메뉴 건너뛰기




Volumn 363, Issue 1489, 2008, Pages 57-70

Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube

Author keywords

Hedgehog signalling; Neural tube patterning; Neurogenesis; Neuronal subtype identity; Transcription factors

Indexed keywords

DEVELOPMENTAL BIOLOGY; DIFFERENTIATION; DISEASE TREATMENT; GENE EXPRESSION; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; VERTEBRATE;

EID: 36448958709     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2006.2012     Document Type: Review
Times cited : (123)

References (128)
  • 2
    • 0033761448 scopus 로고    scopus 로고
    • Expression of the vertebrate gli proteins in Drosophila reveals a distribution of activator and repressor activities
    • Aza-Blanc, P., Lin, H., Ruiz, I. A. A. & Kornberg, T. B. 2000 Expression of the vertebrate gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127, 4293-4301.
    • (2000) Development , vol.127 , pp. 4293-4301
    • Aza-Blanc, P.1    Lin, H.2    Ruiz, I.A.A.3    Kornberg, T.B.4
  • 3
    • 0035691773 scopus 로고    scopus 로고
    • Gli1 can rescue the in vivo function of Gli2
    • Bai, C. B. & Joyner, A. L. 2001 Gli1 can rescue the in vivo function of Gli2. Development 128, 5161-5172.
    • (2001) Development , vol.128 , pp. 5161-5172
    • Bai, C.B.1    Joyner, A.L.2
  • 4
    • 0347764480 scopus 로고    scopus 로고
    • All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3
    • doi:10.1016/S1534-5807(03)00394- 0
    • Bai, C. B., Stephen, D. & Joyner, A. L. 2004 All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6, 103-115. (doi:10.1016/S1534-5807(03)00394- 0)
    • (2004) Dev. Cell , vol.6 , pp. 103-115
    • Bai, C.B.1    Stephen, D.2    Joyner, A.L.3
  • 5
    • 0033405806 scopus 로고    scopus 로고
    • Bmp activity establishes a gradient of positional information throughout the entire neural plate
    • Barth, K. A., Kishimoto, Y., Rohr, K. B., Seydler, C., Schulte-Merker, S. & Wilson, S. W. 1999 Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development 126, 4977-4987.
    • (1999) Development , vol.126 , pp. 4977-4987
    • Barth, K.A.1    Kishimoto, Y.2    Rohr, K.B.3    Seydler, C.4    Schulte-Merker, S.5    Wilson, S.W.6
  • 6
    • 0033636103 scopus 로고    scopus 로고
    • FGF signalling controls the timing of Pax6 activation in the neural tube
    • Bertrand, N., Medevielle, F. & Pituello, F. 2000 FGF signalling controls the timing of Pax6 activation in the neural tube. Development 127, 4837-4843.
    • (2000) Development , vol.127 , pp. 4837-4843
    • Bertrand, N.1    Medevielle, F.2    Pituello, F.3
  • 7
    • 0036631456 scopus 로고    scopus 로고
    • Proneural genes and the specification of neural cell types
    • doi:10.1038/nrn874
    • Bertrand, N., Castro, D. S. & Guillemot, F. 2002 Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 3, 517-530. (doi:10.1038/nrn874)
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 517-530
    • Bertrand, N.1    Castro, D.S.2    Guillemot, F.3
  • 8
    • 0035252990 scopus 로고    scopus 로고
    • Specification of neuronal fates in the ventral neural tube
    • doi:10.1016/S0959-4388(00)00172-0
    • Briscoe, J. & Ericson, J. 2001 Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 11, 43-49. (doi:10.1016/S0959-4388(00)00172-0)
    • (2001) Curr. Opin. Neurobiol , vol.11 , pp. 43-49
    • Briscoe, J.1    Ericson, J.2
  • 9
    • 0033560895 scopus 로고    scopus 로고
    • Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
    • doi:10.1038/19315
    • Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T. M., Rubenstein, J. L. & Ericson, J. 1999 Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature 398, 622-627. (doi:10.1038/19315)
    • (1999) Nature , vol.398 , pp. 622-627
    • Briscoe, J.1    Sussel, L.2    Serup, P.3    Hartigan-O'Connor, D.4    Jessell, T.M.5    Rubenstein, J.L.6    Ericson, J.7
  • 10
    • 0034640087 scopus 로고    scopus 로고
    • A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
    • doi:10.1016/S0092- 8674(00)80853-3
    • Briscoe, J., Pierani, A., Jessell, T. M. & Ericson, J. 2000 A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101, 435-445. (doi:10.1016/S0092- 8674(00)80853-3)
    • (2000) Cell , vol.101 , pp. 435-445
    • Briscoe, J.1    Pierani, A.2    Jessell, T.M.3    Ericson, J.4
  • 11
    • 0034964445 scopus 로고    scopus 로고
    • A Hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of Sonic hedge-hog in the neural tube
    • doi:10.1016/S1097-2765(01)00271-4
    • Briscoe, J., Chen, Y., Jessell, T. M. & Struhl, G. 2001 A Hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of Sonic hedge-hog in the neural tube. Mol. Cell 7, 1279-1291. (doi:10.1016/S1097-2765(01)00271-4)
    • (2001) Mol. Cell , vol.7 , pp. 1279-1291
    • Briscoe, J.1    Chen, Y.2    Jessell, T.M.3    Struhl, G.4
  • 12
    • 0242353154 scopus 로고    scopus 로고
    • Vertebrate neurogenesis is counteracted by Sox1-3 activity
    • doi:10.1038/nn1131
    • Bylund, M., Andersson, E., Novitch, B. G. & Muhr, J. 2003 Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat. Neurosci. 6, 1162-1168. (doi:10.1038/nn1131)
    • (2003) Nat. Neurosci , vol.6 , pp. 1162-1168
    • Bylund, M.1    Andersson, E.2    Novitch, B.G.3    Muhr, J.4
  • 13
    • 11344277387 scopus 로고    scopus 로고
    • Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling
    • doi:10.1016/j.neuron.2004.12.028
    • Cai, J., Qi, Y., Hu, X., Tan, M., Liu, Z., Zhang, J., Li, Q., Sander, M. & Qiu, M. 2005 Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 45, 41-53. (doi:10.1016/j.neuron.2004.12.028)
    • (2005) Neuron , vol.45 , pp. 41-53
    • Cai, J.1    Qi, Y.2    Hu, X.3    Tan, M.4    Liu, Z.5    Zhang, J.6    Li, Q.7    Sander, M.8    Qiu, M.9
  • 14
    • 0036966642 scopus 로고    scopus 로고
    • Hox genes and spinal cord development
    • doi:10.1159/000064943
    • Carpenter, E. M. 2002 Hox genes and spinal cord development. Dev. Neurosci. 24, 24-34. (doi:10.1159/000064943)
    • (2002) Dev. Neurosci , vol.24 , pp. 24-34
    • Carpenter, E.M.1
  • 15
    • 0035090226 scopus 로고    scopus 로고
    • Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors
    • Chambers, C. B., Peng, Y., Nguyen, H., Gaiano, N., Fishell, G. & Nye, J. S. 2001 Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors. Development 128, 689-702.
    • (2001) Development , vol.128 , pp. 689-702
    • Chambers, C.B.1    Peng, Y.2    Nguyen, H.3    Gaiano, N.4    Fishell, G.5    Nye, J.S.6
  • 17
    • 4644360723 scopus 로고    scopus 로고
    • Coordinate regulation of neural tube patterning and proliferation by TGFβ and WNT activity
    • doi:10.1016/j.ydbio. 2004.07.019
    • Chesnutt, C., Burrus, L. W., Brown, A. M. C. & Niswander, L. 2004 Coordinate regulation of neural tube patterning and proliferation by TGFβ and WNT activity. Dev. Biol. 274, 334-347. (doi:10.1016/j.ydbio. 2004.07.019)
    • (2004) Dev. Biol , vol.274 , pp. 334-347
    • Chesnutt, C.1    Burrus, L.W.2    Brown, A.M.C.3    Niswander, L.4
  • 18
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • doi:10.1038/383407a0
    • Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. & Beachy, P. A. 1996 Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413. (doi:10.1038/383407a0)
    • (1996) Nature , vol.383 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6    Beachy, P.A.7
  • 19
    • 0033583035 scopus 로고    scopus 로고
    • Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
    • doi:10.1074/jbc.274.12.8143
    • Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. & Ishii, S. 1999 Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274, 8143-8152. (doi:10.1074/jbc.274.12.8143)
    • (1999) J. Biol. Chem , vol.274 , pp. 8143-8152
    • Dai, P.1    Akimaru, H.2    Tanaka, Y.3    Maekawa, T.4    Nakafuku, M.5    Ishii, S.6
  • 20
    • 0242569162 scopus 로고    scopus 로고
    • Motor neuron columnar fate imposed by sequential phases of Hox-c activity
    • doi:10.1038/nature02051
    • Dasen, J. S., Liu, J. P. & Jessell, T. M. 2003 Motor neuron columnar fate imposed by sequential phases of Hox-c activity. Nature 425, 926-933. (doi:10.1038/nature02051)
    • (2003) Nature , vol.425 , pp. 926-933
    • Dasen, J.S.1    Liu, J.P.2    Jessell, T.M.3
  • 21
    • 4344583103 scopus 로고    scopus 로고
    • Opposing FGF and retinoid pathways: A signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis
    • doi:10.1002/bies.20080
    • Diez del Corral, R. & Storey, K. G. 2004 Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis. Bioessays 26, 857-869. (doi:10.1002/bies.20080)
    • (2004) Bioessays , vol.26 , pp. 857-869
    • Diez del Corral, R.1    Storey, K.G.2
  • 22
    • 0036333089 scopus 로고    scopus 로고
    • Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling
    • Diez del Corral, R., Breitkreuz, D. N. & Storey, K. G. 2002 Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling. Development 129, 1681-1691.
    • (2002) Development , vol.129 , pp. 1681-1691
    • Diez del Corral, R.1    Breitkreuz, D.N.2    Storey, K.G.3
  • 23
    • 0141862018 scopus 로고    scopus 로고
    • Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension
    • doi:10.1016/S0896-6273(03)00565-8
    • Diez del Corral, R., Olivera-Martinez, I., Goriely, A., Gale, E., Maden, M. & Storey, K. 2003 Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40, 65-79. (doi:10.1016/S0896-6273(03)00565-8)
    • (2003) Neuron , vol.40 , pp. 65-79
    • Diez del Corral, R.1    Olivera-Martinez, I.2    Goriely, A.3    Gale, E.4    Maden, M.5    Storey, K.6
  • 24
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • doi:10.1016/0092-8674(93)90627-3
    • Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. & McMahon, A. P. 1993 Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430. (doi:10.1016/0092-8674(93)90627-3)
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 25
    • 0033593304 scopus 로고    scopus 로고
    • Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system
    • doi:10.1016/S0092-8674(00)80561-9
    • Edlund, T. & Jessell, T. M. 1999 Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system. Cell 96, 211-224. (doi:10.1016/S0092-8674(00)80561-9)
    • (1999) Cell , vol.96 , pp. 211-224
    • Edlund, T.1    Jessell, T.M.2
  • 26
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity
    • doi:10.1016/S0092-8674(00)81386-0
    • Ericson, J., Morton, S., Kawakami, A., Roelink, H. & Jessell, T. M. 1996 Two critical periods of Sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673. (doi:10.1016/S0092-8674(00)81386-0)
    • (1996) Cell , vol.87 , pp. 661-673
    • Ericson, J.1    Morton, S.2    Kawakami, A.3    Roelink, H.4    Jessell, T.M.5
  • 28
    • 0031458813 scopus 로고    scopus 로고
    • Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    • doi:10.1016/S0092-8674(00)80323-2
    • Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V., Jessell, T. M. & Briscoe, J. 1997b Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90, 169-180. (doi:10.1016/S0092-8674(00)80323-2)
    • (1997) Cell , vol.90 , pp. 169-180
    • Ericson, J.1    Rashbass, P.2    Schedl, A.3    Brenner-Morton, S.4    Kawakami, A.5    van Heyningen, V.6    Jessell, T.M.7    Briscoe, J.8
  • 29
    • 19344373750 scopus 로고    scopus 로고
    • A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis
    • doi:10.1016/j.ydbio.2005.03.017
    • Fior, R. & Henrique, D. 2005 A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. Dev. Biol. 281, 318-333. (doi:10.1016/j.ydbio.2005.03.017)
    • (2005) Dev. Biol , vol.281 , pp. 318-333
    • Fior, R.1    Henrique, D.2
  • 30
    • 0033715815 scopus 로고    scopus 로고
    • rax, Hes1, and notch1 promote the formation of Muller glia by postnatal retinal progenitor cells
    • doi:10.1016/S0896- 6273(00)81171-X
    • Furukawa, T., Mukherjee, S., Bao, Z. Z., Morrow, E. M. & Cepko, C. L. 2000 rax, Hes1, and notch1 promote the formation of Muller glia by postnatal retinal progenitor cells. Neuron 26, 383-394. (doi:10.1016/S0896- 6273(00)81171-X)
    • (2000) Neuron , vol.26 , pp. 383-394
    • Furukawa, T.1    Mukherjee, S.2    Bao, Z.Z.3    Morrow, E.M.4    Cepko, C.L.5
  • 31
    • 0033697009 scopus 로고    scopus 로고
    • Radial glial identity is promoted by Notch1 signaling in the murine forebrain
    • doi:10.1016/S0896-6273(00)81172-1
    • Gaiano, N., Nye, J. S. & Fishell, G. 2000 Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 26, 395-404. (doi:10.1016/S0896-6273(00)81172-1)
    • (2000) Neuron , vol.26 , pp. 395-404
    • Gaiano, N.1    Nye, J.S.2    Fishell, G.3
  • 32
    • 19544383964 scopus 로고    scopus 로고
    • Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning
    • Gotz, K., Briscoe, J. & Ruther, U. 2005 Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning. Dev. Dyn. 233, 623-630.
    • (2005) Dev. Dyn , vol.233 , pp. 623-630
    • Gotz, K.1    Briscoe, J.2    Ruther, U.3
  • 33
    • 13844270921 scopus 로고    scopus 로고
    • Development of circuits that generate simple rhythmic behaviors in vertebrates
    • doi:10.1016/j.conb.2005.01.017
    • Goulding, M. & Pfaff, S. L. 2005 Development of circuits that generate simple rhythmic behaviors in vertebrates. Curr. Opin. Neurobiol. 15, 14-20. (doi:10.1016/j.conb.2005.01.017)
    • (2005) Curr. Opin. Neurobiol , vol.15 , pp. 14-20
    • Goulding, M.1    Pfaff, S.L.2
  • 34
    • 0041880122 scopus 로고    scopus 로고
    • SOX2 functions to maintain neural progenitor identity
    • doi:10.1016/S0896-6273(03)00497-5
    • Graham, V., Khudyakov, J., Ellis, P. & Pevny, L. 2003 SOX2 functions to maintain neural progenitor identity. Neuron 39, 749-765. (doi:10.1016/S0896-6273(03)00497-5)
    • (2003) Neuron , vol.39 , pp. 749-765
    • Graham, V.1    Khudyakov, J.2    Ellis, P.3    Pevny, L.4
  • 35
    • 0035881919 scopus 로고    scopus 로고
    • The whereabouts of a morphogen: Direct evidence for short- and graded long-range activity of hedgehog signaling peptides
    • doi:10.1006/dbio.2001.0336
    • Gritli-Linde, A., Lewis, P., McMahon, A. P. & Linde, A. 2001 The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Biol. 236, 364-386. (doi:10.1006/dbio.2001.0336)
    • (2001) Dev. Biol , vol.236 , pp. 364-386
    • Gritli-Linde, A.1    Lewis, P.2    McMahon, A.P.3    Linde, A.4
  • 36
    • 0033945494 scopus 로고    scopus 로고
    • Presenilin-1 regulates neuronal differentiation during neurogenesis
    • Handler, M., Yang, X. & Shen, J. 2000 Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127, 2593-2606.
    • (2000) Development , vol.127 , pp. 2593-2606
    • Handler, M.1    Yang, X.2    Shen, J.3
  • 37
    • 10344264425 scopus 로고    scopus 로고
    • Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
    • doi:10.1242/dev. 01436
    • Hatakeyama, J., Bessho, Y., Katoh, K., Ookawara, S., Fujioka, M., Guillemot, F. & Kageyama, R. 2004 Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 131, 5539-5550. (doi:10.1242/dev. 01436)
    • (2004) Development , vol.131 , pp. 5539-5550
    • Hatakeyama, J.1    Bessho, Y.2    Katoh, K.3    Ookawara, S.4    Fujioka, M.5    Guillemot, F.6    Kageyama, R.7
  • 38
    • 21644470944 scopus 로고    scopus 로고
    • Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons
    • doi:10.1242/dev.01859
    • Helms, A. W., Battiste, J., Henke, R. M., Nakada, Y., Simplicio, N., Guillemot, F. & Johnson, J. E. 2005 Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons. Development 132, 2709-2719. (doi:10.1242/dev.01859)
    • (2005) Development , vol.132 , pp. 2709-2719
    • Helms, A.W.1    Battiste, J.2    Henke, R.M.3    Nakada, Y.4    Simplicio, N.5    Guillemot, F.6    Johnson, J.E.7
  • 39
    • 0033917984 scopus 로고    scopus 로고
    • Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina
    • Hojo, M., Ohtsuka, T., Hashimoto, N., Gradwohl, G., Guillemot, F. & Kageyama, R. 2000 Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development 127, 2515-2522.
    • (2000) Development , vol.127 , pp. 2515-2522
    • Hojo, M.1    Ohtsuka, T.2    Hashimoto, N.3    Gradwohl, G.4    Guillemot, F.5    Kageyama, R.6
  • 40
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • doi:10.1038/nature02061
    • Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L. & Anderson, K. V. 2003 Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426, 83-87. (doi:10.1038/nature02061)
    • (2003) Nature , vol.426 , pp. 83-87
    • Huangfu, D.1    Liu, A.2    Rakeman, A.S.3    Murcia, N.S.4    Niswander, L.5    Anderson, K.V.6
  • 41
    • 0028281306 scopus 로고
    • Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development
    • doi:10.1006/dbio.1994.1097
    • Hui, C. C., Slusarski, D., Platt, K. A., Holmgren, R. & Joyner, A. L. 1994 Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev. Biol. 162, 402-413. (doi:10.1006/dbio.1994.1097)
    • (1994) Dev. Biol , vol.162 , pp. 402-413
    • Hui, C.C.1    Slusarski, D.2    Platt, K.A.3    Holmgren, R.4    Joyner, A.L.5
  • 42
    • 0033993990 scopus 로고    scopus 로고
    • The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types
    • doi:10.1038/71114
    • Hynes, M., Ye, W., Wang, K., Stone, D., Murone, M., Sauvage, F. & Rosenthal, A. 2000 The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. Nat. Neurosci. 3, 41-46. (doi:10.1038/71114)
    • (2000) Nat. Neurosci , vol.3 , pp. 41-46
    • Hynes, M.1    Ye, W.2    Wang, K.3    Stone, D.4    Murone, M.5    Sauvage, F.6    Rosenthal, A.7
  • 43
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • doi:10.1101/gad.938601
    • Ingham, P. W. & McMahon, A. P. 2001 Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087. (doi:10.1101/gad.938601)
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 44
    • 0023032969 scopus 로고
    • Cross-regulatory interactions among the gap genes of Drosophila
    • doi:10.1038/324668a0
    • Jäckle, H., Tautz, D., Schuh, R., Seifert, E. & Lehmann, R. 1986 Cross-regulatory interactions among the gap genes of Drosophila. Nature 324, 668-670. (doi:10.1038/324668a0)
    • (1986) Nature , vol.324 , pp. 668-670
    • Jäckle, H.1    Tautz, D.2    Schuh, R.3    Seifert, E.4    Lehmann, R.5
  • 45
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
    • doi:10.1038/35049541
    • Jessell, T. M. 2000 Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat. Rev. Genet. 1, 20-29. (doi:10.1038/35049541)
    • (2000) Nat. Rev. Genet , vol.1 , pp. 20-29
    • Jessell, T.M.1
  • 46
    • 0036382663 scopus 로고    scopus 로고
    • GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord
    • doi:10.1006/dbio.2002.0754
    • Karunaratne, A., Hargrave, M., Poh, A. & Yamada, T. 2002 GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord. Dev. Biol. 249, 30-43. (doi:10.1006/dbio.2002.0754)
    • (2002) Dev. Biol , vol.249 , pp. 30-43
    • Karunaratne, A.1    Hargrave, M.2    Poh, A.3    Yamada, T.4
  • 47
    • 0034010531 scopus 로고    scopus 로고
    • Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm
    • Kishi, M., Mizuseki, K., Sasai, N., Yamazaki, H., Shiota, K., Nakanishi, S. & Sasai, Y. 2000 Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm. Development 127, 791-800.
    • (2000) Development , vol.127 , pp. 791-800
    • Kishi, M.1    Mizuseki, K.2    Sasai, N.3    Yamazaki, H.4    Shiota, K.5    Nakanishi, S.6    Sasai, Y.7
  • 48
    • 0027749249 scopus 로고
    • A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
    • doi:10.1016/0092-8674(93)90628-4
    • Krauss, S., Concordet, J. P. & Ingham, P. W. 1993 A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444. (doi:10.1016/0092-8674(93)90628-4)
    • (1993) Cell , vol.75 , pp. 1431-1444
    • Krauss, S.1    Concordet, J.P.2    Ingham, P.W.3
  • 49
    • 0025981573 scopus 로고
    • Mutually repressive interactions between the gap genes giant and Kruppel define middle body regions of the Drosophila embryo
    • Kraut, R. & Levine, M. 1991 Mutually repressive interactions between the gap genes giant and Kruppel define middle body regions of the Drosophila embryo. Development 111, 611-621.
    • (1991) Development , vol.111 , pp. 611-621
    • Kraut, R.1    Levine, M.2
  • 50
    • 0038386025 scopus 로고    scopus 로고
    • Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors
    • doi:10.1016/S0896- 6273(03)00296-4
    • Lee, S. K. & Pfaff, S. L. 2003 Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 38, 731-745. (doi:10.1016/S0896- 6273(03)00296-4)
    • (2003) Neuron , vol.38 , pp. 731-745
    • Lee, S.K.1    Pfaff, S.L.2
  • 51
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee, J., Platt, K. A., Censullo, P. & Ruiz i Altaba, A. 1997 Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz i Altaba, A.4
  • 52
    • 4243150837 scopus 로고    scopus 로고
    • Analysis of embryonic motoneuron gene regulation: Derepression of general activators function in concert with enhancer factors
    • doi:10.1242/dev.01179
    • Lee, S. K., Jurata, L. W., Funahashi, J., Ruiz, E. C. & Pfaff, S. L. 2004 Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development 131, 3295-3306. (doi:10.1242/dev.01179)
    • (2004) Development , vol.131 , pp. 3295-3306
    • Lee, S.K.1    Jurata, L.W.2    Funahashi, J.3    Ruiz, E.C.4    Pfaff, S.L.5
  • 53
    • 12144271676 scopus 로고    scopus 로고
    • Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
    • doi:10.1101/gad.1257105
    • Lee, S. K., Lee, B., Ruiz, E. C. & Pfaff, S. L. 2005 Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev. 19, 282-294. (doi:10.1101/gad.1257105)
    • (2005) Genes Dev , vol.19 , pp. 282-294
    • Lee, S.K.1    Lee, B.2    Ruiz, E.C.3    Pfaff, S.L.4
  • 54
    • 4444220296 scopus 로고    scopus 로고
    • Transduction of graded hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    • doi:10.1242/dev.01230
    • Lei, Q., Zelman, A. K., Kuang, E., Li, S. & Matise, M. P. 2004 Transduction of graded hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131, 3593-3604. (doi:10.1242/dev.01230)
    • (2004) Development , vol.131 , pp. 3593-3604
    • Lei, Q.1    Zelman, A.K.2    Kuang, E.3    Li, S.4    Matise, M.P.5
  • 55
    • 0342684481 scopus 로고    scopus 로고
    • A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord
    • doi:10.1016/S0092-8674(01) 80015-5
    • Liem Jr, K. F., Tremml, G. & Jessell, T. M. 1997 A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord. Cell 91, 127-138. (doi:10.1016/S0092-8674(01) 80015-5)
    • (1997) Cell , vol.91 , pp. 127-138
    • Liem Jr, K.F.1    Tremml, G.2    Jessell, T.M.3
  • 56
    • 0033637101 scopus 로고    scopus 로고
    • Regulation of the neural patterning activity of Sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites
    • Liem, K. F., Jessell, T. M. & Briscoe, J. 2000 Regulation of the neural patterning activity of Sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development 127, 4855-4866.
    • (2000) Development , vol.127 , pp. 4855-4866
    • Liem, K.F.1    Jessell, T.M.2    Briscoe, J.3
  • 57
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between shh and gli3
    • doi:10.1038/79916
    • Litingtung, Y. & Chiang, C. 2000 Specification of ventral neuron types is mediated by an antagonistic interaction between shh and gli3. Nat. Neurosci. 3, 979-985. (doi:10.1038/79916)
    • (2000) Nat. Neurosci , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 58
    • 0035924596 scopus 로고    scopus 로고
    • Assigning the positional identity of spinal motor neurons: Rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids
    • doi:10.1016/S0896-6273(01)00544-X
    • Liu, J. P., Laufer, E. & Jessell, T. M. 2001 Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids. Neuron 32, 997-1012. (doi:10.1016/S0896-6273(01)00544-X)
    • (2001) Neuron , vol.32 , pp. 997-1012
    • Liu, J.P.1    Laufer, E.2    Jessell, T.M.3
  • 59
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    • doi:10.1242/dev.01894
    • Liu, A., Wang, B. & Niswander, L. A. 2005 Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132, 3103-3111. (doi:10.1242/dev.01894)
    • (2005) Development , vol.132 , pp. 3103-3111
    • Liu, A.1    Wang, B.2    Niswander, L.A.3
  • 60
    • 0033767315 scopus 로고    scopus 로고
    • Sonic hedgehog - regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    • doi:10.1016/S0896- 6273(00)80897-1
    • Lu, Q. R., Yuk, D., Alberta, J. A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A. P., Stiles, C. D. & Rowitch, D. H. 2000 Sonic hedgehog - regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25, 317-329. (doi:10.1016/S0896- 6273(00)80897-1)
    • (2000) Neuron , vol.25 , pp. 317-329
    • Lu, Q.R.1    Yuk, D.2    Alberta, J.A.3    Zhu, Z.4    Pawlitzky, I.5    Chan, J.6    McMahon, A.P.7    Stiles, C.D.8    Rowitch, D.H.9
  • 61
    • 0037023529 scopus 로고    scopus 로고
    • Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    • doi:10.1016/S0092-8674(02)00678-5
    • Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D. & Rowitch, D. H. 2002 Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109, 75-86. (doi:10.1016/S0092-8674(02)00678-5)
    • (2002) Cell , vol.109 , pp. 75-86
    • Lu, Q.R.1    Sun, T.2    Zhu, Z.3    Ma, N.4    Garcia, M.5    Stiles, C.D.6    Rowitch, D.H.7
  • 62
    • 2942738996 scopus 로고    scopus 로고
    • The hedgehog response network: Sensors, switches, and routers
    • doi:10.1126/science.1098020
    • Lum, L. & Beachy, P. A. 2004 The hedgehog response network: sensors, switches, and routers. Science 304, 1755-1759. (doi:10.1126/science.1098020)
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 63
    • 0030611973 scopus 로고    scopus 로고
    • Mash1 and neurogen in1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands
    • Ma, Q., Sommer, L., Cserjesi, P. & Anderson, D. J. 1997 Mash1 and neurogen in1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands. J. Neurosci. 17, 3644-3652.
    • (1997) J. Neurosci , vol.17 , pp. 3644-3652
    • Ma, Q.1    Sommer, L.2    Cserjesi, P.3    Anderson, D.J.4
  • 64
    • 0029843937 scopus 로고    scopus 로고
    • Regulation of patched by Sonic hedgehog in the developing neural tube
    • doi:10.1073/pnas.93.18.9346
    • Marigo, V. & Tabin, C. J. 1996 Regulation of patched by Sonic hedgehog in the developing neural tube. Proc. Natl Acad. Sci. USA 93, 9346-9351. (doi:10.1073/pnas.93.18.9346)
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9346-9351
    • Marigo, V.1    Tabin, C.J.2
  • 65
    • 0029019627 scopus 로고
    • Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
    • doi:10.1038/ 375322a0
    • Marti, E., Bumcrot, D. A., Takada, R. & McMahon, A. P. 1995 Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325. (doi:10.1038/ 375322a0)
    • (1995) Nature , vol.375 , pp. 322-325
    • Marti, E.1    Bumcrot, D.A.2    Takada, R.3    McMahon, A.P.4
  • 66
    • 0034965648 scopus 로고    scopus 로고
    • FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression
    • doi:10.1038/35078535
    • Mathis, L., Kulesa, P. M. & Fraser, S. E. 2001 FGF receptor signalling is required to maintain neural progenitors during Hensen's node progression. Nat. Cell Biol. 3, 559-566. (doi:10.1038/35078535)
    • (2001) Nat. Cell Biol , vol.3 , pp. 559-566
    • Mathis, L.1    Kulesa, P.M.2    Fraser, S.E.3
  • 67
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. & Joyner, A. L. 1998 Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.
    • (1998) Development , vol.125 , pp. 2759-2770
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 68
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
    • Megason, S. G. & McMahon, A. P. 2002 A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129, 2087-2098.
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2
  • 69
    • 0035855786 scopus 로고    scopus 로고
    • Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons
    • doi:10.1016/S0896-6273(01)00413-5
    • Mizuguchi, R., Sugimori, M., Takebayashi, H., Kosako, H., Nagao, M., Yoshida, S., Nabeshima, Y., Shimamura, K. & Nakafuku, M. 2001 Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31, 757-771. (doi:10.1016/S0896-6273(01)00413-5)
    • (2001) Neuron , vol.31 , pp. 757-771
    • Mizuguchi, R.1    Sugimori, M.2    Takebayashi, H.3    Kosako, H.4    Nagao, M.5    Yoshida, S.6    Nabeshima, Y.7    Shimamura, K.8    Nakafuku, M.9
  • 70
    • 0034716909 scopus 로고    scopus 로고
    • Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
    • doi:10.1016/S0092-8674(00)80860-0
    • Morrison, S. J., Perez, S. E., Qiao, Z., Verdi, J. M., Hicks, C., Weinmaster, G. & Anderson, D. J. 2000 Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell 101, 499-510. (doi:10.1016/S0092-8674(00)80860-0)
    • (2000) Cell , vol.101 , pp. 499-510
    • Morrison, S.J.1    Perez, S.E.2    Qiao, Z.3    Verdi, J.M.4    Hicks, C.5    Weinmaster, G.6    Anderson, D.J.7
  • 71
    • 0035937415 scopus 로고    scopus 로고
    • Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    • doi:10.1016/S0092-8674(01)00283-5
    • Muhr, J., Andersson, E., Persson, M., Jessell, T. M. & Ericson, J. 2001 Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104, 861-873. (doi:10.1016/S0092-8674(01)00283-5)
    • (2001) Cell , vol.104 , pp. 861-873
    • Muhr, J.1    Andersson, E.2    Persson, M.3    Jessell, T.M.4    Ericson, J.5
  • 72
    • 15444365575 scopus 로고    scopus 로고
    • The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
    • doi:10.1101/gad.326105
    • Muller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M. & Birchmeier, C. 2005 The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. Genes Dev. 19, 733-743. (doi:10.1101/gad.326105)
    • (2005) Genes Dev , vol.19 , pp. 733-743
    • Muller, T.1    Anlag, K.2    Wildner, H.3    Britsch, S.4    Treier, M.5    Birchmeier, C.6
  • 73
    • 0036499974 scopus 로고    scopus 로고
    • Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
    • doi:10.1101/gad.937102
    • Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H. & Takada, S. 2002 Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev. 16, 548-553. (doi:10.1101/gad.937102)
    • (2002) Genes Dev , vol.16 , pp. 548-553
    • Muroyama, Y.1    Fujihara, M.2    Ikeya, M.3    Kondoh, H.4    Takada, S.5
  • 74
    • 27844606461 scopus 로고    scopus 로고
    • Specification of astrocytes by bHLH protein SCL in a restricted region of the nerual tube
    • doi:10.1038/nature04139
    • Muroyama, Y., Fujiwara, Y., Orkin, S. H. & Rowitch, D. H. 2005 Specification of astrocytes by bHLH protein SCL in a restricted region of the nerual tube. Nature 438, 360-363. (doi:10.1038/nature04139)
    • (2005) Nature , vol.438 , pp. 360-363
    • Muroyama, Y.1    Fujiwara, Y.2    Orkin, S.H.3    Rowitch, D.H.4
  • 75
    • 0034112411 scopus 로고    scopus 로고
    • Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway
    • Nguyen, V. H., Trout, J., Connors, S. A., Andermann, P., Weinberg, E. & Mullins, M. C. 2000 Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development 127, 1209-1220.
    • (2000) Development , vol.127 , pp. 1209-1220
    • Nguyen, V.H.1    Trout, J.2    Connors, S.A.3    Andermann, P.4    Weinberg, E.5    Mullins, M.C.6
  • 76
    • 0035855795 scopus 로고    scopus 로고
    • Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    • doi:10.1016/S0896- 6273(01)00407-X
    • Novitch, B. G., Chen, A. I. & Jessell, T. M. 2001 Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31, 773-789. (doi:10.1016/S0896- 6273(01)00407-X)
    • (2001) Neuron , vol.31 , pp. 773-789
    • Novitch, B.G.1    Chen, A.I.2    Jessell, T.M.3
  • 77
    • 0141862010 scopus 로고    scopus 로고
    • A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification
    • doi:10.1016/j.neuron.2003.08.006
    • Novitch, B. G., Wichterle, H., Jessell, T. M. & Sockanathan, S. 2003 A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron 40, 81-95. (doi:10.1016/j.neuron.2003.08.006)
    • (2003) Neuron , vol.40 , pp. 81-95
    • Novitch, B.G.1    Wichterle, H.2    Jessell, T.M.3    Sockanathan, S.4
  • 78
    • 0033561365 scopus 로고    scopus 로고
    • Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation
    • doi:10.1093/emboj/18.8. 2196
    • Ohtsuka, T., Ishibashi, M., Gradwohl, G., Nakanishi, S., Guillemot, F. & Kageyama, R. 1999 Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 18, 2196-2207. (doi:10.1093/emboj/18.8. 2196)
    • (1999) EMBO J , vol.18 , pp. 2196-2207
    • Ohtsuka, T.1    Ishibashi, M.2    Gradwohl, G.3    Nakanishi, S.4    Guillemot, F.5    Kageyama, R.6
  • 79
    • 0035839458 scopus 로고    scopus 로고
    • Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain
    • doi:10.1074/jbc.M102420200
    • Ohtsuka, T., Sakamoto, M., Guillemot, F. & Kageyama, R. 2001 Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. J. Biol. Chem. 276, 30 467-30 474. (doi:10.1074/jbc.M102420200)
    • (2001) J. Biol. Chem , vol.276
    • Ohtsuka, T.1    Sakamoto, M.2    Guillemot, F.3    Kageyama, R.4
  • 80
    • 0041508452 scopus 로고    scopus 로고
    • Delta-Notch signaling regulates oligodendrocyte specification
    • doi:10.1242/dev.00576
    • Park, H. C. & Appel, B. 2003 Delta-Notch signaling regulates oligodendrocyte specification. Development 130, 3747-3755. (doi:10.1242/dev.00576)
    • (2003) Development , vol.130 , pp. 3747-3755
    • Park, H.C.1    Appel, B.2
  • 81
    • 0034055649 scopus 로고    scopus 로고
    • Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    • Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M. & Joyner, A. L. 2000 Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-1605.
    • (2000) Development , vol.127 , pp. 1593-1605
    • Park, H.L.1    Bai, C.2    Platt, K.A.3    Matise, M.P.4    Beeghly, A.5    Hui, C.C.6    Nakashima, M.7    Joyner, A.L.8
  • 82
    • 0036467664 scopus 로고    scopus 로고
    • Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity
    • doi:10.1101/gad.940902
    • Parras, C. M., Schuurmans, C., Scardigli, R., Kim, J., Anderson, D. J. & Guillemot, F. 2002 Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 16, 324-338. (doi:10.1101/gad.940902)
    • (2002) Genes Dev , vol.16 , pp. 324-338
    • Parras, C.M.1    Schuurmans, C.2    Scardigli, R.3    Kim, J.4    Anderson, D.J.5    Guillemot, F.6
  • 83
    • 0037039161 scopus 로고    scopus 로고
    • Opponent activities of Shh and BMP signaling during floor plate induction in vivo
    • doi:10.1016/S0960-9822(01)00631-5
    • Patten, I. & Placzek, M. 2002 Opponent activities of Shh and BMP signaling during floor plate induction in vivo. Curr. Biol. 12, 47-52. (doi:10.1016/S0960-9822(01)00631-5)
    • (2002) Curr. Biol , vol.12 , pp. 47-52
    • Patten, I.1    Placzek, M.2
  • 84
    • 0037111829 scopus 로고    scopus 로고
    • Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
    • doi:10.1101/gad.243402
    • Persson, M., Stamataki, D., te Welscher, P., Andersson, E., Bose, J., Ruther, U., Ericson, J. & Briscoe, J. 2002 Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 16, 2865-2878. (doi:10.1101/gad.243402)
    • (2002) Genes Dev , vol.16 , pp. 2865-2878
    • Persson, M.1    Stamataki, D.2    te Welscher, P.3    Andersson, E.4    Bose, J.5    Ruther, U.6    Ericson, J.7    Briscoe, J.8
  • 85
    • 13844250648 scopus 로고    scopus 로고
    • SOX genes and neural progenitor identity
    • doi:10.1016/j.conb. 2005.01.016
    • Pevny, L. & Placzek, M. 2005 SOX genes and neural progenitor identity. Curr. Opin. Neurobiol. 15, 7-13. (doi:10.1016/j.conb. 2005.01.016)
    • (2005) Curr. Opin. Neurobiol , vol.15 , pp. 7-13
    • Pevny, L.1    Placzek, M.2
  • 87
    • 0033603209 scopus 로고    scopus 로고
    • A Sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
    • doi:10.1016/S0092-8674(00) 80802-8
    • Pierani, A., Brenner-Morton, S., Chiang, C. & Jessell, T. M. 1999 A Sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell 97, 903-915. (doi:10.1016/S0092-8674(00) 80802-8)
    • (1999) Cell , vol.97 , pp. 903-915
    • Pierani, A.1    Brenner-Morton, S.2    Chiang, C.3    Jessell, T.M.4
  • 88
    • 0026339029 scopus 로고
    • Control of dorsoventral pattern in vertebrate neural development: Induction and polarizing properties of the floor plate
    • Placzek, M., Yamada, T., Tessier-Lavigne, M., Jessell, T. & Dodd, J. 1991 Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate. Development, Suppl. 2, 105-122.
    • (1991) Development, Suppl , vol.2 , pp. 105-122
    • Placzek, M.1    Yamada, T.2    Tessier-Lavigne, M.3    Jessell, T.4    Dodd, J.5
  • 90
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • doi:10.1016/0092-8674(93)90626-2
    • Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. 1993 Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416. (doi:10.1016/0092-8674(93)90626-2)
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 91
    • 1542318381 scopus 로고    scopus 로고
    • Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3-like signal
    • doi:10.1002/dvdy.10501
    • Robertson, C. P., Braun, M. M. & Roelink, H. 2004 Sonic hedgehog patterning in chick neural plate is antagonized by a Wnt3-like signal. Dev. Dyn. 229, 510-519. (doi:10.1002/dvdy.10501)
    • (2004) Dev. Dyn , vol.229 , pp. 510-519
    • Robertson, C.P.1    Braun, M.M.2    Roelink, H.3
  • 92
    • 23444440157 scopus 로고
    • Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
    • doi:10.1016/0092-8674(94)90514-2
    • Roelink, H. et al. 1994 Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775. (doi:10.1016/0092-8674(94)90514-2)
    • (1994) Cell , vol.76 , pp. 761-775
    • Roelink, H.1
  • 93
    • 0029004233 scopus 로고
    • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis
    • doi:10.1016/0092- 8674(95)90397-6
    • Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. & Jessell, T. M. 1995 Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455. (doi:10.1016/0092- 8674(95)90397-6)
    • (1995) Cell , vol.81 , pp. 445-455
    • Roelink, H.1    Porter, J.A.2    Chiang, C.3    Tanabe, Y.4    Chang, D.T.5    Beachy, P.A.6    Jessell, T.M.7
  • 94
    • 0031820135 scopus 로고    scopus 로고
    • Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
    • Ruiz i Altaba, A. 1998 Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 25, 2203-2212.
    • (1998) Development , vol.25 , pp. 2203-2212
    • Ruiz i Altaba, A.1
  • 95
    • 0032808138 scopus 로고    scopus 로고
    • Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
    • Ruiz i Altaba, A. 1999 Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 26, 3205-3216.
    • (1999) Development , vol.26 , pp. 3205-3216
    • Ruiz i Altaba, A.1
  • 96
    • 23044451795 scopus 로고    scopus 로고
    • Sox21 promotes the progression of vertebrate neurogenesis
    • doi:10.1038/nn1493
    • Sandberg, M., Kallstrom, M. & Muhr, J. 2005 Sox21 promotes the progression of vertebrate neurogenesis. Nat. Neurosci. 8, 995-1001. (doi:10.1038/nn1493)
    • (2005) Nat. Neurosci , vol.8 , pp. 995-1001
    • Sandberg, M.1    Kallstrom, M.2    Muhr, J.3
  • 97
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki, H., Hui, C., Nakafuku, M. & Kondoh, H. 1997 A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322.
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 98
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. & Kondoh, H. 1999 Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 99
    • 0035797449 scopus 로고    scopus 로고
    • Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    • doi:10.1016/S0896-6273(01) 00358-0
    • Scardigli, R., Schuurmans, C., Gradwohl, G. & Guillemot, F. 2001 Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31, 203-217. (doi:10.1016/S0896-6273(01) 00358-0)
    • (2001) Neuron , vol.31 , pp. 203-217
    • Scardigli, R.1    Schuurmans, C.2    Gradwohl, G.3    Guillemot, F.4
  • 100
    • 0035028574 scopus 로고    scopus 로고
    • An instructive function for Notch in promoting gliogenesis in the zebrafish retina
    • Scheer, N., Groth, A., Hans, S. & Campos-Ortega, J. A. 2001 An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development 128, 1099-1107.
    • (2001) Development , vol.128 , pp. 1099-1107
    • Scheer, N.1    Groth, A.2    Hans, S.3    Campos-Ortega, J.A.4
  • 101
    • 0036304223 scopus 로고    scopus 로고
    • Transcriptional codes and the control of neuronal identity
    • doi:10.1146/annurev.neuro.25.112701.142916
    • Shirasaki, R. & Pfaff, S. L. 2002 Transcriptional codes and the control of neuronal identity. Annu. Rev. Neurosci. 25, 251-281. (doi:10.1146/annurev.neuro.25.112701.142916)
    • (2002) Annu. Rev. Neurosci , vol.25 , pp. 251-281
    • Shirasaki, R.1    Pfaff, S.L.2
  • 102
    • 0035862770 scopus 로고    scopus 로고
    • Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers
    • doi:10.1006/dbio.2000.9984
    • Simmons, A. D., Horton, S., Abney, A. L. & Johnson, J. E. 2001 Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers. Dev. Biol. 229, 327-339. (doi:10.1006/dbio.2000.9984)
    • (2001) Dev. Biol , vol.229 , pp. 327-339
    • Simmons, A.D.1    Horton, S.2    Abney, A.L.3    Johnson, J.E.4
  • 103
    • 0035988949 scopus 로고    scopus 로고
    • Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord
    • doi:10.1002/dvdy. 10093
    • Smith, E., Hargrave, M., Yamada, T., Begley, C. G. & Little, M. H. 2002 Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord. Dev. Dyn. 224, 231-237. (doi:10.1002/dvdy. 10093)
    • (2002) Dev. Dyn , vol.224 , pp. 231-237
    • Smith, E.1    Hargrave, M.2    Yamada, T.3    Begley, C.G.4    Little, M.H.5
  • 104
    • 0030268113 scopus 로고    scopus 로고
    • neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    • doi:10.1006/mcne. 1996.0060
    • Sommer, L., Ma, Q. & Anderson, D. J. 1996 neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell Neurosci. 8, 221-241. (doi:10.1006/mcne. 1996.0060)
    • (1996) Mol. Cell Neurosci , vol.8 , pp. 221-241
    • Sommer, L.1    Ma, Q.2    Anderson, D.J.3
  • 105
    • 14644401158 scopus 로고    scopus 로고
    • A gradient of Gli activity mediates graded Sonic hedgehog signaling in the neural tube
    • doi:10.1101/gad.325905
    • Stamataki, D., Ulloa, F., Tsoni, S. V., Mynett, A. & Briscoe, J. 2005 A gradient of Gli activity mediates graded Sonic hedgehog signaling in the neural tube. Genes Dev. 19, 626-641. (doi:10.1101/gad.325905)
    • (2005) Genes Dev , vol.19 , pp. 626-641
    • Stamataki, D.1    Ulloa, F.2    Tsoni, S.V.3    Mynett, A.4    Briscoe, J.5
  • 106
    • 0034612499 scopus 로고    scopus 로고
    • Initiation of neural induction by FGF signalling before gastrulation
    • doi:10.1038/35017617
    • Streit, A., Berliner, A. J., Papanayotou, C., Sirulnik, A. & Stern, C. D. 2000 Initiation of neural induction by FGF signalling before gastrulation. Nature 406, 74-78. (doi:10.1038/35017617)
    • (2000) Nature , vol.406 , pp. 74-78
    • Streit, A.1    Berliner, A.J.2    Papanayotou, C.3    Sirulnik, A.4    Stern, C.D.5
  • 107
    • 0037046813 scopus 로고    scopus 로고
    • The basic helix-loop-helix factor Olig2 is essential for the development of motoneuron and oligodendrocyte lineages
    • doi:10.1016/S0960-9822(02)00926-0
    • Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O. & Ikenaka, K. 2002a The basic helix-loop-helix factor Olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr. Biol. 12, 1157-1163. (doi:10.1016/S0960-9822(02)00926-0)
    • (2002) Curr. Biol , vol.12 , pp. 1157-1163
    • Takebayashi, H.1    Nabeshima, Y.2    Yoshida, S.3    Chisaka, O.4    Ikenaka, K.5
  • 109
    • 0037389626 scopus 로고    scopus 로고
    • Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals
    • doi:10.1016/S1534-5807(03)00088-1
    • Uchikawa, M., Ishida, Y., Takemoto, T., Kamachi, Y. & Kondoh, H. 2003 Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals. Dev. Cell 4, 509-519. (doi:10.1016/S1534-5807(03)00088-1)
    • (2003) Dev. Cell , vol.4 , pp. 509-519
    • Uchikawa, M.1    Ishida, Y.2    Takemoto, T.3    Kamachi, Y.4    Kondoh, H.5
  • 110
    • 0035855712 scopus 로고    scopus 로고
    • Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification
    • doi:10.1016/S0896-6273(01)00412-3
    • Vallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T. M. & Ericson, J. 2001 Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron 31, 743-755. (doi:10.1016/S0896-6273(01)00412-3)
    • (2001) Neuron , vol.31 , pp. 743-755
    • Vallstedt, A.1    Muhr, J.2    Pattyn, A.3    Pierani, A.4    Mendelsohn, M.5    Sander, M.6    Jessell, T.M.7    Ericson, J.8
  • 111
    • 11344261775 scopus 로고    scopus 로고
    • Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain
    • doi:10.1016/j.neuron.2004.12.026
    • Vallstedt, A., Klos, J. M. & Ericson, J. 2005 Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45, 55-67. (doi:10.1016/j.neuron.2004.12.026)
    • (2005) Neuron , vol.45 , pp. 55-67
    • Vallstedt, A.1    Klos, J.M.2    Ericson, J.3
  • 113
    • 0033915930 scopus 로고    scopus 로고
    • Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis
    • Wakamatsu, Y., Maynard, T. M. & Weston, J. A. 2000 Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis. Development 127, 2811-2821.
    • (2000) Development , vol.127 , pp. 2811-2821
    • Wakamatsu, Y.1    Maynard, T.M.2    Weston, J.A.3
  • 114
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • doi:10.1016/S0092-8674(00)80678-9
    • Wang, B., Fallon, J. F. & Beachy, P. A. 2000 Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434. (doi:10.1016/S0092-8674(00)80678-9)
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 115
    • 6844220018 scopus 로고
    • The influence of adjacent structures upon the shape of the neural tube and neural plate of chick embryos
    • doi:10.1002/ar. 1091220405
    • Watterson, R. L., Goodheart, C. R. & Lindberg, G. 1955 The influence of adjacent structures upon the shape of the neural tube and neural plate of chick embryos. Anat. Rec. 122, 539-559. (doi:10.1002/ar. 1091220405)
    • (1955) Anat. Rec , vol.122 , pp. 539-559
    • Watterson, R.L.1    Goodheart, C.R.2    Lindberg, G.3
  • 116
    • 0031043087 scopus 로고    scopus 로고
    • The Xenopus homolog of Drosophila suppressor of hairless mediates Notch signaling during primary neurogenesis
    • Wettstein, D. A., Turner, D. L. & Kintner, C. 1997 The Xenopus homolog of Drosophila suppressor of hairless mediates Notch signaling during primary neurogenesis. Development 124, 693-702.
    • (1997) Development , vol.124 , pp. 693-702
    • Wettstein, D.A.1    Turner, D.L.2    Kintner, C.3
  • 117
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • doi:10.1016/S0092-8674(02)00835-8
    • Wichterle, H., Lieberam, I., Porter, J. A. & Jessell, T. M. 2002 Directed differentiation of embryonic stem cells into motor neurons. Cell 110, 385-397. (doi:10.1016/S0092-8674(02)00835-8)
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 118
    • 0037111827 scopus 로고    scopus 로고
    • A direct requirement for hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    • doi:10.1101/gad.1025702
    • Wijgerde, M., McMahon, J. A., Rule, M. & McMahon, A. P. 2002 A direct requirement for hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16, 2849-2864. (doi:10.1101/gad.1025702)
    • (2002) Genes Dev , vol.16 , pp. 2849-2864
    • Wijgerde, M.1    McMahon, J.A.2    Rule, M.3    McMahon, A.P.4
  • 119
    • 20344380662 scopus 로고    scopus 로고
    • The mechanisms of dorsoventral patterning in the vertebrate neural tube
    • doi:10.1016/j.ydbio.2005.02.027
    • Wilson, L. & Maden, M. 2005 The mechanisms of dorsoventral patterning in the vertebrate neural tube. Dev. Biol. 282, 1-13. (doi:10.1016/j.ydbio.2005.02.027)
    • (2005) Dev. Biol , vol.282 , pp. 1-13
    • Wilson, L.1    Maden, M.2
  • 120
    • 0034175873 scopus 로고    scopus 로고
    • An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo
    • doi:10.1016/S0960-9822(00)00431-0
    • Wilson, S. I., Graziano, E., Harland, R., Jessell, T. M. & Edlund, T. 2000 An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo. Curr. Biol. 10, 421-429. (doi:10.1016/S0960-9822(00)00431-0)
    • (2000) Curr. Biol , vol.10 , pp. 421-429
    • Wilson, S.I.1    Graziano, E.2    Harland, R.3    Jessell, T.M.4    Edlund, T.5
  • 121
    • 0035902074 scopus 로고    scopus 로고
    • The status of Wnt signalling regulates neural and epidermal fates in the chick embryo
    • doi:10.1038/35077115
    • Wilson, S. I., Rydstrom, A., Trimborn, T., Willert, K., Nusse, R., Jessell, T. M. & Edlund, T. 2001 The status of Wnt signalling regulates neural and epidermal fates in the chick embryo. Nature 411, 325-330. (doi:10.1038/35077115)
    • (2001) Nature , vol.411 , pp. 325-330
    • Wilson, S.I.1    Rydstrom, A.2    Trimborn, T.3    Willert, K.4    Nusse, R.5    Jessell, T.M.6    Edlund, T.7
  • 122
    • 1942489385 scopus 로고    scopus 로고
    • Retinoic acid and the control of dorsoventral patterning in the avian spinal cord
    • doi:10.1016/j.ydbio.2004.01.034
    • Wilson, L., Gale, E., Chambers, D. & Maden, M. 2004 Retinoic acid and the control of dorsoventral patterning in the avian spinal cord. Dev. Biol. 269, 433-446. (doi:10.1016/j.ydbio.2004.01.034)
    • (2004) Dev. Biol , vol.269 , pp. 433-446
    • Wilson, L.1    Gale, E.2    Chambers, D.3    Maden, M.4
  • 123
    • 0026061044 scopus 로고
    • Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord
    • doi:10.1016/0092-8674(91)90247-V
    • Yamada, T., Placzek, M., Tanaka, H., Dodd, J. & Jessell, T. M. 1991 Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64, 635-647. (doi:10.1016/0092-8674(91)90247-V)
    • (1991) Cell , vol.64 , pp. 635-647
    • Yamada, T.1    Placzek, M.2    Tanaka, H.3    Dodd, J.4    Jessell, T.M.5
  • 124
    • 0029079881 scopus 로고
    • Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
    • Zecca, M., Basler, K. & Struhl, G. 1995 Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.
    • (1995) Development , vol.121 , pp. 2265-2278
    • Zecca, M.1    Basler, K.2    Struhl, G.3
  • 125
    • 0035958941 scopus 로고    scopus 로고
    • Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    • doi:10.1016/S0092-8674(01)00385-3
    • Zhang, X. M., Ramalho-Santos, M. & McMahon, A. P. 2001 Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106, 781-792. (doi:10.1016/S0092-8674(01)00385-3)
    • (2001) Cell , vol.106 , pp. 781-792
    • Zhang, X.M.1    Ramalho-Santos, M.2    McMahon, A.P.3
  • 126
    • 0037023492 scopus 로고    scopus 로고
    • The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification
    • doi:10.1016/S0092-8674(02)00677-3
    • Zhou, Q. & Anderson, D. J. 2002 The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109, 61-73. (doi:10.1016/S0092-8674(02)00677-3)
    • (2002) Cell , vol.109 , pp. 61-73
    • Zhou, Q.1    Anderson, D.J.2
  • 127
    • 0033764232 scopus 로고    scopus 로고
    • Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
    • doi:10.1016/S0896-6273(00)80898-3
    • Zhou, Q., Wang, S. & Anderson, D. J. 2000 Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25, 331-343. (doi:10.1016/S0896-6273(00)80898-3)
    • (2000) Neuron , vol.25 , pp. 331-343
    • Zhou, Q.1    Wang, S.2    Anderson, D.J.3
  • 128
    • 0035855787 scopus 로고    scopus 로고
    • The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2
    • doi:10.1016/S0896-6273(01)00414-7
    • Zhou, Q., Choi, G. & Anderson, D. J. 2001 The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 31, 791-807. (doi:10.1016/S0896-6273(01)00414-7)
    • (2001) Neuron , vol.31 , pp. 791-807
    • Zhou, Q.1    Choi, G.2    Anderson, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.