Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17

Physiological Genomics

Volumn 21, Issue , 2005, Pages 112-116

  Grondin, Myrian ^a   Eliopoulos, Vasiliki ^a   Lambert, Raphaelle ^a   Deng, Yishu ^b   Ariyarajah, Anita ^a   Moujahidine, Myriam ^a   Dutil, Julie ^a   Charron, Sophie ^a   Deng, Alan Y ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Number Three People's Hospital of Yunnan   (China)

Author keywords

Congenic strain; Congenic substrain; Dahl salt sensitive rat; Normotensive Lewis rat

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CHROMOSOME 17; CONFIDENCE INTERVAL; CONGENIC STRAIN; CONTROLLED STUDY; GENE LOCATION; GENE MAPPING; GENETIC LINKAGE; HOMOZYGOSITY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN;

ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; CHROMOSOME MAPPING; CHROMOSOMES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME; HOMOZYGOTE; HYPERTENSION; LINKAGE (GENETICS); LOD SCORE; MODELS, GENETIC; MODELS, STATISTICAL; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; RATS; RATS, INBRED DAHL;

EID: 18244377271     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00275.2004     Document Type: Article

References (28)

1. Alemayehu A, Breen L, Krenova D, and Printz MP. Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL. Physiol Genomics 10: 199-210, 2002.
2. Ariyarajah A, Palijan A, Dutil J, Prithiviraj K, Deng Y, and Deng AY. Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat Chromosome 8 by congenic strains. J Hypertens 22: 1495-1502, 2004.
3. Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, and Kwitek AE. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. Hypertension 44: 695-701, 2004.
4. Deng AY. Functional genomics of blood pressure determination: dissecting and assembling a polygenic strait by experimental genetics. Curr Hypertension Rev 1: 35-50, 2005.
5. Deng AY. In search of hypertension genes in Dahl salt-sensitive rats. J Hypertens 16: 1707-1717, 1998.
6. Deng AY, Dene H, Pravenec M, and Rapp JP. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 93: 2701-2709, 1994.
7. Deng AY, Dutil J, and Sivo Z. Utilization of marker-assisted congenics to map two blood pressure quantitative trait loci in Dahl rats. Mamm Genome 12: 612-616, 2001.
8. Deng AY, Smith-Mensah WH, Hoebee B, Garrett M, and Rapp JP. Linkage mapping of rat chromosome markers generated from chromosome-sorted DNA. Mamm Genome 9: 38-43, 1998.
9. Dutil J and Deng AY. Further chromosomal mapping of a blood pressure QTL in Dahl rats on chromosome 2 using congenic strains. Physiol Genomics 6: 3-9, 2001.
10. Dutil J and Deng AY. Mapping a blood pressure quantitative trait locus to a 5.7-cM region in Dahl salt-sensitive rats. Mamm Genome 12: 362-365, 2001.
11. Frantz S, Clemitson JR, Bihoreau MT, Gauguier D, and Samani NJ. Genetic dissection of region around the Sa gene on rat chromosome 1: evidence for multiple loci affecting blood pressure. Hypertension 38: 216-221, 2001.
12. Garret MR, Dene H, Walder R, Zhang Q, Cicila GT, Assadnia S, Deng AY, and Rapp JP. Genomic scan and congenic strains for blood pressure quantitative trait loci using Dahl salt-sensitive rats. Genome Res 8: 711-723, 1998.
13. Garret MR, Zhang X, Dukhanina OI, Deng AY, and Rapp JP. Two linked blood pressure QTL on chromosome 10 defined by Dahl-rat congenic strains. Hypertension 38: 779-785, 2001.
14. Garrett MR and Rapp JP. Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Mamm Genome 14: 268-273, 2003.
15. Gibbs et al. (Rat Genome Sequencing Project Consortium). Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428: 493-521, 2004.
16. Glazier AM, Nadeau JH, and Aitman TJ. Finding genes that underlie complex traits. Science 298: 2345-2349, 2002.
17. Jeffs B, Negrin CD, Graham D, Clark JS, Anderson NH, Gauguier D, and Dominiczak AF. Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. Hypertension 35: 179-187, 2000.
18. Moujahidine M, Dutil J, Hamet P, and Deng AY. Congenic mapping of a blood pressure QTL on Chromosome 16 of Dahl rats. Mamm Genome 13: 153-156, 2002.
19. Moujahidine M, Lambert R, Dutil J, Palijan A, Sivo Z, Ariyarajah A, and Deng AY. Combining congenic coverage with gene profiling in search of candidates for blood pressure QTLs in Dahl rats. Hypertens Res 27: 203-212, 2004.
20. Palijan A, Dutil J, and Deng AY. Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Physiol Genomics 15: 1-8, 2003.
21. Palijan A, Lambert R, Sivo Z, Dutil J, and Deng AY. Comprehensive congenic coverage revealing multiple BP QTLs on Dahl rat Chromosome 10. Hypertension 42: 515-522, 2003.
22. Pravenee M, Gauguier D, Schott JJ, Buard J, Kren V, Bila V, Szpirer C, Szpirer J, Wang JM, and Huang H. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest 96: 1973-1978, 1995.
23. Rapp JP and Deng AY. Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Hypertension 25: 1121-1128, 1995.
24. Sivo Z, Malo B, Dutil J, and Deng AY. Accelerated congenics for mapping two blood pressure quantitative trait loci on Chromosome 10 of Dahl rats. J Hypertens 20: 1-9, 2002.
25. Wong C, Mahapatra NR, Chitbangonsyn S, Mahboubi P, Mahata M, Mahata SK, and O'Connor DT. The angiotensin II receptor (Agtrla): functional regulatory polymorphisms in a locus genetically linked to blood pressure variation in the mouse. Physiol Genomics 14: 83-93, 2003.
26. Yagil C, Hubner N, Kreutz R, Ganten D, and Yagil Y. Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension. Physiol Genomics 12: 85-95, 2003.
27. Yagil C, Sapojnikov M, Kreutz R, Katni G, Lindpaintner K, Ganten D, and Yagil Y. Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension 31: 119-124, 1998.
28. Zhao L, Sebkhi A, Nunez DJ, Long L, Haley CS, Szpirer J, Szpirer C, Williams AJ, and Wilkins MR. Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate. Circulation 103: 442-447, 2001.