The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

Nature Neuroscience

Volumn 3, Issue 1, 2000, Pages 41-46

  Hynes, Mary ^a   Ye, Weilan ^a   Wang, Kevin ^a   Stone, Donna ^a   Murone, Maximilien ^a   De Sauvage, Frederic ^a   Rosenthal, Arnon ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN; MEMBRANE RECEPTOR; NETRIN; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ARTICLE; CELL FATE; DOPAMINERGIC NERVE CELL; EMBRYO; GENE ACTIVATION; GENE ACTIVITY; GENE REPRESSION; MITOGENESIS; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SEROTONINERGIC NERVE CELL; SIGNAL TRANSDUCTION; VENTRAL ROOT;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, DIFFERENTIATION; BODY PATTERNING; BRAIN; CHICK EMBRYO; EMBRYO; EMBRYONIC INDUCTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEDGEHOG PROTEINS; INTERNEURONS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; NEURAL CREST; PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SPINAL CORD; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0033993990     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/71114     Document Type: Article

References (50)

1. Belloni, E. et al. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat. Genet. 14, 353-356 (1996).
2. Roessler, E. et al. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat. Genet. 14, 357-360 (1996).
3. Chiang, C. et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 382, 407-413 (1996).
4. Tanabe, Y. & Jessell, T. M. Diversity and pattern in the developing spinal cord. Science 274, 1115-1123 (1996).
5. Hynes, M. et al. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26 (1997).
6. Ericson, J. et al. Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell 81, 747-756 (1995).
7. Ericson, J. et al. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90, 169-180 (1997).
8. Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. & Scott, M. P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10, 301-312 (1996).
9. Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424 (1994).
10. Kennedy, T. E., Serafini, T., de la Torre, J. R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425-435 (1994).
11. Yamada, T., Placzek, M., Tanaka, H., Dodd, J. & Jessell, T. M. Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64, 635-647 (1991).
12. Hynes, M. et al. Induction of midbrain dopaminergic neurons by Sonic Hedgehog. Neuron 80, 95-101 (1995).
13. Wang, M. Z. et al. Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat. Med. 1, 1184-1188 (1995).
14. Marigo, V., Johnson, R. L., Vortkamp, A. & Tabin, C. J. Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development. Dev. Biol. 180, 273-283 (1996).
15. Stone, D. M. et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134 (1996).
16. Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. & Hooper, J. E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232 (1996).
17. van den Heuvel, M. & Ingham, P. W. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382, 547-551 (1996).
18. Ingham, P. W., Taylor, A. M. & Nakano, Y. Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187 (1991).
19. Goodrich, L. V., Milenkovic, K. M., Higgins, L. & Scott, M. P. Altered cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113 (1997).
20. Chen, Y. & Struhl, G. In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125, 4943-4948 (1998).
21. Johnson, R. L. et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671 (1996).
22. Xie, J. et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391, 90-92 (1998).
23. Chen, Y. & Struhl, G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 87, 553-563 (1996).
24. Johnson, R. L., Grenier, J. K. & Scott, M. P. Patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121, 4161-4170 (1995).
25. Yang, Y. et al. Relationship between dose, distance and time in Sonic Hedgehogmediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404 (1997).
26. Perrimon, N. Hedgehog and beyond. Cell 80, 517-520 (1995).
27. Struhl, G., Barbash, D. A. & Lawrence, P. A. Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila. Development 124, 2155-2165 (1997).
28. Heemskerk, J. & DiNardo, S. Drosophila hedgehog acts as a morphogen in cellular patterning. Cell 76, 449-460 (1994).
29. Roelink, H. et al. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455 (1995).
30. Sasaki, H. & Hogan, B. L. M. HNF-3β as a regulator of floor plate development. Cell 76, 103-115 (1994).
31. Murone, M., Rosenthal, A. & de Sauvage, F. J. Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 9, 76-84 (1999).
32. Echelard, Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430 (1993).
33. Davis, C. A. & Joyner, A. L. Expression patterns of the homeobox containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev. 2, 1736-1744 (1988).
34. Davis, C. A., Noble-Topham, S. E., Rossant, J. & Joyner, A. L. Expression patterns of the homeobox containing gene en-2 delineates a specific region in the developing mouse brain. Genes Dev. 2, 361-371 (1988).
35. Tremblay, P., Pituello, F. & Gruss, P. Inhibition of floor plate differentiation by pax3: evidence from ectopic expression in transgenic mice. Development 122, 2555-2567 (1996).
36. Winslow, J. W. et al. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron 14, 973-981 (1995).
37. Ruiz i Altaba, A. Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-2212 (1998).
38. Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. & Tabin, C. J. Biochemical evidence that Patched is the Hedgehog receptor. Nature 384, 176-179 (1996).
39. Marigo, V., Scott, M. P., Johnson, R. L., Goodrich, L. V. & Tabin, C. J. Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233 (1996).
40. Roelink, H. et al. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775 (1994)
41. Krauss, S., Concordet, J.-P. & Ingham, P. W. A functionally conserved homolog of the drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444 (1993).
42. Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. Sonic hedgehog mediates the polarizing activity of the limb. Cell 75, 1401-1416 (1993).
43. Hynes, M., Poulsen, K., Tessier-Lavigne, M. & Rosenthal, A. Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons. Cell 80, 95-101 (1995).
44. Ye, W., Shimamura, K., Rubenstein, J. L. R., Hynes, M. A. & Rosenthal, A. FGF8 and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766 (1998).
45. Specht, L. A., Pickel, V. M., Joh, T. H. & Reis, D. J. Light-microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny. J. Comp. Neurol. 199, 255-276 (1981).
46. Parent, A. in Serotonin Neurotransmission and Behavior (eds. Jacobs, B. L. & Gelperin, A.) 3-34 (MIT Press, Cambridge, Massachusetts, 1981).
47. Pfaff, S. & Kintner, C. Neuronal diversification: development of motor neuron subtypes. Curr. Opin. Neurobiol. 8, 27-36 (1998).
48. Tsuchida, T. et al. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79, 957-970 (1994).
49. Thaler, J. et al. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron 23, 659-674 (1999).
50. Sasaki, H., Hui, C.-C., Nakafuku, M. & Kondoh, H. A binding site of Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322 (1997).