The α1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitive(HSD) rat

Journal of Clinical Investigation

Volumn 102, Issue 6, 1998, Pages 1102-1111

  Herrera, Victoria L M ^a   Xie, Hou Xiang ^a   Lopez, Lyle V ^a   Schork, Nicholas J ^b   Ruiz Opazo, Nelson ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cosegregation analysis; Genetics; Hypertension; Na,K ATPase; Transgenic model

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); COMPLEMENTARY DNA; SODIUM CHLORIDE; DEXTRAN; HYPERTONIC SALINE DEXTRAN SOLUTION; HYPERTONIC SALINE-DEXTRAN SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 2; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE SEGREGATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HYPERTENSION; MALE; NONHUMAN; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RAT; TRANSGENIC ANIMAL; ANIMAL; BLOOD PRESSURE MEASUREMENT; CHROMOSOME MAP; COMPARATIVE STUDY; CROSS BREEDING; DISEASE PREDISPOSITION; DRUG RESISTANCE; GENETICS; HETEROZYGOTE; HOMOZYGOTE; PATHOLOGY; RENOVASCULAR HYPERTENSION; SURVIVAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD PRESSURE DETERMINATION; CHROMOSOME MAPPING; CROSSES, GENETIC; DEXTRANS; DISEASE SUSCEPTIBILITY; DRUG RESISTANCE; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HYPERTENSION; HYPERTENSION, RENAL; LINKAGE (GENETICS); NA(+)-K(+)-EXCHANGING ATPASE; PHENOTYPE; RATS; SODIUM CHLORIDE; SURVIVAL ANALYSIS;

EID: 0032529929     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3868     Document Type: Article

References (31)

1. Herrera, V.L.M., and N. Ruiz-Opazo. 1991. Genetics of hypertension: a multidisciplinary challenge. Trends Cardiovasc. Med. 1:185-189.
2. Herrera, V.L.M., and N. Ruiz-Opazo. 1994. Beyond genetic markers: hypertension genes. J. Hypertension. 12:847-856.
3. Dahl, L.K, M. Heine, and L. Tassinari. 1972. Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature. 194:480-482.
4. Dahl, L.K., M. Heine, and K. Thompson. 1974. Genetic influence of the kidneys on blood pressure: evidence from chronic renal homografts in rats with opposite predispositions to hypertension. Circ. Res. 34:94-101.
5. Vander, A.J. 1991. Renal Physiology. 4th edition. McGraw-Hill. Inc. New York. 83-111.
6. Herrera, V.L.M., T. Cova, D. Sassoon, and N. Ruiz-Opazo. 1994. Developmental cell-specific regulation of α1. α2. and α3 Na,K-ATPase gene expression. Am. J. Physiol. 266:C1301-C1312.
7. DeWardener, H.E. 1990. The primary role of the kidney and salt intake in the aetiology of essential hypertension, part II. Clin. Sci. 79:289-297.
8. + influx by a single amino acid substitution. Science. 249:1023-1026.
9. Ruiz-Opazo, N., F. Barany, K. Hirayama, and V.L.M. Herrera. 1994. Confirmation of mutant α1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Hypertension. 24:260-270.
10. Simonet, L., E. St. Lezin, T.W. Kurtz. 1991. Sequence analysis of the α1 Na,K-ATPase gene in the Dahl salt-sensitive rat. Hypertension. 18:689-693.
11. Schull, G.E., J. Greeb, J.B. Lingrel. 1989. Molecular cloning of three distinct forms of the Na,K-ATPase α-subunit from rat brain. Biochetnistry. 25: 8125-8132.
12. + transport in red blood cells. J. Membr. Biol. 134:107-122.
13. Orosz, D.E., and U. Hopfer. 1996. Pathophysiologic consequences of changes in the coupling ratio of Na,K-ATPase for renal sodium reabsorption and its implications for hypertension. Hypertension. 27:219-227.
14. Jacob, H.J., Brown, D.M., Bunker, R.K., Daly, M.J., Dzau, V.J., Goodman, A., Koike, G., Kren, V. Kurtz, T., Lernmark, et al. 1995. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat. Genet. 9:63-69.
15. Ruiz-Opazo, N., J.F. Cloix, M.G. Melis, X.H. Xiang, and V.L.M. Herrera. 1997. Characterization of a sodium-response transcriptional mechanism. Hypertension. 30:191-198.
16. Ruiz-Opazo, N., X.H. Xiang, and V.L.M. Herrera. 1997. Pressure-overload deinduction of human α2 Na,K-ATPase gene expression in transgenic rats. Hypertension. 29:606-612.
17. Dallner, G. 1974. Isolation of rough and smooth microsomes - general. In Methods in Enzymology, Vol. XXXI. S. Fleischer and L. Packer, editors. Academic Press. New York. 191-201.
18. Raij, L., S. Azar, and W.K. Keane. 1984. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int. 26: 137-143.
19. Herrera, V.L.M., R.J. Russell, Q. Fang, J.R. McGinley, and N. RuizOpazo. 1995. Genotypic and phenotypic characterization of inbred Dahl saltsensitive (SS/JR Hsd) and salt-resistant (SR/JRHsd) rats. Contemp. Top. 34:51.
20. Lewis, J.L., R.J. Russell, and D.G. Warnock. 1994. Analysis of the genetic contamination of salt-sensitive Dahl/Rapp rats. Hypertension. 24:255-259.
21. Rapp, J.P., and H. Dene. 1985. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension. 7:340-349.
22. Deng, A.Y., H. Dene, and J.P. Rapp. 1994. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.J. Clin. Invest. 94:431-436.
23. Dubay, C., M. Vincent, N.J. Samani, P. Hilbert, M.A. Kaiser, J.P. Beressi, Y. Kotelevtsev, J.S. Beckmann, F. Soubrier, J. Sassard, and G.M. Lathrop. 1993. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Nat. Genet. 3:354-357.
24. St. Lezin, E.M., M. Pravenec, A. Wong, J.-M. Wang, T. Merriouns, S. Newton, D.E. Stec, R.J. Roman, D. Lau, R.C. Morris, and T.W. Kurtz. 1994. Genetic contamination of Dahl SS/JR rats: impact on studies of salt-sensitive hypertension. Hypertension. 23:786-790.
25. Clark, J.S., B. Jeffs, A.O. Davidson, W.K. Lee, N.H. Andersen, M.T. Bihoreau, M.J. Brosnan, A.M. Devlin, A.W. Kelman, K. Lindpaintner, and A.F. Dominiczak. 1996. Quantitative trait loci in genetically hypertensive rats. Hypertension. 28:898-906.
26. Samani, N.J., D. Gauguier, M. Vincent, M.A. Kaiser, M.T. Bihoreau, D. Lodwick, R. Wallis, V. Parent, P. Kimber, F. Rattray, et al. 1996. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Hypertension. 28:1118-1122.
27. Lander, E., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241-247.
28. National Heart, Lung and Blood Institute Report of the Task Force on Research in Hypertension. United States Department of Health and Human Services. May 1991.
29. Goldman, D. 1996. High anxiety. Science. 274:1483.
30. Lcsch, K.P., D. Bengel, A. Heils, S.Z. Sabol, B.D. Greenberg, S. Petri, J. Benjamin. C.R. Muller, D.H. Hamer, and D.L. Murphy. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1527-1531.
31. Lander, E., and N.J. Schork. 1994. Genetic dissection of complex traits. Science. 265:2037-2048.