Genetics of polygenic hypertension from animal models to humans

Current Hypertension Reviews

Volumn 3, Issue 4, 2007, Pages 284-297

  Deng, Alan Y ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE SYNTHASE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADDUCIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1A RECEPTOR; ANGIOTENSIN 1B RECEPTOR; ANGIOTENSINOGEN; ATRIAL NATRIURETIC FACTOR RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN; ENDOTHELIN 2; ENDOTHELIN 3; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; RENIN; STEROID 11BETA MONOOXYGENASE;

BLOOD PRESSURE; DISEASE MODEL; EPISTASIS; ESSENTIAL HYPERTENSION; GENE CONTROL; GENE IDENTIFICATION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETIC REGULATION; HUMAN; LINKAGE ANALYSIS; MEDICAL RESEARCH; MOLECULAR MECHANICS; MULTIFACTORIAL INHERITANCE; NONHUMAN; POPULATION GENETICS; POPULATION RESEARCH; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE;

EID: 36949019522     PISSN: 15734021     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340207782403908     Document Type: Review

References (145)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 217-223.
2. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104: 545-556.
3. Wilson FH, Disse-Nicodeme S, Choate KA, et al. Human hypertension caused by mutations in WNK kinases. Science 2001; 293: 1107-1112.
4. Boyle CR, Elston RC. Multifactorial genetic models for quantitative traits in humans. Biometrics 1979; 35: 55-68.
5. Mendell NR, Elston RC. Multifactorial qualitative traits: genetic analysis and prediction of recurrence risks. Biometrics 1974; 30: 41-57.
6. Hamet P, Pausova Z, Adarichev V, Adaricheva. K, Tremblay J. Hypertension: genes and environment. J Hypertens 1999; 16: 397-418.
7. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 2000; 80: 135-172.
8. Knudsen KD, Dahl LK, Thompson K, Iwai J, Heine M, Leitl G. Effects of chronic excess salt ingestion: inheritance of hypertension in the rats. J Exp Med 1970; 132: 976-1000.
9. Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 1998; 18: 19-24.
10. Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 2005; 6: 271-286.
11. Garrett MR, Dene H, Walder R, et al. Genomic scan and congenic strains for blood pressure quantitative trait loci using Dahl salt-sensitive rats. Genome Res 1998; 8: 711-723.
12. Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA. Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. Genetics 2005; 169: 1699-1709.
13. Darvasi A, Weinreb A, Minke V, Welter JI, Soller M. Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 1993; 134: 943-951.
14. Sen S, Churchill GA. A statistical framework for quantitative trait mapping. Genetics 2001; 159: 371-387.
15. Deng AY, Rapp JP. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest 1995; 95: 2170-2177.
16. Deng Y, Rapp JP. Cosegregation of blood pressure with angio-tensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat Genet 1992; 1: 267-272.
17. Hilbert P, Lindpaintner K, Beckmann JS, et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991; 353: 521-529.
18. Jacob HJ, Lindpaintner K, Lincoln SE, et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991; 67: 213-224.
19. Nara Y, Nabika T, Ikeda K, Sawamura M, Endo J, Yamori Y. Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP). Biochem Biophys Res Commun 1991; 181: 941-946.
20. Charron S, Duong C, Menard A, et al. Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension 2005; 46: 1300-1308.
21. Saad Y, Garrett MR, Manickavasagam E, et al. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Genomics 2007; 89: 343-353.
22. Palijan A, Lambert R, Dutil J, Sivo Z, Deng AY. Comprehensive congenic coverage revealing multiple blood pressure quantitative trait loci on Dahl rat chromosome 10. Hypertension 2003; 42: 515-522.
23. Deng AY, Dene H, Rapp JP. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest 1994; 94: 431-436.
24. Dutil J, Eliopoulos V, Tremblay J, Hamet P, Charron S, Deng AY. Multiple quantitative trait loci for blood pressure interacting epistatically and additively on Dahl rat chromosome 2. Hypertension 2005; 45: 557-564.
25. Deng AY. Is the nitric oxide system involved in genetic hypertension in Dahl rats? Kidney Int 1998; 53: 1501-1511.
26. Snell GD. Methods for the study of histocompatibility genes. J Genet 1948; 49: 87-103.
27. Deng AY. In search of hypertension genes in Dahl salt-sensitive rats. J Hypertens 1998; 16: 1707-1717.
28. Deng AY. Positional cloning of quantitative trait loci for blood pressure: how close are we?: A Critical Perspective. Hypertension 2007; 49: 740-747.
29. Duong C, Charron S, Deng Y, et al. Individual QTLs controlling quantitative variation in blood pressure inherited in a Mendelian mode. Heredity 2007; 98: 165-171.
30. Palijan A, Dutil J, Deng AY. Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol Genomics 2003; 15: 1-8.
31. Ariyarajab A, Palijan A, Dutil J, Prithiviraj K, Deng Y, Deng AY. Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains. J Hypertens 2004; 22: 1495-1502.
32. Eliopoulos V, Dutil J, Deng Y, Grondin M, Deng AY. Severe hypertension caused by alleles from normotensive Lewis for a quantitative trait locus on chromosome 2. Physiol Genomics 2005; 22: 70-75.
33. Cordell HJ. Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 2002; 11: 2463-2468.
34. Sugiyama F, Churchill GA, Higginsa DC, et al. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 2001; 71: 70-77.
35. Wittenburg H, Lammert F, Wang DQ, et al. Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice. Physiol Genomics 2002; 8: 67-77.
36. Ohno Y, Tanase H, Nabika T, et al. Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in rats. Genetics 2000; 155: 785-792.
37. Garrett MR, Zhang X, Dukhanina OI, Deng AY, Rapp JP. Two linked blood pressure QTL on chromosome 10 defined by Dahl-rat congenic strains. Hypertension 2001; 38: 779-785.
38. Rapp JP, Garret MR, Deng AY. Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. J Clin Invest 1998; 101: 1591-1595.
39. Baker BS, Ridge KA. Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. Genetics 1980; 94: 383-423.
40. Baker BS. Sex in flies: the splice of life. Nature 1989; 340: 521-520.
41. Charron S, Lambert R, Etiopoulos V, et al. A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension. Hum Mol Genet 2005; 14: 3877-884.
42. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
43. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265: 2037-2048.
44. Agarwal A, Williams GH, Fisher ND. Genetics ofhurnan hypertension. Trends Endocrinol Metab 2005; 16: 127-133.
45. Benjafield AV, Wang WY, Speirs HJ, Morris BJ. Genome-wide scan for hypertension in Sydney Sibships: the GENIHUSS study. Am J Hypertens 2005; 18: 828-832.
46. Caulfield M, Munroe P, Pembroke J, et al. Genome-wide mapping of human loci for essential hypertension. Lancet 2003; 361: 2118-2123.
47. Garcia EA, Newhouse S, Caulfield MJ, Munroe PH. Genes and hypertension. Curr Pharm Des 2003; 9: 1679-1689.
48. Lalouel JM. Large-scale search for genes predisposing to essential hypertension. Am J Hypertens 2003; 16: 163-166.
49. Mein CA, Caulfield MJ, Dobson RJ, Munroe PB. Genetics of essential hypertension. Hum Mol Genet 2004; 13 Spec No 1: R169-R175.
50. Morris BJ, Benjafield AV, Lin RC. Essential hypertension: genes and dreams. Clin Chem Lab Med 2003; 41: 834-844.
51. Munroe PB, Wallace C, Xue MZ, et al. Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study. Hypertension 2006; 48: 105-111.
52. Pausova Z, Gaudet D, Gossard F, et al. Genome-wide scan for linkage to obesity-associated hypertension in French Canadians. Hypertension 2005; 46: 1280-1285.
53. Samani NJ. Genome scans for hypertension and blood pressure regulation. Am J Hypertens 2003; 16: 167-171.
54. Tang H, Jorgenson E, Gadde M, et al. Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Genet 2006; 119: 624-633.
55. Wit H, Tang W, Li H, et al. Association of the beta2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population. J Hypertens 2006; 24: 1041-1047.
56. Hahntow IN, Koopmans RP, Michel MC. The beta2-adrenoceptor gene and hypertension: is it the promoter or the coding region or neither? J Hypertens 2006; 24: 1003-1007.
57. Stoll M, Cowley AW, Jr., Tonellato PJ, et al. A genomic-systems biology map for cardiovascular function. Science 2001; 294: 1723-1726.
58. Kato N, Hyne G, Bihoreau MT, Gauguier D, Lathrop GM, Rapp JP. Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Mamm Genome 1999; 10: 259-265.
59. Wu H, Tang W, Li H, et al. Functional significance of single nucleotide polymorphisms within the 5′-flanking region of beta2-adrenergic receptor gene. J Hypertens 2006; 24: 2474-2476.
60. Harrap SB. Where are all the blood-pressure genes? Lancet 2003; 361: 2149-2151.
61. Jeunemaitre X, Soubrier F, Kotelevtsev YV, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71: 169-180.
62. Hamet P, Merlo E, Seda O, et al. Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet 2005; 76: 815-832.
63. Cicila GT, Rapp JP, Wang JM, St Lezin E, Ng SC, Kurtz TW. Linkage of 11 beta-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Nat Genet 1993; 3: 346-353.
64. Garrett MR, Rapp JP. Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Mamm Genome 2003; 14: 268-273.
65. Huang BS, Ahmad M, Deng AY, Leenen FHH. Neuronal responsiveness to central Na+ in 2 congenic strains of Dahl salt-sensitive rats. Hypertension 2007; 49: 1315-1320.
66. Ioannidis JP, Ntzani EE, Trikalinos TA. 'Racial' differences in genetic effects for complex diseases. Nat Genet 2004; 36: 1312-1318.
67. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003; 33: 177-182.
68. Wang WY, Barratt BJ, Clayton DG, Todd JA. Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet 2005; 6: 109-118.
69. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-678.
70. Gu L, Dene H, Deng AY, Hoebee B, Bihoreau MT, James M, Rapp JP. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J Clin Invest 1996; 97: 777-788.
71. Deng AY, Rapp JP. Evaluation of the angiotensin II receptor AT1B gene as a candidate gene for blood pressure. J Hypertens 1994; 12: 1001-1006.
72. Deng AY, Dene H, Pravenec M, Rapp JP. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 1994; 93: 2701-2709.
73. Rapp JP, Garrett MR, Dene H, Meng H, Hoebee B, Lathrop GM. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Genomics 1998; 51: 191-196.
74. Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome 1997; 8: 636-641.
75. Moreno C, Dumas P, Kaldunski ML, et al. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics 2003; 15: 243-257.
76. Herrera VLM, Tsikoudakis A, Ponce LRB, Matsubara Y, Ruiz-Opazo N. Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jrHS hypertensive rats. Physiol Genomics 2006; 26: 172-179.
77. Mattson DL, Kunert MP, Kaldunski ML, et al. Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. Physiol Genomics 2004; 16: 194-203.
78. Joe B, Garrett MR, Dene H, Rapp JP. Substitution mapping of a blood pressure quantitative trait locus to a 2.73 Mb region on rat chromosome 1. J Hypertens 2003; 21: 2077-2084.
79. Saad Y, Garret MR, Rapp JP. Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains. Physiol Genomics 2001; 4: 201-214.
80. Garrett MR, Rapp JP. Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats. Mamm Genome 2002; 13: 41-44.
81. Lee SJ, Liu J, Westcott AM, Vieth JA, et al. Substitution mapping in Dahl rats identifies two distinct blood pressure quantitative trait loci within 1.12- and 1.25-mb intervals on chromosome 3. Genetics 2006; 174: 2203-2213.
82. Duong C, Charron S, Xiao C, et al. [Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Mamm Genome 2006; 17: 1147-1161.
83. Garrett MR, Rapp JP. Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. Physiol Genomics 2002; 8: 81-86.
84. Garrett MR, Meng H, Rapp JP, Joe B. Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution mapping and renal expression analysis. Hypertension 2005; 45: 451-459.
85. Grondin M, Eliopoulos V, Lambert R, et al. Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17. Physiol Genomics 2005; 21: 112-116.
86. Barbalic M, Skaric-Juric T, Cambien F, et al. Gene polymorphisms of the renin-angiotensin system and early development of hypertension. Am J Hypertens 2006; 19: 837-842.
87. Bouzekri N, Zhu X, Jiang Y, et al. Ward R. Angiotensin I-converting enzyme polymorphisms, ACE level and blood pressure among Nigerians, Jamaicans and African-Americans. Eur J Hum Genet 2004; 12: 460-468.
88. Gu D, So S, Ge D, et al. Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese. Hypertension 2006; 47: 1147-1154.
89. Gui-yan W, Yan-hua W, Qun X, et al. Associations between RAS Gene polymorphisms, environmental factors and hypertension in Mongolian people. Eur J Epidemiol 2006; 21: 287-292.
90. Henderson SO, Haiman CA, Mack W. Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. Am J Med Sci 2004; 328: 266-273.
91. Ismail M, Akhtar N, Nasir M, Firasat S, Ayub Q, Khaliq S. Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and essential hypertension in young Pakistani patients. J Biochem Mol Biol 2004; 37: 552-555.
92. Spiering W, Zwaan IM, Kroon AA, de Leeuw PW. Genetic influences on 24 h blood pressure profiles in a hypertensive population: role of the angiotensin-converting enzyme insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms. Blood Press Monit 2005; 10: 135-141.
93. Sub I, Nam CM, Kim SJ, Shin DJ, Hur NW, Kang DR. Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study. J Prev Med Pub Health 2006; 39: 177-183.
94. Wang X, Wang S, Lin F, et al. GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate. J Hum Hypertens 2004; 18: 663-668.
95. Yi L, Gu YH, Wang XL, et al. Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China. J Int Med Res 2006; 34: 272-283.
96. Marcun VN, Zagradisnik B, Herodez SS, Kokalj VN, Gregoric A. Polymorphisms in four candidate genes in young patients with essential hypertension. Acta Paediatr 2006; 95: 353-358.
97. Lanzani C, Citterio L, Jankaricova M, et al. Role of the adducin family genes in human essential hypertension. J Hypertens 2005; 23: 543-549.
98. von Wowern F, Bengtsson K, Lindblad U, Rastam L, Melander O. Functional Variant in the {alpha}2B Adrenoceptor Gene, a Positional Candidate on Chromosome 2, Associates With Hypertension. Hypertension 2004; 43: 592-597.
99. Etzel JP, Rana BK, Wen G, et al. Genetic variation at the human {alpha}2B-adrenergic receptor locus: role in blood pressure variation and Yohimbine response. Hypertension 2005; 45: 1207-1213.
100. Li JL, Canham RM, Vongpatanasin W, Leonard D, Auchus RJ, Victor RG. Do Allelic variants in {alpha}2A and {alpha}2C adrenergic receptors predispose to hypertension in blacks? Hypertension 2006; 47: 1140-1146.
101. Markovic D, Tang X, Guruju M, et al. Association of angiotensinogen gene polymorphisms with essential hypertension in African-Americans and Caucasians. Hum Hered 2005; 60: 89-96.
102. Say YH, Ling KH, Duraisamy G, Isaac S, Rush R. Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study. BMC Cardiovasc Disord 2005; 5: 7.
103. Renner W, Nauck M, Winkelmann BR, et al. Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study. J Mol Med 2005; 83: 235-239.
104. Sun B, Dronma T, Qin WJ, et al. Polymorphisms of renin-angiotensin system in essential hypertension in Chinese Tibetans. Biomed Environ Sci 2004; 17: 209-216.
105. Wu SJ, Chiang FT, Chen WJ, et al. Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis. Physiol Genomics 2004; 17: 79-86.
106. Sugimoto K, Katsuya T, Ohkubo T, et al. Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study. Hypertens; Res 2004; 27: 551-556.
107. Gardier S, Vincent M, Lantelme P, Rial MO, Bricca G, Milon H. A1166C polymorphism of angiotensin II type 1 receptor, blood pressure and arterial stiffness in hypertension. J Hypertens 2004; 22: 2135-2142.
108. Matsubara M, Sato T, Nishimura T, et al. CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study. Hypertens Res 2004; 27: 1-6.
109. Connell JM, Fraser R, MacKenzie SM, et al. The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Mol Cell Endocrinol 2004; 217: 243-247.
110. Russo P, Venezia A, Lauria F, et al. HindHl(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids: no evidence of association in three white populations. Am J Hypertens 2006; 19: 331-338.
111. Tang W, Wu H, Zhou X, et al. Association of the C-344T polymorphism of CYP11B2 gone with essential hypertension in Hani and Yi minorities of China. Clin Chim Acta 2006; 364: 222-225.
112. Yamamoto M, Jin JJ, Wit Z, et al. Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese. Hyperters Res 2006; 29: 227-232.
113. Kaetsu A, Kishimoto T, Osaki Y, Okamoto M, Fukumoto S, Kurozawa Y. The lack of relationship between an endothelin-1 gene p,olymorphism (Ala288ser) and incidence of hypertension: a retrospective cohort study among Japanese workers. J Epidemiol 2004; 14:129-136.
114. Olcay A, Ekmekci CG, Ozbek U, et al. Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: effect of eNOS polymorphism on left ventricular hypertrophy. Cardiovasc Ultrasound 2006; 4: 33.
115. Zhao Q, Su SY, Chen SF, Li B, Gu DF. Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han Chinese. Chin Med J (Engl) 2006; 119: 1065-1071.
116. Djuric T, Zivkovic M, Stankovic A, Mecanin S, Alavantic D. Endothelial NOS G894 T and MMP-3 5A/6A gene polymorphisms and hypertension in Serbian population. J Clin Lab Anal 2005; 19: 241-246.
117. Sandrim VC, Coelbo EB, Nobre F, Arado GM, Lanchote VL, Tanus-Santos JE. Susceptible and protective eNOS haplotypes in hypertensive black and white subjects. Atherosclerosis 2006; 186: 428-432.
118. Wolff B, Grabe HJ, Schluter C, et al. Endothelial nitric oxide synthase Glu298Asp gene polymorphism, blood pressure and hypertension in a general population sample. J Hypertens 2005; 23: 1361-1366.
119. Persu A, Vinck WJ, El Khattabi O, et al. Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study. J Hypertens 2005; 23: 759-765.
120. Kishimoto T, Misawa Y, Kaetu A, et al. eNOS Glu298Asp polymorphism and hypertension in a cohort study in Japanese. Prev Med 2004; 39: 927-931.
121. Chen W, Srinivasan SR, Li S, Boerwinkle E, Berenson GS. Gender-specific influence of NO synthase gene on blood pressure since childhood: the Bogalusa Heart Study. Hypertension 2004; 44: 668-673.
122. Li R, Lyn D, Lapu-Bula R, et al. Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans. Am J Hypertens 2004; 17: 560-567.
123. Ahmad U, Saleheen D, Bokhari A, Frossard PM. Strong association of a renin intronic dimorphism with essential hypertension. Hypertens Res 2005; 28: 339-344.
124. Manunta P, Bianchi G. Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives-the adducin paradigm. J Am Soc Nephrol 2006; 17: S30-S35.
125. Zhang L, Summers KM, West MJ. Angiotensin I converting enzyme gene cosegregates with blood pressure and heart weight in F2 progeny derived from spontaneously hypertensive and normotensive Wistar-Kyoto rats. Clin Exp Hypertens 1996; 18: 753-771.
126. Kreutz R, Hubner N, James MR, et al. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc Natl Acad Sci U S A 1995; 92: 8778-8782.
127. Bianchi G, Tripodi G, Casari G, et al. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci U S A 1994; 91: 3999-4003.
128. Tripodi G, Florio M, Ferrandi M, et al. Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats. Biochem Biophys Res Commun 2004; 324: 562-568.
129. Ginn DI, Baptista CA, Alam KY, et al. Genetic analysis of alpha 2-adrenergic receptors and blood pressure using Dahl salt-sensitive rats. J Hypertens 1994; 12: 357-365.
130. Kreutz R, Hubner N, James MR, et al. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc Natl Acad Sci U S A 1995; 92: 8778-8782.
131. Hubner N, Kreutz R, Takahashi S, Ganten D, Lindpaintner K. Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus. Hypertension 1994; 23: 797-801.
132. Lodwick D, Kaiser MA, Harris J, Cumin F, Vincent M, Samani NJ. Analysis of the role of angiotensinogen in spontaneous hypertension. Hypertension 1995; 25: 1245-1251.
133. St Lezin E, Zhang L, Yang Y, et al. Effect of chromosome 19 transfer on blood pressure in the spontaneously hypertensive rat. Hypertension 1999; 33: 256-260.
134. Dutil J, Deng AY. Mapping a blood pressure quantitative trait locus to a 5.7-cM region in Dahl salt-sensitive rats. Mamm Genome 2001; 12: 362-365.
135. Herrera VL, Xie HX, Lopez LV, Schork NJ, Ruiz-Opazo N. The alphal Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat. J Clin Invest 1998; 102: 1102-1111.
136. Rapp JP, Dene H. Failure of alleles at the Na+, K(+)-ATPase alpha l locus to cosegregate with blood pressure in Dahl rats. J Hypertens 1990; 8: 457-462.
137. Cicila GT, Rapp JP, Bloch KD, et al. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in in-bred Dahl rats. J Hypertens 1994; 12: 643-651.
138. Dukhanina OI, Dene H, Deng AY, Choi CR, Hoebee B, Rapp JP. Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm Genome 1997; 8: 229-235.
139. Deng AY, Rapp JP. Absence of linkage for "endothelial" nitric oxide synthase locus to blood pressure in Dahl rats. Hypertension 1997; 29: 49-52.
140. Pravenec M, Gauguier D, Schott JJ, et al. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Cho Invest 1995; 96: 1973-1978.
141. Rapp JP, Dene H, Deng AY. Seven renin alleles in rats and their effects on blood pressure. J Hypertens 1994; 12: 349-355.
142. Samani NJ, Gauguier D, Vincent M, et al. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect. Hypertension 1996; 28: 1118-1122.
143. Yu. H, Harrap SB, Di Nicolantonio R. Cosegregation of spontaneously hypertensive rat renin gene with elevated blood pressure in an F2 generation. J Hypertens 1998; 16: 1141-1147.
144. Kurtz TW, Simonet L, Kabra PM, Wolfe S, Chan L, Hjelle BL. Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure. J Chn Invest 1990; 85: 1328-1332.
145. Pravenec M, Simonet L, Kren V, et al. The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure. Genomics 1991; 9: 466-472.