Defining the blood pressure QTL on Chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1

Mammalian Genome

Volumn 14, Issue 4, 2003, Pages 268-273

  Garrett, Michael R ^a   Rapp, John P ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEROID 11BETA MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHROMOSOME 7; CONGENIC STRAIN; CONTROLLED STUDY; GENE FUNCTION; GENE MAPPING; GENETIC ANALYSIS; GENETIC VARIABILITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; RAT;

ANIMALS; BLOOD PRESSURE; CHROMOSOME MAPPING; MALE; QUANTITATIVE TRAIT LOCI; RATS; STEROID 11-BETA-HYDROXYLASE;

ANIMALIA; RODENTIA;

EID: 0037385533     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00335-002-2245-9     Document Type: Article

References (29)

1. Belknap JK, Hitzemann R, Crabbe JC, Phillips TJ, Buck KJ et al. (2001) QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits. Behav Genet 31, 5-15
2. Brand E, Chatelain N, Mulatero P, Fery I, Curnow K et al. (1998) Structural analysis and evaluation of the aldosterone synthase gene in hypertension. Hypertension 32, 198-204
3. Brand E, Schorr U, Ringel J, Beige J, Distler A et al. (1999) Aldosterone synthase gene (CYP11B2) C-344T polymorphism in Caucasians from the Berlin salt-sensitivity trial (BeSST). J Hypertens 17, 1563-1567
4. Bunag R, Butterfield J (1982) Tail-cuff blood pressure measurement without external preheating in awake rats. Hypertension 4, 898-903
5. Cicila GT, Rapp JP, Wang J-M, St. Lezin E, Ng SC et al. (1993) Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Nat Genet 3, 346-353
6. Cicila GT, Dukhanina OI, Kurtz TW, Walder R, Garrett MR et al. (1997) Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Mamm Genome 8, 896-902
7. Cicila GT, Garrett MR, Lee SJ, Liu J, Dene H et al. (2001) High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Genomics 72, 51-60
8. Dahl LK, Heine M, Tassinari L (1962) Effects of chronic excess salt ingestion. J Exp Med 115, 1173-1190
9. Davies E, Holloway CD, Ingram MC, Inglis GC, Friel EC et al. (1999) Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Hypertension 33, 703-707
10. Fridman E, Pleban T, Zamir D (2000) A recombination hotspot delimits a wild-species quantitative trait locus for tomato sugar content to 484 bp within an invertase gene. Proc Natl Acad Sci USA 97, 4718-4723
11. Hengstenberg C, Holmer SR, Mayer B, Lowel H, Engel S et al. (2000) Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction. Hypertension 35, 704-709
12. 173 Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension. Hypertension 35, 699-703
13. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S et al. (1992) A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355, 262-265
14. Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ et al. (2000) Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Res 10, 446-453
15. Matsukawa M, Nonaka Y, Higaki J, Nagano M, Mikami H et al. (1993) Dahl's salt-resistant normotensive rat has mutations in cytochrome P-450 (11-β), but the salt-sensitive hypertensive rat does not. J Biol Chem 268, 9117-9121
16. Nonaka Y, Fujii T, Kagawa N, Waterman MR, Takemori H et al. (1998) Structure/function relationship of CYP11B1 associated with Dahl's salt-resistant rats. Expression of rat CYP11B1 and CYP11B2 in Escherichia coli. Eur J Biochem 258, 869-878
17. Rankinen T, An P, Rice T, Sun G, Chagnon YC et al. (2001) Genomic scan for exercise blood pressure in the health, risk factors, exercise training and genetics (HERITAGE) family study. Hypertension 38, 30-37
18. Rapp JP, Dahl LK (1971) Adrenal steroidogenesis in rats bred for susceptibility and resistance to the hypertensive effect of salt. Endocrinology 88, 52-65
19. Rapp JP, Dahl LK (1972a) Mendelian inheritance of 18-and 11-steroid hydroxylase activities in the adrenals of rats genetically susceptible or resistant to hypertension. Endocrinology 90, 1435-1446
20. Rapp JP, Dahl LK (1972b) Possible role of 18-hydroxydeoxycorticosterone in hypertension. Nature 237, 338-339
21. Rapp JP, Dahl LK (1976)Mutant forms of cytochrome P-450 controlling both 18- and 11β-steroid hydroxylation in the rat. Biochemistry 15, 1235-1242
22. Rapp JP, Dene H (1985) Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 7, 340-349
23. Rapp JP, Tan SY, Margolius HS (1978) Plasma mineralcorticoids, plasma renin, and urinary kallikrein in salt-sensitive and salt-resistant rats. Endocr Res Commun 5, 35-41
24. Rice T, Rankinen T, Province MA, Chagnon YC, Perusse L et al. (2000) Genome-wide linkage analysis of systolic and diastolic blood pressures - the Quebec family study. Circulation 102, 1956-1963
25. Silver LM (1995) Mouse Genetics: Concepts and Applications. (New York: Oxford Univ Press), pp 144-147
26. Tamaki S, Iwai N, Tsujita Y, Kinoshita M (1999) Genetic polymorphism of CYP11B2 gene and hypertension in Japanese. Hypertension 33, 266-270
27. Tsujita Y, Iwai N, Katsuya T, Higaki J, Ogihara T et al. (2001) Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita study. Hypertens Res 24, 105-109
28. White PC (1996) Inherited forms of mineralocorticoid hypertension. Hypertension 28, 927-936
29. White PC, Hautanen A, Kupari M (1998) Aldosterone synthase (CYP11B2) polymorphisms and cardiovascular function. Endocr Res 24, 797-804