Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: Substitution mapping and renal Expression analysis

Hypertension

Volumn 45, Issue 3, 2005, Pages 451-459

  Garrett, Michael R ^a   Meng, Haijin ^a,b   Rapp, John P ^a   Joe, Bina ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiovascular diseases; Genes; Hypertension, genetic

Indexed keywords

GENE PRODUCT; GENOMIC DNA; PROTEIN RESP18; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CONGENIC STRAIN; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; GENE MAPPING; HYPERTENSION; INTROGRESSION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN; SEQUENCE ANALYSIS;

ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; CHROMOSOME MAPPING; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOME; KIDNEY; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED DAHL; RATS, INBRED STRAINS; SPECIES SPECIFICITY;

EID: 14644437750     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000154678.64340.7f     Document Type: Article

References (33)

1. Dahl LK, Heine M, Tassinari L. Effects of chronic excess salt ingestion: evidence that genetic factors play an important role in the susceptibility to experimental hypertension. J Exp Med. 1962;115:1173-1190.
2. Rapp JP, Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension. l985;7:340-349.
3. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev. 2000;80:135-172.
4. Joe B, Garrett MR. Substitution mapping: using congenic strains to detect genes controlling blood pressure. In: Raizada MKPJ, Kasparov S, Katovich MJ, eds, Cardiovascular Genomics: Gene Mining for Pharmacogenomics and Gene Therapy. Totowa, NJ: Humana Press Inc.; 2004: 39-56.
5. Glazier AM, Nadeau JH, Aitman TJ. Finding genes that underlie complex traits. Science. 2002;298:2345-2349.
6. Cicila GT, Garrett MR, Lee SJ, Liu J, Dene H, Rapp JP. High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Genomics. 2001;72:51-60.
7. Garrett MR, Rapp JP. Defining the blood pressure QTL on chromosome 7 in Dahl rats by a 177kb congenic segment containing Cyp11b1. Mamm Genome. 2003;14:268-273.
8. Lee SJ, Cicila GT. Functional genomics in rat models of hypertension: using differential expression and congenic strains to identify and evaluate candidate genes. Crit Rev Eukaryotic Gene Expression. 2002;12: 297-316.
9. Pravenec M, Wallace C, Aitman TJ, Kurtz TW. Gene expression profiling in hypertension research: a critical perspective. Hypertension. 2003; 41:3-8.
10. Liang M, Cowley AW Jr, Greene AS. High throughput gene expression profiling: a molecular approach to integrative physiology. J Physiol. 2003;554.1:22-30.
11. Rapp JP, Garrett MR, Dene H, Meng H, Hoebee B, Lathrop GM. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Genomics. 1998;51:191-196.
12. Meng H, Garrett MR, Dene H, Rapp JP. Localization of a blood pressure QTL to a 2.4-cM interval on rat chromosome 9 using congenic strains. Genomics. 2003;81:210-220.
13. Saad Y, Garrett MR, Rapp JP. Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains. Physiol Genomics. 2001;4:201-214.
14. Bloomquist BT, Darlington DN, Mains RE, Eipper BA. RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes. J Biol Chem. 1994;269:9113-9122.
15. Nishi A, Eklof AC, Bertorello AM, Aperia A. Dopamine regulation of renal Na+, K(+)-ATPase activity is lacking in Dahl salt-sensitive rats. Hypertension. 1993;21:767-771.
16. Wang ZQ, Siragy HM, Felder RA, Carey RM. Intrarenal dopamine production and distribution in the rat. Physiological control of sodium excretion. Hypertension. 1997;29:228-234.
17. Aperia AC. Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism. Annu Rev Physiol. 2000;62:621-647.
18. Carey RM. Theodore Cooper Lecture: renal dopamine system: paracrine regulator of sodium homeostasis and blood pressure. Hypertension. 2001; 38:297-302.
19. Iwai N, Inagami T. Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension. 1991;17:161-169.
20. St. Lezin E, Liu W, Wang J-M, Wang N, Kren V, Krenova D, Musilova A, Zdobinska M, Zidek V, Lau D, Pravenec M. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. Hypertension. 1997;30:854-859.
21. Frantz SA, Kaiser M, Gardiner SM, Gauguier D, Vincent M, Thompson JR, Bennett T, Samani NJ. Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains. Hypertension. 1998;32:639-646.
22. Iwai N, Tsujita Y, Kinoshita M. Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity. Hypertension. 1998;32:636-638.
23. Garrett MR, Dene H, Walder R, Zhang Q-Y, Cicila GT, Assadnia S, Deng AY, Rapp JP. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res. 1998;8:711-723.
24. Hubner N, Lee YA, Lindpaintner K, Ganten D, Kreutz R. Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1. Hypertension. 1999;34:643-648.
25. Saad Y, Garrett MR, Lee SJ, Dene H, Rapp JP. Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains. Physiol Genomics. 1999;1:119-125.
26. St Lezin E, Liu W, Wang JM, Yang Y, Qi N, Kren V, Zidek V, Kurtz TW, Pravenec M. Genetic analysis of rat chromosome 1 and the Sa gene in spontaneous hypertension. Hypertension. 2000;35:225-230.
27. Walsh V, Somody L, Farrell A, Zhang B, Brown J, Pritchard C, Vincent M, Samani NJ. Analysis of the role of the SA gene in blood pressure regulation by gene targeting. Hypertension. 2003;41:1212-1218.
28. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Alba M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hubner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Ernes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Cunven V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Payseur BA, Bourque G, Lopez-Otin C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004;428:493-521.
29. Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St. Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 1999;21:76-83.
30. Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Kohl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol. 2000;1:221-226.
31. Fehr C, Shirley RL, Belknap JK, Crabbe JC, Buck KJ. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a < 1 centimorgan interval or murine chromosome 4: identification of Mpdz as a candidate gene. J Neurosci. 2002;22:3730-3738.
32. Rozzo SJ, Allard JD, Choubey D, Vyse TJ, Izui S, Peltz G, Kotzin BL. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity. 2001;15:435-443.
33. Nadeau JH, Singer JB, Matin A, Lander ES. Analyzing complex genetic traits with chromosome substitution strains. Nat Genet. 2000;24:221-225.