In search of hypertension genes in Dahl salt-sensitive rats

Journal of Hypertension

Volumn 16, Issue 12, 1998, Pages 1707-1717

  Deng, Alan Y ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Blood pressure; Congenic strains; Epistasis; Genetic mapping; Position effects; Quantitative trait locus

Indexed keywords

SODIUM CHLORIDE;

ALLELE; BLOOD PRESSURE; GENE LOCUS; GENE MAPPING; GENETIC EPISTASIS; HYPERTENSION; HYPOTENSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RAT; REVIEW; SALT INTAKE;

EID: 0031737247     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816120-00001     Document Type: Review

References (82)

1. Dahl LK, Hein M, Tassinari L. Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 1962; 194:480-482.
2. Deng AY. Is the nitric oxide system involved in genetic hypertension in Dahl rats? Kidney Int 1998; 53:1501-1511.
3. Collins FS. Positional cloning moves from perditional to traditional. Nat Genet 1995; 9:347-350.
4. Lifton RP. Molecular genetics of human blood pressure variation. Science 1996; 272:676-680.
5. Zhang YR, Proenca M, Maffel M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372:425-432.
6. Rapp JP, Deng AY. Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Hypertension 1995; 25: 1121-1128.
7. Schork NJ, Nath SP, Lindpainter K, Jacob HJ. Extensions to quantitative trait locus mapping in experimental organisms. Hypertension 1996; 28:1104-1111.
8. Harriet P, Pausova Z, Adarichev V, Adaricheva K, Tremblay J. Hypertension: genes and environment. J Hypertens 1998; 16:397-418.
9. Deng AY. Determining quantitative trait loci for blood pressure in the rat: implication for human genetic hypertension. In: Dragani TA (editor): Human polygenic diseases: animal models. Amsterdam: Harwood Academic Publishers; 1998. pp. 81-111.
10. Harris EL, Dene H, Rapp JP. SA gene and blood pressure cosegregation using Dahl salt-sensitive rats. Am J Hypertens 1993; 6:330-334.
11. Gu L, Dene H, Deng AY, Hoebel B, Biboreau M, James M, et al. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J Clin Invest 1996; 97:777-788.
12. Garrett MR, Dene H, Walder R, Zhang Q, Cicila GT, Assadnia S, et al. Genomic scan and congenic strains for blood pressure quantitative trait loci using Dahl salt sensitive rats. Genome Res 1998; 8:711-723.
13. Deng AY, Rapp JP. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat Genet 1992; 1:267-272.
14. Deng AY, Dene H, Rapp JP. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest 1994; 94:431-436.
15. 1B gene as a candidate gene for blood pressure. J Hypertens 1994; 12:1001-1006.
16. Deng AY, Dene H, Rapp JP. Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. Hypertension 1997; 30:199-202.
17. Cicila GT, Rapp JP , Bloch KD, Kurtz TW, Pravenec M, Kren V, et al. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J Hypertens 1994; 12:643-651.
18. Cicila GT, Choi C, Dene H, Dukhanina OI, Rapp JP. Two blood pressure/cardiac mass quantitative trait loci are present on chromosome 3 of Dahl salt-sensitive and salt-resistant rats [abstract]. Hypertension 1997; 30:492.
19. Deng AY, Dene H, Pravenec M, Rapp JP. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 1994; 93:2701-2709.
20. Rapp JP, Dahl LK. Mendelian inheritance of 18- and 11β-steroid hydroxylase activities in the adrenals of rats genetically susceptible or resistant to hypertension. Endocrinology 1972; 90:1435-1446.
21. Cicila GT, Rapp JP, Wang JM, St Lezin E, Ng SC, Kurtz TW. Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Nat Genet 1993; 3:346-353.
22. Matsukawa N, Nonaka Y, Higaki J, Nagano M, Mikami H, Opihara T, et al. Dahl S salt-resistant normotensive rat has mutations in cytochromic p450 (11β), but the salt-sensitive hypertensive rat does not. J Biol Chem 1993; 268:9117-9121.
23. Cicila GT, Dukhanina OI, Kurtz TW, Walder R, Garrett MR, Dene H, et al. Blood pressure and survival of chromosome 7 congenic strain bred from Dahl rats. Mamm Genome 1997; 8:896-902.
24. Deng AY, Rapp JP. Locus for the inducible but not a constitutive nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest 1995; 95:2170-2177.
25. Dukhanina OI, Dene H, Deng AY, Hoebee B, Rapp JP. Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm Genome 1997; 8:229-235.
26. Rapp JP, Wang S-M, Dene H. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 1989; 243:542-544.
27. Rapp JP, Dene H, Deng AY. Seven renin alleles in rats and their effect on blood pressure. J Hypertens 1994; 12:119-125.
28. Zhang Q, Dene H, Deng AY, Jacob H, Rapp JP. Interval mapping and congenic strains for blood pressure QTL on rat chromosome 13. Mamm Genome 1997; 8:636-641.
29. Deng AY. Linkage analysis for blood pressure with rat chromosome 15 markers. Fol Biol 1997; 43:183-193.
30. Lander ES, Schork NJ. Genetic dissection of complex traits. Science 1994; 265:2037-2048.
31. Sturtevant AH. The effects of unequal crossing-over at the bar locus in Drosophila. Genetics 1925; 10:117-147.
32. Tsubota SI, Rosenberg D, Szostak H, Rubin D, Schedl P. The cloning of the bar region and the B breakpoint in Drosophila melanogaster: evidence for a transposon-induced rearrangement. Genetics 1989; 122:881-890.
33. Wilson C, Bellen HJ, Gehring WK. Position effects on eukaryotic gene expression. Annu Rev Cell Biol 1990; 6:679-714.
34. Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, et al. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 1997; 17:280-284.
35. Behringer R. Supersonic congenics? Nat Genet 1997; 17:108.
36. Hedrich HJ. Genetic monitoring of inbred strains of rats. New York: ICLAS, Gustav Fischer Verlag; 1990.
37. Ginn DI, Baptista CAC, Alam K, Deng AY, Cicila GT, Margolius HS, et al. Estimate of the genetic divergence between inbred Dahl salt-sensitive and salt-resistant rats. J Hypertens 1993; 11:477-481.
38. Laragh JH, Brenner B. Hypertension. New York: Raven Press; 1995.
39. Sharma P, Hingorani A, Jia H, Stevens P, Brown MJ. A newly identified endothelin-2 gene molecular variant is associated with diastolic blood pressure in essential hypertensives [abstract]. J Hypertens 1996; 14 (suppl):S6.
40. 86RB influx by a single amino acid substitution. Science 1990; 249:1023-1026.
41. +-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Hypertension 1994; 24:260-270.
42. +-ATPase gene in the Dahl salt-sensitive rat. Hypertension 1991; 18:689-693.
43. 1 locus to cosegregate with blood pressure in Dahl rats. J Hypertens 1990; 8:456-462.
44. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 1994; 79:407-414.
45. Friedman JM. The alphabet of weight control. Nature 1997; 385:119-120.
46. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543-546.
47. Sinnott EW, Dunn LC, Dobzhansky TH. Principles of genetics. New York: McGraw-Hill Book Company, Inc; 1950. pp. 108-110.
48. Rapp JP, Garrett MR, Deng AY. Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. J Clin Invest 1998; 101:1591-1595.
49. Beadle GW, Ephrussi B. The differentiation of eye pigments in Drosophila as studied by transplantation. Genetics 1936; 21:225-247.
50. Rizki TM, Rizki RM. Allele specific patterns of suppression of the vermilion locus in Drosophila melangogaster. Genetics 1968; 59:477-485.
51. Sullivan DT, Kitos RJ, Sullivan MC. Developmental and genetic studies on kynurenine hydroxylase from Drosophila melanogaster. Genetics 1973; 75:651-661.
52. Baker BS. Sex in flies: the splice of life. Nature 1989; 340:521-524.
53. Baker BS, Ridge KA. Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melangogaster. Genetics 1980; 94:383-423.
54. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994; 368:703-710.
55. Brockway BP, Hassler CR. Application of radiotelemetry to cardiovascular measurements in pharmacology and toxicology. In: Salem E, Baskin SI (editors): New technologies and concepts for reducing drug toxicities, ch 9. Boca Raton, Florida: CRC Press; 1993. pp. 109-132.
56. Rapp JP, Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 1985; 7: 340-349.
57. Okamoto K, Aoki K. Development of strain of spontaneously hypertensive rats. Jpn Circ J 1963; 27:282-293.
58. Schlager G. Selection for blood pressure levels in mice. Genetics 1974; 76:537-549.
59. Schork NJ, Krieger JE, Trolliet MR, Franchini KG, Koike G, Kreiger EM, et al. A biometrical genome search in the rats reveals the multigenetic basis for blood pressure variation. Genome Res 1995; 5:164-172.
60. Pravenec M, Gauguier D, Schott J-J, Buard J, Kren V, Bila V, et al. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest 1995; 96:1973-1978.
61. Samani NJ, Lodwick D, Vincent M, Dubay C, Kaiser MA, Bihoreau M-T, et al. Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13: age-related differences in effect. Hypertension 1996; 28:1118-1122.
62. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau M-T, et al. Quantitative trait loci in genetically hypertensive rats: possible sex specificity. Hypertension 1996; 28:898-906.
63. Harris EL, Phelan EL, Thompson CM, Miller JA, Grigor MR. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. J Hypertens 1995; 13:397-404.
64. Vincent M, Samani NJ, Gauguier D, Thompson JR, Lathrop GM, Sassard J. A pharmacogenic approach to blood pressure in Lyon Hypertensive rats. J Clin Invest 1997; 100:2000-2006.
65. Hilbert P, Lindpaintner K, Beckmann S, Serikawa T, Soubrier F, Dubay C, et al. Chromosomal mapping of two genetic loci associated with blood pressure regulation in hereditary hypertensive rats. Nature 1991; 353:521-529.
66. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y, et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991; 67:213-224.
67. Mune T, Rogerson FM, Nikkilä H, Agarawl, AK White PC. Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nat Genet 1995; 10:394-399.
68. Simon DB, Karet FE, Hamdan JM, DiPietro A, Sanjad SA, Lifton RP. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter, NKCC2. Nat Genet 1996; 13:183-188.
69. + channel, ROMK. Nat Genet 1996; 14:152-156.
70. Jeunemaitre X, Soubrier F, Kotelevtsev W, Lifton RP, Williams CS, Charru A, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71:169-180.
71. Wu D-A, Bu X, Warden CH, Shen DDC, Jeng C-Y, Sheu WHH, et al. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest 1996; 97:2111-2118.
72. 3 subunit variant with hypertension. Nat Genet 1998; 18:45-48.
73. Yamada J, Kuramoto T, Serikawa T. A rat genetic linkage map and comparative maps for mouse or human homologous rat genes. Mamm Genome 1994; 5:63-83.
74. Miklos GLG, Rubin GM. The role of the genome project in determining gene function: insights from model organisms. Cell 1996; 86:521-529.
75. Koike G, Krieger JE, Jacob HJ, Mukoyama M, Pratt RE, Dzau VJ. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. Biochem Biophys Res Commun 1994; 198:380-386.
76. Julier C, Delépine M, Keavney B, Terwilliger J, Davis S, Weeks DE, et al. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum Mol Genet 1997; 6:2077-2085.
77. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, et al. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 1994; 91: 3999-4003.
78. Casari G, Barlassina C, Cusi D, Zagato L, Muirhead R, Righetti M, et al. Association of the α-adducin locus with essential hypertension. Hypertension 1995; 25:320-326.
79. Zee RYL, Lou Y-K, Griffiths LR, Morris BJ. Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun 1992; 84:9-15.
80. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel JM. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat Genet 1992; 1:72-75.
81. Harrap SB, Davidson HR, Connor JM, Soubrier F, Corvol P, Fraser R, et al. The angiotensin I-converting enzyme gene and predisposition to high blood pressure. Hypertension 1993; 1:455-460.
82. Schmidt S, van Hooft IMS, Grobbee DE, Ganten D, Ritz E. Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. J Hypertens 1993; 1:345-348.