Substitution mapping in dahl rats identifies two distinct blood pressure quantitative trait loci within 1.12- and 1.25-Mb intervals on chromosome 3

Genetics

Volumn 174, Issue 4, 2006, Pages 2203-2213

  Soon, Jin Lee ^a   Liu, Jun ^a   Westcott, Allison M ^a   Vieth, Joshua A ^a   DeRaedt, Sarah J ^a   Yang, Siming ^a   Joe, Bina ^a   Cicila, George T ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CHROMOSOME 3; CONGENIC STRAIN; CONTROLLED STUDY; CROSSING OVER; DAHL SALT SENSITIVE RAT; DNA POLYMORPHISM; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN;

ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; CHROMOSOME MAPPING; CHROMOSOMES; CROSSES, GENETIC; FEMALE; MALE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED DAHL;

EID: 33845750086     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.106.061747     Document Type: Article

References (59)

1. ABE, M., J. NAKURA, Y. YAMAMOTO, J. J. JIN, Z. WU et al., 2002 Association of GNAS1 gene variant with hypertension depending on smoking status. Hypertension 40: 261-265.
2. BECANOVIC, K., M. JAGODIC, J. R. SHENG, I. DAHLMAN, F. ABOUL-ENEIN et al., 2006 Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis. J. Immunol. 175: 6055-6064.
3. BENETOS, A., K. OKUDA, M. LAJEMI, M. KIMURA, F. THOMAS et al., 2001 Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37: 381.
4. BUÑAG, R., and J. BUTTERFIELD, 1982 Tail cuff blood pressure measurement without external preheating in awake rats. Hypertension 4: 898-903.
5. CAO, Y., H. LI, F.-T. MU, O. EBISUI, J. W. FUNDER et al., 2002 Telomerase activation causes vascular smooth muscle cell proliferation in genetic hypertension. FASEB J. 16: 96-98.
6. CICILA, G. T., J. P. RAPP, K. D. BLOCH, T. W. KURTZ, M. PRAVENEC et al., 1994 Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J. Hypertens. 12: 643-650.
7. CICILA, G. T., O. I. DUKHANINA, T. W. KURTZ, R. WALDER, M. R. GARRETT et al., 1997 Blood pressure and survival of a chromosome 7 congenic strain derived from Dahl rats. Mamm. Genome 8: 896-902.
8. CICILA, G. T., C. CHOI, H. DENE, S. J. LEE and J. P. RAPP, 1999 Two blood pressure/cardiac mass quantitative trait loci are present on chromosome3 of Dahl salt-sensitive and salt-resistant rats. Mamm. Genome 10: 112-116.
9. CICILA, G. T., M. R. GARRETT, S. J. LEE, J. LIU, H. DENE et al., 2001 High resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Genomics 72: 51-60.
10. CLARK, C. J., G. MILLIGAN and J. M. C. CONNELL, 1993 Guanine nucleotide regulatory protein alterations in the Milan hypertensive rat strain. J. Hypertens. 11: 1161-1169.
11. CLARK, C. J., G. MILLIGAN and J. M. C. CONNELL, 1994 Guanine nucleotide regulatory protein alterations in young Milan hypertensive strain rats. Biochim. Biophys. Acta 1225: 149-157.
12. DAHL, L. K., M. HEINE and L. TASSINARI, 1962 Effects of chronic excess salt ingestion: evidence that genetic factors play an important role in the susceptibility to experimental hypertension. J. Exp. Med. 115: 1173-1190.
13. DARVASI, A., A. WEINREB, V. MINKE, J. I. WELLER and M. SOLLER, 1993 Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 134: 943-951.
14. DIAMENT, A. L., P. FARAHANI, S. CHIU, J. FISLER and C. H. WARDEN, 2004 A novel mouse chromosome 2 congenic strain with obesity phenotypes. Mamm. Genome 15: 452-459.
15. DING, H., M. SCHERTZER, X. WU, M. GERTSENSTEIN, S. SELIG et al., 2004 Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell 117: 873-886.
16. DOSTIE, J., Z. MOURELATOS, M. YANG, A. SHARMA and G. DREYFYSS, 2006 Numerous microRNPs in neuronal cells containing novel microRNAs. RNA 9: 180-186.
17. ESTRADA-SMITH, D., L. W. CASTELLANI, H. WONG, P. Z. WEN, A. CHUI et al., 2004 Dissection of multigenic obesity traits in congenic mouse strains. Mamm. Genome 15: 14-22.
18. GARRETT, M. P., H. DENE, R. WALDER, Q. ZHANG, G. T. CICILA et al., 1998 Genomic scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res. 8: 711-723.
19. GARRETT, M. R., and B. JOE, 2006 Genetic analysis of inherited hypertension in the rat, pp. 177-200 in Handbook of Hypertension, edited by A. DOMINICZAK. Elsevier Science, The Netherlands (in press).
20. GARRETT, M. R., and J. P. RAPP, 2002 Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using Dahl rats. Physiol. Genomics 8: 81-86.
21. GARRETT, M. R., Y. SAAD, H. DENE and J. P. RAPP, 2000 Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats. Physiol. Genomics 3: 33-38.
22. HAMET, P., N. THORIN-TRESCASES, P. MOREAU, P. DUMAS, B. S. TEA et al., 2001 Excess growth and apoptosis: Is hypertension a case of accelerated aging of cardiovascular cells? Hypertension 37: 760-766.
23. HSD rats. Mol. Med. 7: 125-134.
24. HUGGHINS, S. Y., H. C. CHAMPION, G. CHENG, P. J. KADOWITZ and J. R. JETER, 2000 Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in isolated rat aorta. Life Sci. 67: 471-476.
25. IMPERATORE, G., W. C. KNOWLER, D. J. PETTITT, S. KOBES, J. H. FULLER et al., 2000 A locus influencing total serum cholesterol on chromosome 19: results from an autosomal genomic scan of serum lipid concentrations in Pima Indians. Arterioscler. Thromb. Vasc. Biol. 20: 2651-2656.
26. ITO, E., G. X. XIE, K. MARUYAMA and P. PIERCE PALMER, 2000 A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5′-adjacent gene GAIP. J. Mol. Biol. 304: 259-270.
27. JEANCLOS, E., N. J. SCHORK, K. O. KYVIK, M. KIMURA, J. H. SKURNICK et al., 2000 Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 36: 195-200.
28. JEREZ-TIMAURE, N. C., F. KEARNEY, E. B. SIMPSON, E. J. EISEN and D. POMP, 2004 Characterization of QTL with major effects on fatness and growth on mouse chromosome 2. Obes. Res. 12: 1408-1420.
29. JEREZ-TIMAURE, N. C., E. J. EISEN and D. POMP, 2005 Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2. Physiol. Genomics 21: 411-422.
30. JIA, H., A. D. HINGORANI, P. SHARMA, R. HOPPER, C. DICKERSON et al., 1999 Association of the GSa gene with essential hypertension and response to β-blockade. Hypertension 34: 8-14.
31. JOE, B., and M. R. GARRETT, 2005 Substitution mapping: using congenic strains to detect genes controlling blood pressure, pp. 41-58 in Contemporary Cardiology: Cardiovascular Genomics, edited by M. K. RAIZADA, J. F. R. PATON, S. KASPAROV and M. J. E. KATOVICH. Humana Press, Totowa, NJ.
32. KATO, N., C. JULIER, F. SOUBRIER, X. JEUNEMAITRE, P. CORVOL et al., 1997 Search for susceptibility loci to hypertension in a region of human chromosome 20q, the homologous region to rat chromosome 3. Am. J. Hypertens. 10(4 Pt. 2): 33A.
33. KATO, N., G. HYNE, M. BIHOREAU, D. GAUGUIER, G. LATHROP et al., 1999 Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Mamm. Genome 10: 259-265.
34. KOMATSU, S., H. KIYOSAWA, A. YOSHIKI, Y. OKAZAKI, M. YOSHINO et al., 2002 Identification of seven loci for static glucokinesis and dynamic glucokinesis in mice. Mamm. Genome 13: 293-298.
35. KURTZ, T. W., K. A. GRIFFIN, A. K. BIDANI, R. L. DAVISSON and J. E. HALL, 2005 Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension 45: 299-310.
36. LAGOS-QUINTANA, M., R. RAUHUT, A. YALCIN, J. MEYER, W. LENDECKEL et al., 2002 Identification of tissue-specific microRNAs from the mouse. Curr. Biol. 12: 735-739.
37. LEMBERTAS, A. Y., L. PERUSSE, Y. C. CHAGNON, J. S. FISLER, C. H. WARDEN et al., 1997 Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J. Clin. Invest. 100: 1240-1247.
38. LI, W.-D., C. DONG, D. LI, C. GARRIGAN and R. A. PRICE, 2005 A genome scan for serum triglyceride in obese nuclear families. J. Lipid Res. 46: 432-438.
39. LÜSCHER, T. F., B.-G. SEO and F. R. BÜHLER, 1993 Potential role of endothelin in hypertension: controversy on endothelin in hypertension. Hypertension 21: 752-757.
40. MALINOWSKA, B., G. GODLEWSKI and E. SCHLICKER, 2002 Function of nociceptin and opiod OP4 receptors in the regulation of the cardiovascular system. J. Physiol. Pharmacol. 53: 301-324.
41. MANLY, K., and J. OLSON, 1999 Overview of QTL mapping software and introduction to Map Manager QT. Mamm. Genome 10: 327-334.
42. MARTEAU, J.-B., M. ZAIOU, G. SIEST and S. VISVIKIS-SIEST, 2005 Genetic determinants of blood pressure regulation. J. Hypertens. 23: 2127-2143.
43. MARTIN, A. M., E. P. BLANKENHORN, M. N. MAXSON, M. ZHAO, J. LEIF et al., 1999 Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes 48: 50-58.
44. MEHRABIAN, M., P. Z. WEN, J. FISLER, R. C. DAVIS and A. J. LUSIS, 1998 Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J. Clin. Invest. 101: 2485-2496.
45. MORENO, C., P. DUMAS, M. L. KALDUNSKI, P. J. TONELLATO, A. S. GREENE et al., 2003 Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol. Genomics 15: 243-257.
46. OGINO, T., D. H. MORALEJO, M. ZHU, K. TOIDE, S. WEI et al., 1999 Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat. Genet. Res. 73: 29-36.
47. OLOFSSON, P., J. HOLMBERG, J. TORDSSON, S. LU, B. AKERSTROM et al., 2003 Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat. Genet. 33: 25-32.
48. PALIJAN, A., J. DUTIL and A. Y. DENG, 2003 Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol. Genomics 15: 1-8.
49. PICKERING, T. G., 1990 Nutritional influences on the pathophysiology of hypertension, pp. 3-16 in Nutritional Factors in Hypertension, edited by H. LANGFORD, B. LEVINE and L. ELLENBOGEN. Alan R. Liss, New York.
50. RAPP, J. P., 2000 Genetic analysis of inherited hypertension in the rat. Physiol. Rev. 8: 135-172.
51. RAPP, J. P., and H. DENE, 1985 Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 7: 340-349.
52. RAPP, J. P., and A. Y. DENG, 1995 Detection and positional cloning of blood pressure quantitative trait loci: Is it possible? Identifying the genes for genetic hypertension. Hypertension 25: 1121-1128.
53. ROCHA, J. L., E. J. EISEN, L. D. VAN VLECK and D. OMP, 2004 A large-sample QTL study in mice: II. Body composition. Mamm. Genome 15: 100-113.
54. SERRANO, A. L., and V. ANDRÉS, 2004 Telomeres and cardiovascular disease: Does size matter? Circ. Res. 94: 575-584.
55. SIEGEL, A.-K., M. PLANERT, S. RADEMACHER, A. P. MEHR, P. KOSSMEHL et al., 2003 Genetic loci contribute to the progression of vascular and cardiac hypertrophy in salt-sensitive spontaneous hypertension. Arterioscler. Thromb. Vasc. Biol. 23: 1211-1217.
56. STOLL, M., A. E. KWITEK-BLACK, A. W. COWLEY, JR., E. I. HARRIS, S. B. HARRAP et al., 2000 New target regions for human hypertension via comparative genomics. Genome Res. 10: 473-482.
57. STOLL, M., A. W. COWLEY, JR., P. J. TONELLATO, A. S. GREENE, M. L. KALDUNSKI et al., 2001 A genomic-systems biology map for cardiovascular function. Science 294: 1723-1726.
58. XIE, G.-X., Y. YANAGISAWA, E. ITO, K. MARUYAMA, X. HAN et al., 2005 N-terminally truncated variant of the mouse GAIP/RGS19 lacks selectivity of full-length GAIP/RGS19 in regulating ORL1 receptor signaling. J. Mol. Biol. 353: 1081-1092.
59. ZHU, L., K. S. HATHCOCK, P. HANDE, P. M. LANSDORP, M. F. SELDIN et al., 1998 Telomere length regulation in mice is linked to a novel chromosome locus. Proc. Natl. Acad. Sci. USA 95: 8648-8653.