Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: Effect of ecNOS polymorphism on left ventricular hypertrophy

Cardiovascular Ultrasound

Volumn 4, Issue , 2006, Pages

  Olcay, Ayhan ^a   Ekmekci, C Gokhan ^a   Ozbek, Ugur ^a   Sezer, Murat ^a   Barcin, Cem ^b   Arslan, Erol ^b   Boztosun, Bilal ^c   Nisanci, Yilmaz ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b Cardiovascular Surgery   (Turkey)

^c KOSUYOLU HEART AND RESEARCH HOSPITAL   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; AGED; ALLELE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ECHOCARDIOGRAPHY; ENDOTHELIUM; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE SEPTUM; HUMAN; HYPERTENSION; INTRON; MAJOR CLINICAL STUDY; MALE; PHYSIOLOGY; TURKEY (REPUBLIC);

CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; INCIDENCE; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS; STATISTICS AS TOPIC; TURKEY;

EID: 33748465709     PISSN: 14767120     EISSN: 14767120     Source Type: Journal    
DOI: 10.1186/1476-7120-4-33     Document Type: Article

References (25)

1. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med 1993, 329:2002-2012.
2. Schmidt HH, Walter U: NO at work. Cell 1994, 78:919-925.
3. Forte P, Copland M, Smith LM, Milne E, Sutherland J, Benjamin N: Basal nitric oxide synthesis in essential hypertension. Lancet 1997, 349:837-842.
4. Devlin AM, Brosnan J, Graham D, Morton JJ, McPhaden AR, McIntyre M, Hamilton CA, Reid JL, Dominiczak AF: Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. Am J Physiol 1998, 274:H52-H59.
5. Haynes WG, Noon JP, Walker BR, Webb DJ: Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens 1993, 11:1375-1380.
6. Heineke J, Kempf T, Kraft T, et al.: Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on myocyte cardiac hypertrophy. Circulation 2003, 107:1424-1432.
7. Nadaud S, Bonnardeaux A, Lathrop M, Soubrier F: Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun 1994, 198:1027-1033.
8. Wang Y, Kikuchi S, Suzuki H, Nagase S, Koyama A: Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases. Nephrol Dial Transplant 1999, 14:2989-2902.
9. Wang XL, Mahaney MC, Sim AS, Wang J, Wang I, Blangero J, Almasy L, Badenhop RB, Wilcken DE: Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol 1997, 17:3147-3153.
10. Hibi K, Ishigami T, Tamura K, Mizushima S, Nyui N, Fujita T, Ochiai H, Kosuge M, Watanabe Y, Yoshii Y, Kihara M, Kimura K, Ishii M, Umemura S: Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 1998, 32:521-526.
11. Matyar S, Attila G, Acarturk E, Akpinar O, Inal T: eNOS gene intron 4 a/b VNTR polymorphism is a risk factor for coronary artery disease in Southern Turkey. Clin Chim Acta 2005, 354(1-2):153-158.
12. Tsukada T, Yokoyama K, Arai T, Takemoto F, Hara S, Yamada A, Kawaguchi Y, Hosoya T, Igari J: Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 1998, 245:190-193.
13. Uwabo J, Soma M, Nakayama T, Kanmatsuse K: Association of a variable number of tandem repeats in the endothelial constitutive nitric oxide synthase gene with essential hypertension in Japanese. Am J Hypertens 1998, 11:125-128.
14. Miyamoto Y, Saito Y, Kajiyama N, Yoshimura M, Shimasaki Y, Nakayama M, Kamitani S, Harada M, Ishikawa M, Kuwahara K, Ogawa E, Hamanaka I, Takahashi N, Kaneshige T, Teraoka H, Akamizu T, Azuma N, Yoshimasa Y, Yoshimasa T, Itoh H, Masuda I, Yasue H, Nakao K: Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 1999, 32:3-8.
15. Yasujima M, Tsutaya S, Shoji M: Endothelial nitric oxide synthase gene polymorphism and hypertension (in Japanese). Rinsho Byori Jap J Clin Pathol 1998, 46:1199-1204.
16. Wood AJ: Racial differences in the response to drugs-pointers to genetic differences. N Eng J Med 2001, 344:1393-1396.
17. Stein CM, Lang CC, Xie HG, Wood AJ: Hypertension in black people: study of specific genotypes and phenotypes will provide a greater understanding of interindividual and interethnic variability in blood pressure regulation than studies based on race. Pharmacogenetics 2001, 11:95-110.
18. Cardillo C, Kilcoyne CM, Cannon RO III, Panza JA: Racial differences in nitric oxide-mediated vasodilator response to mental stress in the forearm circulation. Hypertension 1998, 31:1235-1239.
19. Devereux RB, Reicek N: Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation 1977, 55:613-618.
20. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutfessell H, Reichek N, Sahn D, Schnittegr I, Silverman NH, Tajik AJ: Recommendations for the quantification of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiography 1989, 2:358-367.
21. Cine N, Hatemi AC, Erginel-Unaltuna N: Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients. Clin Genet 2002, 61:66-70.
22. Sandrim VC, Coelho EB, Nobre F, Arado GM, Lanchote VL, Tanus-Santos JE: Susceptible and protective eNOS haplotypes in hypertensive black and white subjects. Atherosclerosis 2006, 186(2):428-432.
23. Persu A, Vinck WJ, El Khattabi O, Janssen RG, Paulussen AD, Devuyst O, Vlietinck R, Fagard RH: Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study. J Hypertens 2005, 23(4):759-765.
24. Karvonen J, Kauma H, Kervinen K, Rantala M, Ikaheimo M, Paivansalo M, Savolainen MJ, Kesaniemi YA: Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort. Journal of Internal Medicine 2002, 251:102-110.
25. Zhu H, Wang X, Dong Y, Treiber FA, Snieder H: Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youth. Pharmacogenet Genomics 2005, 15(9):669-675.