Motions of the fingers subdomain of Klentaq1 are fast and not rate limiting: Implications for the molecular basis of fidelity in DNA polymerases

Molecular Cell

Volumn 19, Issue 3, 2005, Pages 345-355

  Rothwell, Paul J ^a   Mitaksov, Vesselin ^b   Waksman, Gabriel ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; KLENTAQ1 POLYMERASE; NUCLEOTIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; ENZYME BINDING; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN SYNTHESIS;

CATALYSIS; CATALYTIC DOMAIN; DEOXYCYTOSINE NUCLEOTIDES; DEOXYRIBONUCLEOTIDES; DNA; DNA-DIRECTED DNA POLYMERASE; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOTION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; TAQ POLYMERASE;

EID: 23044492225     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.06.032     Document Type: Article

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