'Racial' differences in genetic effects for complex diseases

Nature Genetics

Volumn 36, Issue 12, 2004, Pages 1312-1318

  Ioannidis, John P A ^a,b,c   Ntzani, Evangelia E ^a   Trikalinos, Thomas A ^a,c  

^a UNIVERSITY OF IOANNINA   (Greece)

^b INSTITUTE OF COMPUTER SCIENCE   (Greece)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENVIRONMENTAL CARRYING CAPACITY; FAMILIAL INCIDENCE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC DISTANCE; GENETIC DRIFT; GENETIC HETEROGENEITY; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RACE DIFFERENCE; VALIDATION PROCESS;

CONTINENTAL POPULATION GROUPS; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETICS, MEDICAL; HUMANS; POLYMORPHISM, GENETIC; VARIATION (GENETICS);

EID: 9644263985     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1474     Document Type: Article

References (20)

1. Cooper, R.S., Kaufman, J.S. & Ward, R. Race and genomics. N. Engl. J. Med. 348, 1166-1170 (2003).
2. Burchard, E.G. et al. The importance of race and ethnic background in biomedical research and clinical practice. N. Engl. J. Med. 348, 1170-1175 (2003).
3. The International HapMap Consortium. The International HapMap Project. Nature 426, 789-796 (2003).
4. Thomas, D.C. & Witte, J.S. Point: population stratification: a problem for case-control studies of candidate-gene associations? Cancer Epidemiol. Biomarkers Prev. 11, 505-512 (2002).
5. Kaufman, J.S. & Cooper, R.S. Commentary: considerations for use of racial/ethnic classification in etiologic research. Am. J. Epidemiol. 154, 291-298 (2001).
6. Wacholder, S., Rothman, N. & Caporaso, N. Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer. Cancer Epidemiol. Biomarkers Prev. 11, 513-520 (2002).
7. Lander, E.S. & Schork, N.J. Genetic dissection of complex traits. Science 265, 2037-2048 (1994).
8. Rosenberg, N.A. et al. Genetic structure of human populations. Science 298, 2381-2385 (2002).
9. King, M.C. & Motulsky, A.G. Human genetics. Mapping human history. Science 298, 2342-2343 (2002).
10. Feldman, M.W., Lewontin, R.C. & King, M.C. Race: a genetic melting-pot. Nature 424, 374 (2003).
11. Risch, N., Burchard, E., Ziv, E. & Tang, H. Categorization of humans in biomedical research: genes, race and disease. Genome Biol. 3, 2007 (2002).
12. Kressin, N.R., Chang, B.H., Hendricks, A. & Kazis, L.E. Agreement between administrative data and patients' self-reports of race/ethnicity. Am. J. Public Health 93, 1734-1739 (2003).
13. Ioannidis, J.P., Ntzani, E.E., Trikalinos, T.A. & Contopoulos-Ioannidis, D.G. Replication validity of genetic association studies. Nat. Genet. 29, 306-309 (2001).
14. Ioannidis, J.P., Trikalinos, T.A., Ntzani, E.E. & Contopoulos-Ioannidis, D.G. Genetic associations in large versus small studies: an empirical assessment. Lancet 361, 567-571 (2003).
15. Pettiti, D. Meta-analysis, Decision Analysis and Cost-Effectiveness Analysis (Oxford University Press, New York, 1999).
16. Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539-1558 (2002).
17. Collins, F.S. The case for a US prospective cohort study of genes and environment. Nature 429, 475-477 (2004).
18. Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
19. Doll, R. & Peto, R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66, 1191-1308 (1981).
20. Cardon, L.R. & Bell, J.I. Association study designs for complex diseases. Nat. Rev. Genet. 2, 91-99 (2001).