Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats

Physiological Genomics

Volumn 2002, Issue 8, 2002, Pages 81-86

  Garrett, Michael R ^a   Rapp, John P ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Genetic hypertension; Hypertension; Quantitative trait loci

Indexed keywords

ALLELE; ANIMAL; ARTICLE; BLOOD PRESSURE; BREEDING; CHROMOSOME MAP; CONGENIC STRAIN; CROSS BREEDING; DAHL SALT SENSITIVE RAT; GENETIC LINKAGE; GENETICS; LEWIS RAT; MALE; METHODOLOGY; QUANTITATIVE TRAIT; RAT;

ALLELES; ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; BREEDING; CHROMOSOME MAPPING; CROSSES, GENETIC; LINKAGE (GENETICS); MALE; QUANTITATIVE TRAIT, HERITABLE; RATS; RATS, INBRED DAHL; RATS, INBRED LEW;

EID: 0346929380     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00080.2001     Document Type: Article

References (33)

1. Brosnan MJ, Clark JS, Jeffs B, Negrin CD, Van Vooren P, Arribas SM, Carswell H, Aitman TJ, Szpirer C, MacRae IM, and Dominiczak AF. Genes encoding atrial and brain natriuretic peptides as candidates for sensitivity to brain ischemia in stroke-prone hypertensive rats. Hypertension 33: 290-297, 1999.
2. Bunag R and Butterfield J. Tail-cuff blood pressure measurement without external preheating in awake rats. Hypertension 4: 898-903, 1982.
3. Chua SC Jr, Hansen MH, Truett GE, and Leibel RL. Utility of a C-Jun microsatellite marker in determining gene dosage for fatty (fa). Obes Res 1: 475-480, 1993.
4. Deng AY, Dene H, Pravenec M, and Rapp JP. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 93: 2701-2709, 1994.
5. Deng AY, Jackson CM, Hoebee B, and Rapp JP. Mapping of rat chromosome 5 markers generated from chromosome-sorted DNA. Mamm Genome 8: 549-553, 1997.
6. Deng AY and Rapp JP. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat Genet 1: 267-272, 1992.
7. Deschepper CF, Masciotra S, Zahabi A, BoutinGanache I, Picard S, and Reudelhuber TL. Functional alterations of the Nppa promoter are linked to cardiac ventricular hypertrophy in WKY/WKHA rat crosses. Circ Res 88: 223-228, 2001.
8. Dukhanina OI, Dene H, Deng AY, Choi CR, Hoebee B, and Rapp JP. Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm Genome 8: 229-235, 1997.
9. Frantz S, Clemitson JR, Bihoreau MT, Gauguier D, and Samani NJ. Genetic dissection of region around the Sa gene on rat chromosome 1. Evidence for multiple loci affecting blood pressure. Hypertension 38: 216-221, 2001.
10. Garrett MR, Dene H, Walder R, Zhang QY, Cicila GT, Assadnia S, Deng AY, and Rapp JP. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res 8: 711-723, 1998.
11. Garrett MR and Rapp JP. Multiple blood pressure QTL on rat chromosome 2 defined by congenic Dahl rats. Mamm Genome 13: 41-44, 2002.
12. Garrett MR, Zhang X, Dukhanina OI, Deng AY, and Rapp JP. Two linked blood pressure quantitative trait loci on chromosome 10 denned by Dahl rat congenic strains. Hypertension 38: 779-785, 2001.
13. Glenn CL, Wang WYS, Benjafield AV, and Morris BJ. Linkage and association of tumor necrosis factor receptor 2 locus with hypertension, hypercholesterolemia and plasma shed receptor. Hum Mol Genet 9: 1943-1949, 2000.
14. Iakoubova O, Dushkin H, Pacella L, and Beier DR. Genetic analysis of modifying loci on mouse chromosome 1 that affect disease severity in a model of recessive PKD. Physiol Genomics 1: 101-105, 1999.
15. Jeffs B, Clark JS, Anderson NH, Gratton J, Brosnan MJ, Gauguier D, Reid JL, MacRae IM, and Dominiczak AF. Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nat Genet 16: 364-367, 1997.
16. Lan H, Shepel LA, Haag JD, and Gould MN. Linkage mapping of rat chromosome 5 markers generated from chromosome-specific libraries. Mamm Genome 10: 687-691, 1999.
17. Lander E, Green P, Abrahamson J, Barlow A, Daly M, Lincoln S, and Newburg L. Mapmaker: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174-181, 1987.
18. Lincoln S, Daly M, and Lander E. Constructing Genetic Maps with Mapmaker/Exp. 3.0 (3rd ed.). Whitehead Institute Technical Report, 1992.
19. Lyons PA, Armitage N, Lord CJ, Phillips MS, Todd JA, Peterson LB, and Wicker LS. High-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. Diabetes 50: 2633-2637, 2001.
20. Pan TH, Chen JW, Fann C, Jou YS, and Wu SY. Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study. Hum Genet 107: 210-215, 2000.
21. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev 80: 135-172, 2000.
22. Rapp JP and Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 7: 340-349, 1985.
23. Rice T, Rankinen T, Province MA, Chagnon YC, Perusse L, Borecki IB, Bouchard C, and Rao DC. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec family study. Hypertens Genet 102: 1956-1963, 2000.
24. Rogner UC, Boitard C, Morin J, Melanitou E, and Avner P. Three loci on mouse chromosome 6 influence onset and final incidence of type 1 diabetes in NOD.C3H congenic strains. Genomics 74: 163-171, 2001.
25. Rubattu S, Volpe M, Kreutz R, Ganten U, Ganten D, and Lindpaintner K. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Nat Genet 13: 429-434, 1996.
26. Saad Y, Garrett MR, and Rapp JP. Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains. Physiol Genomics 4: 201-214, 2001.
27. Stec DE, Deng AY, Rapp JP, and Roman RJ. Cytochrome P-4504A genotype cosegregates with hypertension in Dahl S rats. Hypertension 27: 564-568, 1996.
28. Stec DE, Trolliet MR, Krieger JE, Jacob HJ, and Roman RJ. Renal cytochrome P-4504A activity and salt sensitivity in spontaneously hypertensive rats. Hypertension 27: 1329-1336, 1996.
29. Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, and Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71: 70-77, 2001.
30. Walder RY, Garrett MR, McClain AM, Beck GE, Brennan TMH, Kramer NA, Kanis AB, Mark AL, Rapp JP, and Sheffield VC. Short tandem repeat polymorphic markers for the rat genome from marker-selected libraries. Mamm Genome 9: 1013-1021, 1998.
31. Wright FA, O'Connor DT, Roberts E, Kutey G, Berry CC, Yoneda LU, Timberlake D, and Schlager G. Genome scan for blood pressure loci in mice. Hypertension 34: 625-630, 1999.
32. Zhang L, Summers KM, and West MJ. Cosegregation of genes on chromosome 5 with heart weight and blood pressure in genetic hypertension. Clin Exp Hypertens 18: 1073-1087, 1996.
33. Zhang L, Xu D, West MJ, and Summers KM. Association of the brain natriuretic peptide gene with blood pressure and heart weight in the rat. Clin Exp Pharmacol Physiol 24: 442-444, 1997.