Where are all the blood-pressure genes?

Lancet

Volumn 361, Issue 9375, 2003, Pages 2149-2151

  Harrap, Stephen B ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0037862904     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)13694-X     Document Type: Short Survey

References (30)

1. Harrap S.B. Genetic analysis of blood pressure and sodium balance in the spontaneously hypertensive rat. Hypertension. 8:1986;572-582.
2. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 2000; 80: 135-72.
3. Caulfield M., Munroe P., Pembroke J., et al. Genome-wide mapping of human loci for essential hypertension. Lancet. 361:2003;2118-2123.
4. Province M.A., Kardia S.L.R., Ranade K., et al. A meta-analysis of genome-wide linkage scans for hypertension: the National Heart Lung and Blood Institute Family Blood Pressure Program. Am J Hypertens. 16:2003;144-147.
5. Lander E., Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 11:1995;241-247.
6. Harrap S.B., Stebbing M., Hopper J.L., Hoang H.N., Giles G.G. Familial patterns of covariation for cardiovascular risk factors in adults - the Victorian Family Heart Study. Am J Epidemiol. 152:2000;704-715.
7. Cooper R.S., Luke A., Zhu X., et al. Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19. Hypertension. 40:2002;629-633.
8. Rice T., Rankinen T., Province M.A., et al. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec family study. Circulation. 102:2000;1956-1963.
9. Harrap S.B., Wong Z.Y., Stebbing M., Lamantia A., Bahlo M. Blood pressure QTLs identified by genome-wide linkage analysis and dependence on associated phenotypes. Physiol Genom. 8:2002;99-105.
10. Thiel B.A., Chakravarti A., Cooper R.S., et al. A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens. 16:2003;151-153.
11. Ranade K., Hinds D., Hsiung C.A., et al. A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. Am J Hypertens. 16:2003;158-162.
12. Altmuller J., Palmer L.J., Fischer G., Scherb H., Wjst M. Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet. 69:2001;936-950.
13. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517.
14. Perola M., Kainulainen K., Pajukanta P., et al. Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings. J Hypertens. 18:2000;1579-1585.
15. Zhu D.L., Wang H.Y., Xiong M.M., et al. Linkage of hypertension to chromosome 2q14-q23 in Chinese families. J Hypertens. 19:2001;55-61.
16. Xu X., Rogus J.J., Terwedow H.A., et al. An extreme sib-pair genome scan for genes regulating blood pressure. Am J Hum Genet. 64:1999;1694-1701.
17. Weiss K.M., Terwilliger J.D. How many diseases does it take to map a gene with SNPs. Nat Genet. 26:2000;151-157.
18. Jaenisch R., Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 33:2003;245-254.
19. Chakravarti A. Population genetics - making sense out of sequence. Nat Genet. 21:1999;56-60.
20. Reich D.E., Lander E.S. On the allelic spectrum of human disease. Trends Genet. 17:2001;502-510.
21. Watterson G.A., Guess H.A. Is the most frequent allele the oldest? Theor Popul Biol. 11:1977;141-160.
22. Stephens J.C., Schneider J.A., Tanguay D.A., et al. Haplotype variation and linkage disequilibrium in 313 human genes. Science. 293:2001;489-493.
23. Kaplan N., Morris R. Issues concerning association studies for fine mapping a susceptibility gene for a complex disease. Genet Epidemiol. 20:(suppl):2001;432-457.
24. Pritchard J.K. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet. 69:2001;124-137.
25. Botstein D., Risch N. Discovering genotypes underlying human phenotypes: past successes for Mendelian disease, future approaches for complex disease. Nat Genet. 33:2003;228-237.
26. Halushka M.K., Fan J.B., Bentley K., et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 22:1999;239-247.
27. Phillips P.C. From complex traits to complex alleles. Trends Genet. 15:1999;6-8.
28. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 22:1999;139-144.
29. Cui J., Hopper J.L., Harrap S.B. Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension. 41:2003;207-210.
30. Bashyam M.D., Savithri G.R., Kumar M.S., Narasimhan C., Nallari P. Molecular genetics of familial hypertrophic cardiomyopathy (FHC). J Hum Genet. 48:2003;55-64.