sercarz, and A. Miller. 1997. Regulatory T cells specific for the same framework 3 region of the Vβ8.2 chain are involved in the control of collagen II-induced arthritis and experimental autoimmune encephalomyelitis. J. Exp. Med. 185:1725.
26. Haqqi, T. M., X. M. Qu, D. Anthony, J. Ma, and M. S. Sy. 1996. Immunization with T cell receptor Vβ chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice. J. Clin. Invest. 97:2849.
27. Vandenbark, A. A., G. Hashim, and H. Offner. 1989. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature 341:541.
28. Gold, D. P., R. A. Smith, A. B. Golding, E. E. Morgan, T. Dafashy, J. Nelson, L. Smith, J. Diveley, J. A. Laxer, S. P. Richieri, D. J. Carlo, S. W. Brostoff, and D. B. Wilson. 1997. Results of a phase I clinical trial of a T-cell receptor vaccine in patients with multiple sclerosis. II. Comparative analysis of TCR utilization in CSF T-cell populations before and after vaccination with a TCRV beta 6 CDR2 peptide. J. Neuroimmunol. 76:29.
29. Medaer, R., P. Stinissen, L. Truyen, J. Raus, and J. Zhang. 1995. Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis. Lancet 346:807.
30. Moreland, L. W., L. W. Heck, Jr., W. J. Koopman, P. A. Saway, T. C. Adamson, Z. Fronek, R. D. O'Connor, E. E. Morgan, J. P. Diveley, S. P. Richieri, D. J. Carlo, and S. W. Brostoff. 1996. V beta 17 T cell receptor peptide vaccination in rheumatoid arthritis: results of phase I dose escalation study. J Rheumatol 23:1353.
31. Vandenbark, A. A., Y. K. Chou, R. Whitham, M. Mass, A. Buenafe, D. Liefeld, D. Kavanagh, S. Cooper, G. A. Hashim, and H. Offner. 1996. Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial. Nat. Med. 2:1109.
32. Kumar, V., V. Bhardwaj, L. Soares, J. Alexander, A. Sette, and E. Sercarz. 1995. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510.
33. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
34. + suppressor cells of autoimmune encephalomyelitis respond to T cell receptor-associated determinants on effector cells by interleukin-4 secretion. Eur. J. Immunol. 22:1757.
35. Metzler, B., and D. C. Wraith. 1996. Mucosal tolerance in a murine model of experimental autoimmune encephalomyelitis. Ann. NY Acad. Sci. 778:228.
36. Scott, P., and G. Trinchieri. 1997. IL-12 as an adjuvant for cell-mediated immunity. Semin. Immunol. 9:285.
37. Kumar, V., and E. Sercarz. 1996. Genetic vaccination: the advantages of going naked. Nat. Med. 2:857.
38. Kumar, V., E. Coulsell, B. Ober, G. Hubbard, E. Sercarz, and E. S. Ward. 1997. Recombinant T cell receptor molecules can prevent and reverse experimental autoimmune encephalomyelitis: dose effects and involvement of both CD4 and CD8 T cells. J. Immunol. 159:5150.
39. Waisman, A., P. J. Ruiz, D. L. Hirschberg, A. Gelman, J. R. Oksenberg, S. Brocke, F. Mor, I. R. Cohen, and L. Steinman. 1996. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat. Med. 2:899.
40. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
41. Offner, H., G. A. Hashim, and A. A. Vandenbark. 1991. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 251: 430.
42. Kumar, V., and E. Sercarz. 1996. Dysregulation of potentially pathogenic self reactivity is crucial for the manifestation of clinical autoimmunity. J. Neurosci. Res. 45:334.
43. Mestecky, J., S. M. Michalek, Z. Moldoveanu, and M. W. Russell. 1997. Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans. Behring Inst. Mitt. Volume 98:33.
44. Mestecky, J., S. Husby, Z. Moldoveanu, F. B. Waldo, A. W. van den Wall Bake, and C. O. Elson. 1996. Induction of tolerance in humans: effectiveness of oral and nasal immunization routes. Ann. NY Acad. Sci. 778:194.
45. Kumar, V., D. H. Kono, J. L. Urban, and L. Hood. 1989. The T-cell receptor repertoire and autoimmune diseases. Annu. Rev. Immunol. 7:657.
46. Vanderlugt, C. J., and S. D. Miller. 1996. Epitope spreading. Curr. Opin. Immunol. 8:831.
47. Kumar, V. 1998. Determinant spreading during experimental autoimmune encephalomyelitis: is it potentiating, protecting or participating in the disease. Immunol. Rev. 164:73.
48. + cells in T cell receptor peptide-induced clonal unresponsiveness. Science 259:91.
49. + T cells expressing Vβ8 TCR: a role of the Qa-1 molecule. Immunity 2:185.
50. + T lymphocytes in the spinal cord during recovery from experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein. J. Neurol. Sci. 139:1.
51. Billiau, A., H. Heremans, F. Vandekerckhove, R. Dijkmans, H. Sobis, E. Meulepas, and H. Carton. 1988. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ. J. Immunol. 140:1506.
52. Caspi, R. R., C. C. Chan, B. G. Grubbs, P. B. Silver, B. Wiggert, C. F. Parsa, S. Bahmanyar, A. Billiau, and H. Heremans. 1994. Endogenous systemic IFN-γ has a protective role against ocular autoimmunity in mice. J. Immunol. 152:890.
53. Duong, T. T., F. D. Finkelman, B. Singh, and G. H. Strejan. 1994. Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains. J. Neuroimmunol. 53:101.
54. Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomy-elitis (EAE). J. Immunol. 156:5.
55. Krakowski, M., and T. Owens. 1996. Interferon-γ confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26:1641.
56. Genain, C. P., K. Abel, N. Belmar, F. Villinger, D. P. Rosenberg, C. Linington, C. S. Raine, and S. L. Hauser. 1996. Late complications of immune deviation therapy in a nonhuman primate. Science 274:2054.