Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 19, 2005, Pages 6819-6824

  Florián, Jan ^a   Goodman, Myron F ^b   Warshel, Arieh ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; NUCLEOTIDE;

ARTICLE; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; MACROMOLECULE; PKA; PRIORITY JOURNAL; PROTEIN FUNCTION;

BASE PAIRING; BINDING SITES; CATALYSIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DNA; DNA-DIRECTED DNA POLYMERASE; HEAT; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IONS; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; MAGNESIUM; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEOTIDES; PROTEIN CONFORMATION; PROTEINS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 18744402486     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408173102     Document Type: Article

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