Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1

Journal of Clinical Investigation

Volumn 97, Issue 3, 1996, Pages 777-788

  Gu, Lingping ^a   Dene, Howard ^a   Deng, Alan Y ^a   Hoebee, Barbara ^b   Bihoreau, Marie Therese ^c   James, Michael ^c   Rapp, John P ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

body weight; cytochrome P450; Dahl rats; hypertension; SA locus

Indexed keywords

CYTOCHROME P450;

ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CHROMOSOME 1; CHROMOSOME MAP; CONTROLLED STUDY; GENE LOCUS; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0030063846     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118477     Document Type: Article

References (38)

1. Tanksley, S.D. 1993. Mapping polygenes Annu. Rev. Genet. 27:205-233
2. Lander, E.S , and M J. Schork. 1994. Genetic dissection of complex traits. Science (Wash. DC). 265:2037-2048.
3. Collins, F S. 1995 Positional cloning moves from perditional to traditional Nat. Genet. 9:347-350
4. Rapp, J.P., and A.Y Deng. 1995. Detection and positional cloning of blood pressure quantitative trait loci: Is it possible? Hypertension (Dallas). 25: 1121-1128.
5. Iwai, N., and T Inagami. 1991 Isolation of preferentially expressed genes in the kidneys of hypertensive rats Hypertension (Dallas). 17:161-169.
6. A-gene, cosegregation with hypertension and mapping to rat chromosome 1. J. Hypertens 11:19-23.
7. A gene. J. Hypertens. 11:919-925.
8. Iwai, N., and T. Inagami. 1992 Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats J Hypertens. 10:1155-1157.
9. Samani, N T , D. Lodwick, M. Vincent, C. Dubay, M.A. Kaiser, M.P. Kelly, M. Lo, J. Harris, J Sassard, M Lathrop, and J D. Swales 1993. A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure. J. Clin. Invest. 92:1099-1103.
10. A gene and blood pressure cosegregation using Dahl salt-sensitive rats. Am. J. Hypertens. 6:330-334.
11. Iwai, N., N. Ohmichi, K. Hanai, Y. Nakamura, and M. Kinoshita. 1994. Human SA gene locus as a candidate locus for essential hypertension. Hypertension (Dallas). 23:375-380
12. Nabika, T , A Bonnardeaux, M. James, C. Julier, X. Jeunemaitre, P. Corvol, M. Lathrop, and F. Soubrier. 1995. Evaluation of the SA locus in human hypertension. Hypertension (Dallas). 25:6-13.
13. Rapp, J P., and H. Dene. 1985. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension (Dallas). 7:340-349
14. Rapp, J.P., H. Dene, and A.Y. Deng 1994. Seven renin alleles in rats and their effects on blood pressure. J. Hypertens. 12:349-355.
15. Buñag, R.D., and J. Butterfield. 1982 Tail-cuff blood pressure measurement without external preheating in awake rats. Hypertension (Dallas). 4:898-903.
16. Blin N., and D W Stafford. 1976. Isolation of high-molecular-weight DNA. Nucleic Acids Res. 3:2303-2308.
17. Hoebee, B., J.M. de Stoppelaar, R F. Suijkerbuijk, and S. Monard 1994. Isolation of rat chromosome-specific paint probes by bivariate flow sorting followed by degenerate oligonucleotide primed-PCR. Cytogenet. Cell Genet. 66: 277-282.
18. Telenius, H., A.H Pelmear, A. Tunnacliffe, N.P. Carter, A. Behmel, M.A. Ferguson-Smith, M. Nordenskjöld, R. Pfragner, and B.A.J. Ponder. 1992. Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes. Genes Chromosomes & Cancer 4:257-263
19. Telenius, H., N.P Carter, C. Bebb, M. Nordenskjold, B.A.J. Ponder, and A. Tunnacliffe. 1992. Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. Genomics. 13:718-725.
20. Serikawa, T., T. Kuiamoto, P. Hilbert, M. Mori, J. Yamada, C J. Dubay, K Lindpainter, D Ganten, J.-L Guénet, G.M Lathrop, and J S Beckmann. 1992 Rat gene mapping using PCR-analyzed microsatellites. Genetics. 131:701-721.
21. Jacob, H.J., D.M. Brown, R.K. Bunker, M.J. Daly, V.J. Dzau, A. Goodman, G. Koike, V. Kren, T Kurtz, A. Lernmark, et al. 1995 A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat. Genet 9:63-69
22. Kunieda, T., E Kobayashi, M. Tachibana, H. Ikadai, and T Imamichi. 1992. Polymorphic microsatellite loci of the rat (Rattus norvegicus) Mamm. Genome 3:564-567.
23. Goldmuntz, E A., E.F. Remmers, H Zha, J.M. Cash, P. Mathern, L.J. Crofford, and R.L Wilder 1993. Genetic map of 12 polymorphic loci on rat chromosome 1. Genomics. 16:761-764.
24. Gu, L., H. Dene, and J P. Rapp. 1994. Three microsatellites defining four alleles for the rat SA gene. Mamm. Genome. 5:833.
25. Deng, A Y., H Dene, M. Pravenec, and J.P. Rapp. 1994. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J. Clin Invest. 93:2701-2709.
26. Lander, E., P. Green, J. Abrahamson, A Barlow, M.J. Daly, S.E. Lincoln, and L. Newburg. 1987. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174-181.
27. Lander, E., and D. Bostein. 1989. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 12:185-199
28. Darvasi, A , A. Weinreb, V. Minke, J.I. Weller, and M. Soller. 1993. Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics. 134:943-951.
29. Martinez, O., and R.N. Curnow. 1992. Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers. Theor. Appl Genet. 85:480-488.
30. Deng, A.Y., H. Dene, and J.P. Rapp. 1994. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin. Invest 94:431-436.
31. Deng, A.Y., and J.P. Rapp. 1995. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J. Clin. Invest. 95:2170-2177.
32. Hansson, J.H., C. Nelson-Williams, H. Suzuki, L. Schild, R. Shimkets, Y. Lu, C. Canessa, T. Iwasaki, B. Rossier, and R.P. Lifton. 1995. Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome. Nat. Genet 11:76-82.
33. Shimkets, R.A., D.G. Warnock, C.M. Bositis, C. Nelson-Williams, J.H. Hansson, M. Schambelan, J.R. Gill, Jr., S. Ulick, R.V. Milora, J.W. Findling, et al. 1994. Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell. 79:407-414.
34. McGiff, J.C. 1991. Cytochrome P-450 metabolism of arachidonic acid. Annu. Rev. Pharmacol Toxicol. 31:339-369.
35. McGiff, J.C., M.A. Carroll, and B. Escalante. 1991. Arachidonate metabolites and kinins in blood pressure regulation. Hypertension (Dallas) 18(suppl. III):III-150-II-157.
36. Hirt, D.L., and H.R. Jacobson. 1991. Functional effects of cytochrome P450 arachidonate metabolites in the kidney Seminars in Nephrology. 11:148-155.
37. Cicila, G.T., J.P. Rapp, K.D. Bloch, T.W. Kurtz, M. Pravenec, V. Křen, C.C Hong, T. Quertermous, and S.C. Ng. 1994. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J. Hypertens. 12:643-651.
38. Deng, Y., and J.P Rapp. 1992. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat. Genet. 1:267-272.